🔗 Main protease

Articles (44)

• An efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS-Cov Mpro) inhibitors

  👤 Al-Gharabli, Samer I. 👤 Ali Shah, Syed T. 👤 Weik, Steffen 👤 Schmidt, Marco F. 👤 Mesters, Jeroen R. 👤 Kuhn, Daniel 👤 Klebe, Gerhard 👤 Hilgenfeld, Rolf 👤 Rademann, Jörg ⏰ 2006 📚 ChemBioChem

• Development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3CLpro

  👤 Bacha, Usman 👤 Barrila, Jennifer 👤 Gabelli, Sandra B. 👤 Kiso, Yoshiaki 👤 Mario Amzel, L. 👤 Freire, Ernesto ⏰ 2008 📚 Chemical Biology and Drug Design

• Identification of Novel Inhibitors of the SARS Coronavirus Main Protease 3CLpro

  👤 Bacha, Usman 👤 Barrila, Jennifer 👤 Velazquez-Campoy, Adrian 👤 Leavitt, Stephanie A. 👤 Freire, Ernesto ⏰ 2004 📚 Biochemistry

• The search for a structural basis for therapeutic intervention against the SARS coronavirus

  👤 Bartlam, Mark 👤 Xue, Xiaoyu 👤 Rao, Zihe ⏰ 2008 📚 Acta Crystallographica Section A: Foundations of Crystallography

• Structural insights into SARS coronavirus proteins

  👤 Bartlam, Mark 👤 Yang, Haitao 👤 Rao, Zihe ⏰ 2005 📚 Current Opinion in Structural Biology

• Reversible unfolding of the severe acute respiratory syndrome coronavirus main protease in guanidinium chloride

  👤 Chang, Hui Ping 👤 Chou, Chi Yuan 👤 Chang, Gu Gang ⏰ 2007 📚 Biophysical Journal

• Mutation of glu-166 blocks the substrate-induced dimerization of SARS coronavirus main protease

  👤 Cheng, Shu Chun 👤 Chang, Gu Gang 👤 Chou, Chi Yuan ⏰ 2010 📚 Biophysical Journal

• Quaternary structure of the severe acute respiratory syndrome (SARS) coronavirus main protease

  👤 Chou, Chi Yuan 👤 Chang, Hui Chuan 👤 Hsu, Wen Chi 👤 Lin, Tien Zheng 👤 Lin, Chao Hsiung 👤 Chang, Gu Gang ⏰ 2004 📚 Biochemistry

• Inhibitor design for SARS coronavirus main protease based on "distorted key theory"

  👤 Du, Qi Shi 👤 Sun, Hao 👤 Chou, Kuo Chen ⏰ 2007 📚 Medicinal Chemistry

• Coronaviruses and their therapy

  👤 Haagmans, Bart L. 👤 Osterhaus, Albert D.M.E. ⏰ 2006 📚 Antiviral Research

• Development of a red-shifted fluorescence-based assay for SARS-coronavirus 3CL protease: Identification of a novel class of anti-SARS agents from the tropical marine sponge Axinella corrugata

  👤 Hamill, Pamela 👤 Hudson, Derek 👤 Kao, Richard Y. 👤 Chow, Polly 👤 Raj, Meera 👤 Xu, Hongyan 👤 Richer, Martin J. 👤 Jean, François ⏰ 2006 📚 Biological Chemistry

• From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design

  👤 Hilgenfeld, Rolf ⏰ 2014 📚 The FEBS journal

• Critical assessment of the important residues involved in the dimerization and catalysis of MERS Coronavirus Main Protease

  👤 Ho, Bo Lin 👤 Cheng, Shu Chun 👤 Shi, Lin 👤 Wang, Ting Yun 👤 Ho, Kuan I. 👤 Chou, Chi Yuan ⏰ 2015 📚 PLoS ONE

• Critical assessment of important regions in the subunit association and catalytic action of the severe acute respiratory syndrome coronavirus main protease

  👤 Hsu, Wen Chi 👤 Chang, Hui Chuan 👤 Chou, Chi Yuan 👤 Tsai, Pui Jen 👤 Lin, Pei In 👤 Chang, Gu Gang ⏰ 2005 📚 Journal of Biological Chemistry

• Discovery, synthesis, and structure-based optimization of a series of N -(tert -Butyl)-2-(N -arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease

  👤 Jacobs, Jon 👤 Grum-Tokars, Valerie 👤 Zhou, Ya 👤 Turlington, Mark 👤 Saldanha, S. Adrian 👤 Chase, Peter 👤 Eggler, Aimee 👤 Dawson, Eric S. 👤 Baez-Santos, Yahira M. 👤 Tomar, Sakshi 👤 Mielech, Anna M. 👤 Baker, Susan C. 👤 Lindsley, Craig W. 👤 Hodder, Peter 👤 Mesecar, Andrew 👤 Stauffer, Shaun R. ⏰ 2013 📚 Journal of Medicinal Chemistry

• Structure of M(pro) from COVID-19 virus and discovery of its inhibitors.

  👤 Jin, Zhenming 👤 Du, Xiaoyu 👤 Xu, Yechun 👤 Deng, Yongqiang 👤 Liu, Meiqin 👤 Zhao, Yao 👤 Zhang, Bing 👤 Li, Xiaofeng 👤 Zhang, Leike 👤 Peng, Chao 👤 Duan, Yinkai 👤 Yu, Jing 👤 Wang, Lin 👤 Yang, Kailin 👤 Liu, Fengjiang 👤 Jiang, Rendi 👤 Yang, Xinglou 👤 You, Tian 👤 Liu, Xiaoce 👤 Yang, Xiuna 👤 Bai, Fang 👤 Liu, Hong 👤 Liu, Xiang 👤 Guddat, Luke W 👤 Xu, Wenqing 👤 Xiao, Gengfu 👤 Qin, Chengfeng 👤 Shi, Zhengli 👤 Jiang, Hualiang 👤 Rao, Zihe 👤 Yang, Haitao ⏰ 2020 📚 Nature

• A new lead for nonpeptidic active-site-directed inhibitors of the severe acute respiratory syndrome coronavirus main protease discovered by a combination of screening and docking methods

  👤 Kaeppler, Ulrich 👤 Stiefl, Nikolaus 👤 Schiller, Markus 👤 Vicik, Radim 👤 Breuning, Alexander 👤 Schmitz, Werner 👤 Rupprecht, Daniel 👤 Schmuck, Carsten 👤 Baumann, Knut 👤 Ziebuhr, John 👤 Schirmeister, Tanja ⏰ 2005 📚 Journal of Medicinal Chemistry

• Virtual screening and repurposing of FDA approved drugs against COVID-19 main protease.

  👤 Kandeel, Mahmoud 👤 Al-Nazawi, Mohammed ⏰ 2020 📚 Life Sci

• From SARS and MERS CoVs to SARS-CoV-2: Moving toward more biased codon usage in viral structural and nonstructural genes.

  👤 Kandeel, Mahmoud 👤 Ibrahim, Abdelazim 👤 Fayez, Mahmoud 👤 Al-Nazawi, Mohammed ⏰ 2020 📚 J Med Virol

• Identification of novel small-molecule inhibitors of severe acute respiratory syndrome-associated coronavirus by chemical genetics

  👤 Kao, Richard Y. 👤 Tsui, Wayne H.W. 👤 Lee, Terri S.W. 👤 Tanner, Julian A. 👤 Watt, Rory M. 👤 Huang, Jian Dong 👤 Hu, Lihong 👤 Chen, Guanhua 👤 Chen, Zhiwei 👤 Zhang, Linqi 👤 He, Tian 👤 Chan, Kwok Hung 👤 Tse, Herman 👤 To, Amanda P.C. 👤 Ng, Louisa W.Y. 👤 Wong, Bonnie C.W. 👤 Tsoi, Hoi Wah 👤 Yang, Dan 👤 Ho, David D. 👤 Yuen, Kwok Yung ⏰ 2004 📚 Chemistry and Biology

• Potent inhibition of feline coronaviruses with peptidyl compounds targeting coronavirus 3C-like protease

  👤 Kim, Yunjeong 👤 Mandadapu, Sivakoteswara Rao 👤 Groutas, William C. 👤 Chang, Kyeong Ok ⏰ 2013 📚 Antiviral Research

• Characterization and inhibition of SARS-coronavirus main protease

  👤 Liang, Po Huang ⏰ 2006 📚 Current Topics in Medicinal Chemistry

• Potential covalent drugs targeting the main protease of the SARS-CoV-2 coronavirus.

  👤 Liu, Sen 👤 Zheng, Qiang 👤 Wang, Zhiying ⏰ 2020 📚 Bioinformatics

• Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease

  👤 Lu, I. Lin 👤 Mahindroo, Neeraj 👤 Liang, Po Huang 👤 Peng, Yi Hui 👤 Kuo, Chih Jung 👤 Tsai, Keng Chang 👤 Hsieh, Hsing Pang 👤 Chao, Yu Sheng 👤 Wu, Su Ying ⏰ 2006 📚 Journal of Medicinal Chemistry

• Autoprocessing mechanism of severe acute respiratory syndrome coronavirus 3C-like protease (SARS-CoV 3CLpro) from its polyproteins

  👤 Muramatsu, Tomonari 👤 Kim, Yong Tae 👤 Nishii, Wataru 👤 Terada, Takaho 👤 Shirouzu, Mikako 👤 Yokoyama, Shigeyuki ⏰ 2013 📚 FEBS Journal

• Unrevealing sequence and structural features of novel coronavirus using in silico approaches: The main protease as molecular target.

  👤 Ortega, Joseph Thomas 👤 Serrano, Maria Luisa 👤 Pujol, Flor Helene 👤 Rangel, Hector Rafael ⏰ 2020 📚 EXCLI J

• Genetic screen for monitoring severe acute respiratory syndrome coronavirus 3C-like protease

  👤 Parera, Mariona 👤 Clotet, Bonaventura 👤 Martinez, Miguel Angel ⏰ 2004 📚 Journal of Virology

• Potential therapies for coronaviruses

  👤 Savarino, Andrea 👤 Bounavoglia, Canio 👤 Norelli, Sandro 👤 Di Trani, Livia 👤 Cassone, Antonio ⏰ 2006 📚 Expert Opinion on Therapeutic Patents

• Evaluation of homology modeling of the severe acute respiratory syndrome (SARS) coronavirus main protease for structure based drug design

  👤 Takeda-Shitaka, Mayuko 👤 Nojima, Hiroyuki 👤 Takaya, Daisuke 👤 Kanou, Kazuhiko 👤 Iwadate, Mitsuo 👤 Umeyama, Hideaki ⏰ 2004 📚 Chemical and Pharmaceutical Bulletin

• Rapid Identification of Potential Inhibitors of SARS-CoV-2 Main Protease by Deep Docking of 1.3 Billion Compounds.

  👤 Ton, Anh-Tien 👤 Gentile, Francesco 👤 Hsing, Michael 👤 Ban, Fuqiang 👤 Cherkasov, Artem ⏰ 2020 📚 Mol Inform

• Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design

  👤 Wang, Fenghua 👤 Chen, Cheng 👤 Tan, Wenjie 👤 Yang, Kailin 👤 Yang, Haitao ⏰ 2016 📚 Scientific Reports

• Crystallization and preliminary crystallographic study of human coronavirus NL63 main protease in complex with an inhibitor

  👤 Wang, Fenghua 👤 Tan, Yusheng 👤 Li, Huiyan 👤 Chen, Xia 👤 Wang, Jinshan 👤 Li, Shuang 👤 Fu, Sheng 👤 Zhao, Qi 👤 Chen, Cheng 👤 Su, Dan 👤 Yang, Haitao ⏰ 2014 📚 Acta Crystallographica Section F:Structural Biology Communications

• Recent progress in the discovery of inhibitors targeting coronavirus proteases

  👤 Wang, Haofeng 👤 Xue, Song 👤 Yang, Haitao 👤 Chen, Cheng ⏰ 2016 📚 Virologica Sinica

• Structural and biochemical characterization of SADS-CoV papain-like protease 2.

  👤 Wang, Lu 👤 Hu, Weihua 👤 Fan, Chengpeng ⏰ 2020 📚 Protein Sci

• Mechanism for controlling the monomer-dimer conversion of SARS coronavirus main protease

  👤 Wu, Cheng Guo 👤 Cheng, Shu Chun 👤 Chen, Shiang Chuan 👤 Li, Juo Yan 👤 Fang, Yi Hsuan 👤 Chen, Yau Hung 👤 Chou, Chi Yuan ⏰ 2013 📚 Acta Crystallographica Section D: Biological Crystallography

• Structures of two coronavirus main proteases: Implications for substrate binding and antiviral drug design

  👤 Xue, Xiaoyu 👤 Yu, Hongwei 👤 Yang, Haitao 👤 Xue, Fei 👤 Wu, Zhixin 👤 Shen, Wei 👤 Li, Jun 👤 Zhou, Zhe 👤 Ding, Yi 👤 Zhao, Qi 👤 Zhang, Xuejun C. 👤 Liao, Ming 👤 Bartlam, Mark 👤 Rao, Zihe ⏰ 2008 📚 Journal of Virology

• Drug design targeting the main protease, the Achilles' heel of coronaviruses

  👤 Yang, Haitao 👤 Bartlam, Mark 👤 Rao, Zihe ⏰ 2006 📚 Current Pharmaceutical Design

• Design of wide-spectrum inhibitors targeting coronavirus main proteases

  👤 Yang, Haitao 👤 Xie, Weiqing 👤 Xue, Xiaoyu 👤 Yang, Kailin 👤 Ma, Jing 👤 Liang, Wenxue 👤 Zhao, Qi 👤 Zhou, Zhe 👤 Pei, Duanqing 👤 Ziebuhr, John 👤 Hilgenfeld, Rolf 👤 Kwok, Yung Yuen 👤 Wong, Luet 👤 Gao, Guangxia 👤 Chen, Saijuan 👤 Chen, Zhu 👤 Ma, Dawei 👤 Bartlam, Mark 👤 Rao, Zihe ⏰ 2005 📚 PLoS Biology

• Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved alpha-ketoamide inhibitors.

  👤 Zhang, Linlin 👤 Lin, Daizong 👤 Sun, Xinyuanyuan 👤 Curth, Ute 👤 Drosten, Christian 👤 Sauerhering, Lucie 👤 Becker, Stephan 👤 Rox, Katharina 👤 Hilgenfeld, Rolf ⏰ 2020 📚 Science

• Structure of the main protease from a global infectious human coronavirus, HCoV-HKU1

  👤 Zhao, Qi 👤 Li, Shuang 👤 Xue, Fei 👤 Zou, Yilong 👤 Chen, Cheng 👤 Bartlam, Mark 👤 Rao, Zihe ⏰ 2008 📚 Journal of Virology

• Without its N-finger, the main protease of severe acute respiratory syndrome coronavirus can form a novel dimer through its C-terminal domain

  👤 Zhong, Nan 👤 Zhang, Shengnan 👤 Zou, Peng 👤 Chen, Jiaxuan 👤 Kang, Xue 👤 Li, Zhe 👤 Liang, Chao 👤 Jin, Changwen 👤 Xia, Bin ⏰ 2008 📚 Journal of Virology

• Identification of novel proteolytically inactive mutations in coronavirus 3C-like protease using a combined approach

  👤 Zhou, Junwei 👤 Fang, Liurong 👤 Yang, Zhixiang 👤 Xu, Shangen 👤 Lv, Mengting 👤 Sun, Zheng 👤 Chen, Jiyao 👤 Wang, Dang 👤 Gao, Jun 👤 Xiao, Shaobo ⏰ 2019 📚 FASEB journal : official publication of the Federation of American Societies for Experimental Biology

• Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease

  👤 Zhu, Lili 👤 George, Shyla 👤 Schmidt, Marco F. 👤 Al-Gharabli, Samer I. 👤 Rademann, Jörg 👤 Hilgenfeld, Rolf ⏰ 2011 📚 Antiviral Research

• Human coronavirus 229E papain-like proteases have overlapping specificities but distinct functions in viral replication

  👤 Ziebuhr, John 👤 Schelle, Barbara 👤 Karl, Nadja 👤 Minskaia, Ekaterina 👤 Bayer, Sonja 👤 Siddell, Stuart G. 👤 Gorbalenya, Alexander E. 👤 Thiel, Volker ⏰ 2007 📚 Journal of Virology