🔗 Viral fusion

Articles (38)

• Influence of hydrophobic and electrostatic residues on SARS-coronavirus S2 protein stability: Insights into mechanisms of general viral fusion and inhibitor design

  👤 Aydin, Halil 👤 Al-Khooly, Dina 👤 Lee, Jeffrey E. ⏰ 2014 📚 Protein Science

• Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites

  👤 Belouzard, Sandrine 👤 Chu, Victor C. 👤 Whittaker, Gary R. ⏰ 2009 📚 Proceedings of the National Academy of Sciences of the United States of America

• Conformational reorganization of the SARS coronavirus spike following receptor binding: Implications for membrane fusion

  👤 Beniac, Daniel R. 👤 de Varennes, Shauna L. 👤 Andonov, Anton 👤 He, Runtao 👤 Booth, Tim F. ⏰ 2007 📚 PLoS ONE

• Cathepsin L functionally cleaves the severe acute respiratory syndrome coronavirus class I fusion protein upstream of rather than adjacent to the fusion peptide

  👤 Bosch, Berend Jan 👤 Bartelink, Willem 👤 Rottier, Peter J.M. ⏰ 2008 📚 Journal of Virology

• Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides

  👤 Bosch, Berend Jan 👤 Martina, Byron E.E. 👤 Van Der Zee, Ruurd 👤 Lepault, Jean 👤 Haijema, Bert Jan 👤 Versluis, Cees 👤 Heck, Albert J.R. 👤 De Groot, Raoul 👤 Osterhaus, Albert D.M.E. 👤 Rottier, Peter J.M. ⏰ 2004 📚 Proceedings of the National Academy of Sciences of the United States of America

• Coronavirus escape from Heptad Repeat 2 (HR2)-derived peptide entry inhibition as a result of mutations in the HR1 domain of the spike fusion protein

  👤 Bosch, Berend Jan 👤 Rossen, John W.A. 👤 Bartelink, Willem 👤 Zuurveen, Stephanie J. 👤 De Haan, Cornelis A.M. 👤 Duquerroy, Stephane 👤 Boucher, Charles A.B. 👤 Rottier, Peter J.M. ⏰ 2008 📚 Journal of Virology

• The coronavirus spike protein is a class I virus fusion protein: Structural and functional characterization of the fusion core complex

  👤 Bosch, Berend Jan 👤 Van der Zee, Ruurd 👤 De Haan, Cornelis A.M. 👤 Rottier, Peter J.M. ⏰ 2003 📚 Journal of Virology

• Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner

  👤 Burkard, Christine 👤 Verheije, Monique H. 👤 Wicht, Oliver 👤 van Kasteren, Sander I. 👤 van Kuppeveld, Frank J. 👤 Haagmans, Bart L. 👤 Pelkmans, Lucas 👤 Rottier, Peter J.M. 👤 Bosch, Berend Jan 👤 de Haan, Cornelis A.M. ⏰ 2014 📚 PLoS Pathogens

• Modulation of coronavirus‐mediated cell fusion by homeostatic control of cholesterol and fatty acid metabolism

  👤 Cervin, Marguerite 👤 Anderson, Robert ⏰ 1991 📚 Journal of Medical Virology

• Coronavirus and influenza virus proteolytic priming takes place in tetraspanin-enriched membrane microdomains

  👤 Earnest, James T. 👤 Hantak, Michael P. 👤 Park, Jung Eun 👤 Gallagher, Tom ⏰ 2015 📚 Journal of Virology

• Serine-scanning mutagenesis studies of the C-terminal heptad repeats in the SARS coronavirus S glycoprotein highlight the important role of the short helical region

  👤 Follis, Kathryn E. 👤 York, Joanne 👤 Nunberg, Jack H. ⏰ 2005 📚 Virology

• Interaction of a peptide from the pre-transmembrane domain of the severe acute respiratory syndrome coronavirus spike protein with phospholipid membranes

  👤 Guillen, Jaime 👤 Moreno, Miguel R. 👤 Pérez-Berná, Ana J. 👤 Bernabeu, Angela 👤 Villalaín, José ⏰ 2007 📚 Journal of Physical Chemistry B

• Solution structure of the severe acute respiratory syndrome-coronavirus heptad repeat 2 domain in the prefusion state

  👤 Hakansson-McReynolds, Susanna 👤 Jiang, Shaokai 👤 Rong, Lijun 👤 Caffrey, Michael ⏰ 2006 📚 Journal of Biological Chemistry

• Aromatic amino acids in the juxtamembrane domain of severe acute respiratory syndrome coronavirus spike glycoprotein are important for receptor-dependent virus entry and cell-cell fusion

  👤 Howard, Megan W. 👤 Travanty, Emily A. 👤 Jeffers, Scott A. 👤 Smith, M. K. 👤 Wennier, Sonia T. 👤 Thackray, Larissa B. 👤 Holmes, Kathryn V. ⏰ 2008 📚 Journal of Virology

• Immunological, structural, and preliminary X-ray diffraction characterizations of the fusion core of the SARS-coronavirus spike protein

  👤 Hsu, Chun Hua 👤 Ko, Tzu Ping 👤 Yu, Hui Ming 👤 Tang, Tswen Kei 👤 Chen, Shui Tsung 👤 Wang, Andrew H.J. ⏰ 2004 📚 Biochemical and Biophysical Research Communications

• A fluorogenic peptide cleavage assay to screen for proteolytic activity: Applications for coronavirus spike protein activation

  👤 Jaimes, Javier A. 👤 Millet, Jean K. 👤 Goldstein, Monty E. 👤 Whittaker, Gary R. 👤 Straus, Marco R. ⏰ 2019 📚 Journal of Visualized Experiments

• The First Disease X is Caused by a Highly Transmissible Acute Respiratory Syndrome Coronavirus.

  👤 Jiang, Shibo 👤 Shi, Zheng-Li ⏰ 2020 📚 Virol Sin

• Biochemical Analysis of Coronavirus Spike Glycoprotein Conformational Intermediates during Membrane Fusion

  👤 Kawase, Miyuki 👤 Kataoka, Michiyo 👤 Shirato, Kazuya 👤 Matsuyama, Shutoku ⏰ 2019 📚 Journal of virology

• Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor

  👤 Lu, Lu 👤 Liu, Qi 👤 Zhu, Yun 👤 Chan, Kwok Hung 👤 Qin, Lili 👤 Li, Yuan 👤 Wang, Qian 👤 Chan, Jasper Fuk Woo 👤 Du, Lanying 👤 Yu, Fei 👤 Ma, Cuiqing 👤 Ye, Sheng 👤 Yuen, Kwok Yung 👤 Zhang, Rongguang 👤 Jiang, Shibo ⏰ 2014 📚 Nature Communications

• Roles in cell-to-cell fusion of two conserved hydrophobic regions in the murine coronavirus spike protein

  👤 Luo, Zongli 👤 Weiss, Susan R. ⏰ 1998 📚 Virology

• Characterization of a highly conserved domain within the severe acute respiratory syndrome coronavirus spike protein S2 domain with characteristics of a viral fusion peptide

  👤 Madu, Ikenna G. 👤 Roth, Shoshannah L. 👤 Belouzard, Sandrine 👤 Whittaker, Gary R. ⏰ 2009 📚 Journal of Virology

• Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2

  👤 Matsuyama, Shutoku 👤 Nagata, Noriyo 👤 Shirato, Kazuya 👤 Kawase, Miyuki 👤 Takeda, Makoto 👤 Taguchi, Fumihiro ⏰ 2010 📚 Journal of Virology

• Production of pseudotyped particles to study highly pathogenic coronaviruses in a biosafety level 2 setting

  👤 Millet, Jean K. 👤 Tang, Tiffany 👤 Nathan, Lakshmi 👤 Jaimes, Javier A. 👤 Hsu, Hung Lun 👤 Daniel, Susan 👤 Whittaker, Gary R. ⏰ 2019 📚 Journal of Visualized Experiments

• Fusion resistance and decreased infectability as major host cell determinants of coronavirus persistence

  👤 Mizzen, Lee 👤 Cheley, Steve 👤 Rao, Meena 👤 Wolf, Robert 👤 Anderson, Robert ⏰ 1983 📚 Virology

• Identification of the fusion peptide-containing region in betacoronavirus spike glycoproteins

  👤 Ou, Xiuyuan 👤 Zheng, Wangliang 👤 Shan, Yiwei 👤 Mu, Zhixia 👤 Dominguez, Samuel R. 👤 Holmes, Kathryn V. 👤 Qian, Zhaohui ⏰ 2016 📚 Journal of Virology

• A three-stemmed mRNA pseudoknot in the SARS coronavirus frameshift signal

  👤 Plant, Ewan P. 👤 Pérez-Alvarado, Gabriela C. 👤 Jacobs, Jonathan L. 👤 Mukhopadhyay, Bani 👤 Hennig, Mirko 👤 Dinman, Jonathan D. ⏰ 2005 📚 PLoS Biology

• Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein

  👤 Sainz Jr., Bruno 👤 Mossel, Eric C. 👤 Gallaher, William R. 👤 Wimley, William C. 👤 Peters, C. J. 👤 Wilson, Russell B. 👤 Garry, Robert F. ⏰ 2006 📚 Virus Research

• The aromatic domain of the coronavirus class I viral fusion protein induces membrane permeabilization: Putative role during viral entry

  👤 Sainz Jr., Bruno 👤 Rausch, Joshua M. 👤 Gallaher, William R. 👤 Garry, Robert F. 👤 Wimley, William C. ⏰ 2005 📚 Biochemistry

• Identification and characterization of the putative fusion peptide of the severe acute respiratory syndrome-associated coronavirus spike protein

  👤 Sainz Jr., Bruno 👤 Rausch, Joshua M. 👤 Gallaher, William R. 👤 Garry, Robert F. 👤 Wimley, William C. ⏰ 2005 📚 Journal of Virology

• Structural characterization of the SARS-coronavirus spike S fusion protein core

  👤 Tripet, Brian 👤 Howard, Megan W. 👤 Jobling, Michael 👤 Holmes, Randall K. 👤 Holmes, Kathryn V. 👤 Hodges, Robert S. ⏰ 2004 📚 Journal of Biological Chemistry

• Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer

  👤 Walls, Alexandra C. 👤 Tortorici, M. Alejandra 👤 Bosch, Berend Jan 👤 Frenz, Brandon 👤 Rottier, Peter J.M. 👤 DiMaio, Frank 👤 Rey, Félix A. 👤 Veesler, David ⏰ 2016 📚 Nature

• Discovery of Hydrocarbon-Stapled Short α-Helical Peptides as Promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Fusion Inhibitors

  👤 Wang, Chao 👤 Xia, Shuai 👤 Zhang, Peiyu 👤 Zhang, Tianhong 👤 Wang, Weicong 👤 Tian, Yangli 👤 Meng, Guangpeng 👤 Jiang, Shibo 👤 Liu, Keliang ⏰ 2018 📚 Journal of Medicinal Chemistry

• Structural basis for coronavirus-mediated membrane fusion: Crystal structure of mouse hepatitis virus spike protein fusion core

  👤 Xu, Yanhui 👤 Liu, Yiwei 👤 Lou, Zhiyong 👤 Qin, Lan 👤 Li, Xu 👤 Bai, Zhihong 👤 Pang, Hai 👤 Tien, Po 👤 Gao, George F. 👤 Rao, Zihe ⏰ 2004 📚 Journal of Biological Chemistry

• Crystal structure of severe acute respiratory syndrome coronavirus spike protein fusion core

  👤 Xu, Yanhui 👤 Lou, Zhiyong 👤 Liu, Yiwei 👤 Pang, Hai 👤 Tien, Po 👤 Gao, George F. 👤 Rao, Zihe ⏰ 2004 📚 Journal of Biological Chemistry

• Crystallization and preliminary crystallographic analysis of the heptad-repeat complex of SARS coronavirus spike protein

  👤 Xu, Yanhui 👤 Su, Nan 👤 Qin, Lan 👤 Bai, Zhihong 👤 Gao, George F. 👤 Rao, Zihe ⏰ 2004 📚 Acta Crystallographica Section D: Biological Crystallography

• Crystal structure of the post-fusion core of the Human coronavirus 229E spike protein at 1.86 Å resolution

  👤 Yan, Lei 👤 Meng, Bing 👤 Xiang, Jiangchao 👤 Wilson, Ian A. 👤 Yang, Bei ⏰ 2018 📚 Acta Crystallographica Section D: Structural Biology

• Genetic analysis of determinants for spike glycoprotein assembly into murine coronavirus virions: Distinct roles for charge-rich and cysteine-rich regions of the endodomain

  👤 Ye, Rong 👤 Montalto-Morrison, Cynthia 👤 Masters, Paul S. ⏰ 2004 📚 Journal of Virology

• Following the rule: Formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors

  👤 Zhu, Jieqing 👤 Xiao, Gengfu 👤 Xu, Yanhui 👤 Yuan, Fang 👤 Zheng, Congyi 👤 Liu, Yueyong 👤 Yan, Huimin 👤 Cole, David K. 👤 Bell, John I. 👤 Rao, Zihe 👤 Tien, Po 👤 Gao, George F. ⏰ 2004 📚 Biochemical and Biophysical Research Communications