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Keywords

🔗 receptor-binding domain (99) 🔗 immune response (314) 🔗 immune responses (142) 🔗 transgenic mice (28) 🔗 severe acute (1373) 🔗 syndrome coronavirus (1074) 🔗 high mortality (78) 🔗 antibody responses (58) 🔗 respiratory syndrome (2004) 🔗 acute respiratory (1734) 🔗 spike protein (353) 🔗 urgently needed (40) 🔗 dipeptidyl peptidase (47) 🔗 results suggest (206) 🔗 health care (123) 🔗 data suggest (146) 🔗 highly conserved (80) 🔗 cells expressing (60) 🔗 host cell (262) 🔗 cell surface (110) 🔗 viral entry (91) 🔗 fatality rate (123) 🔗 epithelial cells (128) 🔗 viral replication (258) 🔗 small intestine (43)

Articles (7)

Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines
👤 Du, Lanying 👤 Tai, Wanbo 👤 Yang, Yang 👤 Zhao, Guangyu 👤 Zhu, Qing 👤 Sun, Shihui 👤 Liu, Chang 👤 Tao, Xinrong 👤 Tseng, Chien Te K. 👤 Perlman, Stanley 👤 Jiang, Shibo 👤 Zhou, Yusen 👤 Li, Fang ⏰ 2016 📚 Nature Communications
Identification of a receptor-binding domain in the S protein of the novel human coronavirus middle east respiratory syndrome coronavirus as an essential target for vaccine development
👤 Du, Lanying 👤 Zhao, Guangyu 👤 Kou, Zhihua 👤 Ma, Cuiqing 👤 Sun, Shihui 👤 Poon, Vincent K.M. 👤 Lu, Lu 👤 Wang, Lili 👤 Debnath, Asim K. 👤 Zheng, Bo Jian 👤 Zhou, Yusen 👤 Jiang, Shibo ⏰ 2013 📚 Journal of Virology
A conformation-dependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in middle east respiratory syndrome coronavirus spike protein
👤 Du, Lanying 👤 Zhao, Guangyu 👤 Yang, Yang 👤 Qiu, Hongjie 👤 Wang, Lili 👤 Kou, Zhihua 👤 Tao, Xinrong 👤 Yu, Hong 👤 Sun, Shihui 👤 Tseng, Chien Te K. 👤 Jiang, Shibo 👤 Li, Fang 👤 Zhou, Yusen ⏰ 2014 📚 Journal of Virology
Single-dose treatment with a humanized neutralizing antibody affords full protection of a human transgenic mouse model from lethal Middle East respiratory syndrome (MERS)-coronavirus infection
👤 Qiu, Hongjie 👤 Sun, Shihui 👤 Xiao, He 👤 Feng, Jiannan 👤 Guo, Yan 👤 Tai, Wanbo 👤 Wang, Yufei 👤 Du, Lanying 👤 Zhao, Guangyu 👤 Zhou, Yusen ⏰ 2016 📚 Antiviral Research
Molecular mechanism for antibody-dependent enhancement of coronavirus entry
👤 Wan, Yushun 👤 Shang, Jian 👤 Sun, Shihui 👤 Tai, Wanbo 👤 Chen, Jing 👤 Geng, Qibin 👤 He, Lei 👤 Chen, Yuehong 👤 Wu, Jianming 👤 Shi, Zhengli 👤 Zhou, Yusen 👤 Du, Lanying 👤 Li, Fang ⏰ 2020 📚 Journal of Virology
A novel nanobody targeting middle east respiratory syndrome coronavirus (MERS-CoV) receptor-binding domain has potent cross-neutralizing activity and protective efficacy against MERS-CoV
👤 Zhao, Guangyu 👤 He, Lei 👤 Sun, Shihui 👤 Qiu, Hongjie 👤 Tai, Wanbo 👤 Chen, Jiawei 👤 Li, Jiangfan 👤 Chen, Yuehong 👤 Guo, Yan 👤 Wang, Yufei 👤 Shang, Jian 👤 Ji, Kaiyuan 👤 Fan, Ruiwen 👤 Du, Enqi 👤 Jiang, Shibo 👤 Li, Fang 👤 Du, Lanying 👤 Zhou, Yusen ⏰ 2018 📚 Journal of Virology
Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus
👤 Zhou, Jie 👤 Li, Cun 👤 Zhao, Guangyu 👤 Chu, Hin 👤 Wang, Dong 👤 Yan, Helen Hoi Ning 👤 Poon, Vincent Kwok Man 👤 Wen, Lei 👤 Wong, Bosco Ho Yin 👤 Zhao, Xiaoyu 👤 Chiu, Man Chun 👤 Yang, Dong 👤 Wang, Yixin 👤 Au-Yeung, Rex K.H. 👤 Chan, Ivy Hau Yee 👤 Sun, Shihui 👤 Chan, Jasper Fuk Woo 👤 To, Kelvin Kai Wang 👤 Memish, Ziad A. 👤 Corman, Victor M. 👤 Drosten, Christian 👤 Hung, Ivan Fan Ngai 👤 Zhou, Yusen 👤 Leung, Suet Yi 👤 Yuen, Kwok Yung ⏰ 2017 📚 Science Advances