📄 Structural biology: Structure of SARS coronavirus spike receptor-binding domain complexed with receptor

The spike protein (S) of SARS coronavirus (SARS-CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction. The crystal structure at 2.9 angstrom resolution of the UBD bound with the peptidass domain of human ACE2 shows that the RBD presents a gently concave surface, which cradles the N-terminal lobe of the peptidase. The atomic details at the interface between the two proteins clarify the importance of residue changes that facilitate efficient cross-species infection and human-to-human transmission. The structure of the RBD suggests ways to make truncated disulfide-stabilized RBD variants for use in the design of coronavirus vaccines.

keywords 🔗 spike protein (353) 🔗 receptor-binding domain (99) 🔗 converting enzyme (162) 🔗 angiotensin-converting enzyme (112) 🔗 crystal structure (114)

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