🔗 Heptad repeat

Articles (55)

• Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides

  👤 Bosch, Berend Jan 👤 Martina, Byron E.E. 👤 Van Der Zee, Ruurd 👤 Lepault, Jean 👤 Haijema, Bert Jan 👤 Versluis, Cees 👤 Heck, Albert J.R. 👤 De Groot, Raoul 👤 Osterhaus, Albert D.M.E. 👤 Rottier, Peter J.M. ⏰ 2004 📚 Proceedings of the National Academy of Sciences of the United States of America

• Coronavirus escape from Heptad Repeat 2 (HR2)-derived peptide entry inhibition as a result of mutations in the HR1 domain of the spike fusion protein

  👤 Bosch, Berend Jan 👤 Rossen, John W.A. 👤 Bartelink, Willem 👤 Zuurveen, Stephanie J. 👤 De Haan, Cornelis A.M. 👤 Duquerroy, Stephane 👤 Boucher, Charles A.B. 👤 Rottier, Peter J.M. ⏰ 2008 📚 Journal of Virology

• Cross-reactive antibodies in convalescent SARS patients' sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests

  👤 Chan, Kwok Hung 👤 Chan, Jasper Fuk Woo 👤 Tse, Herman 👤 Chen, Honglin 👤 Lau, Candy Choi Yi 👤 Cai, Jian Piao 👤 Tsang, Alan Ka Lun 👤 Xiao, Xincai 👤 To, Kelvin Kai Wang 👤 Lau, Susanna Kar Pui 👤 Woo, Patrick Chiu Yat 👤 Zheng, Bo Jiang 👤 Wang, Ming 👤 Yuen, Kwok Yung ⏰ 2013 📚 Journal of Infection

• Functional characterization of heptad repeat 1 and 2 mutants of the spike protein of severe acute respiratory syndrome coronavirus

  👤 Chan, Woan Eng 👤 Chuang, Chin Kai 👤 Yeh, Shiou Hwei 👤 Chang, Mau Sun 👤 Chen, Steve S.L. ⏰ 2006 📚 Journal of Virology

• Protective effect of intranasal regimens containing peptidic middle east respiratory syndrome coronavirus fusion inhibitor against MERS-CoV infection

  👤 Channappanavar, Rudragouda 👤 Lu, Lu 👤 Xia, Shuai 👤 Du, Lanying 👤 Meyerholz, David K. 👤 Perlman, Stanley 👤 Jiang, Shibo ⏰ 2015 📚 Journal of Infectious Diseases

• Genotyping of turkey coronavirus field isolates from various geographic locations in the Unites States based on the spike gene

  👤 Chen, Yi Ning 👤 Loa, Chien Chang 👤 Ababneh, Mustafa Mohammed Khair 👤 Wu, Ching Ching 👤 Lin, Tsang Long ⏰ 2015 📚 Archives of Virology

• Fusion core structure of the severe acute respiratory syndrome coronavirus (SARS-CoV): In search of potent SARS-CoV entry inhibitors

  👤 Chu, Ling Hon Matthew 👤 Chan, Siu Hong 👤 Tsai, Sau Na 👤 Wang, Yi 👤 Cheng, Christopher Hon Ki 👤 Wong, Kam Bo 👤 Waye, Mary Miu Yee 👤 Ngai, Sai Ming ⏰ 2008 📚 Journal of Cellular Biochemistry

• Cooperative involvement of the S1 and S2 subunits of the murine coronavirus spike protein in receptor binding and extended host range

  👤 De Haan, Cornelis A.M. 👤 Te Lintelo, Eddie 👤 Li, Zhen 👤 Raaben, Matthijs 👤 Wurdinger, Tom 👤 Bosch, Berend Jan 👤 Rottier, Peter J.M. ⏰ 2006 📚 Journal of Virology

• Central ions and lateral asparagine/glutamine zippers stabilize the post-fusion hairpin conformation of the SARS coronavirus spike glycoprotein

  👤 Duquerroy, Stéphane 👤 Vigouroux, Armelle 👤 Rottier, Peter J.M. 👤 Rey, Félix A. 👤 Jan Bosch, Berend ⏰ 2005 📚 Virology

• The heptad repeat region is a major selection target in MERS-CoV and related coronaviruses

  👤 Forni, Diego 👤 Filippi, Giulia 👤 Cagliani, Rachele 👤 De Gioia, Luca 👤 Pozzoli, Uberto 👤 Al-Daghri, Nasser 👤 Clerici, Mario 👤 Sironi, Manuela ⏰ 2015 📚 Scientific Reports

• Structure of the fusion core and inhibition of fusion by a heptad repeat peptide derived from the S protein of middle east respiratory syndrome coronavirus

  👤 Gao, Jing 👤 Lu, Guangwen 👤 Qi, Jianxun 👤 Li, Yan 👤 Wu, Ying 👤 Deng, Yao 👤 Geng, Heyuan 👤 Li, Hongbin 👤 Wang, Qihui 👤 Xiao, Haixia 👤 Tan, Wenjie 👤 Yan, Jinghua 👤 Gao, George F. ⏰ 2013 📚 Journal of Virology

• Identification of the membrane-active regions of the severe acute respiratory syndrome coronavirus spike membrane glycoprotein using a 16/18-mer peptide scan: Implications for the viral fusion mechanism

  👤 Guillén, Jaime 👤 Pérez-Berná, Ana J. 👤 Moreno, Miguel R. 👤 Villalaín, José ⏰ 2005 📚 Journal of Virology

• Solution structure of the severe acute respiratory syndrome-coronavirus heptad repeat 2 domain in the prefusion state

  👤 Hakansson-McReynolds, Susanna 👤 Jiang, Shaokai 👤 Rong, Lijun 👤 Caffrey, Michael ⏰ 2006 📚 Journal of Biological Chemistry

• Cloning, sequencing and expression of the S protein gene from two geographically distinct strains of canine coronavirus

  👤 Horsburgh, Brian C. 👤 Brown, T. David K. ⏰ 1995 📚 Virus Research

• Immunological, structural, and preliminary X-ray diffraction characterizations of the fusion core of the SARS-coronavirus spike protein

  👤 Hsu, Chun Hua 👤 Ko, Tzu Ping 👤 Yu, Hui Ming 👤 Tang, Tswen Kei 👤 Chen, Shui Tsung 👤 Wang, Andrew H.J. ⏰ 2004 📚 Biochemical and Biophysical Research Communications

• Novel Gold Nanorod-Based HR1 Peptide Inhibitor for Middle East Respiratory Syndrome Coronavirus

  👤 Huang, Xinyu 👤 Li, Meng 👤 Xu, Yurui 👤 Zhang, Jikang 👤 Meng, Xia 👤 An, Xueying 👤 Sun, Lei 👤 Guo, Leilei 👤 Shan, Xue 👤 Ge, Junliang 👤 Chen, Jiao 👤 Luo, Yadong 👤 Wu, Heming 👤 Zhang, Yu 👤 Jiang, Qing 👤 Ning, Xinghai ⏰ 2019 📚 ACS Applied Materials and Interfaces

• Structural characterization of the fusion-active complex of severe acute respiratory syndrome (SARS) coronavirus

  👤 Ingallinella, Paolo 👤 Bianchi, Elisabetta 👤 Finotto, Marco 👤 Cantoni, Giovanna 👤 Eckert, Debra M. 👤 Supekar, Vinit M. 👤 Bruckmann, Chiara 👤 Carfi, Andrea 👤 Pessi, Antonello ⏰ 2004 📚 Proceedings of the National Academy of Sciences of the United States of America

• The First Disease X is Caused by a Highly Transmissible Acute Respiratory Syndrome Coronavirus.

  👤 Jiang, Shibo 👤 Shi, Zheng-Li ⏰ 2020 📚 Virol Sin

• Molecular dynamics of Middle East Respiratory Syndrome Coronavirus (MERS CoV) fusion heptad repeat trimers

  👤 Kandeel, Mahmoud 👤 Al-Taher, Abdulla 👤 Li, Huifang 👤 Schwingenschlogl, Udo 👤 Al-Nazawi, Mohamed ⏰ 2018 📚 Computational Biology and Chemistry

• Biochemical Analysis of Coronavirus Spike Glycoprotein Conformational Intermediates during Membrane Fusion

  👤 Kawase, Miyuki 👤 Kataoka, Michiyo 👤 Shirato, Kazuya 👤 Matsuyama, Shutoku ⏰ 2019 📚 Journal of virology

• Amino acids 1055 to 1192 in the S2 region of severe acute respiratory syndrome coronavirus S protein induce neutralizing antibodies: Implications for the development of vaccines and antiviral agents

  👤 Keng, Choong Tat 👤 Zhang, Aihua 👤 Shen, Shuo 👤 Lip, Kuo Ming 👤 Fielding, Burtram C. 👤 Tan, Timothy H.P. 👤 Chou, Chih Fong 👤 Chay, Boon Loh 👤 Wang, Sifang 👤 Fu, Jianlin 👤 Yang, Xiaoming 👤 Seng, Gee Lim 👤 Hong, Wanjin 👤 Tan, Yee Joo ⏰ 2005 📚 Journal of Virology

• Characterization of neutralizing monoclonal antibodies recognizing a 15-residues epitope on the spike protein HR2 region of severe acute respiratory syndrome coronavirus (SARS-CoV)

  👤 Lai, Szu Chia 👤 Chong, Pele Choi Sing 👤 Yeh, Chia Tsui 👤 Liu, Levent Shih Jen 👤 Jan, Jia Tsrong 👤 Chi, Hsiang Yun 👤 Liu, Hwan Wun 👤 Chen, Ann 👤 Wang, Yeau Ching ⏰ 2005 📚 Journal of Biomedical Science

• Monoclonal antibodies targeting the HR2 domain and the region immediately upstream of the HR2 of the S protein neutralize in vitro infection of severe acute respiratory syndrome coronavirus

  👤 Lip, Kuo Ming 👤 Shen, Shuo 👤 Yang, Xiaoming 👤 Keng, Choong Tat 👤 Zhang, Aihua 👤 Oh, Hsueh Ling Janice 👤 Li, Zhi Hong 👤 Hwang, Le Ann 👤 Chou, Chih Fong 👤 Fielding, Burtram C. 👤 Tan, Timothy H.P. 👤 Mayrhofer, Josef 👤 Falkner, Falko G. 👤 Fu, Jianlin 👤 Lim, Seng Gee 👤 Hong, Wanjin 👤 Tan, Yee Joo ⏰ 2006 📚 Journal of Virology

• Peptides corresponding to the predicted heptad repeat 2 domain of the feline coronavirus spike protein are potent inhibitors of viral infection

  👤 Liu, I. Jung 👤 Tsai, Wan Ting 👤 Hsieh, Li En 👤 Chueh, Ling Ling ⏰ 2013 📚 PLoS ONE

• Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: Implications for virus fusogenic mechanism and identification of fusion inhibitors

  👤 Liu, Shuwen 👤 Xiao, Gengfu 👤 Chen, Yibang 👤 He, Yuxian 👤 Niu, Jinkui 👤 Escalante, Carlos R. 👤 Xiong, Huabao 👤 Farmar, James 👤 Debnath, Asim K. 👤 Tien, Po 👤 Jiang, Shibo ⏰ 2004 📚 Lancet

• Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2

  👤 Matsuyama, Shutoku 👤 Nagata, Noriyo 👤 Shirato, Kazuya 👤 Kawase, Miyuki 👤 Takeda, Makoto 👤 Taguchi, Fumihiro ⏰ 2010 📚 Journal of Virology

• Receptor-induced conformational changes of murine coronavirus spike protein

  👤 Matsuyama, Shutoku 👤 Taguchi, Fumihiro ⏰ 2002 📚 Journal of Virology

• Two-step conformational changes in a coronavirus envelope glycoprotein mediated by receptor binding and proteolysis

  👤 Matsuyama, Shutoku 👤 Taguchi, Fumihiro ⏰ 2009 📚 Journal of Virology

• Characterization of the prefusion and transition states of severe acute respiratory syndrome coronavirus S2-HR2

  👤 McReynolds, Susanna 👤 Jiang, Shaokai 👤 Guo, Ying 👤 Celigoy, Jessica 👤 Schar, Christine 👤 Rong, Lijun 👤 Caffrey, Michael ⏰ 2008 📚 Biochemistry

• Genetic analysis of the SARS-coronavirus spike glycoprotein functional domains involved in cell-surface expression and cell-to-cell fusion

  👤 Petit, Chad M. 👤 Melancon, Jeffrey M. 👤 Chouljenko, Vladimir N. 👤 Colgrove, Robin 👤 Farzan, Michael 👤 Knipe, David M. 👤 Kousoulas, K. G. ⏰ 2005 📚 Virology

• Inhibition of human coronavirus NL63 infection at early stages of the replication cycle

  👤 Pyrc, Krzysztof 👤 Bosch, Berend Jan 👤 Berkhout, Ben 👤 Jebbink, Maarten F. 👤 Dijkman, Ronald 👤 Rottier, Peter 👤 Van Der Hoek, Lia ⏰ 2006 📚 Antimicrobial Agents and Chemotherapy

• Nucleotide sequence of the gene encoding the spike glycoprotein of human coronavirus HCV 229E

  👤 Raabe, T. 👤 Schelle-Prinz, B. 👤 Siddell, S. G. ⏰ 1990 📚 Journal of General Virology

• Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein

  👤 Sainz Jr., Bruno 👤 Mossel, Eric C. 👤 Gallaher, William R. 👤 Wimley, William C. 👤 Peters, C. J. 👤 Wilson, Russell B. 👤 Garry, Robert F. ⏰ 2006 📚 Virus Research

• The aromatic domain of the coronavirus class I viral fusion protein induces membrane permeabilization: Putative role during viral entry

  👤 Sainz Jr., Bruno 👤 Rausch, Joshua M. 👤 Gallaher, William R. 👤 Garry, Robert F. 👤 Wimley, William C. ⏰ 2005 📚 Biochemistry

• Identification and characterization of the putative fusion peptide of the severe acute respiratory syndrome-associated coronavirus spike protein

  👤 Sainz Jr., Bruno 👤 Rausch, Joshua M. 👤 Gallaher, William R. 👤 Garry, Robert F. 👤 Wimley, William C. ⏰ 2005 📚 Journal of Virology

• Role of spike protein endodomains in regulating coronavirus entry

  👤 Shulla, Ana 👤 Gallagher, Tom ⏰ 2009 📚 Journal of Biological Chemistry

• Identification of a novel inhibitor against middle east respiratory syndrome coronavirus

  👤 Sun, Yaping 👤 Zhang, Huaidong 👤 Shi, Jian 👤 Zhang, Zhe 👤 Gong, Rui ⏰ 2017 📚 Viruses

• Structure of a proteolytically resistant core from the severe acute respiratory syndrome coronavirus S2 fusion protein

  👤 Supekar, Vinit M. 👤 Bruckmann, Chiara 👤 Ingallinella, Paolo 👤 Bianchi, Elisabetta 👤 Pessi, Antonello 👤 Carfi, Andrea ⏰ 2004 📚 Proceedings of the National Academy of Sciences of the United States of America

• Structural characterization of the SARS-coronavirus spike S fusion protein core

  👤 Tripet, Brian 👤 Howard, Megan W. 👤 Jobling, Michael 👤 Holmes, Randall K. 👤 Holmes, Kathryn V. 👤 Hodges, Robert S. ⏰ 2004 📚 Journal of Biological Chemistry

• Template-based coiled-coil antigens elicit neutralizing antibodies to the SARS-coronavirus

  👤 Tripet, Brian 👤 Kao, Daniel J. 👤 Jeffers, Scott A. 👤 Holmes, Kathryn V. 👤 Hodges, Robert S. ⏰ 2006 📚 Journal of Structural Biology

• Amino acid substitutions within the heptad repeat domain 1 of murine coronavirus spike protein restrict viral antigen spread in the central nervous system

  👤 Tsai, Jean C. 👤 De Groot, Linda 👤 Pinon, Josefina D. 👤 Iacono, Kathryn T. 👤 Phillips, Joanna J. 👤 Seo, Su Hun 👤 Lavi, Ehud 👤 Weiss, Susan R. ⏰ 2003 📚 Virology

• Heptad repeat-derived peptides block protease-mediated direct entry from the cell surface of severe acute respiratory syndrome coronavirus but not entry via the endosomal pathway

  👤 Ujike, Makoto 👤 Nishikawa, Hiroki 👤 Otaka, Akira 👤 Yamamoto, Naoki 👤 Yamamoto, Norio 👤 Matsuoka, Masao 👤 Kodama, Eiichi 👤 Fujii, Nobutaka 👤 Taguchi, Fumihiro ⏰ 2008 📚 Journal of Virology

• Discovery of Hydrocarbon-Stapled Short α-Helical Peptides as Promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Fusion Inhibitors

  👤 Wang, Chao 👤 Xia, Shuai 👤 Zhang, Peiyu 👤 Zhang, Tianhong 👤 Wang, Weicong 👤 Tian, Yangli 👤 Meng, Guangpeng 👤 Jiang, Shibo 👤 Liu, Keliang ⏰ 2018 📚 Journal of Medicinal Chemistry

• Entry from the cell surface of severe acute respiratory syndrome coronavirus with cleaved S protein as revealed by pseudotype virus bearing cleaved S protein

  👤 Watanabe, Rie 👤 Matsuyama, Shutoku 👤 Shirato, Kazuya 👤 Maejima, Masami 👤 Fukushi, Shuetsu 👤 Morikawa, Shigeru 👤 Taguchi, Fumihiro ⏰ 2008 📚 Journal of Virology

• Nucleotide sequence and expression of the spike (S) gene of canine coronavirus and comparison with the S proteins of feline and porcine coronaviruses

  👤 Wesseling, J. G. 👤 Vennema, H. 👤 Godeke, G. J. 👤 Horzinek, M. C. 👤 Rottier, P. J.M. ⏰ 1994 📚 Journal of General Virology

• Soluble receptor-mediated targeting of mouse hepatitis coronavirus to the human epidermal growth factor receptor

  👤 Würdinger, T. 👤 Verheije, M. H. 👤 Broen, K. 👤 Bosch, B. J. 👤 Haijema, B. J. 👤 De Haan, C. A.M. 👤 Van Beusechem, V. W. 👤 Gerritsen, W. R. 👤 Rottier, P. J.M. ⏰ 2005 📚 Journal of Virology

• Construct design, biophysical, and biochemical characterization of the fusion core from mouse hepatitis virus (a coronavirus) spike protein

  👤 Xu, Yanhui 👤 Cole, David K. 👤 Lou, Zhiyong 👤 Liu, Yiwei 👤 Qin, Lan 👤 Li, Xu 👤 Bai, Zhihong 👤 Yuan, Fang 👤 Rao, Zihe 👤 Gao, George F. ⏰ 2004 📚 Protein Expression and Purification

• Structural basis for coronavirus-mediated membrane fusion: Crystal structure of mouse hepatitis virus spike protein fusion core

  👤 Xu, Yanhui 👤 Liu, Yiwei 👤 Lou, Zhiyong 👤 Qin, Lan 👤 Li, Xu 👤 Bai, Zhihong 👤 Pang, Hai 👤 Tien, Po 👤 Gao, George F. 👤 Rao, Zihe ⏰ 2004 📚 Journal of Biological Chemistry

• Crystal structure of severe acute respiratory syndrome coronavirus spike protein fusion core

  👤 Xu, Yanhui 👤 Lou, Zhiyong 👤 Liu, Yiwei 👤 Pang, Hai 👤 Tien, Po 👤 Gao, George F. 👤 Rao, Zihe ⏰ 2004 📚 Journal of Biological Chemistry

• Characterization of the heptad repeat regions, HR1 and HR2, and design of a fusion core structure model of the spike protein from Severe Acute Respiratory Syndrome (SARS) coronavirus

  👤 Xu, Yanhui 👤 Zhu, Jieqing 👤 Liu, Yiwei 👤 Lou, Zhiyong 👤 Yuan, Fang 👤 Liu, Yueyong 👤 Cole, David K. 👤 Ni, Ling 👤 Su, Nan 👤 Qin, Lan 👤 Li, Xu 👤 Bai, Zhihong 👤 Bell, John I. 👤 Pang, Hai 👤 Tien, Po 👤 Gao, George F. 👤 Rao, Zihe ⏰ 2004 📚 Biochemistry

• Crystal structure of the post-fusion core of the Human coronavirus 229E spike protein at 1.86 Å resolution

  👤 Yan, Lei 👤 Meng, Bing 👤 Xiang, Jiangchao 👤 Wilson, Ian A. 👤 Yang, Bei ⏰ 2018 📚 Acta Crystallographica Section D: Structural Biology

• Biophysical characterization of HRC peptide analogs interaction with heptad repeat regions of the SARS-coronavirus Spike fusion protein core

  👤 Yan, Zhe 👤 Tripet, Brian 👤 Hodges, Robert S. ⏰ 2006 📚 Journal of Structural Biology

• Severe acute respiratory syndrome coronavirus entry into host cells: Opportunities for therapeutic intervention

  👤 Yeung, Kap Sun 👤 Yamanaka, Gregory A. 👤 Meanwell, Nicholas A. ⏰ 2006 📚 Medicinal Research Reviews

• Adaptive evolution of the spike gene of SARS coronavirus: Changes in positively selected sites in different epidemic groups

  👤 Zhang, Chi Yu 👤 Wei, Ji Fu 👤 He, Shao Ng ⏰ 2006 📚 BMC Microbiology

• Following the rule: Formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors

  👤 Zhu, Jieqing 👤 Xiao, Gengfu 👤 Xu, Yanhui 👤 Yuan, Fang 👤 Zheng, Congyi 👤 Liu, Yueyong 👤 Yan, Huimin 👤 Cole, David K. 👤 Bell, John I. 👤 Rao, Zihe 👤 Tien, Po 👤 Gao, George F. ⏰ 2004 📚 Biochemical and Biophysical Research Communications