🔗 Drug development

Articles (25)

• Computational modeling of the bat HKU4 coronavirus 3CLpro inhibitors as a tool for the development of antivirals against the emerging Middle East respiratory syndrome (MERS) coronavirus

  👤 Abuhammad, Areej 👤 Al-Aqtash, Rua'a A. 👤 Anson, Brandon J. 👤 Mesecar, Andrew D. 👤 Taha, Mutasem O. ⏰ 2017 📚 Journal of Molecular Recognition

• Synthesis and anti-coronavirus activity of a series of 1-thia-4-azaspiro[4.5]decan-3-one derivatives

  👤 Apaydın, Çağla Begüm 👤 Cesur, Nesrin 👤 Stevaert, Annelies 👤 Naesens, Lieve 👤 Cesur, Zafer ⏰ 2019 📚 Archiv der Pharmazie

• Identification of Novel Inhibitors of the SARS Coronavirus Main Protease 3CLpro

  👤 Bacha, Usman 👤 Barrila, Jennifer 👤 Velazquez-Campoy, Adrian 👤 Leavitt, Stephanie A. 👤 Freire, Ernesto ⏰ 2004 📚 Biochemistry

• Structural insights into the Middle East respiratory syndrome coronavirus 4a protein and its dsRNA binding mechanism

  👤 Batool, Maria 👤 Shah, Masaud 👤 Patra, Mahesh Chandra 👤 Yesudhas, Dhanusha 👤 Choi, Sangdun ⏰ 2017 📚 Scientific Reports

• Prediction of functional class of the SARS coronavirus proteins by a statistical learning method

  👤 Cai, C. Z. 👤 Han, L. Y. 👤 Chen, X. 👤 Cao, Z. W. 👤 Chen, Y. Z. ⏰ 2005 📚 Journal of Proteome Research

• Structure-based virtual screening and experimental validation of the discovery of inhibitors targeted towards the human coronavirus nucleocapsid protein

  👤 Chang, Chung Ke 👤 Jeyachandran, Sivakamavalli 👤 Hu, Nien Jen 👤 Liu, Chia Ling 👤 Lin, Shing Yen 👤 Wang, Yong Sheng 👤 Chang, Yu Ming 👤 Hou, Ming Hon ⏰ 2016 📚 Molecular BioSystems

• Thiopurine analogue inhibitors of severe acute respiratory syndrome-coronavirus papain-like protease, a deubiquitinating and deISGylating enzyme

  👤 Chen, Xin 👤 Chou, Chi Yuan 👤 Chang, Gu Gang ⏰ 2009 📚 Antiviral Chemistry and Chemotherapy

• Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus

  👤 Cheng, Kai Wen 👤 Cheng, Shu Chun 👤 Chen, Wei Yi 👤 Lin, Min Han 👤 Chuang, Shang Ju 👤 Cheng, I. Hsin 👤 Sun, Chiao Yin 👤 Chou, Chi Yuan ⏰ 2015 📚 Antiviral Research

• Rapid peptide-based screening on the substrate specificity of severe acute respiratory syndrome (SARS) coronavirus 3C-like protease by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

  👤 Chu, Ling Hon Matthew 👤 Choy, Wai Yan 👤 Tsai, Sau Na 👤 Rao, Zihe 👤 Ngai, Sai Ming ⏰ 2006 📚 Protein Science

• Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture

  👤 De Wilde, Adriaan H. 👤 Jochmans, Dirk 👤 Posthuma, Clara C. 👤 Zevenhoven-Dobbe, Jessika C. 👤 Van Nieuwkoop, Stefan 👤 Bestebroer, Theo M. 👤 Van Den Hoogen, Bernadette G. 👤 Neyts, Johan 👤 Snijder, Eric J. ⏰ 2014 📚 Antimicrobial Agents and Chemotherapy

• A guideline for homology modeling of the proteins from newly discovered betacoronavirus, 2019 novel coronavirus (2019-nCoV).

  👤 Dong, Shengjie 👤 Sun, Jiachen 👤 Mao, Zhuo 👤 Wang, Lu 👤 Lu, Yi-Lin 👤 Li, Jiesen ⏰ 2020 📚 J Med Virol

• Evaluating the 3C-like protease activity of SARS-Coronavirus: Recommendations for standardized assays for drug discovery

  👤 Grum-Tokars, Valerie 👤 Ratia, Kiira 👤 Begaye, Adrian 👤 Baker, Susan C. 👤 Mesecar, Andrew D. ⏰ 2008 📚 Virus Research

• Immunological, structural, and preliminary X-ray diffraction characterizations of the fusion core of the SARS-coronavirus spike protein

  👤 Hsu, Chun Hua 👤 Ko, Tzu Ping 👤 Yu, Hui Ming 👤 Tang, Tswen Kei 👤 Chen, Shui Tsung 👤 Wang, Andrew H.J. ⏰ 2004 📚 Biochemical and Biophysical Research Communications

• Natural products and their derivatives against coronavirus: A review of the non-clinical and pre-clinical data.

  👤 Islam, Muhammad Torequl 👤 Sarkar, Chandan 👤 El-Kersh, Dina M 👤 Jamaddar, Sarmin 👤 Uddin, Shaikh Jamal 👤 Shilpi, Jamil A 👤 Mubarak, Mohammad S ⏰ 2020 📚 Phytother Res

• Cell-based antiviral screening against coronaviruses: Developing virus-specific and broad-spectrum inhibitors

  👤 Kilianski, Andy 👤 Baker, Susan C. ⏰ 2014 📚 Antiviral Research

• Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds

  👤 Lin, Cheng Wen 👤 Tsai, Fuu Jen 👤 Tsai, Chang Hai 👤 Lai, Chien Chen 👤 Wan, Lei 👤 Ho, Tin Yun 👤 Hsieh, Chang Chi 👤 Chao, Pei Dawn Lee ⏰ 2005 📚 Antiviral Research

• Current Drugs with Potential for Treatment of COVID-19: A Literature Review.

  👤 Md Insiat Islam Rabby ⏰ 2020 📚 J Pharm Pharm Sci

• Inhibition of cytosolic phospholipase A2α impairs an early step of coronavirus replication in cell culture

  👤 Müller, Christin 👤 Hardt, Martin 👤 Schwudke, Dominik 👤 Neuman, Benjamin W. 👤 Pleschka, Stephan 👤 Ziebuhr, John ⏰ 2018 📚 Journal of Virology

• Protease inhibitors broadly effective against feline, ferret and mink coronaviruses

  👤 Perera, Krishani Dinali 👤 Galasiti Kankanamalage, Anushka C. 👤 Rathnayake, Athri D. 👤 Honeyfield, Amanda 👤 Groutas, William 👤 Chang, Kyeong Ok 👤 Kim, Yunjeong ⏰ 2018 📚 Antiviral Research

• Nucleoside analogues for the treatment of coronavirus infections

  👤 Pruijssers, Andrea J. 👤 Denison, Mark R. ⏰ 2019 📚 Current Opinion in Virology

• Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association

  👤 Sui, Jianhua 👤 Li, Wenhui 👤 Murakami, Akikazu 👤 Tamin, Azaibi 👤 Matthews, Leslie J. 👤 Wong, Swee Kee 👤 Moore, Michael J. 👤 Tallarico, Aimee St Clair 👤 Olurinde, Mobolaji 👤 Choe, Hyeryun 👤 Anderson, Larry J. 👤 Bellini, William J. 👤 Farzan, Michael 👤 Marasco, Wayne A. ⏰ 2004 📚 Proceedings of the National Academy of Sciences of the United States of America

• Exploring the binding mechanism of the main proteinase in SARS-associated coronavirus and its implication to anti-SARS drug design

  👤 Zhang, Xue Wu 👤 Yap, Yee Leng ⏰ 2004 📚 Bioorganic and Medicinal Chemistry

• The 2019 novel coronavirus resource.

  👤 Zhao, Wen-Ming 👤 Song, Shu-Hui 👤 Chen, Mei-Li 👤 Zou, Dong 👤 Ma, Li-Na 👤 Ma, Ying-Ke 👤 Li, Ru-Jiao 👤 Hao, Li-Li 👤 Li, Cui-Ping 👤 Tian, Dong-Mei 👤 Tang, Bi-Xia 👤 Wang, Yan-Qing 👤 Zhu, Jun-Wei 👤 Chen, Huan-Xin 👤 Zhang, Zhang 👤 Xue, Yong-Biao 👤 Bao, Yi-Ming ⏰ 2020 📚 Yi Chuan

• Core structure of S2 from the human coronavirus NL63 spike glycoprotein

  👤 Zheng, Qi 👤 Deng, Yiqun 👤 Liu, Jie 👤 Van Der Hoek, Lia 👤 Berkhout, Ben 👤 Lu, Min ⏰ 2006 📚 Biochemistry

• Without its N-finger, the main protease of severe acute respiratory syndrome coronavirus can form a novel dimer through its C-terminal domain

  👤 Zhong, Nan 👤 Zhang, Shengnan 👤 Zou, Peng 👤 Chen, Jiaxuan 👤 Kang, Xue 👤 Li, Zhe 👤 Liang, Chao 👤 Jin, Changwen 👤 Xia, Bin ⏰ 2008 📚 Journal of Virology