mettelman-robert-c

Keywords

🔗 papain-like protease (67) 🔗 drug design (36) 🔗 amino acid (454) 🔗 innate immune (105) 🔗 statistically significant (37) 🔗 immune response (314) 🔗 murine coronavirus (140) 🔗 viral replication (258) 🔗 bone marrow (31) 🔗 infected cells (307) 🔗 reverse genetics (49) 🔗 hepatitis virus (437) 🔗 mouse hepatitis (371) 🔗 epithelial cells (128)

Articles (5)

X-ray structure and enzymatic activity profile of a core papain-like protease of MERS coronavirus with utility for structure-based drug design
👤 Clasman, Jozlyn R. 👤 Bez-Santos, Yahira M. 👤 Mettelman, Robert C. 👤 O'Brien, Amornrat 👤 Baker, Susan C. 👤 Mesecar, Andrew D. ⏰ 2017 📚 Scientific Reports
Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus.
👤 Deng, Xufang 👤 Chen, Yafang 👤 Mielech, Anna M 👤 Hackbart, Matthew 👤 Kesely, Kristina R 👤 Mettelman, Robert C 👤 O'Brien, Amornrat 👤 Chapman, Mackenzie E 👤 Mesecar, Andrew D 👤 Baker, Susan C ⏰ 2020 📚 J Virol
Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages
👤 Deng, Xufang 👤 Hackbart, Matthew 👤 Mettelman, Robert C. 👤 O'Brien, Amornrat 👤 Mielech, Anna M. 👤 Yi, Guanghui 👤 Kao, C. Cheng 👤 Baker, Susan C. ⏰ 2017 📚 Proceedings of the National Academy of Sciences of the United States of America
Analysis of coronavirus temperature-sensitive mutants reveals an interplay between the macrodomain and Papain-like protease impacting replication and pathogenesis
👤 Deng, Xufang 👤 Mettelman, Robert C. 👤 O'Brien, Amornrat 👤 Thompson, John A. 👤 O'Brien, Timothy E. 👤 Baker, Susan C. ⏰ 2019 📚 Journal of Virology
The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species
👤 Niemeyer, Daniela 👤 Mösbauer, Kirstin 👤 Klein, Eva M. 👤 Sieberg, Andrea 👤 Mettelman, Robert C. 👤 Mielech, Anna M. 👤 Dijkman, Ronald 👤 Baker, Susan C. 👤 Drosten, Christian 👤 Müller, Marcel A. ⏰ 2018 📚 PLoS Pathogens