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Articles (200)

• Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms

  👤 Adedeji, Adeyemi O. 👤 Severson, William 👤 Jonsson, Colleen 👤 Singh, Kamalendra 👤 Weiss, Susan R. 👤 Sarafianosa, Stefan G. ⏰ 2013 📚 Journal of Virology

• Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms.

  👤 Baig, Abdul Mannan 👤 Khaleeq, Areeba 👤 Ali, Usman 👤 Syeda, Hira ⏰ 2020 📚 ACS Chem Neurosci

• Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy?

  👤 Batlle, Daniel 👤 Wysocki, Jan 👤 Satchell, Karla ⏰ 2020 📚 Clin Sci (Lond)

• Conformational reorganization of the SARS coronavirus spike following receptor binding: Implications for membrane fusion

  👤 Beniac, Daniel R. 👤 de Varennes, Shauna L. 👤 Andonov, Anton 👤 He, Runtao 👤 Booth, Tim F. ⏰ 2007 📚 PLoS ONE

• Cleavage and activation of the severe acute respiratory syndrome coronavirus spike protein by human airway trypsin-like protease

  👤 Bertram, Stephanie 👤 Glowacka, Ilona 👤 Müller, Marcel A. 👤 Lavender, Hayley 👤 Gnirss, Kerstin 👤 Nehlmeier, Inga 👤 Niemeyer, Daniela 👤 He, Yuxian 👤 Simmons, Graham 👤 Drosten, Christian 👤 Soilleux, Elizabeth J. 👤 Jahn, Olaf 👤 Steffen, Imke 👤 Pöhlmann, Stefan ⏰ 2011 📚 Journal of Virology

• Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts

  👤 Bertram, Stephanie 👤 Heurich, Adeline 👤 Lavender, Hayley 👤 Gierer, Stefanie 👤 Danisch, Simon 👤 Perin, Paula 👤 Lucas, Jared M. 👤 Nelson, Peter S. 👤 Pöhlmann, Stefan 👤 Soilleux, Elizabeth J. ⏰ 2012 📚 PLoS ONE

• Membrane ectopeptidases targeted by human coronaviruses

  👤 Bosch, Berend Jan 👤 Smits, Saskia L. 👤 Haagmans, Bart L. ⏰ 2014 📚 Current Opinion in Virology

• Long-term human coronavirus-myelin cross-reactive T-cell clones derived from multiple sclerosis patients

  👤 Boucher, Annie 👤 Desforges, Marc 👤 Duquette, Pierre 👤 Talbot, Pierre J. ⏰ 2007 📚 Clinical Immunology

• Smoking Upregulates Angiotensin-Converting Enzyme-2 Receptor: A Potential Adhesion Site for Novel Coronavirus SARS-CoV-2 (Covid-19).

  👤 Brake, Samuel James 👤 Barnsley, Kathryn 👤 Lu, Wenying 👤 McAlinden, Kielan Darcy 👤 Eapen, Mathew Suji 👤 Sohal, Sukhwinder Singh ⏰ 2020 📚 J Clin Med

• In Silico Discovery of Candidate Drugs against Covid-19.

  👤 Cava, Claudia 👤 Bertoli, Gloria 👤 Castiglioni, Isabella ⏰ 2020 📚 Viruses

• The SARS coronavirus S glycoprotein receptor binding domain: Fine mapping and functional characterization

  👤 Chakraborti, Samitabh 👤 Prabakaran, Ponraj 👤 Xiao, Xiaodong 👤 Dimitrov, Dimiter S. ⏰ 2005 📚 Virology Journal

• Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility.

  👤 Chan, Jasper Fuk-Woo 👤 Zhang, Anna Jinxia 👤 Yuan, Shuofeng 👤 Poon, Vincent Kwok-Man 👤 Chan, Chris Chung-Sing 👤 Lee, Andrew Chak-Yiu 👤 Chan, Wan-Mui 👤 Fan, Zhimeng 👤 Tsoi, Hoi-Wah 👤 Wen, Lei 👤 Liang, Ronghui 👤 Cao, Jianli 👤 Chen, Yanxia 👤 Tang, Kaiming 👤 Luo, Cuiting 👤 Cai, Jian-Piao 👤 Kok, Kin-Hang 👤 Chu, Hin 👤 Chan, Kwok-Hung 👤 Sridhar, Siddharth 👤 Chen, Zhiwei 👤 Chen, Honglin 👤 To, Kelvin Kai-Wang 👤 Yuen, Kwok-Yung ⏰ 2020 📚 Clin Infect Dis

• Persistent infection of SARS coronavirus in colonic cells in vitro

  👤 Chan, Paul K.S. 👤 To, Ka Fai 👤 Lo, Anthony W.I. 👤 Cheung, Jo L.K. 👤 Chu, Ida 👤 Au, Florence W.L. 👤 Tong, Joanna H.M. 👤 Tam, John S. 👤 Sung, Joseph J.Y. 👤 Ng, Ho Keung ⏰ 2004 📚 Journal of Medical Virology

• Functional characterization of heptad repeat 1 and 2 mutants of the spike protein of severe acute respiratory syndrome coronavirus

  👤 Chan, Woan Eng 👤 Chuang, Chin Kai 👤 Yeh, Shiou Hwei 👤 Chang, Mau Sun 👤 Chen, Steve S.L. ⏰ 2006 📚 Journal of Virology

• Upregulation of the chemokine (C-C Motif) Ligand 2 via a severe acute respiratory syndrome coronavirus spike-ACE2 signaling pathway

  👤 Chen, I. Yin 👤 Chang, Shin C. 👤 Wu, Hung Yi 👤 Yu, Ting Chun 👤 Wei, Wen Chin 👤 Lin, Shiming 👤 Chien, Chung Liang 👤 Chang, Ming Fu ⏰ 2010 📚 Journal of Virology

• The role of angiotensin-converting enzyme 2 in coronaviruses/influenza viruses and cardiovascular disease.

  👤 Chen, Li 👤 Hao, Guang ⏰ 2020 📚 Cardiovasc Res

• The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2.

  👤 Chen, Liang 👤 Li, Xiangjie 👤 Chen, Mingquan 👤 Feng, Yi 👤 Xiong, Chenglong ⏰ 2020 📚 Cardiovasc Res

• The SARS-CoV-2 Vaccine Pipeline: an Overview.

  👤 Chen, Wen-Hsiang 👤 Strych, Ulrich 👤 Hotez, Peter J 👤 Bottazzi, Maria Elena ⏰ 2020 📚 Curr Trop Med Rep

• Structure analysis of the receptor binding of 2019-nCoV.

  👤 Chen, Yun 👤 Guo, Yao 👤 Pan, Yihang 👤 Zhao, Zhizhuang Joe ⏰ 2020 📚 Biochem Biophys Res Commun

• Rhesus angiotensin converting enzyme 2 supports entry of severe acute respiratory syndrome coronavirus in Chinese macaques

  👤 Chen, Yunxin 👤 Liu, Li 👤 Wei, Qiang 👤 Zhu, Hua 👤 Jiang, Hong 👤 Tu, Xinming 👤 Qin, Chuan 👤 Chen, Zhiwei ⏰ 2008 📚 Virology

• Recombinant modified vaccinia virus Ankara expressing the spike glycoprotein of severe acute respiratory syndrome coronavirus induces protective neutralizing antibodies primarily targeting the receptor binding region

  👤 Chen, Zhiwei 👤 Zhang, Linqi 👤 Qin, Chuan 👤 Ba, Lei 👤 Yi, Christopher E. 👤 Zhang, Fengwen 👤 Wei, Qiang 👤 He, Tian 👤 Yu, Wenjie 👤 Yu, Jian 👤 Gao, Hong 👤 Tu, Xinming 👤 Gettie, Agegnehu 👤 Farzan, Michael 👤 Yuen, Kwok Yung 👤 Ho, David D. ⏰ 2005 📚 Journal of Virology

• Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19.

  👤 Cheng, Hao 👤 Wang, Yan 👤 Wang, Gui-Qiang ⏰ 2020 📚 J Med Virol

• The use of hepatitis C virus NS3/4A and secreted alkaline phosphatase to quantitate cell-cell membrane fusion mediated by severe acute respiratory syndrome coronavirus S protein and the receptor angiotensin-converting enzyme 2

  👤 Chou, Chih Fong 👤 Shen, Shuo 👤 Mahadevappa, Geetha 👤 Lim, Seng Gee 👤 Hong, Wanjin 👤 Tan, Yee Joo ⏰ 2007 📚 Analytical Biochemistry

• Expression of SARS-coronavirus spike glycoprotein in Pichia pastoris

  👤 Chuck, Chi Pang 👤 Wong, Chi Hang 👤 Chow, Larry Ming Cheung 👤 Fung, Kwok Pui 👤 Waye, Mary Miu Yee 👤 Tsui, Stephen Kwok Wing ⏰ 2009 📚 Virus Genes

• Coronavirus COV-19/SARS-CoV-2 affects women less than men: clinical response to viral infection.

  👤 Conti, P 👤 Younes, A ⏰ 2020 📚 J Biol Regul Homeost Agents

• Comment on "Organ-protective Effect of Angiotensin-converting Enzyme 2 and its Effect on the Prognosis of COVID-19".

  👤 Cure, Erkan 👤 Cumhur Cure, Medine ⏰ 2020 📚 J Med Virol

• Renin-Angiotensin System Blockers and the COVID-19 Pandemic: At Present There Is No Evidence to Abandon Renin-Angiotensin System Blockers.

  👤 Danser, A H Jan 👤 Epstein, Murray 👤 Batlle, Daniel ⏰ 2020 📚 Hypertension

• Interferon-γ and interleukin-4 downregulate expression of the SARS coronavirus receptor ACE2 in Vero E6 cells

  👤 de Lang, Anna 👤 Osterhaus, Albert D.M.E. 👤 Haagmans, Bart L. ⏰ 2006 📚 Virology

• Pathogenicity of severe acute respiratory coronavirus deletion mutants in hACE-2 transgenic mice

  👤 DeDiego, Marta L. 👤 Pewe, Lecia 👤 Alvarez, Enrique 👤 Rejas, Maria Teresa 👤 Perlman, Stanley 👤 Enjuanes, Luis ⏰ 2008 📚 Virology

• Evidence for ACE2-utilizing coronaviruses (covs) related to severe acute respiratory syndrome cov in bats

  👤 Demogines, Ann 👤 Farzan, Michael 👤 Sawyer, Sara L. ⏰ 2012 📚 Journal of Virology

• Hypothesis: angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may increase the risk of severe COVID-19.

  👤 Diaz, James H ⏰ 2020 📚 J Travel Med

• Replication-dependent downregulation of cellular angiotensin-converting enzyme 2 protein expression by human coronavirus NL63

  👤 Dijkman, Ronald 👤 Jebbink, Maarten F. 👤 Deijs, Martin 👤 Milewska, Aleksandra 👤 Pyrc, Krzysztof 👤 Buelow, Elena 👤 van der Bijl, Anna 👤 van der Hoek, Lia ⏰ 2012 📚 Journal of General Virology

• The interaction between severe acute respiratory syndrome coronavirus 3C-like proteinase and a dimeric inhibitor by capillary electrophoresis

  👤 Ding, Li 👤 Zhang, Xin Xiang 👤 Wei, Ping 👤 Fan, Keqiang 👤 Lai, Luhua ⏰ 2005 📚 Analytical Biochemistry

• SARS coronavirus spike protein-induced innate immune response occurs via activation of the NF-κB pathway in human monocyte macrophages in vitro

  👤 Dosch, Susan F. 👤 Mahajan, Supriya D. 👤 Collins, Arlene R. ⏰ 2009 📚 Virus Research

• Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus (2019-nCoV) related coronavirus model.

  👤 Fan, Hua-Hao 👤 Wang, Li-Qin 👤 Liu, Wen-Li 👤 An, Xiao-Ping 👤 Liu, Zhen-Dong 👤 He, Xiao-Qi 👤 Song, Li-Hua 👤 Tong, Yi-Gang ⏰ 2020 📚 Chin Med J (Engl)

• Structural and molecular modeling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection.

  👤 Fantini, Jacques 👤 Scala, Coralie Di 👤 Chahinian, Henri 👤 Yahi, Nouara ⏰ 2020 📚 Int J Antimicrob Agents

• Hiding in Plain Sight: an Approach to Treating Patients with Severe COVID-19 Infection.

  👤 Fedson, David S 👤 Opal, Steven M 👤 Rordam, Ole Martin ⏰ 2020 📚 mBio

• Reconstitution of the receptor-binding motif of the SARS coronavirus

  👤 Freund, Natalia T. 👤 Roitburd-Berman, Anna 👤 Sui, Jianhua 👤 Marasco, Wayne A. 👤 Gershoni, Jonathan M. ⏰ 2015 📚 Protein Engineering, Design and Selection

• Molecular determinants of severe acute respiratory syndrome coronavirus pathogenesis and virulence in young and aged mouse models of human disease

  👤 Frieman, Matthew 👤 Yount, Boyd 👤 Agnihothram, Sudhakar 👤 Page, Carly 👤 Donaldson, Eric 👤 Roberts, Anjeanette 👤 Vogel, Leatrice 👤 Woodruff, Becky 👤 Scorpio, Diana 👤 Subbarao, Kanta 👤 Baric, Ralph S. ⏰ 2012 📚 Journal of Virology

• Vesicular stomatitis virus pseudotyped with severe acute respiratory syndrome coronavirus spike protein

  👤 Fukushi, Shuetsu 👤 Mizutani, Tetsuya 👤 Saijo, Masayuki 👤 Matsuyama, Shutoku 👤 Miyajima, Naoko 👤 Taguchi, Fumihiro 👤 Itamura, Shigeyuki 👤 Kurane, Ichiro 👤 Morikawa, Shigeru ⏰ 2005 📚 Journal of General Virology

• Amino acid substitutions in the S2 region enhance severe acute respiratory syndrome coronavirus infectivity in rat angiotensin-converting enzyme 2-expressing cells

  👤 Fukushi, Shuetsu 👤 Mizutani, Tetsuya 👤 Sakai, Kouji 👤 Saijo, Masayuki 👤 Taguchi, Fumihiro 👤 Yokoyama, Masaru 👤 Kurane, Ichiro 👤 Morikawa, Shigeru ⏰ 2007 📚 Journal of Virology

• Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor

  👤 Ge, Xing Yi 👤 Li, Jia Lu 👤 Yang, Xing Lou 👤 Chmura, Aleksei A. 👤 Zhu, Guangjian 👤 Epstein, Jonathan H. 👤 Mazet, Jonna K. 👤 Hu, Ben 👤 Zhang, Wei 👤 Peng, Cheng 👤 Zhang, Yu Ji 👤 Luo, Chu Ming 👤 Tan, Bing 👤 Wang, Ning 👤 Zhu, Yan 👤 Crameri, Gary 👤 Zhang, Shu Yi 👤 Wang, Lin Fa 👤 Daszak, Peter 👤 Shi, Zheng Li ⏰ 2013 📚 Nature

• Angiotensin Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System.

  👤 Gheblawi, Mahmoud 👤 Wang, Kaiming 👤 Viveiros, Anissa 👤 Nguyen, Quynh 👤 Zhong, Jiu-Chang 👤 Turner, Anthony J 👤 Raizada, Mohan K 👤 Grant, Maria B 👤 Oudit, Gavin Y ⏰ 2020 📚 Circ Res

• The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies

  👤 Gierer, Stefanie 👤 Bertram, Stephanie 👤 Kaup, Franziska 👤 Wrensch, Florian 👤 Heurich, Adeline 👤 Krämer-Kühl, Annika 👤 Welsch, Kathrin 👤 Winkler, Michael 👤 Meyer, Benjamin 👤 Drosten, Christian 👤 Dittmer, Ulf 👤 von Hahn, Thomas 👤 Simmons, Graham 👤 Hofmann, Heike 👤 Pöhlmann, Stefan ⏰ 2013 📚 Journal of Virology

• Importance of cholesterol-rich membrane microdomains in the interaction of the S protein of SARS-coronavirus with the cellular receptor angiotensin-converting enzyme 2

  👤 Glende, Joerg 👤 Schwegmann-Wessels, Christel 👤 Al-Falah, Marwan 👤 Pfefferle, Susanne 👤 Qu, Xiuxia 👤 Deng, Hongkui 👤 Drosten, Christian 👤 Naim, Hassan Y. 👤 Herrler, Georg ⏰ 2008 📚 Virology

• Differential downregulation of ACE2 by the spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus NL63

  👤 Glowacka, Ilona 👤 Bertram, Stephanie 👤 Herzog, Petra 👤 Pfefferle, Susanne 👤 Steffen, Imke 👤 Muench, Marcus O. 👤 Simmons, Graham 👤 Hofmann, Heike 👤 Kuri, Thomas 👤 Weber, Friedemann 👤 Eichler, Jutta 👤 Drosten, Christian 👤 Pöhlmann, Stefan ⏰ 2010 📚 Journal of Virology

• Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response

  👤 Glowacka, Ilona 👤 Bertram, Stephanie 👤 Müller, Marcel A. 👤 Allen, Paul 👤 Soilleux, Elizabeth 👤 Pfefferle, Susanne 👤 Steffen, Imke 👤 Tsegaye, Theodros Solomon 👤 He, Yuxian 👤 Gnirss, Kerstin 👤 Niemeyer, Daniela 👤 Schneider, Heike 👤 Drosten, Christian 👤 Pöhlmann, Stefan ⏰ 2011 📚 Journal of Virology

• [Exploring the mechanism of liver enzyme abnormalities in patients with novel coronavirus-infected pneumonia].

  👤 Guan, G W 👤 Gao, L 👤 Wang, J W 👤 Wen, X J 👤 Mao, T H 👤 Peng, S W 👤 Zhang, T 👤 Chen, X M 👤 Lu, F M ⏰ 2020 📚 Zhonghua Gan Zang Bing Za Zhi

• The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status.

  👤 Guo, Yan-Rong 👤 Cao, Qing-Dong 👤 Hong, Zhong-Si 👤 Tan, Yuan-Yang 👤 Chen, Shou-Deng 👤 Jin, Hong-Jun 👤 Tan, Kai-Sen 👤 Wang, De-Yun 👤 Yan, Yan ⏰ 2020 📚 Mil Med Res

• Contentious issues and evolving concepts in the clinical presentation and management of patients with COVID-19 infectionwith reference to use of therapeutic and other drugs used in Co-morbid diseases (Hypertension, diabetes etc).

  👤 Gupta, Ritesh 👤 Misra, Anoop ⏰ 2020 📚 Diabetes Metab Syndr

• Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics.

  👤 Gurwitz, David ⏰ 2020 📚 Drug Dev Res

• Master Regulator Analysis of the SARS-CoV-2/Human Interactome.

  👤 Guzzi, Pietro H 👤 Mercatelli, Daniele 👤 Ceraolo, Carmine 👤 Giorgi, Federico M ⏰ 2020 📚 J Clin Med

• Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis

  👤 Hamming, I. 👤 Timens, W. 👤 Bulthuis, M. L.C. 👤 Lely, A. T. 👤 Navis, G. J. 👤 van Goor, H. ⏰ 2004 📚 Journal of Pathology

• Specific asparagine-linked glycosylation sites are critical for DC-SIGN- and L-SIGN-mediated severe acute respiratory syndrome coronavirus entry

  👤 Han, Dong P. 👤 Lohani, Motashim 👤 Cho, Michael W. ⏰ 2007 📚 Journal of Virology

• Is There an Association Between COVID-19 Mortality and the Renin-Angiotensin System-a Call for Epidemiologic Investigations.

  👤 Hanff, Thomas C 👤 Harhay, Michael O 👤 Brown, Tyler S 👤 Cohen, Jordana B 👤 Mohareb, Amir M ⏰ 2020 📚 Clin Infect Dis

• Susceptibility of different eukaryotic cell lines to SARS-coronavirus

  👤 Hattermann, K. 👤 Müller, M. A. 👤 Nitsche, A. 👤 Wendt, S. 👤 Donoso Mantke, O. 👤 Niedrig, M. ⏰ 2005 📚 Archives of Virology

• A single amino acid substitution (R441A) in the receptor-binding domain of SARS coronavirus spike protein disrupts the antigenic structure and binding activity

  👤 He, Yuxian 👤 Li, Jingjing 👤 Jiang, Shibo ⏰ 2006 📚 Biochemical and Biophysical Research Communications

• Identification of a critical neutralization determinant of severe acute respiratory syndrome (SARS)-associated coronavirus: Importance for designing SARS vaccines

  👤 He, Yuxian 👤 Zhu, Qingyu 👤 Liu, Shuwen 👤 Zhou, Yusen 👤 Yang, Baoan 👤 Li, Jiaming 👤 Jiang, Shibo ⏰ 2005 📚 Virology

• TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein

  👤 Heurich, Adeline 👤 Hofmann-Winkler, Heike 👤 Gierer, Stefanie 👤 Liepold, Thomas 👤 Jahn, Olaf 👤 Pöhlmann, Stefan ⏰ 2014 📚 Journal of Virology

• Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction

  👤 Ho, Tin Yun 👤 Wu, Shih Lu 👤 Chen, Jaw Chyun 👤 Li, Chia Cheng 👤 Hsiang, Chien Yun ⏰ 2007 📚 Antiviral Research

• SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.

  👤 Hoffmann, Markus 👤 Kleine-Weber, Hannah 👤 Schroeder, Simon 👤 Kruger, Nadine 👤 Herrler, Tanja 👤 Erichsen, Sandra 👤 Schiergens, Tobias S 👤 Herrler, Georg 👤 Wu, Nai-Huei 👤 Nitsche, Andreas 👤 Muller, Marcel A 👤 Drosten, Christian 👤 Pohlmann, Stefan ⏰ 2020 📚 Cell

• Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor

  👤 Hofmann, Heike 👤 Geier, Martina 👤 Marzi, Andrea 👤 Krumbiegel, Mandy 👤 Peipp, Matthias 👤 Fey, Georg H. 👤 Gramberg, Thomas 👤 Pöhlmann, Stefan ⏰ 2004 📚 Biochemical and Biophysical Research Communications

• Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry

  👤 Hofmann, Heike 👤 Pyrc, Krzysztof 👤 Van Der Hoek, Lia 👤 Geier, Martina 👤 Berkhout, Ben 👤 Pöhlmann, Stefan ⏰ 2005 📚 Proceedings of the National Academy of Sciences of the United States of America

• Cellular entry of the SARS coronavirus

  👤 Hofmann, Heike 👤 Pöhlmann, Stefan ⏰ 2004 📚 Trends in Microbiology

• Highly conserved regions within the spike proteins of human coronaviruses 229E and NL63 determine recognition of their respective cellular receptors

  👤 Hofmann, Heike 👤 Simmons, Graham 👤 Rennekamp, Andrew J. 👤 Chaipan, Chawaree 👤 Gramberg, Thomas 👤 Heck, Elke 👤 Geier, Martina 👤 Wegele, Anja 👤 Marzi, Andrea 👤 Bates, Paul 👤 Pöhlmann, Stefan ⏰ 2006 📚 Journal of Virology

• Aromatic amino acids in the juxtamembrane domain of severe acute respiratory syndrome coronavirus spike glycoprotein are important for receptor-dependent virus entry and cell-cell fusion

  👤 Howard, Megan W. 👤 Travanty, Emily A. 👤 Jeffers, Scott A. 👤 Smith, M. K. 👤 Wennier, Sonia T. 👤 Thackray, Larissa B. 👤 Holmes, Kathryn V. ⏰ 2008 📚 Journal of Virology

• Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus

  👤 Hu, Ben 👤 Zeng, Lei Ping 👤 Yang, Xing Lou 👤 Ge, Xing Yi 👤 Zhang, Wei 👤 Li, Bei 👤 Xie, Jia Zheng 👤 Shen, Xu Rui 👤 Zhang, Yun Zhi 👤 Wang, Ning 👤 Luo, Dong Sheng 👤 Zheng, Xiao Shuang 👤 Wang, Mei Niang 👤 Daszak, Peter 👤 Wang, Lin Fa 👤 Cui, Jie 👤 Shi, Zheng Li ⏰ 2017 📚 PLoS Pathogens

• Putative Receptor Binding Domain of Bat-Derived Coronavirus HKU9 Spike Protein: Evolution of Betacoronavirus Receptor Binding Motifs

  👤 Huang, Canping 👤 Qi, Jianxun 👤 Lu, Guangwen 👤 Wang, Qihui 👤 Yuan, Yuan 👤 Wu, Ying 👤 Zhang, Yanfang 👤 Yan, Jinghua 👤 Gao, George F. ⏰ 2016 📚 Biochemistry

• SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells

  👤 Huang, I. Chueh 👤 Bosch, Berend Jan 👤 Li, Fang 👤 Li, Wenhui 👤 Kyoung, Hoa Lee 👤 Ghiran, Sorina 👤 Vasilieva, Natalya 👤 Dermody, Terence S. 👤 Harrison, Stephen C. 👤 Dormitzer, Philip R. 👤 Farzan, Michael 👤 Rottier, Peter J.M. 👤 Choe, Hyeryun ⏰ 2006 📚 Journal of Biological Chemistry

• Structural Variations in Human ACE2 may Influence its Binding with SARS-CoV-2 Spike Protein.

  👤 Hussain, Mushtaq 👤 Jabeen, Nusrat 👤 Raza, Fozia 👤 Shabbir, Sanya 👤 Baig, Ayesha Ashraf 👤 Amanullah, Anusha 👤 Aziz, Basma ⏰ 2020 📚 J Med Virol

• Renin-Angiotensin System Inhibition in Cardiovascular Patients at the Time of COVID19: Much Ado for Nothing? A Statement of Activity from the Directors of the Board and the Scientific Directors of the Italian Society of Hypertension.

  👤 Iaccarino, Guido 👤 Borghi, Claudio 👤 Cicero, Arrigo F G 👤 Ferri, Claudio 👤 Minuz, Pietro 👤 Muiesan, Maria Lorenza 👤 Mulatero, Paolo 👤 Mule, Giuseppe 👤 Pucci, Giacomo 👤 Salvetti, Massimo 👤 Savoia, Carmine 👤 Sechi, Leonardo Alberto 👤 Volpe, Massimo 👤 Grassi, Guido ⏰ 2020 📚 High Blood Press Cardiovasc Prev

• Clathrin-dependent entry of severe acute respiratory syndrome coronavirus into target cells expressing ACE2 with the cytoplasmic tail deleted

  👤 Inoue, Yuuki 👤 Tanaka, Nobuyuki 👤 Tanaka, Yoshinori 👤 Inoue, Shingo 👤 Morita, Kouichi 👤 Zhuang, Min 👤 Hattori, Toshio 👤 Sugamura, Kazuo ⏰ 2007 📚 Journal of Virology

• Evolution of genomes, host shifts and the geographic spread of SARS-CoV and related coronaviruses

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• Anti-severe acute respiratory syndrome coronavirus spike antibodies trigger infection of human immune cells via a pH- and cysteine protease-independent Fcγr pathway

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• CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus

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• ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia

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• A Comprehensive Literature Review on the Clinical Presentation, and Management of the Pandemic Coronavirus Disease 2019 (COVID-19).

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• Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry

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• Tumor necrosis factor-α convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2)

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• Seroprevalence of porcine respiratory coronavirus infection in Spanish breeding sows

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• Transplantation of ACE2(-) Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia.

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• Structural analysis of major species barriers between humans and palm civets for severe acute respiratory syndrome coronavirus infections

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• Efficient replication of severe acute respiratory syndrome coronavirus in mouse cells is limited by murine angiotensin-converting enzyme 2

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• Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus

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• The S proteins of human coronavirus NL63 and severe acute respiratory syndrome coronavirus bind overlapping regions of ACE2

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• Characterization of the spike protein of human coronavirus NL63 in receptor binding and pseudotype virus entry

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• Identification of residues in the receptor-binding domain (RBD) of the spike protein of human coronavirus NL63 that are critical for the RBD-ACE2 receptor interaction

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• Epithelial cells lining salivary gland ducts are early target cells of severe acute respiratory syndrome coronavirus infection in the upper respiratory tracts of rhesus macaques

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• Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2.

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• siRNA silencing of angiotensin-converting enzyme 2 reduced severe acute respiratory syndrome-associated coronavirus replications in Vero E6 cells

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• SARS-CoV-2 spike protein favors ACE2 from Bovidae and Cricetidae.

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• Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection.

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• SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells.

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• Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2

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• Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus

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• A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

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• Human coronavirus NL63 utilizes heparan sulfate proteoglycans for attachment to target cells

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• Retroviruses pseudotyped with the severe acute respiratory syndrome coronavirus spike protein efficiently infect cells expressing angiotensin-converting enzyme 2

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• Exogenous ACE2 expression allows refractory cell lines to support severe acute respiratory syndrome coronavirus replication

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• Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian cell lines

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• Immunization with an attenuated severe acute respiratory syndrome coronavirus deleted in E protein protects against lethal respiratory disease

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• Potential enhancement of osteoclastogenesis by severe acute respiratory syndrome coronavirus 3a/X1 protein.

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• Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses.

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• Predicting the angiotensin converting enzyme 2 (ACE2) utilizing capability as the receptor of SARS-CoV-2.

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• Identification of two critical amino acid residues of the severe acute respiratory syndrome coronavirus spike protein for its variation in zoonotic tropism transition via a double substitution strategy

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• Difference in receptor usage between Severe Acute Respiratory Syndrome (SARS) coronavirus and SARS-like coronavirus of bat origin

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• Analysis of ACE2 in polarized epithelial cells: Surface expression and function as receptor for severe acute respiratory syndrome-associated coronavirus

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• Early upregulation of acute respiratory distress syndrome-associated cytokines promotes lethal disease in an aged-mouse model of severe acute respiratory syndrome coronavirus infection

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• Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients.

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• COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?

  👤 Sargiacomo, Camillo 👤 Sotgia, Federica 👤 Lisanti, Michael P ⏰ 2020 📚 Aging (Albany NY)

• Severe acute respiratory syndrome coronavirus replication is severely impaired by MG132 due to proteasome-independent inhibition of M-calpain

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• COVID-19 And Older Adults: What We Know.

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• Structural basis of receptor recognition by SARS-CoV-2.

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• Pathways of cross-species transmission of synthetically reconstructed zoonotic severe acute respiratory syndrome coronavirus

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• Mechanisms of zoonotic severe acute respiratory syndrome coronavirus host range expansion in human airway epithelium

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• A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry

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• Different host cell proteases activate the SARS-coronavirus spike-protein for cell-cell and virus-cell fusion

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• Severe acute respiratory syndrome coronavirus infection of human ciliated airway epithelia: Role of ciliated cells in viral spread in the conducting airways of the lungs

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• Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2

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• COVID-19, ACE2 and the Cardiovascular Consequences.

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• Effects of human anti-spike protein receptor binding domain antibodies on severe acute respiratory syndrome coronavirus neutralization escape and fitness

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• Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association

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• [Inhibitors of RAS Might Be a Good Choice for the Therapy of COVID-19 Pneumonia].

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• CD-sACE2 Inclusion Compounds: An Effective Treatment for Corona Virus Disease 2019 (COVID-19).

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• Potential Factors Influencing Repeated SARS Outbreaks in China.

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• Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine.

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• A consensus statement on the use of angiotensin receptor blockers and angiotensin converting enzyme inhibitors in relation to COVID-19 (corona virus disease 2019).

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• Exploring the pathogenesis of severe acute respiratory syndrome (SARS): The tissue distribution of the coronavirus (SARS-CoV) and its putative receptor, angiotensin-converting enzyme 2 (ACE2)

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• ACE2 the Janus-faced protein - from cardiovascular protection to severe acute respiratory syndrome-coronavirus and COVID-19.

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• Apical entry and release of severe acute respiratory syndrome-associated coronavirus in polarized Calu-3 lung epithelial cells

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• Pathology of experimental SARS coronavirus infection in cats and ferrets

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• SARS-Like coronavirus WIV1-CoV does not replicate in Egyptian fruit bats (Rousettus aegyptiacus)

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• Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein.

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• Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus.

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• SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway

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• Angiotensin-converting enzyme 2 (ACE2) from raccoon dog can serve as an efficient receptor for the spike protein of severe acute respiratory syndrome coronavirus

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• Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes

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• Phosphatidylinositol 4-kinase IIIβ is required for severe acute respiratory syndrome coronavirus spike-mediated cell entry

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• Interrupting COVID-19 transmission by implementing enhanced traffic control bundling: Implications for global prevention and control efforts.

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• A single asparagine-linked glycosylation site of the severe acute respiratory syndrome coronavirus spike glycoprotein facilitates inhibition by mannose-binding lectin through multiple mechanisms

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