🔗 Interferon

Articles (270)

• Interference of ribosomal frameshifting by antisense peptide nucleic acids suppresses SARS coronavirus replication

  👤 Ahn, Dae Gyun 👤 Lee, Wooseong 👤 Choi, Jin Kyu 👤 Kim, Seong Jun 👤 Plant, Ewan P. 👤 Almazán, Fernando 👤 Taylor, Deborah R. 👤 Enjuanes, Luis 👤 Oh, Jong Won ⏰ 2011 📚 Antiviral Research

• Treatment outcomes for patients with Middle Eastern Respiratory Syndrome Coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia

  👤 Al Ghamdi, Mohammed 👤 Alghamdi, Khalid M. 👤 Ghandoora, Yasmeen 👤 Alzahrani, Ameera 👤 Salah, Fatmah 👤 Alsulami, Abdulmoatani 👤 Bawayan, Mayada F. 👤 Vaidya, Dhananjay 👤 Perl, Trish M. 👤 Sood, Geeta ⏰ 2016 📚 BMC Infectious Diseases

• Update on therapeutic options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV)

  👤 Al-Tawfiq, Jaffar A. 👤 Memish, Ziad A. ⏰ 2017 📚 Expert Review of Anti-Infective Therapy

• Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: An observational study

  👤 Al-Tawfiq, Jaffar A. 👤 Momattin, Hisham 👤 Dib, Jean 👤 Memish, Ziad A. ⏰ 2014 📚 International Journal of Infectious Diseases

• Clinical predictors of mortality of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: A cohort study

  👤 Alfaraj, Sarah H. 👤 Al-Tawfiq, Jaffar A. 👤 Assiri, Ayed Y. 👤 Alzahrani, Nojoom A. 👤 Alanazi, Amal A. 👤 Memish, Ziad A. ⏰ 2019 📚 Travel Medicine and Infectious Disease

• Binding of the methyl donor S-adenosyl-Lmethionine to Middle East respiratory syndrome coronavirus 2'-Omethyltransferase nsp16 promotes recruitment of the allosteric activator nsp10

  👤 Aouadi, Wahiba 👤 Blanjoie, Alexandre 👤 Vasseur, Jean Jacques 👤 Debart, Françoise 👤 Canard, Bruno 👤 Decroly, Etienne ⏰ 2017 📚 Journal of Virology

• Lipoteichoic acid from Staphylococcus aureus exacerbates respiratory disease in porcine respiratory coronavirus-infected pigs

  👤 Atanasova, Kalina 👤 Van Gucht, Steven 👤 Barbé, Filip 👤 Duchateau, Luc 👤 Van Reeth, Kristien ⏰ 2011 📚 Veterinary Journal

• Selective packaging in murine coronavirus promotes virulence by limiting type I interferon responses

  👤 Athmer, Jeremiah 👤 Fehr, Anthony R. 👤 Grunewald, Matthew E. 👤 Qu, Wen 👤 Wheeler, D. Lori 👤 Graepel, Kevin W. 👤 Channappanavar, Rudragouda 👤 Sekine, Aimee 👤 Aldabeeb, Dana Saud 👤 Gale, Michael 👤 Denison, Mark R. 👤 Perlman, Stanley ⏰ 2018 📚 mBio

• Molecular Pathogenesis of Middle East Respiratory Syndrome (MERS) Coronavirus

  👤 Banerjee, Arinjay 👤 Baid, Kaushal 👤 Mossman, Karen ⏰ 2019 📚 Current Clinical Microbiology Reports

• Interferon regulatory factor 3-mediated signaling limits middle-east respiratory syndrome (MERS) coronavirus propagation in cells from an insectivorous bat

  👤 Banerjee, Arinjay 👤 Falzarano, Darryl 👤 Rapin, Noreen 👤 Lew, Jocelyne 👤 Misra, Vikram ⏰ 2019 📚 Viruses

• RNase L-independent specific 28S rRNA cleavage in murine coronavirus-infected cells

  👤 Banerjee, S. 👤 An, S. 👤 Zhou, A. 👤 Silverman, R. H. 👤 Makino, S. ⏰ 2000 📚 Journal of Virology

• Structural insights into the Middle East respiratory syndrome coronavirus 4a protein and its dsRNA binding mechanism

  👤 Batool, Maria 👤 Shah, Masaud 👤 Patra, Mahesh Chandra 👤 Yesudhas, Dhanusha 👤 Choi, Sangdun ⏰ 2017 📚 Scientific Reports

• Mutagenesis of coronavirus nsp14 reveals its potential role in modulation of the innate immune response

  👤 Becares, Martina 👤 Pascual-Iglesias, Alejandro 👤 Nogales, Aitor 👤 Sola, Isabel 👤 Enjuanes, Luis 👤 Zuñiga, Sonia ⏰ 2016 📚 Journal of Virology

• PCR array profiling of antiviral genes in human embryonic kidney cells expressing human coronavirus OC43 structural and accessory proteins

  👤 Beidas, Meshal 👤 Chehadeh, Wassim ⏰ 2018 📚 Archives of Virology

• Effect of Human Coronavirus OC43 Structural and Accessory Proteins on the Transcriptional Activation of Antiviral Response Elements

  👤 Beidas, Meshal 👤 Chehadeh, Wassim ⏰ 2018 📚 Intervirology

• Pathogenesis of murine coronavirus in the central nervous system

  👤 Bender, Susan J. 👤 Weiss, Susan R. ⏰ 2010 📚 Journal of Neuroimmune Pharmacology

• Perforin and Gamma Interferon-Mediated Control of Coronavirus Central Nervous System Infection by CD8 T Cells in the Absence of CD4 T Cells

  👤 Bergmann, Cornelia C. 👤 Parra, Beatriz 👤 Hinton, David R. 👤 Ramakrishna, Chandran 👤 Dowdell, Konechi C. 👤 Stohlman, Stephen A. ⏰ 2004 📚 Journal of Virology

• Activation of RNase L by murine coronavirus in myeloid cells is dependent on basal Oas gene expression and independent of virus-induced interferon

  👤 Birdwell, L. Dillon 👤 Zalinger, Zachary B. 👤 Li, Yize 👤 Wright, Patrick W. 👤 Elliott, Ruth 👤 Rose, Kristine M. 👤 Silverman, Robert H. 👤 Weiss, Susan R. ⏰ 2016 📚 Journal of Virology

• Myd88 Initiates Early Innate Immune Responses and Promotes CD4 T Cells during Coronavirus Encephalomyelitis

  👤 Butchi, Niranjan 👤 Kapil, Parul 👤 Puntambekar, Shweta 👤 Stohlman, Stephen A. 👤 Hinton, David R. 👤 Bergmann, Cornelia C. ⏰ 2015 📚 Journal of Virology

• Ifit2 deficiency results in uncontrolled neurotropic coronavirus replication and enhanced encephalitis via impaired alpha/beta interferon induction in macrophages

  👤 Butchi, Niranjan B. 👤 Hinton, David R. 👤 Stohlman, Stephen A. 👤 Kapil, Parul 👤 Fensterl, Volker 👤 Sen, Ganes C. 👤 Bergmann, Cornelia C. ⏰ 2014 📚 Journal of Virology

• Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the middle east respiratory syndrome coronavirus

  👤 Báez-Santos, Yahira M. 👤 Mielech, Anna M. 👤 Deng, Xufang 👤 Baker, Susan 👤 Mesecar, Andrew D. ⏰ 2014 📚 Journal of Virology

• Identification and characterization of three novel small interference RNAs that effectively down-regulate the isolated nucleocapsid gene expression of SARS coronavirus

  👤 Cao, Ying Li 👤 Wang, Ying 👤 Guo, Rong 👤 Yang, Fan 👤 Zhang, Yun 👤 Wang, Shu Hui 👤 Liu, Li ⏰ 2011 📚 Molecules

• Mutagenesis of S-adenosyl-L-methionine-binding residues in coronavirus nsp14 N7-methyltransferase demonstrates differing requirements for genome translation and resistance to innate immunity

  👤 Case, James Brett 👤 Ashbrook, Alison W. 👤 Dermody, Terence S. 👤 Denisona, Mark R. ⏰ 2016 📚 Journal of Virology

• Establishment and maintenance of a persistent infection of L132 cells by human coronavirus strain 229E

  👤 Chaloner-Larsson, Gillian 👤 Johnson-Lussenburg, C. Margaret ⏰ 1981 📚 Archives of Virology

• Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus

  👤 Chan, Jasper F.W. 👤 Chan, Kwok Hung 👤 Kao, Richard Y.T. 👤 To, Kelvin K.W. 👤 Zheng, Bo Jian 👤 Li, Clara P.Y. 👤 Li, Patrick T.W. 👤 Dai, Jun 👤 Mok, Florence K.Y. 👤 Chen, Honglin 👤 Hayden, Frederick G. 👤 Yuen, Kwok Yung ⏰ 2013 📚 Journal of Infection

• Middle East Respiratory syndrome coronavirus: Another zoonotic betacoronavirus causing SARS-like disease

  👤 Chan, Jasper F.W. 👤 Lau, Susanna K.P. 👤 To, Kelvin K.W. 👤 Cheng, Vincent C.C. 👤 Woo, Patrick C.Y. 👤 Yue, Kwok Yung ⏰ 2015 📚 Clinical Microbiology Reviews

• COVID-19: An Update on the Epidemiological, Clinical, Preventive and Therapeutic Evidence and Guidelines of Integrative Chinese-Western Medicine for the Management of 2019 Novel Coronavirus Disease.

  👤 Chan, Kam Wa 👤 Wong, Vivian Taam 👤 Tang, Sydney Chi Wai ⏰ 2020 📚 Am J Chin Med

• Tropism of and innate immune responses to the novel human betacoronavirus lineage C virus in human ex vivo respiratory organ cultures

  👤 Chan, Renee W.Y. 👤 Chan, Michael C.W. 👤 Agnihothram, Sudhakar 👤 Chan, Louisa L.Y. 👤 Kuok, Denise I.T. 👤 Fong, Joanne H.M. 👤 Guan, Y. 👤 Poon, Leo L.M. 👤 Baric, Ralph S. 👤 Nicholls, John M. 👤 Peiris, J. S.Malik ⏰ 2013 📚 Journal of Virology

• Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: An in-vitro and ex-vivo study

  👤 Chan, Renee W.Y. 👤 Hemida, Maged G. 👤 Kayali, Ghazi 👤 Chu, Daniel K.W. 👤 Poon, Leo L.M. 👤 Alnaeem, Abdelmohsen 👤 Ali, Mohamed A. 👤 Tao, Kin P. 👤 Ng, Hoi Y. 👤 Chan, Michael C.W. 👤 Guan, Yi 👤 Nicholls, John M. 👤 Peiris, J. S.Malik ⏰ 2014 📚 The Lancet Respiratory Medicine

• The emergence of human coronavirus EMC: How scared should we be?

  👤 Chan, Renee W.Y. 👤 Poon, Leo L.M. ⏰ 2013 📚 mBio

• Virus-specific memory CD8 T cells provide substantial protection from lethal severe acute respiratory syndrome coronavirus infection

  👤 Channappanavar, Rudragouda 👤 Fett, Craig 👤 Zhao, Jincun 👤 Meyerholz, David K. 👤 Perlman, Stanley ⏰ 2014 📚 Journal of Virology

• Protective effect of intranasal regimens containing peptidic middle east respiratory syndrome coronavirus fusion inhibitor against MERS-CoV infection

  👤 Channappanavar, Rudragouda 👤 Lu, Lu 👤 Xia, Shuai 👤 Du, Lanying 👤 Meyerholz, David K. 👤 Perlman, Stanley 👤 Jiang, Shibo ⏰ 2015 📚 Journal of Infectious Diseases

• Characterization of blood mononuclear cells producing IFNα following induction by coronavirus-infected cells (porcine transmissible gastroenteritis virus)

  👤 Charley, B. 👤 Lavenant, L. ⏰ 1990 📚 Research in Immunology

• Glycosylation is Required for Coronavirus TGEV to Induce an Efficient Production of IFNα by Blood Mononuclear Cells

  👤 CHARLEY, B. 👤 LAVENANT, L. 👤 DELMAS, B. ⏰ 1991 📚 Scandinavian Journal of Immunology

• Myxovirus- and coronavirus-induced in vitro stimulation of spontaneous cell-mediated cytotoxicity by porcine blood leukocytes

  👤 Charley, B. 👤 Petit, E. 👤 Laude, H. 👤 La Bonnardière, C. ⏰ 1983 📚 Annales de l'Institut Pasteur Virology

• In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds

  👤 Chen, F. 👤 Chan, K. H. 👤 Jiang, Y. 👤 Kao, R. Y.T. 👤 Lu, H. T. 👤 Fan, K. W. 👤 Cheng, V. C.C. 👤 Tsui, W. H.W. 👤 Hung, I. F.N. 👤 Lee, T. S.W. 👤 Guan, Y. 👤 Peiris, J. S.M. 👤 Yuen, K. Y. ⏰ 2004 📚 Journal of Clinical Virology

• Cellular immune responses to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in senescent BALB/c mice: CD4+ T Cells are important in control of SARS-CoV infection

  👤 Chen, Jun 👤 Lau, Yuk Fai 👤 Lamirande, Elaine W. 👤 Paddock, Christopher D. 👤 Bartlett, Jeanine H. 👤 Zaki, Sherif R. 👤 Subbarao, Kanta ⏰ 2010 📚 Journal of Virology

• Comparative evaluation of two hemagglutinating encephalomyelitis coronavirus vaccine candidates in mice

  👤 Chen, Keyan 👤 Zhao, Kui 👤 He, Wenqi 👤 Gao, Wei 👤 Zhao, Chuanbo 👤 Wang, Li 👤 Pan, Wei 👤 Song, Deguang 👤 Wang, Chengli 👤 Gao, Feng ⏰ 2012 📚 Clinical and Vaccine Immunology

• [Exploration of omics mechanism and drug prediction of coronavirus-induced heart failure based on clinical bioinformatics].

  👤 Chen, X M 👤 Cao, F 👤 Zhang, H M 👤 Chen, H R 👤 Zhang, J D 👤 Zhi, P 👤 Li, Z Y 👤 Wang, Y X 👤 Lu, X C ⏰ 2020 📚 Zhonghua Xin Xue Guan Bing Za Zhi

• SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex

  👤 Chen, Xiaojuan 👤 Yang, Xingxing 👤 Zheng, Yang 👤 Yang, Yudong 👤 Xing, Yaling 👤 Chen, Zhongbin ⏰ 2014 📚 Protein and Cell

• Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus

  👤 Cheng, Kai Wen 👤 Cheng, Shu Chun 👤 Chen, Wei Yi 👤 Lin, Min Han 👤 Chuang, Shang Ju 👤 Cheng, I. Hsin 👤 Sun, Chiao Yin 👤 Chou, Chi Yuan ⏰ 2015 📚 Antiviral Research

• Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal degradation of N-Myc (and STAT) interactor

  👤 Cheng, Weijia 👤 Chen, Shiyou 👤 Li, Ruiling 👤 Chen, Yu 👤 Wang, Min 👤 Guo, Deyin ⏰ 2015 📚 Virologica Sinica

• Cytokine responses in severe acute respiratory syndrome coronavirus-infected macrophages in vitro: Possible relevance to pathogenesis

  👤 Cheung, Chung Y. 👤 Poon, Leo L.M. 👤 Ng, Iris H.Y. 👤 Luk, Winsie 👤 Sia, Sin Fun 👤 Wu, Mavis H.S. 👤 Chan, Kwok Hung 👤 Yuen, Kwok Yung 👤 Gordon, Siamon 👤 Guan, Yi 👤 Peiris, Joseph S.M. ⏰ 2005 📚 Journal of Virology

• Significance of the Myxovirus resistance A (MxA) gene - 123C>A single-nucleotide polymorphism in suppressed interferon ß induction of severe acute respiratory syndrome coronavirus infection

  👤 Ching, Johannes Chi Yun 👤 Chan, Kelvin Yuen Kwong 👤 Lee, Eric Hing Leung 👤 Xu, Mei Shu 👤 Ting, Campbell Kam Po 👤 So, Thomas M.K. 👤 Sham, Pak C. 👤 Leung, Gabriel M. 👤 Peiris, Joseph S.M. 👤 Khoo, Ui Soon ⏰ 2010 📚 Journal of Infectious Diseases

• Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19.

  👤 Chu, Hin 👤 Chan, Jasper Fuk-Woo 👤 Wang, Yixin 👤 Yuen, Terrence Tsz-Tai 👤 Chai, Yue 👤 Hou, Yuxin 👤 Shuai, Huiping 👤 Yang, Dong 👤 Hu, Binjie 👤 Huang, Xiner 👤 Zhang, Xi 👤 Cai, Jian-Piao 👤 Zhou, Jie 👤 Yuan, Shuofeng 👤 Kok, Kin-Hang 👤 To, Kelvin Kai-Wang 👤 Chan, Ivy Hau-Yee 👤 Zhang, Anna Jinxia 👤 Sit, Ko-Yung 👤 Au, Wing-Kuk 👤 Yuen, Kwok-Yung ⏰ 2020 📚 Clin Infect Dis

• X-ray structure and enzymatic activity profile of a core papain-like protease of MERS coronavirus with utility for structure-based drug design

  👤 Clasman, Jozlyn R. 👤 Bez-Santos, Yahira M. 👤 Mettelman, Robert C. 👤 O'Brien, Amornrat 👤 Baker, Susan C. 👤 Mesecar, Andrew D. ⏰ 2017 📚 Scientific Reports

• Primary severe acute respiratory syndrome coronavirus infection limits replication but not lung inflammation upon homologous rechallenge

  👤 Clay, Candice 👤 Donart, Nathan 👤 Fomukong, Ndingsa 👤 Knight, Jennifer B. 👤 Lei, Wanli 👤 Price, Lance 👤 Hahn, Fletcher 👤 Westrienen, Jesse Van 👤 Harrod, Kevin S. ⏰ 2012 📚 Journal of Virology

• Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases

  👤 Clementz, Mark A. 👤 Chen, Zhongbin 👤 Banach, Bridget S. 👤 Wang, Yanhua 👤 Sun, Li 👤 Ratia, Kiira 👤 Baez-Santos, Yahira M. 👤 Wang, Jie 👤 Takayama, Jun 👤 Ghosh, Arun K. 👤 Li, Kui 👤 Mesecar, Andrew D. 👤 Baker, Susan C. ⏰ 2010 📚 Journal of Virology

• Interferon γ potentiates human coronavirus OC43 infection of neuronal cells by modulation of HLA class I expression

  👤 Collins, Arlene R. ⏰ 1995 📚 Immunological Investigations

• Antagonism of dsRNA-induced innate immune pathways by NS4a and NS4b accessory proteins during MERS coronavirus infection

  👤 Comar, Courtney E. 👤 Goldstein, Stephen A. 👤 Li, Yize 👤 Yount, Boyd 👤 Baric, Ralph S. 👤 Weiss, Susan R. ⏰ 2019 📚 mBio

• Link of a ubiquitous human coronavirus to dromedary camels

  👤 Corman, Victor M. 👤 Eckerle, Isabella 👤 Memish, Ziad A. 👤 Liljander, Anne M. 👤 Dijkman, Ronald 👤 Jonsdottir, Hulda 👤 Ngeiywa, Kisi J.Z.Juma 👤 Kamau, Esther 👤 Younan, Mario 👤 Al Masri, Malakita 👤 Assiri, Abdullah 👤 Gluecks, Ilona 👤 Musa, Bakri E. 👤 Meyer, Benjamin 👤 Müller, Marcel A. 👤 Hilali, Mosaad 👤 Bornstein, Set 👤 Wernery, Ulrich 👤 Thiel, Volker 👤 Jores, Joerg 👤 Drexler, Jan Felix 👤 Drosten, Christian ⏰ 2016 📚 Proceedings of the National Academy of Sciences of the United States of America

• Alphacoronavirus protein 7 modulates host innate immune response

  👤 Cruz, Jazmina L.G. 👤 Becares, Martina 👤 Sola, Isabel 👤 Oliveros, Juan Carlos 👤 Enjuanes, Luis 👤 Zúñiga, Sonia ⏰ 2013 📚 Journal of Virology

• Structural Insights into the Interaction of Coronavirus Papain-Like Proteases and Interferon-Stimulated Gene Product 15 from Different Species

  👤 Daczkowski, Courtney M. 👤 Dzimianski, John V. 👤 Clasman, Jozlyn R. 👤 Goodwin, Octavia 👤 Mesecar, Andrew D. 👤 Pegan, Scott D. ⏰ 2017 📚 Journal of Molecular Biology

• Bystander CD8 T-Cell-Mediated Demyelination is Interferon-γ -Dependent in a Coronavirus Model of Multiple Sclerosis

  👤 Dandekar, Ajai A. 👤 Anghelina, Daniela 👤 Perlman, Stanley ⏰ 2004 📚 American Journal of Pathology

• Important roles for gamma interferon and NKG2D in γδ T-cell-induced demyelination in T-cell receptor β-deficient mice infected with a coronavirus

  👤 Dandekar, Ajai A. 👤 O'Malley, Katherine 👤 Perlman, Stanley ⏰ 2005 📚 Journal of Virology

• Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation

  👤 Danesh, Ali 👤 Cameron, Cheryl M. 👤 León, Alberto J. 👤 Ran, Longsi 👤 Xu, Luoling 👤 Fang, Yuan 👤 Kelvin, Alyson A. 👤 Rowe, Thomas 👤 Chen, Honglin 👤 Guan, Yi 👤 Jonsson, Colleen B. 👤 Cameron, Mark J. 👤 Kelvin, David J. ⏰ 2011 📚 Virology

• Considerations for statin therapy in patients with COVID-19.

  👤 Dashti-Khavidaki, Simin 👤 Khalili, Hossein ⏰ 2020 📚 Pharmacotherapy

• Potential antivirals and antiviral strategies against SARS coronavirus infections

  👤 De Clercq, Erik ⏰ 2006 📚 Expert Review of Anti-Infective Therapy

• The glycosylation status of the murine hepatitis coronavirus M protein affects the interferogenic capacity of the virus in vitro and its ability to replicate in the liver but not the brain

  👤 De Haan, Cornelis A.M. 👤 De Wit, Marèl 👤 Kuo, Lili 👤 Montalto-Morrison, Cynthia 👤 Haagmans, Bart L. 👤 Weiss, Susan R. 👤 Masters, Paul S. 👤 Rottier, Peter J.M. ⏰ 2003 📚 Virology

• MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment

  👤 de Wilde, Adriaan H. 👤 Raj, V. Stalin 👤 Oudshoorn, Diede 👤 Bestebroer, Theo M. 👤 van Nieuwkoop, Stefan 👤 Limpens, Ronald W.A.L. 👤 Posthuma, Clara C. 👤 van der Meer, Yvonne 👤 Bárcena, Montserrat 👤 Haagmans, Bart L. 👤 Snijder, Eric J. 👤 van den Hoogen, Bernadette G. ⏰ 2013 📚 Journal of General Virology

• Coronavirus virulence genes with main focus on SARS-CoV envelope gene

  👤 DeDiego, Marta L. 👤 Nieto-Torres, Jose L. 👤 Jimenez-Guardeño, Jose M. 👤 Regla-Nava, Jose A. 👤 Castaño-Rodriguez, Carlos 👤 Fernandez-Delgado, Raul 👤 Usera, Fernando 👤 Enjuanes, Luis ⏰ 2014 📚 Virus Research

• A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses

  👤 Deng, Xufang 👤 Agnihothram, Sudhakar 👤 Mielech, Anna M. 👤 Nichols, Daniel B. 👤 Wilson, Michael W. 👤 St. John, Sarah E. 👤 Larsen, Scott D. 👤 Mesecar, Andrew D. 👤 Lenschow, Deborah J. 👤 Baric, Ralph S. 👤 Baker, Susan C. ⏰ 2014 📚 Journal of Virology

• Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus.

  👤 Deng, Xufang 👤 Chen, Yafang 👤 Mielech, Anna M 👤 Hackbart, Matthew 👤 Kesely, Kristina R 👤 Mettelman, Robert C 👤 O'Brien, Amornrat 👤 Chapman, Mackenzie E 👤 Mesecar, Andrew D 👤 Baker, Susan C ⏰ 2020 📚 J Virol

• Analysis of coronavirus temperature-sensitive mutants reveals an interplay between the macrodomain and Papain-like protease impacting replication and pathogenesis

  👤 Deng, Xufang 👤 Mettelman, Robert C. 👤 O'Brien, Amornrat 👤 Thompson, John A. 👤 O'Brien, Timothy E. 👤 Baker, Susan C. ⏰ 2019 📚 Journal of Virology

• Coronavirus endoribonuclease activity in porcine epidemic diarrhea virus suppresses type I and type III interferon responses

  👤 Deng, Xufang 👤 Van Geelen, Albert 👤 Buckley, Alexandra C. 👤 O’Brien, Amornrat 👤 Pillatzki, Angela 👤 Lager, Kelly M. 👤 Faaberg, Kay S. 👤 Baker, Susan C. ⏰ 2019 📚 Journal of Virology

• Enhanced protection in mice induced by immunization with inactivated whole viruses compare to spike protein of middle east respiratory syndrome coronavirus

  👤 Deng, Yao 👤 Lan, Jiaming 👤 Bao, Linlin 👤 Huang, Baoying 👤 Ye, Fei 👤 Chen, Yingzhu 👤 Yao, Yanfeng 👤 Wang, Wenling 👤 Qin, Chuan 👤 Tan, Wenjie ⏰ 2018 📚 Emerging Microbes and Infections

• Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus

  👤 Devaraj, Santhana G. 👤 Wang, Nan 👤 Chen, Zhongbin 👤 Chen, Zihong 👤 Tseng, Monica 👤 Barretto, Naina 👤 Lin, Rongtuan 👤 Peters, Clarence J. 👤 Tseng, Chien Te K. 👤 Baker, Susan C. 👤 Li, Kui ⏰ 2007 📚 Journal of Biological Chemistry

• Human Coronavirus HKU1 Infection of Primary Human Type II Alveolar Epithelial Cells: Cytopathic Effects and Innate Immune Response

  👤 Dominguez, Samuel R. 👤 Travanty, Emily A. 👤 Qian, Zhaohui 👤 Mason, Robert J. ⏰ 2013 📚 PLoS ONE

• An observational, laboratory-based study of outbreaks of middle east respiratory syndrome coronavirus in Jeddah and Riyadh, Kingdom of Saudi Arabia, 2014

  👤 Drosten, Christian 👤 Muth, Doreen 👤 Corman, Victor M. 👤 Hussain, Raheela 👤 Al Masri, Malaki 👤 HajOmar, Waleed 👤 Landt, Olfert 👤 Assiri, Abdullah 👤 Eckerle, Isabella 👤 Al Shangiti, Ali 👤 Al-Tawfiq, Jaffar A. 👤 Albarrak, Ali 👤 Zumla, Alimuddin 👤 Rambaut, Andrew 👤 Memish, Ziad A. ⏰ 2015 📚 Clinical Infectious Diseases

• Favipiravir: pharmacokinetics and concerns about clinical trials for 2019-nCoV infection.

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• Tilorone: A Broad-Spectrum Antiviral For Emerging Viruses.

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• Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin

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• Porcine deltacoronavirus accessory protein NS6 antagonizes interferon beta production by interfering with the binding of RIG-I/MDA5 to double-stranded RNA

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• Annexin A2 on lung epithelial cell surface is recognized by severe acute respiratory syndrome-associated coronavirus spike domain 2 antibodies

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• The nsp3 macrodomain promotes virulence in mice with coronavirus-induced encephalitis

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• The conserved coronavirus macrodomain promotes virulence and suppresses the innate immune response during severe acute respiratory syndrome coronavirus infection

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• Molecular determinants for subcellular localization of the severe acute respiratory syndrome coronavirus open reading frame 3b protein

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• SARS coronavirus and innate immunity

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• Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-κB signaling

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• Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane

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• Metronidazole; a Potential Novel Addition to the COVID-19 Treatment Regimen.

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• T-cell response profiling to biological threat agents including the SARS coronavirus

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• Interferon-γ in the serum and effusions of cats with feline coronavirus infection

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• Non-major histocompatibility complex-restricted cytotoxicity of bovine coronavirus-infected target cells mediated by bovine intestinal intraepithelial leukocytes

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• Inhibition of interferon-γ signaling in oligodendroglia delays coronavirus clearance without altering demyelination

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• Molecular pathology of emerging coronavirus infections

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• The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression

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• Murine coronavirus infection activates the aryl hydrocarbon receptor in an indoleamine 2,3-dioxygenase-independent manner, contributing to cytokine modulation and proviral TCDD-inducible-PARP expression

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• Cell-mediated immune responses in the head-associated lymphoid tissues induced to a live attenuated avian coronavirus vaccine

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• Murine AKAP7 has a 2ʹ,5ʹ-phosphodiesterase domain that can complement an inactive murine coronavirus ns2 gene

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• Pegylated interferon-α protects type 1 pneumocytes against SARS coronavirus infection in macaques

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• Coronavirus endoribonuclease targets viral polyuridine sequences to evade activating host sensors.

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• In vitro and in ovo expression of chicken gamma interferon by a defective RNA of avian coronavirus infectious bronchitis virus

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• Interferon lambda 4 signals via the IFNλ receptor to regulate antiviral activity against HCV and coronaviruses

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• High-magnitude, virus-specific CD4 T-cell response in the central nervous system of coronavirus-infected mice

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• Potent and selective inhibition of SARS coronavirus replication by aurintricarboxylic acid

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• Interferon-β 1a and SARS Coronavirus Replication

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• Rapid identification of coronavirus replicase inhibitors using a selectable replicon RNA

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• Intranasal interferon as protection against experimental respiratory coronavirus infection in volunteers

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• Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1

  👤 Hogan, Robert J. 👤 Gao, Guangping 👤 Rowe, Thomas 👤 Bell, Peter 👤 Flieder, Douglas 👤 Paragas, Jason 👤 Kobinger, Gary P. 👤 Wivel, Nelson A. 👤 Crystal, Ronald G. 👤 Boyer, Julie 👤 Feldmann, Heinz 👤 Voss, Thomas G. 👤 Wilson, James M. ⏰ 2004 📚 Journal of Virology

• Severe acute respiratory syndrome-associated coronavirus vaccines formulated with delta inulin adjuvants provide enhanced protection while ameliorating lung eosinophilic immunopathology

  👤 Honda-Okubo, Yoshikazu 👤 Barnard, Dale 👤 Ong, Chun Hao 👤 Peng, Bi Hung 👤 Tseng, Chien Te Kent 👤 Petrovsky, Nikolai ⏰ 2015 📚 Journal of Virology

• The critical role of IFN-γ in experimental coronavirus retinopathy

  👤 Hooks, John J. 👤 Wang, Yun 👤 Detrick, Barbara ⏰ 2003 📚 Investigative Ophthalmology and Visual Science

• The severe acute respiratory syndrome coronavirus nucleocapsid inhibits type I interferon production by interfering with TRIM25- mediated RIG-I ubiquitination

  👤 Hu, Yong 👤 Li, Wei 👤 Gao, Ting 👤 Cui, Yan 👤 Jin, Yanwen 👤 Li, Ping 👤 Ma, Qingjun 👤 Liu, Xuan 👤 Cao, Cheng ⏰ 2017 📚 Journal of Virology

• Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus

  👤 Huang, I. Chueh 👤 Bailey, Charles C. 👤 Weyer, Jessica L. 👤 Radoshitzky, Sheli R. 👤 Becker, Michelle M. 👤 Chiang, Jessica J. 👤 Brass, Abraham L. 👤 Ahmed, Asim A. 👤 Chi, Xiaoli 👤 Dong, Lian 👤 Longobardi, Lindsay E. 👤 Boltz, Dutch 👤 Kuhn, Jens H. 👤 Elledge, Stephen J. 👤 Bavari, Sina 👤 Denison, Mark R. 👤 Choe, Hyeryun 👤 Farzan, Michael ⏰ 2011 📚 PLoS Pathogens

• Phage display technique identifies the interaction of severe acute respiratory syndrome coronavirus open reading frame 6 protein with nuclear pore complex interacting protein NPIPB3 in modulating Type I interferon antagonism

  👤 Huang, Su Hua 👤 Lee, Tzu Ying 👤 Lin, Ying Ju 👤 Wan, Lei 👤 Lai, Chih Ho 👤 Lin, Cheng Wen ⏰ 2017 📚 Journal of Microbiology, Immunology and Infection

• Type I interferons are essential in controlling neurotropic coronavirus infection irrespective of functional CD8 T cells

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• Infection of human alveolar macrophages by human coronavirus strain 229E

  👤 Joel Funk, C. 👤 Wang, Jieru 👤 Ito, Yoko 👤 Travanty, Emily A. 👤 Voelker, Dennis R. 👤 Holmes, Kathryn V. 👤 Mason, Robert J. ⏰ 2012 📚 Journal of General Virology

• Altered pathogenesis of porcine respiratory coronavirus in pigs due to immunosuppressive effects of dexamethasone: Implications for corticosteroid use in treatment of severe acute respiratory syndrome coronavirus

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• Porcine reproductive and respiratory syndrome virus modifies innate immunity and alters disease outcome in pigs subsequently infected with porcine respiratory coronavirus: Implications for respiratory viral co-infections

  👤 Jung, Kwonil 👤 Renukaradhya, Gourapura J. 👤 Alekseev, Konstantin P. 👤 Fang, Ying 👤 Tang, Yuxin 👤 Saif, L. J. ⏰ 2009 📚 Journal of General Virology

• A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein

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• Acute management and long-term survival among subjects with severe middle east respiratory syndrome coronavirus pneumonia and ARDS

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• Ribavirin and interferon-α2b as primary and preventive treatment for Middle East respiratory syndrome coronavirus: A preliminary report of two cases

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• Efficient replication of the novel human betacoronavirus EMC on primary human epithelium highlights its zoonotic potential

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• To sense or not to sense viral RNA-essentials of coronavirus innate immune evasion

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• Infectious bronchitis coronavirus inhibits STAT1 signaling and requires accessory proteins for resistance to type I interferon activity

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• Activation of the chicken type I interferon response by infectious bronchitis coronavirus

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• Infectious bronchitis coronavirus limits interferon production by inducing a host shutoff that requires accessory protein 5b

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• Accessory protein 5a is a major antagonist of the antiviral action of interferon against murine coronavirus

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• Efficient induction of cytotoxic T lymphocytes specific for severe acute respiratory syndrome (SARS)-associated coronavirus by immunization with surface-linked liposomal peptides derived from a non-structural polyprotein 1a

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• PEDV and PDCoV pathogenesis: The interplay between host innate immune responses and porcine enteric coronaviruses

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• Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonists

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• Severe acute respiratory syndrome coronavirus triggers apoptosis via protein kinase R but is resistant to its antiviral activity

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• The ADP-ribose-1″-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses

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• Interferon interplay helps tissue cells to cope with SARS-coronavirus infection

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• Interferon priming enables cells to partially overturn the SARS coronavirus-induced block in innate immune activation

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• Acute hepatic failure in IFN-γ-deficient BALB/c mice after murine coronavirus infection

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• Middle East respiratory syndrome coronavirus-encoded ORF8b strongly antagonizes IFN-β promoter activation: its implication for vaccine design

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• Effect of interferon alpha and cyclosporine treatment separately and in combination on Middle East Respiratory Syndrome Coronavirus (MERS-CoV) replication in a human in-vitro and ex-vivo culture model

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• Murine coronavirus induces type i interferon in oligodendrocytes through recognition by RIG-I and MDA5

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• Porcine intestinal enteroids: A new model for studying enteric coronavirus porcine epidemic diarrhea virus infection and the host innate response

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• Severe acute respiratory syndrome coronavirus papain-like protease suppressed alpha interferon-induced responses through downregulation of extracellular signal-regulated kinase 1-mediated signalling pathways

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• SARS coronavirus papain-like protease inhibits the TLR7 signaling pathway through removing Lys63-linked polyubiquitination of TRAF3 and TRAF6

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• Correlation between TGF-β1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain-like protease

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• Porcine deltacoronavirus nucleocapsid protein suppressed IFN-β production by interfering porcine RIG-I dsRNA-binding and K63-linked polyubiquitination

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• Accessory proteins of SARS-CoV and other coronaviruses

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• Peptides corresponding to the predicted heptad repeat 2 domain of the feline coronavirus spike protein are potent inhibitors of viral infection

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• Porcine deltacoronavirus nsp15 antagonizes interferon-β production independently of its endoribonuclease activity

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• Immune responses against severe acute respiratory syndrome coronavirus induced by virus-like particles in mice

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• Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3

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• Type IVB pilus operon promoter controlling expression of the severe acute respiratory syndrome-associated coronavirus nucleocapsid gene in Salmonella enterica serovar Typhi elicits full immune response by intranasal vaccination

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• Porcine deltacoronavirus (PDCoV) infection suppresses RIG-I-mediated interferon-β production

  👤 Luo, Jingyi 👤 Fang, Liurong 👤 Dong, Nan 👤 Fang, Puxian 👤 Ding, Zhen 👤 Wang, Dang 👤 Chen, Huanchun 👤 Xiao, Shaobo ⏰ 2016 📚 Virology

• Protein interferon-stimulated gene 15 conjugation delays but does not overcome coronavirus proliferation in a model of fulminant hepatitis

  👤 Ma, Xue Zhong 👤 Bartczak, Agata 👤 Zhang, Jianhua 👤 He, Wei 👤 Shalev, Itay 👤 Smil, David 👤 Chen, Limin 👤 Phillips, Jim 👤 Feld, Jordan J. 👤 Selzner, Nazia 👤 Levy, Gary 👤 McGilvray, Ian ⏰ 2014 📚 Journal of Virology

• The coronavirus transmissible gastroenteritis virus evades the type i interferon response through IRE1α-mediated manipulation of the MicroRNA miR-30a-5p/SOCS1/3 Axis

  👤 Ma, Yanlong 👤 Wang, Changlin 👤 Xue, Mei 👤 Fu, Fang 👤 Zhang, Xin 👤 Li, Liang 👤 Yin, Lingdan 👤 Xu, Wanhai 👤 Feng, Li 👤 Liu, Pinghuang ⏰ 2018 📚 Journal of Virology

• Combined action of type I and type III interferon restricts initial replication of severe acute respiratory syndrome coronavirus in the lung but fails to inhibit systemic virus spread

  👤 Mahlakõiv, Tanel 👤 Ritz, Daniel 👤 Mordstein, Markus 👤 DeDiego, Marta L. 👤 Enjuanes, Luis 👤 Müller, Marcel A. 👤 Drosten, Christian 👤 Staeheli, Peter ⏰ 2012 📚 Journal of General Virology

• Inflammatory Mediators in the Mesenteric Lymph Nodes, Site of a Possible Intermediate Phase in the Immune Response to Feline Coronavirus and the Pathogenesis of Feline Infectious Peritonitis?

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• A highly immunogenic and protective middle east respiratory syndrome coronavirus vaccine based on a recombinant measles virus vaccine platform

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• Middle east respiratory syndrome coronavirus during pregnancy, Abu Dhabi, United Arab Emirates, 2013

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• Identification of a gamma interferon-activated inhibitor of translation-like RNA motif at the 3′ end of the transmissible gastroenteritis coronavirus genome modulating innate immune response

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• Compounds with therapeutic potential against novel respiratory 2019 coronavirus.

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• The SARS coronavirus papain like protease can inhibit IRF3 at a post activation step that requires deubiquitination activity

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• Fatal outcome of human coronavirus NL63 infection despite successful viral elimination by IFN-alpha in a patient with newly diagnosed ALL

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• Protective role of toll-like receptor 3-induced type I interferon in murine coronavirus infection of macrophages

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• Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses

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• Middle East respiratory syndrome coronavirus nonstructural protein 16 is necessary for interferon resistance and viral pathogenesis

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• Attenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking 2'-o-methyltransferase activity

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• Immune response to a murine coronavirus: Identification of a homing receptor-negative CD4+ T cell subset that responds to viral glycoproteins

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• A Systematic Review of therapeutic agents for the treatment of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV)

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• Ribavirin and interferon-β synergistically inhibit SARS-associated coronavirus replication in animal and human cell lines

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• Attenuation of replication by a 29 nucleotide deletion in SARS-coronavirus acquired during the early stages of human-to-human transmission

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• Mouse-passaged severe acute respiratory syndrome-associated coronavirus leads to lethal pulmonary edema and diffuse alveolar damage in adult but not young mice

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• Inhibition of stress granule formation by middle east respiratory syndrome coronavirus 4a accessory protein facilitates viral translation, leading to efficient virus replication

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• Severe acute respiratory syndrome coronavirus nsp1 suppresses host gene expression, including that of type I interferon, in infected cells

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• The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species

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• Middle east respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist

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• Engineering T cells specific for a dominant severe acute respiratory syndrome coronavirus CD8 T cell epitope

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• Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: A retrospective cohort study

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• New antiviral drugs, vaccines and classic public health interventions against SARS coronavirus

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• Induction of alternatively activated macrophages enhances pathogenesis during severe acute respiratory syndrome coronavirus infection

  👤 Page, Carly 👤 Goicochea, Lindsay 👤 Matthews, Krystal 👤 Zhang, Yong 👤 Klover, Peter 👤 Holtzman, Michael J. 👤 Hennighausen, Lothar 👤 Frieman, Matthew ⏰ 2012 📚 Journal of Virology

• Gamma interferon signaling in oligodendrocytes is critical for protection from neurotropic coronavirus infection

  👤 Parra, Gabriel I. 👤 Bergmann, Cornelia C. 👤 Phares, Timothy W. 👤 Hinton, David R. 👤 Atkinson, Roscoe 👤 Stohlman, Stephen A. ⏰ 2010 📚 Journal of Virology

• Reverse genetic characterization of the natural genomic deletion in SARS-Coronavirus strain Frankfurt-1 open reading frame 7b reveals an attenuating function of the 7b protein in-vitro and in-vivo

  👤 Pfefferle, Susanne 👤 Krähling, Verena 👤 Ditt, Vanessa 👤 Grywna, Klaus 👤 Mühlberger, Elke 👤 Drosten, Christian ⏰ 2009 📚 Virology Journal

• Anti-severe acute respiratory syndrome coronavirus immune responses: The role played by Vγ9Vδ2 T cells

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• Characterization of cytotoxic T-lymphocyte epitopes and immune responses to SARS coronavirus spike DNA vaccine expressing the RGD-integrin-binding motif

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• Quantification of mRNA encoding cytokines and chemokines and assessment of ciliary function in canine tracheal epithelium during infection with canine respiratory coronavirus (CRCoV)

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• Innate immune response of human alveolar type II cells infected with severe acute respiratory syndrome-coronavirus

  👤 Qian, Zhaohui 👤 Travanty, Emily A. 👤 Oko, Lauren 👤 Edeen, Karen 👤 Berglund, Andrew 👤 Wang, Jieru 👤 Ito, Yoko 👤 Holmes, Kathryn V. 👤 Mason, Robert J. ⏰ 2013 📚 American Journal of Respiratory Cell and Molecular Biology

• Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study.

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• Type I interferon receptor-independent and -dependent host transcriptional responses to mouse hepatitis coronavirus infection in vivo

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• Non-invasive imaging of mouse hepatitis coronavirus infection reveals determinants of viral replication and spread in vivo

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• Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses

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• Early upregulation of acute respiratory distress syndrome-associated cytokines promotes lethal disease in an aged-mouse model of severe acute respiratory syndrome coronavirus infection

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• Clinical trials on drug repositioning for COVID-19 treatment.

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• Murine coronavirus delays expression of a subset of interferon-stimulated genes

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• Murine coronavirus cell type dependent interaction with the type I interferon response

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• Murine coronavirus mouse hepatitis virus is recognized by MDA5 and induces type I interferon in brain macrophages/microglia

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• Interferon-beta and interferon-gamma synergistically inhibit the replication of severe acute respiratory syndrome-associated coronavirus (SARS-CoV)

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• Fine Tuning the Cytokine Storm by IFN and IL-10 Following Neurotropic Coronavirus Encephalomyelitis

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• Memory CD4+ T-cell-mediated protection from lethal coronavirus encephalomyelitis

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• Severe acute respiratory syndrome coronavirus elicits a weak interferon response compared to traditional interferon-inducing viruses

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• High secretion of interferons by human plasmacytoid dendritic cells upon recognition of middle east respiratory syndrome coronavirus

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• Gold nanoparticle-adjuvanted S protein induces a strong antigen-specific IgG response against severe acute respiratory syndrome-related coronavirus infection, but fails to induce protective antibodies and limit eosinophilic infiltration in lungs

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• Modulation of the immune response by Middle East respiratory syndrome coronavirus

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• Release of severe acute respiratory syndrome coronavirus nuclear import block enhances host transcription in human lung cells

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• Suppression of innate antiviral response by severe acute respiratory syndrome coronavirus M protein is mediated through the first transmembrane domain

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• Severe acute respiratory syndrome coronavirus nucleocapsid protein does not modulate transcription of the human FGL2 gene

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• Severe acute respiratory syndrome coronavirus M protein inhibits type I interferon production by impeding theformation of TRAF3·TANK·TBK1/IKKε complex

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• Middle east respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in the innate antiviral response

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• Chemokine CXCL10 and Coronavirus-Induced Neurologic Disease

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• The role of gamma interferon in infection of susceptible mice with murine coronavirus, MHV-JHM

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• Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen

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• Inhibition of beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3

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