🔗 Crystal structure

Articles (114)

• Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra α-helical domain

  👤 Anand, Kanchan 👤 Palm, Gottfried J. 👤 Mesters, Jeroen R. 👤 Siddell, Stuart G. 👤 Ziebuhr, John 👤 Hilgenfeld, Rolf ⏰ 2002 📚 EMBO Journal

• Coronavirus main proteinase (3CLpro) Structure: Basis for design of anti-SARS drugs

  👤 Anand, Kanchan 👤 Ziebuhr, John 👤 Wadhwani, Parvesh 👤 Mesters, Jeroen R. 👤 Hilgenfeld, Rolf ⏰ 2003 📚 Science

• In situ tagged nsp15 reveals interactions with coronavirus replication/transcription complex associated proteins

  👤 Athmer, Jeremiah 👤 Fehr, Anthony R. 👤 Grunewald, Matthew 👤 Smith, Everett Clinton 👤 Denison, Mark R. 👤 Perlman, Stanley ⏰ 2017 📚 mBio

• Development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3CLpro

  👤 Bacha, Usman 👤 Barrila, Jennifer 👤 Gabelli, Sandra B. 👤 Kiso, Yoshiaki 👤 Mario Amzel, L. 👤 Freire, Ernesto ⏰ 2008 📚 Chemical Biology and Drug Design

• Crystal structure of the middle east respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression

  👤 Bailey-Elkin, Ben A. 👤 Knaap, Robert C.M. 👤 Johnson, Garrett G. 👤 Dalebout, Tim J. 👤 Ninaber, Dennis K. 👤 Van Kasteren, Puck B. 👤 Bredenbeek, Peter J. 👤 Snijder, Eric J. 👤 Kikkert, Marjolein 👤 Mark, Brian L. ⏰ 2014 📚 Journal of Biological Chemistry

• Coronavirus receptor switch explained from the stereochemistry of protein-carbohydrate interactions and a single mutation

  👤 Bakkers, Mark J.G. 👤 Zeng, Qinghong 👤 Feitsma, Louris J. 👤 Hulswit, Ruben J.G. 👤 Li, Zeshi 👤 Westerbeke, Aniek 👤 Van Kuppeveld, Frank J.M. 👤 Boons, Geert Jan 👤 Langereis, Martijn A. 👤 Huizinga, Eric G. 👤 De Groot, Raoul J. ⏰ 2016 📚 Proceedings of the National Academy of Sciences of the United States of America

• X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases

  👤 Báez-Santos, Yahira M. 👤 Barraza, Scott J. 👤 Wilson, Michael W. 👤 Agius, Michael P. 👤 Mielech, Anna M. 👤 Davis, Nicole M. 👤 Baker, Susan C. 👤 Larsen, Scott D. 👤 Mesecar, Andrew D. ⏰ 2014 📚 Journal of Medicinal Chemistry

• Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease

  👤 Békés, Miklós 👤 van der Heden van Noort, Gerbrand J. 👤 Ekkebus, Reggy 👤 Ovaa, Huib 👤 Huang, Tony T. 👤 Lima, Christopher D. ⏰ 2016 📚 Molecular Cell

• Structural genomics of the SARS coronavirus: Cloning, expression, crystallization and preliminary crystallographic study of the Nsp9 protein

  👤 Campanacci, Valérie 👤 Egloff, Marie Pierre 👤 Longhi, Sonia 👤 Ferron, François 👤 Rancurel, Corinne 👤 Salomoni, Aurelia 👤 Durousseau, Cécile 👤 Tocque, Fabienne 👤 Brémond, Nicolas 👤 Dobbe, Jessika C. 👤 Snijder, Eric J. 👤 Canard, Bruno 👤 Cambillau, Christian ⏰ 2003 📚 Acta Crystallographica - Section D Biological Crystallography

• The SARS coronavirus S glycoprotein receptor binding domain: Fine mapping and functional characterization

  👤 Chakraborti, Samitabh 👤 Prabakaran, Ponraj 👤 Xiao, Xiaodong 👤 Dimitrov, Dimiter S. ⏰ 2005 📚 Virology Journal

• Structure of the SARS Coronavirus Nucleocapsid Protein RNA-binding Dimerization Domain Suggests a Mechanism for Helical Packaging of Viral RNA

  👤 Chen, Chun Yuan 👤 Chang, Chung ke 👤 Chang, Yi Wei 👤 Sue, Shih Che 👤 Bai, Hsin I. 👤 Riang, Lilianty 👤 Hsiao, Chwan Deng 👤 Huang, Tai huang ⏰ 2007 📚 Journal of Molecular Biology

• Crystal structure-based exploration of the important role of Arg106 in the RNA-binding domain of human coronavirus OC43 nucleocapsid protein

  👤 Chen, I. Jung 👤 Yuann, Jeu Ming P. 👤 Chang, Yu Ming 👤 Lin, Shing Yen 👤 Zhao, Jincun 👤 Perlman, Stanley 👤 Shen, Yo Yu 👤 Huang, Tai Huang 👤 Hou, Ming Hon ⏰ 2013 📚 Biochimica et Biophysica Acta - Proteins and Proteomics

• Mutation of Gly-11 on the dimer interface results in the complete crystallographic dimer dissociation of severe acute respiratory syndrome coronavirus 3C-like protease: Crystal structure with molecular dynamics simulations

  👤 Chen, Shuai 👤 Hu, Tiancen 👤 Zhang, Jian 👤 Chen, Jing 👤 Chen, Kaixian 👤 Ding, Jianping 👤 Jiang, Hualiang 👤 Shen, Xu ⏰ 2008 📚 Journal of Biological Chemistry

• Residues on the dimer interface of SARS coronavirus 3C-like protease: Dimer stability characterization and enzyme catalytic activity analysis

  👤 Chen, Shuai 👤 Zhang, Jian 👤 Hu, Tiancen 👤 Chen, Kaixian 👤 Jiang, Hualiang 👤 Shen, Xu ⏰ 2008 📚 Journal of Biochemistry

• Thiopurine analogue inhibitors of severe acute respiratory syndrome-coronavirus papain-like protease, a deubiquitinating and deISGylating enzyme

  👤 Chen, Xin 👤 Chou, Chi Yuan 👤 Chang, Gu Gang ⏰ 2009 📚 Antiviral Chemistry and Chemotherapy

• Crystal structure of the receptor-binding domain from newly emerged middle east respiratory syndrome coronavirus

  👤 Chen, Yaoqing 👤 Rajashankar, Kanagalaghatta R. 👤 Yang, Yang 👤 Agnihothram, Sudhakar S. 👤 Liu, Chang 👤 Lin, Yi Lun 👤 Baric, Ralph S. 👤 Li, Fang ⏰ 2013 📚 Journal of Virology

• Biochemical and structural insights into the mechanisms of sars coronavirus RNA ribose 2′-O-methylation by nsp16/nsp10 protein complex

  👤 Chen, Yu 👤 Su, Ceyang 👤 Ke, Min 👤 Jin, Xu 👤 Xu, Lirong 👤 Zhang, Zhou 👤 Wu, Andong 👤 Sun, Ying 👤 Yang, Zhouning 👤 Tien, Po 👤 Ahola, Tero 👤 Liang, Yi 👤 Liu, Xinqi 👤 Guo, Deyin ⏰ 2011 📚 PLoS Pathogens

• Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CL (pro)) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidates.

  👤 Chen, Yu Wai 👤 Yiu, Chin-Pang Bennu 👤 Wong, Kwok-Yin ⏰ 2020 📚 F1000Res

• Mutation of glu-166 blocks the substrate-induced dimerization of SARS coronavirus main protease

  👤 Cheng, Shu Chun 👤 Chang, Gu Gang 👤 Chou, Chi Yuan ⏰ 2010 📚 Biophysical Journal

• Macro domain from middle east respiratory syndrome coronavirus (MERS-CoV) is an efficient ADP-ribose binding module: Crystal structure and biochemical studies

  👤 Cho, Chao Cheng 👤 Lin, Meng Hsuan 👤 Chuang, Chien Ying 👤 Hsu, Chun Hua ⏰ 2016 📚 Journal of Biological Chemistry

• Quaternary structure of the severe acute respiratory syndrome (SARS) coronavirus main protease

  👤 Chou, Chi Yuan 👤 Chang, Hui Chuan 👤 Hsu, Wen Chi 👤 Lin, Tien Zheng 👤 Lin, Chao Hsiung 👤 Chang, Gu Gang ⏰ 2004 📚 Biochemistry

• Structural basis for catalysis and ubiquitin recognition by the Severe acute respiratory syndrome coronavirus papain-like protease

  👤 Chou, Chi Yuan 👤 Lai, Hsing Yi 👤 Chen, Hung Yi 👤 Cheng, Shu Chun 👤 Cheng, Kai Wen 👤 Chou, Ya Wen ⏰ 2014 📚 Acta Crystallographica Section D: Biological Crystallography

• Crystallization and diffraction analysis of the SARS coronavirus nsp10-nsp16 complex

  👤 Debarnot, Claire 👤 Imbert, Isabelle 👤 Ferron, François 👤 Gluais, Laure 👤 Varlet, Isabelle 👤 Papageorgiou, Nicolas 👤 Bouvet, Mickal 👤 Lescar, Julien 👤 Decroly, Etienne 👤 Canard, Bruno ⏰ 2011 📚 Acta Crystallographica Section F: Structural Biology and Crystallization Communications

• Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2′-o-methyltransferase nsp10/nsp16 complex

  👤 Decroly, Etienne 👤 Debarnot, Claire 👤 Ferron, François 👤 Bouvet, Mickael 👤 Coutard, Bruno 👤 Imbert, Isabelle 👤 Gluais, Laure 👤 Papageorgiou, Nicolas 👤 Sharff, Andrew 👤 Bricogne, Gérard 👤 Ortiz-Lombardia, Miguel 👤 Lescar, Julien 👤 Canard, Bruno ⏰ 2011 📚 PLoS Pathogens

• A guideline for homology modeling of the proteins from newly discovered betacoronavirus, 2019 novel coronavirus (2019-nCoV).

  👤 Dong, Shengjie 👤 Sun, Jiachen 👤 Mao, Zhuo 👤 Wang, Lu 👤 Lu, Yi-Lin 👤 Li, Jiesen ⏰ 2020 📚 J Med Virol

• The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world

  👤 Egloff, Marie Pierre 👤 Ferron, François 👤 Campanacci, Valérie 👤 Longhi, Sonia 👤 Rancurel, Corinne 👤 Dutartre, Hélène 👤 Snijder, Eric J. 👤 Gorbalenya, Alexander E. 👤 Cambillau, Christian 👤 Canard, Bruno ⏰ 2004 📚 Proceedings of the National Academy of Sciences of the United States of America

• The nucleocapsid protein of coronavirus infectious bronchitis virus: Crystal structure of its N-terminal domain and multimerization properties

  👤 Fan, Hui 👤 Ooi, Amy 👤 Tan, Yong Wah 👤 Wang, Sifang 👤 Fang, Shouguo 👤 Liu, Ding Xiang 👤 Lescar, Julien ⏰ 2005 📚 Structure

• Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA

  👤 Ferron, François 👤 Subissi, Lorenzo 👤 De Morais, Ana Theresa Silveira 👤 Le, Nhung Thi Tuyet 👤 Sevajol, Marion 👤 Gluais, Laure 👤 Decroly, Etienne 👤 Vonrhein, Clemens 👤 Bricogne, Gérard 👤 Canard, Bruno 👤 Imbert, Isabelle ⏰ 2017 📚 Proceedings of the National Academy of Sciences of the United States of America

• Structure-based design, synthesis, and biological evaluation of a series of novel and reversible inhibitors for the severe acute respiratory syndrome - Coronavirus papain-like protease

  👤 Ghosh, Arun K. 👤 Takayama, Jun 👤 Aubin, Yoann 👤 Ratia, Kiira 👤 Chaudhuri, Rima 👤 Baez, Yahira 👤 Sleeman, Katrina 👤 Coughlin, Melissa 👤 Nichols, Daniel B. 👤 Mulhearn, Debbie C. 👤 Prabhakar, Bellur S. 👤 Baker, Susan C. 👤 Johnson, Michael E. 👤 Mesecar, Andrew D. ⏰ 2009 📚 Journal of Medicinal Chemistry

• Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: Design, synthesis, protein-ligand X-ray structure and biological evaluation

  👤 Ghosh, Arun K. 👤 Takayama, Jun 👤 Rao, Kalapala Venkateswara 👤 Ratia, Kiira 👤 Chaudhuri, Rima 👤 Mulhearn, Debbie C. 👤 Lee, Hyun 👤 Nichols, Daniel B. 👤 Baliji, Surendranath 👤 Baker, Susan C. 👤 Johnson, Michael E. 👤 Mesecar, Andrew D. ⏰ 2010 📚 Journal of Medicinal Chemistry

• Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS Coronavirus

  👤 Goetz, D. H. 👤 Choe, Y. 👤 Hansell, E. 👤 Chen, Y. T. 👤 McDowell, M. 👤 Jonsson, C. B. 👤 Roush, W. R. 👤 McKerrow, J. 👤 Craik, C. S. ⏰ 2007 📚 Biochemistry

• Structure of the S1 subunit C-terminal domain from bat-derived coronavirus HKU5 spike protein

  👤 Han, Xue 👤 Qi, Jianxun 👤 Song, Hao 👤 Wang, Qihui 👤 Zhang, Yanfang 👤 Wu, Ying 👤 Lu, Guangwen 👤 Yuen, Kwok Yung 👤 Shi, Yi 👤 Gao, George F. ⏰ 2017 📚 Virology

• From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design

  👤 Hilgenfeld, Rolf ⏰ 2014 📚 The FEBS journal

• Critical assessment of the important residues involved in the dimerization and catalysis of MERS Coronavirus Main Protease

  👤 Ho, Bo Lin 👤 Cheng, Shu Chun 👤 Shi, Lin 👤 Wang, Ting Yun 👤 Ho, Kuan I. 👤 Chou, Chi Yuan ⏰ 2015 📚 PLoS ONE

• Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure

  👤 Hu, Tiancen 👤 Zhang, Yu 👤 Li, Lianwei 👤 Wang, Kuifeng 👤 Chen, Shuai 👤 Chen, Jing 👤 Ding, Jianping 👤 Jiang, Hualiang 👤 Shen, Xu ⏰ 2009 📚 Virology

• Human coronaviruses OC43 and HKU1 bind to 9-O-acetylated sialic acids via a conserved receptor-binding site in spike protein domain A

  👤 Hulswit, Ruben J.G. 👤 Lang, Yifei 👤 Bakkers, Mark J.G. 👤 Li, Wentao 👤 Li, Zeshi 👤 Schouten, Arie 👤 Ophorst, Bram 👤 Van Kuppeveld, Frank J.M. 👤 Boons, Geert Jan 👤 Bosch, Berend Jan 👤 Huizinga, Eric G. 👤 De Groot, Raoul J. ⏰ 2019 📚 Proceedings of the National Academy of Sciences of the United States of America

• Structure of M(pro) from COVID-19 virus and discovery of its inhibitors.

  👤 Jin, Zhenming 👤 Du, Xiaoyu 👤 Xu, Yechun 👤 Deng, Yongqiang 👤 Liu, Meiqin 👤 Zhao, Yao 👤 Zhang, Bing 👤 Li, Xiaofeng 👤 Zhang, Leike 👤 Peng, Chao 👤 Duan, Yinkai 👤 Yu, Jing 👤 Wang, Lin 👤 Yang, Kailin 👤 Liu, Fengjiang 👤 Jiang, Rendi 👤 Yang, Xinglou 👤 You, Tian 👤 Liu, Xiaoce 👤 Yang, Xiuna 👤 Bai, Fang 👤 Liu, Hong 👤 Liu, Xiang 👤 Guddat, Luke W 👤 Xu, Wenqing 👤 Xiao, Gengfu 👤 Qin, Chengfeng 👤 Shi, Zhengli 👤 Jiang, Hualiang 👤 Rao, Zihe 👤 Yang, Haitao ⏰ 2020 📚 Nature

• Crystal structure of nonstructural protein 10 from the severe acute respiratory syndrome coronavirus reveals a novel fold with two zinc-binding motifs

  👤 Joseph, Jeremiah S. 👤 Saikatendu, Kumar Singh 👤 Subramanian, Vanitha 👤 Neuman, Benjamin W. 👤 Brooun, Alexei 👤 Griffith, Mark 👤 Moy, Kin 👤 Yadav, Maneesh K. 👤 Velasquez, Jeffrey 👤 Buchmeier, Michael J. 👤 Stevens, Raymond C. 👤 Kuhn, Peter ⏰ 2006 📚 Journal of Virology

• Virtual screening and repurposing of FDA approved drugs against COVID-19 main protease.

  👤 Kandeel, Mahmoud 👤 Al-Nazawi, Mohammed ⏰ 2020 📚 Life Sci

• Short peptides derived from the interaction domain of SARS coronavirus nonstructural protein nsp10 can suppress the 2'-O-methyltransferase activity of nsp10/nsp16 complex

  👤 Ke, Min 👤 Chen, Yu 👤 Wu, Andong 👤 Sun, Ying 👤 Su, Ceyang 👤 Wu, Hao 👤 Jin, Xu 👤 Tao, Jiali 👤 Wang, Yi 👤 Ma, Xiao 👤 Pan, Ji An 👤 Guo, Deyin ⏰ 2012 📚 Virus Research

• Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses

  👤 Kim, Yunjeong 👤 Lovell, Scott 👤 Tiew, Kok Chuan 👤 Mandadapu, Sivakoteswara Rao 👤 Alliston, Kevin R. 👤 Battaile, Kevin K. 👤 Groutas, William C. 👤 Chang, Kyeong Ok ⏰ 2012 📚 Journal of Virology

• Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor.

  👤 Lan, Jun 👤 Ge, Jiwan 👤 Yu, Jinfang 👤 Shan, Sisi 👤 Zhou, Huan 👤 Fan, Shilong 👤 Zhang, Qi 👤 Shi, Xuanling 👤 Wang, Qisheng 👤 Zhang, Linqi 👤 Wang, Xinquan ⏰ 2020 📚 Nature

• The murine coronavirus hemagglutinin-esterase receptor-binding site: A major shift in ligand specificity through modest changes in architecture

  👤 Langereis, Martijn A. 👤 Zeng, Qinghong 👤 Heesters, Balthasar 👤 Huizinga, Eric G. 👤 de Groot, Raoul J. ⏰ 2012 📚 PLoS Pathogens

• Crystal structures of the main peptidase from the SARS coronavirus inhibited by a substrate-like aza-peptide epoxide

  👤 Lee, Ting Wai 👤 Cherney, Maia M. 👤 Huitema, Carly 👤 Liu, Jie 👤 James, Karen Ellis 👤 Powers, James C. 👤 Eltis, Lindsay D. 👤 James, Michael N.G. ⏰ 2005 📚 Journal of Molecular Biology

• Crystal Structures Reveal an Induced-fit Binding of a Substrate-like Aza-peptide Epoxide to SARS Coronavirus Main Peptidase

  👤 Lee, Ting Wai 👤 Cherney, Maia M. 👤 Liu, Jie 👤 James, Karen Ellis 👤 Powers, James C. 👤 Eltis, Lindsay D. 👤 James, Michael N.G. ⏰ 2007 📚 Journal of Molecular Biology

• Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin

  👤 Lei, Jian 👤 Hilgenfeld, Rolf ⏰ 2016 📚 Virologica Sinica

• Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features

  👤 Lei, Jian 👤 Mesters, Jeroen R. 👤 Drosten, Christian 👤 Anemüller, Stefan 👤 Ma, Qingjun 👤 Hilgenfeld, Rolf ⏰ 2014 📚 Antiviral Research

• Structural analysis of major species barriers between humans and palm civets for severe acute respiratory syndrome coronavirus infections

  👤 Li, Fang ⏰ 2008 📚 Journal of Virology

• Structural biology: Structure of SARS coronavirus spike receptor-binding domain complexed with receptor

  👤 Li, Fang 👤 Li, Wenhui 👤 Farzan, Michael 👤 Harrison, Stephen C. ⏰ 2005 📚 Science

• Structural basis for the identification of the N-terminal domain of coronavirus nucleocapsid protein as an antiviral target

  👤 Lin, Shing Yen 👤 Liu, Chia Ling 👤 Chang, Yu Ming 👤 Zhao, Jincun 👤 Perlman, Stanley 👤 Hou, Ming Hon ⏰ 2014 📚 Journal of Medicinal Chemistry

• Molecular dynamics simulations of various coronavirus main proteinases

  👤 Liu, Hsuan Liang 👤 Lin, Jin Chung 👤 Ho, Yih 👤 Hsieh, Wei Chan 👤 Chen, Chin Wen 👤 Su, Yuan Chen ⏰ 2004 📚 Journal of Biomolecular Structure and Dynamics

• Novel immunodominant peptide presentation strategy: A featured HLA-A*2402-restricted cytotoxic T-lymphocyte epitope stabilized by intrachain hydrogen bonds from severe acute respiratory syndrome coronavirus nucleocapsid protein

  👤 Liu, Jun 👤 Wu, Peng 👤 Gao, Feng 👤 Qi, Jianxun 👤 Kawana-Tachikawa, Ai 👤 Xie, Jing 👤 Vavricka, Christopher J. 👤 Iwamoto, Aikichi 👤 Li, Taisheng 👤 Gao, George F. ⏰ 2010 📚 Journal of Virology

• Protective T cell responses featured by concordant recognition of middle east respiratory syndrome coronavirus-derived CD8+ T Cell Epitopes and Host MHC

  👤 Liu, William J. 👤 Lan, Jiaming 👤 Liu, Kefang 👤 Yao, Deng 👤 Yao, Yanfeng 👤 Wu, Shaolian 👤 Chen, Hong 👤 Bao, Lingling 👤 Zhang, Haifeng 👤 Zhao, Min 👤 Qihui, Wang 👤 Han, Lingxia 👤 Chai, Yan 👤 Qi, Jianxun 👤 Zhao, Jincun 👤 Meng, Songdong 👤 Qin, Chuan 👤 Gao, George F. 👤 Tan, Wenjie ⏰ 2017 📚 Journal of Immunology

• Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26

  👤 Lu, Guangwen 👤 Hu, Yawei 👤 Wang, Qihui 👤 Qi, Jianxun 👤 Gao, Feng 👤 Li, Yan 👤 Zhang, Yanfang 👤 Zhang, Wei 👤 Yuan, Yuan 👤 Bao, Jinku 👤 Zhang, Buchang 👤 Shi, Yi 👤 Yan, Jinghua 👤 Gao, George F. ⏰ 2013 📚 Nature

• Structures of the N- and C-terminal domains of MHV-A59 nucleocapsid protein corroborate a conserved RNA-protein binding mechanism in coronavirus

  👤 Ma, Yanlin 👤 Tong, Xiaohang 👤 Xu, Xiaoling 👤 Li, Xuemei 👤 Lou, Zhiyong 👤 Rao, Zihe ⏰ 2010 📚 Protein and Cell

• Structural basis and functional analysis of the SARS coronavirus nsp14-nsp10 complex

  👤 Ma, Yuanyuan 👤 Wu, Lijie 👤 Shaw, Neil 👤 Gao, Yan 👤 Wang, Jin 👤 Sun, Yuna 👤 Lou, Zhiyong 👤 Yan, Liming 👤 Zhang, Rongguang 👤 Rao, Zihe ⏰ 2015 📚 Proceedings of the National Academy of Sciences of the United States of America

• Structure of the C-terminal domain of nsp4 from feline coronavirus

  👤 Manolaridis, Ioannis 👤 Wojdyla, Justyna A. 👤 Panjikar, Santosh 👤 Snijder, Eric J. 👤 Gorbalenya, Alexander E. 👤 Berglind, Hanna 👤 Nordlund, Pär 👤 Coutard, Bruno 👤 Tucker, Paul A. ⏰ 2009 📚 Acta Crystallographica Section D: Biological Crystallography

• Influenza C virus and bovine coronavirus esterase reveal a similar catalytic mechanism: New insights for drug discovery

  👤 Mayr, Juliane 👤 Haselhorst, Thomas 👤 Langereis, Martijn A. 👤 Dyason, Jeffrey C. 👤 Huber, Wolfgang 👤 Frey, Barbara 👤 Vlasak, Reinhard 👤 De Groot, Raoul J. 👤 Von Itzstein, Mark ⏰ 2008 📚 Glycoconjugate Journal

• The Crystal Structure of ORF-9b, a Lipid Binding Protein from the SARS Coronavirus

  👤 Meier, Christoph 👤 Aricescu, A. Radu 👤 Assenberg, Rene 👤 Aplin, Robin T. 👤 Gilbert, Robert J.C. 👤 Grimes, Jonathan M. 👤 Stuart, David I. ⏰ 2006 📚 Structure

• Structures of the Middle East respiratory syndrome coronavirus 3C-like protease reveal insights into substrate specificity

  👤 Needle, Danielle 👤 Lountos, George T. 👤 Waugh, David S. ⏰ 2015 📚 Acta Crystallographica Section D: Biological Crystallography

• Structure and intracellular targeting of the SARS-coronavirus orf7a accessory protein

  👤 Nelson, Christopher A. 👤 Pekosz, Andrew 👤 Lee, Chung A. 👤 Diamond, Michael S. 👤 Fremont, Daved H. ⏰ 2005 📚 Structure

• Structure and oligomerization state of the C-terminal region of the Middle East respiratory syndrome coronavirus nucleoprotein

  👤 Nguyen, Thi Hong Van 👤 Lichière, Julie 👤 Canard, Bruno 👤 Papageorgiou, Nicolas 👤 Attoumani, Sarah 👤 Ferron, François 👤 Coutard, Bruno ⏰ 2019 📚 Acta Crystallographica Section D: Structural Biology

• Crystal structure of the receptor binding domain of the spike glycoprotein of human betacoronavirus HKU1

  👤 Ou, Xiuyuan 👤 Guan, Hongxin 👤 Qin, Bo 👤 Mu, Zhixia 👤 Wojdyla, Justyna A. 👤 Wang, Meitian 👤 Dominguez, Samuel R. 👤 Qian, Zhaohui 👤 Cui, Sheng ⏰ 2017 📚 Nature Communications

• Structural Insights into Immune Recognition of the Severe Acute Respiratory Syndrome Coronavirus S Protein Receptor Binding Domain

  👤 Pak, John E. 👤 Sharon, Chetna 👤 Satkunarajah, Malathy 👤 Auperin, Thierry C. 👤 Cameron, Cheryl M. 👤 Kelvin, David J. 👤 Seetharaman, Jayaraman 👤 Cochrane, Alan 👤 Plummer, Francis A. 👤 Berry, Jody D. 👤 Rini, James M. ⏰ 2009 📚 Journal of Molecular Biology

• Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor

  👤 Peng, Guiqing 👤 Sun, Dawei 👤 Rajashankar, Kanagalaghatta R. 👤 Qian, Zhaohui 👤 Holmes, Kathryn V. 👤 Li, Fang ⏰ 2011 📚 Proceedings of the National Academy of Sciences of the United States of America

• Crystal structure of bovine coronavirus spike protein lectin domain

  👤 Peng, Guiqing 👤 Xu, Liqing 👤 Lin, Yi Lun 👤 Chen, Lang 👤 Pasquarella, Joseph R. 👤 Holmes, Kathryn V. 👤 Li, Fang ⏰ 2012 📚 Journal of Biological Chemistry

• Structural and molecular evidence suggesting coronavirus-driven evolution of mouse receptor

  👤 Peng, Guiqing 👤 Yang, Yang 👤 Pasquarella, Joseph R. 👤 Xu, Liqing 👤 Qian, Zhaohui 👤 Holmes, Kathryn V. 👤 Li, Fang ⏰ 2017 📚 Journal of Biological Chemistry

• Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved property

  👤 Piotrowski, Yvonne 👤 Hansen, Guido 👤 Boomaars-van Der Zanden, A. Linda 👤 Snijder, Eric J. 👤 Gorbalenya, Alexander E. 👤 Hilgenfeld, Rolf ⏰ 2009 📚 Protein Science

• Variable Oligomerization Modes in Coronavirus Non-structural Protein 9

  👤 Ponnusamy, Rajesh 👤 Moll, Ralf 👤 Weimar, Thomas 👤 Mesters, Jeroen R. 👤 Hilgenfeld, Rolf ⏰ 2008 📚 Journal of Molecular Biology

• Structure of severe acute respiratory syndrome coronavirus receptor-binding domain complexed with neutralizing antibody

  👤 Prabakaran, Ponraj 👤 Gan, Jianhua 👤 Feng, Yang 👤 Zhu, Zhongyu 👤 Choudhry, Vidita 👤 Xiao, Xiaodong 👤 Ji, Xinhua 👤 Dimitrov, Dimiter S. ⏰ 2006 📚 Journal of Biological Chemistry

• Drug targets for corona virus: A systematic review.

  👤 Prajapat, Manisha 👤 Sarma, Phulen 👤 Shekhar, Nishant 👤 Avti, Pramod 👤 Sinha, Shweta 👤 Kaur, Hardeep 👤 Kumar, Subodh 👤 Bhattacharyya, Anusuya 👤 Kumar, Harish 👤 Bansal, Seema 👤 Medhi, Bikash ⏰ 2020 📚 Indian J Pharmacol

• ADP-ribose-1″-monophosphatase: A conserved coronavirus enzyme that is dispensable for viral replication in tissue culture

  👤 Putics, Ákos 👤 Filipowicz, Witold 👤 Hall, Jonathan 👤 Gorbalenya, Alexander E. 👤 Ziebuhr, John ⏰ 2005 📚 Journal of Virology

• Severe acute respiratory syndrome coronavirus papain-like-protease: Structure of a viral deubiquitinating enzyme

  👤 Ratia, Kiira 👤 Saikatendu, Kumar Singh 👤 Santarsiero, Bernard D. 👤 Barreto, Naina 👤 Baker, Susan C. 👤 Stevens, Raymond C. 👤 Mesecar, Andrew D. ⏰ 2006 📚 Proceedings of the National Academy of Sciences of the United States of America

• A structural view of coronavirus-receptor interactions

  👤 Reguera, Juan 👤 Mudgal, Gaurav 👤 Santiago, César 👤 Casasnovas, José M. ⏰ 2014 📚 Virus Research

• Structural Bases of Coronavirus Attachment to Host Aminopeptidase N and Its Inhibition by Neutralizing Antibodies

  👤 Reguera, Juan 👤 Santiago, César 👤 Mudgal, Gaurav 👤 Ordoño, Desiderio 👤 Enjuanes, Luis 👤 Casasnovas, José M. ⏰ 2012 📚 PLoS Pathogens

• Crystal structure and mechanistic determinants of SARS coronavirus nonstructural protein 15 define an endoribonuclease family

  👤 Ricagno, Stefano 👤 Egloff, Marie Pierre 👤 Ulferts, Rachel 👤 Coutard, Bruno 👤 Nurizzo, Didier 👤 Campanacci, Valérie 👤 Cambillau, Christian 👤 Ziebuhr, John 👤 Canard, Bruno ⏰ 2006 📚 Proceedings of the National Academy of Sciences of the United States of America

• Structure of a SARS coronavirus-derived peptide bound to the human major histocompatibility complex class I molecule HLA-B*1501

  👤 Røder, Gustav 👤 Kristensen, Ole 👤 Kastrup, Jette S. 👤 Buus, Søren 👤 Gajhede, Michael ⏰ 2008 📚 Acta Crystallographica Section F: Structural Biology and Crystallization Communications

• Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1″-phosphate dephosphorylation by a conserved domain of nsP3

  👤 Saikatendu, Kumar Singh 👤 Joseph, Jeremiah S. 👤 Subramanian, Vanitha 👤 Clayton, Tom 👤 Griffith, Mark 👤 Moy, Kin 👤 Velasquez, Jeffrey 👤 Neuman, Benjamin W. 👤 Buchmeier, Michael J. 👤 Stevens, Raymond C. 👤 Kuhn, Peter ⏰ 2005 📚 Structure

• Structural basis of receptor recognition by SARS-CoV-2.

  👤 Shang, Jian 👤 Ye, Gang 👤 Shi, Ke 👤 Wan, Yushun 👤 Luo, Chuming 👤 Aihara, Hideki 👤 Geng, Qibin 👤 Auerbach, Ashley 👤 Li, Fang ⏰ 2020 📚 Nature

• A conserved region of nonstructural protein 1 from alphacoronaviruses inhibits host gene expression and is critical for viral virulence

  👤 Shen, Zhou 👤 Wang, Gang 👤 Yang, Yiling 👤 Shi, Jiale 👤 Fang, Liurong 👤 Li, Fang 👤 Xiao, Shaobo 👤 Fu, Zhen F. 👤 Peng, Guiqing ⏰ 2019 📚 Journal of Biological Chemistry

• Mechanism for controlling the dimer-monomer switch and coupling dimerization to catalysis of the severe acute respiratory syndrome coronavirus 3C-like protease

  👤 Shi, Jiahai 👤 Sivaraman, J. 👤 Song, Jianxing ⏰ 2008 📚 Journal of Virology

• Molecular modelling of S1 and S2 subunits of SARS coronavirus spike glycoprotein

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• Dodecamer structure of severe acute respiratory syndrome coronavirus nonstructural protein nsp10

  👤 Su, Dan 👤 Lou, Zhiyong 👤 Sun, Fei 👤 Zhai, Yujia 👤 Yang, Haitao 👤 Zhang, Rongguang 👤 Joachimiak, Andrzej 👤 Zhang, Xuejun C. 👤 Bartlam, Mark 👤 Rao, Zihe ⏰ 2006 📚 Journal of Virology

• The nsp9 Replicase Protein of SARS-Coronavirus, Structure and Functional Insights

  👤 Sutton, Geoff 👤 Fry, Elizabeth 👤 Carter, Lester 👤 Sainsbury, Sarah 👤 Walter, Tom 👤 Nettleship, Joanne 👤 Berrow, Nick 👤 Owens, Ray 👤 Gilbert, Robert 👤 Davidson, Andrew 👤 Siddell, Stuart 👤 Poon, Leo L.M. 👤 Diprose, Jonathan 👤 Alderton, David 👤 Walsh, Martin 👤 Grimes, Jonathan M. 👤 Stuart, David I. ⏰ 2004 📚 Structure

• Solution Structure of the C-terminal Dimerization Domain of SARS Coronavirus Nucleocapsid Protein Solved by the SAIL-NMR Method

  👤 Takeda, Mitsuhiro 👤 Chang, Chung ke 👤 Ikeya, Teppei 👤 Güntert, Peter 👤 Chang, Yuan hsiang 👤 Hsu, Yen lan 👤 Huang, Tai huang 👤 Kainosho, Masatsune ⏰ 2008 📚 Journal of Molecular Biology

• The SARS-Unique Domain (SUD) of SARS coronavirus contains two macrodomains that bind G-quadruplexes

  👤 Tan, Jinzhi 👤 Vonrhein, Clemens 👤 Smart, Oliver S. 👤 Bricogne, Gerard 👤 Bollati, Michela 👤 Kusov, Yuri 👤 Hansen, Guido 👤 Mesters, Jeroen R. 👤 Schmidt, Christian L. 👤 Hilgenfeld, Rolf ⏰ 2009 📚 PLoS Pathogens

• Crystal structure of murine sCEACAM1a[1, 4]: A coronavirus receptor in the CEA family

  👤 Tan, Kemin 👤 Zelus, Bruce D. 👤 Meijers, Rob 👤 Liu, Jin Huan 👤 Bergelson, Jeffrey M. 👤 Duke, Norma 👤 Zhang, Rongguang 👤 Joachimiak, Andrzej 👤 Holmes, Kathryn V. 👤 Wang, Jia Huai ⏰ 2002 📚 EMBO Journal

• Mapping a Neutralizing Epitope on the SARS Coronavirus Spike Protein: Computational Prediction Based on Affinity-selected Peptides

  👤 Tarnovitski, Natalia 👤 Matthews, Leslie J. 👤 Sui, Jianhua 👤 Gershoni, Jonathan M. 👤 Marasco, Wayne A. ⏰ 2006 📚 Journal of Molecular Biology

• A Structural View of the Inactivation of the SARS Coronavirus Main Proteinase by Benzotriazole Esters

  👤 Verschueren, Koen H.G. 👤 Pumpor, Ksenia 👤 Anemüller, Stefan 👤 Chen, Shuai 👤 Mesters, Jeroen R. 👤 Hilgenfeld, Rolf ⏰ 2008 📚 Chemistry and Biology

• Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer

  👤 Walls, Alexandra C. 👤 Tortorici, M. Alejandra 👤 Bosch, Berend Jan 👤 Frenz, Brandon 👤 Rottier, Peter J.M. 👤 DiMaio, Frank 👤 Rey, Félix A. 👤 Veesler, David ⏰ 2016 📚 Nature

• Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design

  👤 Wang, Fenghua 👤 Chen, Cheng 👤 Tan, Wenjie 👤 Yang, Kailin 👤 Yang, Haitao ⏰ 2016 📚 Scientific Reports

• Structural and biochemical characterization of SADS-CoV papain-like protease 2.

  👤 Wang, Lu 👤 Hu, Weihua 👤 Fan, Chengpeng ⏰ 2020 📚 Protein Sci

• The N-terminal octapeptide acts as a dimerization inhibitor of SARS coronavirus 3C-like proteinase

  👤 Wei, Ping 👤 Fan, Keqiang 👤 Chen, Hao 👤 Ma, Liang 👤 Huang, Changkang 👤 Tan, Lei 👤 Xi, Dong 👤 Li, Chunmei 👤 Liu, Ying 👤 Cao, Aoneng 👤 Lai, Luhua ⏰ 2006 📚 Biochemical and Biophysical Research Communications

• Receptor-binding loops in alphacoronavirus adaptation and evolution

  👤 Wong, Alan H.M. 👤 Tomlinson, Aidan C.A. 👤 Zhou, Dongxia 👤 Satkunarajah, Malathy 👤 Chen, Kevin 👤 Sharon, Chetna 👤 Desforges, Marc 👤 Talbot, Pierre J. 👤 Rini, James M. ⏰ 2017 📚 Nature Communications

• A virus-binding hot spot on human angiotensin-converting enzyme 2 is critical for binding of two different coronaviruses

  👤 Wu, Kailang 👤 Chen, Lang 👤 Peng, Guiqing 👤 Zhou, Wenbo 👤 Pennell, Christopher A. 👤 Mansky, Louis M. 👤 Geraghty, Robert J. 👤 Li, Fang ⏰ 2011 📚 Journal of Virology

• Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor

  👤 Wu, Kailang 👤 Li, Weikai 👤 Peng, Guiqing 👤 Li, Fang ⏰ 2009 📚 Proceedings of the National Academy of Sciences of the United States of America

• Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion.

  👤 Xia, Shuai 👤 Liu, Meiqin 👤 Wang, Chao 👤 Xu, Wei 👤 Lan, Qiaoshuai 👤 Feng, Siliang 👤 Qi, Feifei 👤 Bao, Linlin 👤 Du, Lanying 👤 Liu, Shuwen 👤 Qin, Chuan 👤 Sun, Fei 👤 Shi, Zhengli 👤 Zhu, Yun 👤 Jiang, Shibo 👤 Lu, Lu ⏰ 2020 📚 Cell Res

• Nonstructural proteins 7 and 8 of feline coronavirus form a 2:1 heterotrimer that exhibits primer-independent RNA polymerase activity

  👤 Xiao, Yibei 👤 Ma, Qingjun 👤 Restle, Tobias 👤 Shang, Weifeng 👤 Svergun, Dmitri I. 👤 Ponnusamy, Rajesh 👤 Sczakiel, Georg 👤 Hilgenfeld, Rolf ⏰ 2012 📚 Journal of Virology

• Construct design, biophysical, and biochemical characterization of the fusion core from mouse hepatitis virus (a coronavirus) spike protein

  👤 Xu, Yanhui 👤 Cole, David K. 👤 Lou, Zhiyong 👤 Liu, Yiwei 👤 Qin, Lan 👤 Li, Xu 👤 Bai, Zhihong 👤 Yuan, Fang 👤 Rao, Zihe 👤 Gao, George F. ⏰ 2004 📚 Protein Expression and Purification

• Structural basis for coronavirus-mediated membrane fusion: Crystal structure of mouse hepatitis virus spike protein fusion core

  👤 Xu, Yanhui 👤 Liu, Yiwei 👤 Lou, Zhiyong 👤 Qin, Lan 👤 Li, Xu 👤 Bai, Zhihong 👤 Pang, Hai 👤 Tien, Po 👤 Gao, George F. 👤 Rao, Zihe ⏰ 2004 📚 Journal of Biological Chemistry

• Crystallization and preliminary crystallographic analysis of the heptad-repeat complex of SARS coronavirus spike protein

  👤 Xu, Yanhui 👤 Su, Nan 👤 Qin, Lan 👤 Bai, Zhihong 👤 Gao, George F. 👤 Rao, Zihe ⏰ 2004 📚 Acta Crystallographica Section D: Biological Crystallography

• Crystal structures of two coronavirus ADP-ribose-1″-monophosphatases and their complexes with ADP-ribose: A systematic structural analysis of the viral ADRP domain

  👤 Xu, Yuanyuan 👤 Cong, Le 👤 Chen, Cheng 👤 Wei, Lei 👤 Zhao, Qi 👤 Xu, Xiaoling 👤 Ma, Yanlin 👤 Bartlam, Mark 👤 Rao, Zihe ⏰ 2009 📚 Journal of Virology

• Structures of two coronavirus main proteases: Implications for substrate binding and antiviral drug design

  👤 Xue, Xiaoyu 👤 Yu, Hongwei 👤 Yang, Haitao 👤 Xue, Fei 👤 Wu, Zhixin 👤 Shen, Wei 👤 Li, Jun 👤 Zhou, Zhe 👤 Ding, Yi 👤 Zhao, Qi 👤 Zhang, Xuejun C. 👤 Liao, Ming 👤 Bartlam, Mark 👤 Rao, Zihe ⏰ 2008 📚 Journal of Virology

• Design of wide-spectrum inhibitors targeting coronavirus main proteases

  👤 Yang, Haitao 👤 Xie, Weiqing 👤 Xue, Xiaoyu 👤 Yang, Kailin 👤 Ma, Jing 👤 Liang, Wenxue 👤 Zhao, Qi 👤 Zhou, Zhe 👤 Pei, Duanqing 👤 Ziebuhr, John 👤 Hilgenfeld, Rolf 👤 Kwok, Yung Yuen 👤 Wong, Luet 👤 Gao, Guangxia 👤 Chen, Saijuan 👤 Chen, Zhu 👤 Ma, Dawei 👤 Bartlam, Mark 👤 Rao, Zihe ⏰ 2005 📚 PLoS Biology

• Synthesis, crystal structure, structure-activity relationships, and antiviral activity of a potent SARS coronavirus 3CL protease inhibitor

  👤 Yang, Syaulan 👤 Chen, Shu Jen 👤 Hsu, Min Feng 👤 Wu, Jen Dar 👤 Tseng, Chien Te K. 👤 Liu, Yu Fan 👤 Chen, Hua Chien 👤 Kuo, Chun Wei 👤 Wu, Chi Shen 👤 Chang, Li Wen 👤 Chen, Wen Chang 👤 Liao, Shao Ying 👤 Chang, Teng Yuan 👤 Hung, Hsin Hui 👤 Shr, Hui Lin 👤 Liu, Cheng Yuan 👤 Huang, Yu An 👤 Chang, Ling Yin 👤 Hsu, Jen Chi 👤 Peters, Clarence J. 👤 Wang, Andrew H.J. 👤 Hsu, Ming Chu ⏰ 2006 📚 Journal of Medicinal Chemistry

• Crystal structure of the severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein dimerization domain reveals evolutionary linkage between Corona- and Arteriviridae

  👤 Yu, I. Mei 👤 Oldham, Michael L. 👤 Zhang, Jingqiang 👤 Chen, Jue ⏰ 2006 📚 Journal of Biological Chemistry

• A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV.

  👤 Yuan, Meng 👤 Wu, Nicholas C 👤 Zhu, Xueyong 👤 Lee, Chang-Chun D 👤 So, Ray T Y 👤 Lv, Huibin 👤 Mok, Chris K P 👤 Wilson, Ian A ⏰ 2020 📚 Science

• Structure of coronavirus hemagglutinin-esterase offers insight into corona and influenza virus evolution

  👤 Zeng, Qinghong 👤 Langereis, Martijn A. 👤 Van Vliet, Arno L.W. 👤 Huizinga, Eric G. 👤 De Groot, Raoul J. ⏰ 2008 📚 Proceedings of the National Academy of Sciences of the United States of America

• Dimerization of coronavirus nsp9 with diverse modes enhances its nucleic acid binding affinity

  👤 Zeng, Zhe 👤 Deng, Feng 👤 Shi, Ke 👤 Ye, Gang 👤 Wang, Gang 👤 Fang, Liurong 👤 Xiao, Shaobo 👤 Fu, Zhenfang 👤 Peng, Guiqing ⏰ 2018 📚 Journal of Virology

• Structural and biochemical characterization of endoribonuclease nsp15 encoded by middle east respiratory syndrome coronavirus

  👤 Zhang, Lianqi 👤 Li, Lei 👤 Yan, Liming 👤 Ming, Zhenhua 👤 Jia, Zhihui 👤 Lou, Zhiyong 👤 Rao, Zihe ⏰ 2018 📚 Journal of Virology

• Exploring the binding mechanism of the main proteinase in SARS-associated coronavirus and its implication to anti-SARS drug design

  👤 Zhang, Xue Wu 👤 Yap, Yee Leng ⏰ 2004 📚 Bioorganic and Medicinal Chemistry

• Computational characterization and design of SARS coronavirus receptor recognition and antibody neutralization

  👤 Zhang, Yuan 👤 Zheng, Nan 👤 Zhong, Yang ⏰ 2007 📚 Computational Biology and Chemistry

• Core structure of S2 from the human coronavirus NL63 spike glycoprotein

  👤 Zheng, Qi 👤 Deng, Yiqun 👤 Liu, Jie 👤 Van Der Hoek, Lia 👤 Berkhout, Ben 👤 Lu, Min ⏰ 2006 📚 Biochemistry

• Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease

  👤 Zhu, Lili 👤 George, Shyla 👤 Schmidt, Marco F. 👤 Al-Gharabli, Samer I. 👤 Rademann, Jörg 👤 Hilgenfeld, Rolf ⏰ 2011 📚 Antiviral Research