👤 Mesecar, Andrew D.

Keywords

Articles (22)

• Computational modeling of the bat HKU4 coronavirus 3CLpro inhibitors as a tool for the development of antivirals against the emerging Middle East respiratory syndrome (MERS) coronavirus

  👤 Abuhammad, Areej 👤 Al-Aqtash, Rua'a A. 👤 Anson, Brandon J. 👤 Mesecar, Andrew D. 👤 Taha, Mutasem O. ⏰ 2017 📚 Journal of Molecular Recognition

• The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity

  👤 Barretto, Naina 👤 Jukneliene, Dalia 👤 Ratia, Kiira 👤 Chen, Zhongbin 👤 Mesecar, Andrew D. 👤 Baker, Susan C. ⏰ 2005 📚 Journal of Virology

• X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases

  👤 Báez-Santos, Yahira M. 👤 Barraza, Scott J. 👤 Wilson, Michael W. 👤 Agius, Michael P. 👤 Mielech, Anna M. 👤 Davis, Nicole M. 👤 Baker, Susan C. 👤 Larsen, Scott D. 👤 Mesecar, Andrew D. ⏰ 2014 📚 Journal of Medicinal Chemistry

• Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the middle east respiratory syndrome coronavirus

  👤 Báez-Santos, Yahira M. 👤 Mielech, Anna M. 👤 Deng, Xufang 👤 Baker, Susan 👤 Mesecar, Andrew D. ⏰ 2014 📚 Journal of Virology

• The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds

  👤 Báez-Santos, Yahira M. 👤 St. John, Sarah E. 👤 Mesecar, Andrew D. ⏰ 2015 📚 Antiviral Research

• Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63

  👤 Chen, Zhongbin 👤 Wang, Yanhua 👤 Ratia, Kiira 👤 Mesecar, Andrew D. 👤 Wilkinson, Keith D. 👤 Baker, Susan C. ⏰ 2007 📚 Journal of Virology

• X-ray structure and enzymatic activity profile of a core papain-like protease of MERS coronavirus with utility for structure-based drug design

  👤 Clasman, Jozlyn R. 👤 Bez-Santos, Yahira M. 👤 Mettelman, Robert C. 👤 O'Brien, Amornrat 👤 Baker, Susan C. 👤 Mesecar, Andrew D. ⏰ 2017 📚 Scientific Reports

• Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases

  👤 Clementz, Mark A. 👤 Chen, Zhongbin 👤 Banach, Bridget S. 👤 Wang, Yanhua 👤 Sun, Li 👤 Ratia, Kiira 👤 Baez-Santos, Yahira M. 👤 Wang, Jie 👤 Takayama, Jun 👤 Ghosh, Arun K. 👤 Li, Kui 👤 Mesecar, Andrew D. 👤 Baker, Susan C. ⏰ 2010 📚 Journal of Virology

• Structural Insights into the Interaction of Coronavirus Papain-Like Proteases and Interferon-Stimulated Gene Product 15 from Different Species

  👤 Daczkowski, Courtney M. 👤 Dzimianski, John V. 👤 Clasman, Jozlyn R. 👤 Goodwin, Octavia 👤 Mesecar, Andrew D. 👤 Pegan, Scott D. ⏰ 2017 📚 Journal of Molecular Biology

• A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses

  👤 Deng, Xufang 👤 Agnihothram, Sudhakar 👤 Mielech, Anna M. 👤 Nichols, Daniel B. 👤 Wilson, Michael W. 👤 St. John, Sarah E. 👤 Larsen, Scott D. 👤 Mesecar, Andrew D. 👤 Lenschow, Deborah J. 👤 Baric, Ralph S. 👤 Baker, Susan C. ⏰ 2014 📚 Journal of Virology

• Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus.

  👤 Deng, Xufang 👤 Chen, Yafang 👤 Mielech, Anna M 👤 Hackbart, Matthew 👤 Kesely, Kristina R 👤 Mettelman, Robert C 👤 O'Brien, Amornrat 👤 Chapman, Mackenzie E 👤 Mesecar, Andrew D 👤 Baker, Susan C ⏰ 2020 📚 J Virol

• Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance

  👤 Deng, Xufang 👤 St John, Sarah E. 👤 Osswald, Heather L. 👤 O'Brien, Amornrat 👤 Banach, Bridget S. 👤 Sleeman, Katrina 👤 Ghosh, Arun K. 👤 Mesecar, Andrew D. 👤 Baker, Susan C. ⏰ 2014 📚 Journal of Virology

• Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-κB signaling

  👤 Frieman, Matthew 👤 Ratia, Kiira 👤 Johnston, Robert E. 👤 Mesecar, Andrew D. 👤 Baric, Ralph S. ⏰ 2009 📚 Journal of Virology

• Structure-based design, synthesis, and biological evaluation of a series of novel and reversible inhibitors for the severe acute respiratory syndrome - Coronavirus papain-like protease

  👤 Ghosh, Arun K. 👤 Takayama, Jun 👤 Aubin, Yoann 👤 Ratia, Kiira 👤 Chaudhuri, Rima 👤 Baez, Yahira 👤 Sleeman, Katrina 👤 Coughlin, Melissa 👤 Nichols, Daniel B. 👤 Mulhearn, Debbie C. 👤 Prabhakar, Bellur S. 👤 Baker, Susan C. 👤 Johnson, Michael E. 👤 Mesecar, Andrew D. ⏰ 2009 📚 Journal of Medicinal Chemistry

• Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: Design, synthesis, protein-ligand X-ray structure and biological evaluation

  👤 Ghosh, Arun K. 👤 Takayama, Jun 👤 Rao, Kalapala Venkateswara 👤 Ratia, Kiira 👤 Chaudhuri, Rima 👤 Mulhearn, Debbie C. 👤 Lee, Hyun 👤 Nichols, Daniel B. 👤 Baliji, Surendranath 👤 Baker, Susan C. 👤 Johnson, Michael E. 👤 Mesecar, Andrew D. ⏰ 2010 📚 Journal of Medicinal Chemistry

• Evaluating the 3C-like protease activity of SARS-Coronavirus: Recommendations for standardized assays for drug discovery

  👤 Grum-Tokars, Valerie 👤 Ratia, Kiira 👤 Begaye, Adrian 👤 Baker, Susan C. 👤 Mesecar, Andrew D. ⏰ 2008 📚 Virus Research

• Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis

  👤 Mielech, Anna M. 👤 Deng, Xufang 👤 Chen, Yafang 👤 Kindler, Eveline 👤 Wheeler, Dorthea L. 👤 Mesecar, Andrew D. 👤 Thiel, Volker 👤 Perlman, Stanley 👤 Baker, Susan C. ⏰ 2015 📚 Journal of Virology

• Severe acute respiratory syndrome coronavirus papain-like-protease: Structure of a viral deubiquitinating enzyme

  👤 Ratia, Kiira 👤 Saikatendu, Kumar Singh 👤 Santarsiero, Bernard D. 👤 Barreto, Naina 👤 Baker, Susan C. 👤 Stevens, Raymond C. 👤 Mesecar, Andrew D. ⏰ 2006 📚 Proceedings of the National Academy of Sciences of the United States of America

• Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4 - The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)

  👤 St. John, Sarah E. 👤 Tomar, Sakshi 👤 Stauffer, Shaun R. 👤 Mesecar, Andrew D. ⏰ 2015 📚 Bioorganic and Medicinal Chemistry

• Chimeric exchange of coronavirus nsp5 proteases (3CLpro) identifies common and divergent regulatory determinants of protease activity

  👤 Stobart, Christopher C. 👤 Sexton, Nicole R. 👤 Munjal, Havisha 👤 Lu, Xiaotao 👤 Molland, Katrina L. 👤 Tomar, Sakshi 👤 Mesecar, Andrew D. 👤 Denison, Mark R. ⏰ 2013 📚 Journal of Virology

• Ligand-induced dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 protease (3CLpro): Implications for nsp5 regulation and the development of antivirals

  👤 Tomar, Sakshi 👤 Johnston, Melanie L. 👤 John, Sarah E.St 👤 Osswald, Heather L. 👤 Nyalapatla, Prasanth R. 👤 Paul, Lake N. 👤 Ghosh, Arun K. 👤 Denison, Mark R. 👤 Mesecar, Andrew D. ⏰ 2015 📚 Journal of Biological Chemistry

• Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding

  👤 Turlington, Mark 👤 Chun, Aspen 👤 Tomar, Sakshi 👤 Eggler, Aimee 👤 Grum-Tokars, Valerie 👤 Jacobs, Jon 👤 Daniels, J. Scott 👤 Dawson, Eric 👤 Saldanha, Adrian 👤 Chase, Peter 👤 Baez-Santos, Yahira M. 👤 Lindsley, Craig W. 👤 Hodder, Peter 👤 Mesecar, Andrew D. 👤 Stauffer, Shaun R. ⏰ 2013 📚 Bioorganic and Medicinal Chemistry Letters