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Articles (39)

• Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra α-helical domain

  👤 Anand, Kanchan 👤 Palm, Gottfried J. 👤 Mesters, Jeroen R. 👤 Siddell, Stuart G. 👤 Ziebuhr, John 👤 Hilgenfeld, Rolf ⏰ 2002 📚 EMBO Journal

• Identification of Novel Inhibitors of the SARS Coronavirus Main Protease 3CLpro

  👤 Bacha, Usman 👤 Barrila, Jennifer 👤 Velazquez-Campoy, Adrian 👤 Leavitt, Stephanie A. 👤 Freire, Ernesto ⏰ 2004 📚 Biochemistry

• Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: Homology modelling and molecular dynamic studies

  👤 Berry, Michael 👤 Fielding, Burtram 👤 Gamieldien, Junaid ⏰ 2015 📚 BMC Structural Biology

• Structural and functional analyses of the severe acute respiratory syndrome coronavirus endoribonuclease Nsp15

  👤 Bhardwaj, Kanchan 👤 Palaninathan, Satheesh 👤 Alcantara, Joanna Maria Ortiz 👤 Yi, Lillian Li 👤 Guarino, Linda 👤 Sacchettini, James C. 👤 Kao, C. Cheng ⏰ 2008 📚 Journal of Biological Chemistry

• Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease

  👤 Békés, Miklós 👤 van der Heden van Noort, Gerbrand J. 👤 Ekkebus, Reggy 👤 Ovaa, Huib 👤 Huang, Tony T. 👤 Lima, Christopher D. ⏰ 2016 📚 Molecular Cell

• Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase

  👤 Chen, Yu 👤 Cai, Hui 👤 Pan, Ji'an 👤 Xiang, Nian 👤 Tien, Po 👤 Ahola, Tero 👤 Guo, Deyin ⏰ 2009 📚 Proceedings of the National Academy of Sciences of the United States of America

• Biochemical and structural insights into the mechanisms of sars coronavirus RNA ribose 2′-O-methylation by nsp16/nsp10 protein complex

  👤 Chen, Yu 👤 Su, Ceyang 👤 Ke, Min 👤 Jin, Xu 👤 Xu, Lirong 👤 Zhang, Zhou 👤 Wu, Andong 👤 Sun, Ying 👤 Yang, Zhouning 👤 Tien, Po 👤 Ahola, Tero 👤 Liang, Yi 👤 Liu, Xinqi 👤 Guo, Deyin ⏰ 2011 📚 PLoS Pathogens

• Binding mechanism of coronavirus main proteinase with ligands and its implication to drug design against SARS

  👤 Chou, Kuo Chen 👤 Wei, Dong Qing 👤 Zhong, Wei Zhu ⏰ 2003 📚 Biochemical and Biophysical Research Communications

• Comparison of bovine coronavirus isolates associated with neonatal calf diarrhoea and winter dysentery in adult dairy cattle in Quebec

  👤 Dea, S. 👤 Michaud, L. 👤 Milane, G. ⏰ 1995 📚 Journal of General Virology

• Coronaviruses: An RNA proofreading machine regulates replication fidelity and diversity

  👤 Denison, Mark R. 👤 Graham, Rachel L. 👤 Donaldson, Eric F. 👤 Eckerle, Lance D. 👤 Baric, Ralph S. ⏰ 2011 📚 RNA Biology

• Proofreading-deficient coronaviruses adapt for increased fitness over long-term passage without reversion of exoribonuclease-inactivating mutations

  👤 Graepel, Kevin W. 👤 Lu, Xiaotao 👤 Case, James Brett 👤 Sexton, Nicole R. 👤 Smith, Everett Clinton 👤 Denisona, Mark R. ⏰ 2017 📚 mBio

• 3C-like Proteinase from SARS Coronavirus Catalyzes Substrate Hydrolysis by a General Base Mechanism

  👤 Huang, Changkang 👤 Wei, Ping 👤 Fan, Keqiang 👤 Liu, Ying 👤 Lai, Luhua ⏰ 2004 📚 Biochemistry

• Multiple enzymatic activities associated with severe acute respiratory syndrome coronavirus helicase

  👤 Ivanov, A. 👤 Thiel, Volker 👤 Dobbe, Jessika C. 👤 Van Der Meer, Yvonne 👤 Snijder, Eric J. 👤 Ziebuhrl, John ⏰ 2004 📚 Journal of Virology

• Human coronavirus 229E nonstructural protein 13: Characterization of duplex-unwinding, nucleoside triphosphatase, and RNA 5′-triphosphatase activities

  👤 Ivanov, Konstantin A. 👤 Ziebuhr, John ⏰ 2004 📚 Journal of Virology

• Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch

  👤 Joseph, Jeremiah S. 👤 Saikatendu, Kumar Singh 👤 Subramanian, Vanitha 👤 Neuman, Benjamin W. 👤 Buchmeier, Michael J. 👤 Stevens, Raymond C. 👤 Kuhn, Peter ⏰ 2007 📚 Journal of Virology

• Targeting SARS-CoV-2: A Systematic Drug Repurposing Approach to Identify Promising Inhibitors Against 3C-like Proteinase and 2'-O-RiboseMethyltransferase.

  👤 Khan, Rameez Jabeer 👤 Jha, Rajat Kumar 👤 Amera, GizachewMuluneh 👤 Jain, Monika 👤 Singh, Ekampreet 👤 Pathak, Amita 👤 Singh, Rashmi Prabha 👤 Muthukumaran, Jayaraman 👤 Singh, Amit Kumar ⏰ 2020 📚 J Biomol Struct Dyn

• Tumor necrosis factor-α convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2)

  👤 Lambert, Daniel W. 👤 Yarski, Mike 👤 Warner, Fiona J. 👤 Thornhill, Paul 👤 Parkin, Edward T. 👤 Smith, A. Ian 👤 Hooper, Nigel M. 👤 Turner, Anthony J. ⏰ 2005 📚 Journal of Biological Chemistry

• Crystal Structures Reveal an Induced-fit Binding of a Substrate-like Aza-peptide Epoxide to SARS Coronavirus Main Peptidase

  👤 Lee, Ting Wai 👤 Cherney, Maia M. 👤 Liu, Jie 👤 James, Karen Ellis 👤 Powers, James C. 👤 Eltis, Lindsay D. 👤 James, Michael N.G. ⏰ 2007 📚 Journal of Molecular Biology

• Influenza C virus and bovine coronavirus esterase reveal a similar catalytic mechanism: New insights for drug discovery

  👤 Mayr, Juliane 👤 Haselhorst, Thomas 👤 Langereis, Martijn A. 👤 Dyason, Jeffrey C. 👤 Huber, Wolfgang 👤 Frey, Barbara 👤 Vlasak, Reinhard 👤 De Groot, Raoul J. 👤 Von Itzstein, Mark ⏰ 2008 📚 Glycoconjugate Journal

• Peptide-Protein Interaction Studies of Antimicrobial Peptides Targeting Middle East Respiratory Syndrome Coronavirus Spike Protein: An In Silico Approach

  👤 Mustafa, Sabeena 👤 Balkhy, Hanan 👤 Gabere, Musa ⏰ 2019 📚 Advances in Bioinformatics

• Structures of the Middle East respiratory syndrome coronavirus 3C-like protease reveal insights into substrate specificity

  👤 Needle, Danielle 👤 Lountos, George T. 👤 Waugh, David S. ⏰ 2015 📚 Acta Crystallographica Section D: Biological Crystallography

• Topographic changes in SARS coronavirus-infected cells during late stages of infection

  👤 Ng, Mah Lee 👤 Lee, J. W.M. 👤 Leong, M. L.N. 👤 Ling, A. E. 👤 Tan, H. C. 👤 Ooi, E. E. ⏰ 2004 📚 Emerging Infectious Diseases

• Flavonoid-mediated inhibition of SARS coronavirus 3C-like protease expressed in Pichia pastoris

  👤 Nguyen, Thi Thanh Hanh 👤 Woo, Hye Jin 👤 Kang, Hee Kyoung 👤 Nguyen, Van Dao 👤 Kim, Young Min 👤 Kim, Do Won 👤 Ahn, Sul Ah 👤 Xia, Yongmei 👤 Kim, Doman ⏰ 2012 📚 Biotechnology Letters

• Unrevealing sequence and structural features of novel coronavirus using in silico approaches: The main protease as molecular target.

  👤 Ortega, Joseph Thomas 👤 Serrano, Maria Luisa 👤 Pujol, Flor Helene 👤 Rangel, Hector Rafael ⏰ 2020 📚 EXCLI J

• ADP-ribose-1″-monophosphatase: A conserved coronavirus enzyme that is dispensable for viral replication in tissue culture

  👤 Putics, Ákos 👤 Filipowicz, Witold 👤 Hall, Jonathan 👤 Gorbalenya, Alexander E. 👤 Ziebuhr, John ⏰ 2005 📚 Journal of Virology

• Severe acute respiratory syndrome coronavirus papain-like-protease: Structure of a viral deubiquitinating enzyme

  👤 Ratia, Kiira 👤 Saikatendu, Kumar Singh 👤 Santarsiero, Bernard D. 👤 Barreto, Naina 👤 Baker, Susan C. 👤 Stevens, Raymond C. 👤 Mesecar, Andrew D. ⏰ 2006 📚 Proceedings of the National Academy of Sciences of the United States of America

• The structure of the endoribonuclease XendoU: From small nucleolar RNA processing to severe acute respiratory syndrome coronavirus replication

  👤 Renzi, Fabiana 👤 Caffarelli, Elisa 👤 Laneve, Pietro 👤 Bozzoni, Irene 👤 Brunori, Maurizio 👤 Vallone, Beatrice ⏰ 2006 📚 Proceedings of the National Academy of Sciences of the United States of America

• Crystal structure and mechanistic determinants of SARS coronavirus nonstructural protein 15 define an endoribonuclease family

  👤 Ricagno, Stefano 👤 Egloff, Marie Pierre 👤 Ulferts, Rachel 👤 Coutard, Bruno 👤 Nurizzo, Didier 👤 Campanacci, Valérie 👤 Cambillau, Christian 👤 Ziebuhr, John 👤 Canard, Bruno ⏰ 2006 📚 Proceedings of the National Academy of Sciences of the United States of America

• Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1″-phosphate dephosphorylation by a conserved domain of nsP3

  👤 Saikatendu, Kumar Singh 👤 Joseph, Jeremiah S. 👤 Subramanian, Vanitha 👤 Clayton, Tom 👤 Griffith, Mark 👤 Moy, Kin 👤 Velasquez, Jeffrey 👤 Neuman, Benjamin W. 👤 Buchmeier, Michael J. 👤 Stevens, Raymond C. 👤 Kuhn, Peter ⏰ 2005 📚 Structure

• A novel auto-cleavage assay for studying mutational effects on the active site of severe acute respiratory syndrome coronavirus 3C-like protease

  👤 Shan, Yu Fei 👤 Li, Shou Feng 👤 Xu, Gen Jun ⏰ 2004 📚 Biochemical and Biophysical Research Communications

• Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4 - The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)

  👤 St. John, Sarah E. 👤 Tomar, Sakshi 👤 Stauffer, Shaun R. 👤 Mesecar, Andrew D. ⏰ 2015 📚 Bioorganic and Medicinal Chemistry

• Temperature-sensitive mutants and revertants in the coronavirus nonstructural protein 5 protease (3CLpro) define residues involved in long-distance communication and regulation of protease activity

  👤 Stobart, Christopher C. 👤 Lee, Alice S. 👤 Lu, Xiaotao 👤 Denisona, Mark R. ⏰ 2012 📚 Journal of Virology

• QM/QM studies for Michael reaction in coronavirus main protease (3CLPro)

  👤 Taranto, Alex G. 👤 Carvalho, Paulo 👤 Avery, Mitchell A. ⏰ 2008 📚 Journal of Molecular Graphics and Modelling

• Structural and biochemical characterization of SADS-CoV papain-like protease 2.

  👤 Wang, Lu 👤 Hu, Weihua 👤 Fan, Chengpeng ⏰ 2020 📚 Protein Sci

• On the mechanisms of bananin activity against severe acute respiratory syndrome coronavirus

  👤 Wang, Zai 👤 Huang, Jian Dong 👤 Wong, Kin Ling 👤 Wang, Pei Gang 👤 Zhang, Hao Jie 👤 Tanner, Julian A. 👤 Spiga, Ottavia 👤 Bernini, Andrea 👤 Zheng, Bo Jian 👤 Niccolai, Neri ⏰ 2011 📚 FEBS Journal

• Human aminopeptidase N is a receptor for human coronavirus 229E

  👤 Yeager, Curtis L. 👤 Ashmun, Richard A. 👤 Williams, Richard K. 👤 Cardellichio, Christine B. 👤 Shapiro, Linda H. 👤 Look, A. Thomas 👤 Holmes, Kathryn V. ⏰ 1992 📚 Nature

• The hemagglutinin/esterase glycoprotein of bovine coronaviruses: Sequence and functional comparisons between virulent and avirulent strains

  👤 Zhang, Xuming 👤 Kousoulas, Konstantin G. 👤 Storz, Johannes ⏰ 1991 📚 Virology

• Identification of novel proteolytically inactive mutations in coronavirus 3C-like protease using a combined approach

  👤 Zhou, Junwei 👤 Fang, Liurong 👤 Yang, Zhixiang 👤 Xu, Shangen 👤 Lv, Mengting 👤 Sun, Zheng 👤 Chen, Jiyao 👤 Wang, Dang 👤 Gao, Jun 👤 Xiao, Shaobo ⏰ 2019 📚 FASEB journal : official publication of the Federation of American Societies for Experimental Biology

• Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease

  👤 Zhu, Lili 👤 George, Shyla 👤 Schmidt, Marco F. 👤 Al-Gharabli, Samer I. 👤 Rademann, Jörg 👤 Hilgenfeld, Rolf ⏰ 2011 📚 Antiviral Research