🔗 3clpro

Articles (73)

• Computational modeling of the bat HKU4 coronavirus 3CLpro inhibitors as a tool for the development of antivirals against the emerging Middle East respiratory syndrome (MERS) coronavirus

  👤 Abuhammad, Areej 👤 Al-Aqtash, Rua'a A. 👤 Anson, Brandon J. 👤 Mesecar, Andrew D. 👤 Taha, Mutasem O. ⏰ 2017 📚 Journal of Molecular Recognition

• An efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS-Cov Mpro) inhibitors

  👤 Al-Gharabli, Samer I. 👤 Ali Shah, Syed T. 👤 Weik, Steffen 👤 Schmidt, Marco F. 👤 Mesters, Jeroen R. 👤 Kuhn, Daniel 👤 Klebe, Gerhard 👤 Hilgenfeld, Rolf 👤 Rademann, Jörg ⏰ 2006 📚 ChemBioChem

• Coronavirus main proteinase (3CLpro) Structure: Basis for design of anti-SARS drugs

  👤 Anand, Kanchan 👤 Ziebuhr, John 👤 Wadhwani, Parvesh 👤 Mesters, Jeroen R. 👤 Hilgenfeld, Rolf ⏰ 2003 📚 Science

• Development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3CLpro

  👤 Bacha, Usman 👤 Barrila, Jennifer 👤 Gabelli, Sandra B. 👤 Kiso, Yoshiaki 👤 Mario Amzel, L. 👤 Freire, Ernesto ⏰ 2008 📚 Chemical Biology and Drug Design

• Identification of Novel Inhibitors of the SARS Coronavirus Main Protease 3CLpro

  👤 Bacha, Usman 👤 Barrila, Jennifer 👤 Velazquez-Campoy, Adrian 👤 Leavitt, Stephanie A. 👤 Freire, Ernesto ⏰ 2004 📚 Biochemistry

• The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity

  👤 Barretto, Naina 👤 Jukneliene, Dalia 👤 Ratia, Kiira 👤 Chen, Zhongbin 👤 Mesecar, Andrew D. 👤 Baker, Susan C. ⏰ 2005 📚 Journal of Virology

• Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: Homology modelling and molecular dynamic studies

  👤 Berry, Michael 👤 Fielding, Burtram 👤 Gamieldien, Junaid ⏰ 2015 📚 BMC Structural Biology

• Potential broad spectrum inhibitors of the Coronavirus 3CLpro: A virtual screening and structure-based drug design study

  👤 Berry, Michael 👤 Fielding, Burtram C. 👤 Gamieldien, Junaid ⏰ 2015 📚 Viruses

• High-throughput screening identifies inhibitors of the SARS coronavirus main proteinase

  👤 Blanchard, Jan E. 👤 Elowe, Nadine H. 👤 Huitema, Carly 👤 Fortin, Pascal D. 👤 Cechetto, Jonathan D. 👤 Eltis, Lindsay D. 👤 Brown, Eric D. ⏰ 2004 📚 Chemistry and Biology

• The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds

  👤 Báez-Santos, Yahira M. 👤 St. John, Sarah E. 👤 Mesecar, Andrew D. ⏰ 2015 📚 Antiviral Research

• Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro

  👤 Chen, Lili 👤 Gui, Chunshan 👤 Luo, Xiaomin 👤 Yang, Qingang 👤 Günther, Stephan 👤 Scandella, Elke 👤 Drosten, Christian 👤 Bai, Donglu 👤 He, Xichang 👤 Ludewig, Burkhard 👤 Chen, Jing 👤 Luo, Haibin 👤 Yang, Yiming 👤 Yang, Yifu 👤 Zou, Jianping 👤 Thiel, Volker 👤 Chen, Kaixian 👤 Shen, Jianhua 👤 Shen, Xu 👤 Jiang, Hualiang ⏰ 2005 📚 Journal of Virology

• Enzymatic activity characterization of SARS coronavirus 3C-like protease by fluorescence resonance energy transfer technique

  👤 Chen, Shuai 👤 Chen, Li Li 👤 Luo, Hai Bin 👤 Sun, Tao 👤 Chen, Jing 👤 Ye, Fei 👤 Cai, Jian Hua 👤 Shen, Jing Kang 👤 Shen, Xu 👤 Jiang, Hua Liang ⏰ 2005 📚 Acta Pharmacologica Sinica

• Severe acute respiratory syndrome coronavirus 3C-like proteinase N terminus is indispensable for proteolytic activity but not for enzyme dimerization: Biochemical and thermodynamic investigation in conjunction with molecular dynamics simulations

  👤 Chen, Shuai 👤 Chen, Lili 👤 Tan, Jinzhi 👤 Chen, Jing 👤 Du, Li 👤 Sun, Tao 👤 Shen, Jianhua 👤 Chen, Kaixian 👤 Jiang, Hualiang 👤 Shen, Xu ⏰ 2005 📚 Journal of Biological Chemistry

• Mutation of Gly-11 on the dimer interface results in the complete crystallographic dimer dissociation of severe acute respiratory syndrome coronavirus 3C-like protease: Crystal structure with molecular dynamics simulations

  👤 Chen, Shuai 👤 Hu, Tiancen 👤 Zhang, Jian 👤 Chen, Jing 👤 Chen, Kaixian 👤 Ding, Jianping 👤 Jiang, Hualiang 👤 Shen, Xu ⏰ 2008 📚 Journal of Biological Chemistry

• Residues on the dimer interface of SARS coronavirus 3C-like protease: Dimer stability characterization and enzyme catalytic activity analysis

  👤 Chen, Shuai 👤 Zhang, Jian 👤 Hu, Tiancen 👤 Chen, Kaixian 👤 Jiang, Hualiang 👤 Shen, Xu ⏰ 2008 📚 Journal of Biochemistry

• Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus

  👤 Chou, Chi Yuan 👤 Chien, Chia Hui 👤 Han, Yu San 👤 Prebanda, Mojca Trstenjak 👤 Hsieh, Hsing Pang 👤 Turk, Boris 👤 Chang, Gu Gang 👤 Chen, Xin ⏰ 2008 📚 Biochemical Pharmacology

• Rapid peptide-based screening on the substrate specificity of severe acute respiratory syndrome (SARS) coronavirus 3C-like protease by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

  👤 Chu, Ling Hon Matthew 👤 Choy, Wai Yan 👤 Tsai, Sau Na 👤 Rao, Zihe 👤 Ngai, Sai Ming ⏰ 2006 📚 Protein Science

• Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases

  👤 Chuck, Chi Pang 👤 Chen, Chao 👤 Ke, Zhihai 👤 Chi-Cheong Wan, David 👤 Chow, Hak Fun 👤 Wong, Kam Bo ⏰ 2013 📚 European Journal of Medicinal Chemistry

• Potential antivirals and antiviral strategies against SARS coronavirus infections

  👤 De Clercq, Erik ⏰ 2006 📚 Expert Review of Anti-Infective Therapy

• Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance

  👤 Deng, Xufang 👤 St John, Sarah E. 👤 Osswald, Heather L. 👤 O'Brien, Amornrat 👤 Banach, Bridget S. 👤 Sleeman, Katrina 👤 Ghosh, Arun K. 👤 Mesecar, Andrew D. 👤 Baker, Susan C. ⏰ 2014 📚 Journal of Virology

• Inhibitor design for SARS coronavirus main protease based on "distorted key theory"

  👤 Du, Qi Shi 👤 Sun, Hao 👤 Chou, Kuo Chen ⏰ 2007 📚 Medicinal Chemistry

• Proteolytic processing of polyproteins 1a and 1ab between non-structural proteins 10 and 11/12 of Coronavirus infectious bronchitis virus is dispensable for viral replication in cultured cells

  👤 Fang, Shou Guo 👤 Shen, Hongyuan 👤 Wang, Jibin 👤 Tay, Felicia P.L. 👤 Liu, Ding Xiang ⏰ 2008 📚 Virology

• Functional and genetic studies of the substrate specificity of coronavirus infectious bronchitis virus 3C-like proteinase

  👤 Fang, Shouguo 👤 Shen, Hongyuan 👤 Wang, Jibin 👤 Tay, Felicia P.L. 👤 Liu, Ding Xiang ⏰ 2010 📚 Journal of Virology

• Evaluating the 3C-like protease activity of SARS-Coronavirus: Recommendations for standardized assays for drug discovery

  👤 Grum-Tokars, Valerie 👤 Ratia, Kiira 👤 Begaye, Adrian 👤 Baker, Susan C. 👤 Mesecar, Andrew D. ⏰ 2008 📚 Virus Research

• Development of a red-shifted fluorescence-based assay for SARS-coronavirus 3CL protease: Identification of a novel class of anti-SARS agents from the tropical marine sponge Axinella corrugata

  👤 Hamill, Pamela 👤 Hudson, Derek 👤 Kao, Richard Y. 👤 Chow, Polly 👤 Raj, Meera 👤 Xu, Hongyan 👤 Richer, Martin J. 👤 Jean, François ⏰ 2006 📚 Biological Chemistry

• Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity

  👤 Harcourt, Brian H. 👤 Jukneliene, Dalia 👤 Kanjanahaluethai, Amornrat 👤 Bechill, John 👤 Severson, Kari M. 👤 Smith, Catherine M. 👤 Rota, Paul A. 👤 Baker, Susan C. ⏰ 2004 📚 Journal of Virology

• Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure

  👤 Hu, Tiancen 👤 Zhang, Yu 👤 Li, Lianwei 👤 Wang, Kuifeng 👤 Chen, Shuai 👤 Chen, Jing 👤 Ding, Jianping 👤 Jiang, Hualiang 👤 Shen, Xu ⏰ 2009 📚 Virology

• Discovery, synthesis, and structure-based optimization of a series of N -(tert -Butyl)-2-(N -arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease

  👤 Jacobs, Jon 👤 Grum-Tokars, Valerie 👤 Zhou, Ya 👤 Turlington, Mark 👤 Saldanha, S. Adrian 👤 Chase, Peter 👤 Eggler, Aimee 👤 Dawson, Eric S. 👤 Baez-Santos, Yahira M. 👤 Tomar, Sakshi 👤 Mielech, Anna M. 👤 Baker, Susan C. 👤 Lindsley, Craig W. 👤 Hodder, Peter 👤 Mesecar, Andrew 👤 Stauffer, Shaun R. ⏰ 2013 📚 Journal of Medicinal Chemistry

• Identification of the murine coronavirus MP1 cleavage site recognized by papain-like proteinase 2

  👤 Kanjanahaluethai, Amornrat 👤 Jukneliene, Dalia 👤 Baker, Susan C. ⏰ 2003 📚 Journal of Virology

• Targeting SARS-CoV-2: A Systematic Drug Repurposing Approach to Identify Promising Inhibitors Against 3C-like Proteinase and 2'-O-RiboseMethyltransferase.

  👤 Khan, Rameez Jabeer 👤 Jha, Rajat Kumar 👤 Amera, GizachewMuluneh 👤 Jain, Monika 👤 Singh, Ekampreet 👤 Pathak, Amita 👤 Singh, Rashmi Prabha 👤 Muthukumaran, Jayaraman 👤 Singh, Amit Kumar ⏰ 2020 📚 J Biomol Struct Dyn

• Assessing activity and inhibition of middle east respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors

  👤 Kilianski, Andy 👤 Mielech, Anna M. 👤 Deng, Xufang 👤 Baker, Susan C. ⏰ 2013 📚 Journal of Virology

• Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor

  👤 Kim, Yunjeong 👤 Liu, Hongwei 👤 Galasiti Kankanamalage, Anushka C. 👤 Weerasekara, Sahani 👤 Hua, Duy H. 👤 Groutas, William C. 👤 Chang, Kyeong Ok 👤 Pedersen, Niels C. ⏰ 2016 📚 PLoS Pathogens

• Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses

  👤 Kim, Yunjeong 👤 Lovell, Scott 👤 Tiew, Kok Chuan 👤 Mandadapu, Sivakoteswara Rao 👤 Alliston, Kevin R. 👤 Battaile, Kevin K. 👤 Groutas, William C. 👤 Chang, Kyeong Ok ⏰ 2012 📚 Journal of Virology

• Broad-spectrum inhibitors against 3C-like proteases of feline coronaviruses and feline caliciviruses

  👤 Kim, Yunjeong 👤 Shivanna, Vinay 👤 Narayanan, Sanjeev 👤 Prior, Allan M. 👤 Weerasekara, Sahani 👤 Hua, Duy H. 👤 Galasiti Kankanamalage, Anushka C. 👤 Groutas, William C. 👤 Chang, Kyeong Ok ⏰ 2015 📚 Journal of Virology

• Mutational and inhibitive analysis of SARS coronavirus 3C-like protease by fluorescence resonance energy transfer-based assays

  👤 Kuang, Wan Fen 👤 Chow, Lu Ping 👤 Wu, Mei Hua 👤 Hwang, Lih Hwa ⏰ 2005 📚 Biochemical and Biophysical Research Communications

• Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CLPro inhibitors

  👤 Kumar, Vathan 👤 Shin, Jin Soo 👤 Shie, Jiun Jie 👤 Ku, Keun Bon 👤 Kim, Chonsaeng 👤 Go, Yun Young 👤 Huang, Kai Fa 👤 Kim, Meehyein 👤 Liang, Po Huang ⏰ 2017 📚 Antiviral Research

• Individual and common inhibitors of coronavirus and picornavirus main proteases

  👤 Kuo, Chih Jung 👤 Liu, Hun Ge 👤 Lo, Yueh Kuei 👤 Seong, Churl Min 👤 Lee, Kee In 👤 Jung, Young Sik 👤 Liang, Po Huang ⏰ 2009 📚 FEBS Letters

• Proteomic analysis of up-regulated proteins in human promonocyte cells expressing severe acute respiratory syndrome coronavirus 3C-like protease

  👤 Lai, Chien Chen 👤 Jou, Ming Jia 👤 Huang, Shiuan Yi 👤 Li, Shih Wein 👤 Wan, Lei 👤 Tsai, Fuu Jen 👤 Lin, Cheng Wen ⏰ 2007 📚 Proteomics

• Maturation mechanism of severe acute respiratory syndrome (SARS) coronavirus 3C-like proteinase

  👤 Li, Chunmei 👤 Qi, Yifei 👤 Teng, Xin 👤 Yang, Zongchang 👤 Wei, Ping 👤 Zhang, Changsheng 👤 Tan, Lei 👤 Zhou, Lu 👤 Liu, Ying 👤 Lai, Luhua ⏰ 2010 📚 Journal of Biological Chemistry

• Characterization and inhibition of SARS-coronavirus main protease

  👤 Liang, Po Huang ⏰ 2006 📚 Current Topics in Medicinal Chemistry

• Picornaviral 3C protease inhibitors and the dual 3C protease/coronaviral 3C-like protease inhibitors

  👤 Liang, Po Huang 👤 Wang, Hui Min ⏰ 2010 📚 Expert Opinion on Therapeutic Patents

• Severe acute respiratory syndrome coronavirus 3C-like protease-induced apoptosis

  👤 Lin, Cheng Wen 👤 Lin, Kuan Hsun 👤 Hsieh, Tsung Han 👤 Shiu, Shi Yi 👤 Li, Jeng Yi ⏰ 2006 📚 FEMS Immunology and Medical Microbiology

• Characterization of trans- and cis-cleavage activity of the SARS coronavirus 3CLpro protease: Basis for the in vitro screening of anti-SARS drugs

  👤 Lin, Cheng Wen 👤 Tsai, Chang Hai 👤 Tsai, Fuu Jen 👤 Chen, Pei Jer 👤 Lai, Chien Chen 👤 Wan, Lei 👤 Chiu, Hua Hao 👤 Lin, Kuan Hsun ⏰ 2004 📚 FEBS Letters

• Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds

  👤 Lin, Cheng Wen 👤 Tsai, Fuu Jen 👤 Tsai, Chang Hai 👤 Lai, Chien Chen 👤 Wan, Lei 👤 Ho, Tin Yun 👤 Hsieh, Chang Chi 👤 Chao, Pei Dawn Lee ⏰ 2005 📚 Antiviral Research

• Binding interaction of SARS coronavirus 3CLpro protease with vacuolar-H+ ATPase G1 subunit

  👤 Lin, Cheng Wen 👤 Tsai, Fuu Jen 👤 Wan, Lei 👤 Lai, Chien Chen 👤 Lin, Kuan Hsun 👤 Hsieh, Tsung Han 👤 Shiu, Shi Yi 👤 Li, Jeng Yi ⏰ 2005 📚 FEBS Letters

• Potential covalent drugs targeting the main protease of the SARS-CoV-2 coronavirus.

  👤 Liu, Sen 👤 Zheng, Qiang 👤 Wang, Zhiying ⏰ 2020 📚 Bioinformatics

• Intracellular and in vitro-translated 27-kDa proteins contain the 3C-like proteinase activity of the coronavirus MHV-A59

  👤 Lu, Xiaotao 👤 Lu, Yiqi 👤 Denison, Mark R. ⏰ 1996 📚 Virology

• Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV.

  👤 Morse, Jared S 👤 Lalonde, Tyler 👤 Xu, Shiqing 👤 Liu, Wenshe Ray ⏰ 2020 📚 Chembiochem

• Autoprocessing mechanism of severe acute respiratory syndrome coronavirus 3C-like protease (SARS-CoV 3CLpro) from its polyproteins

  👤 Muramatsu, Tomonari 👤 Kim, Yong Tae 👤 Nishii, Wataru 👤 Terada, Takaho 👤 Shirouzu, Mikako 👤 Yokoyama, Shigeyuki ⏰ 2013 📚 FEBS Journal

• Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors

  👤 Park, Ji Young 👤 Yuk, Heung Joo 👤 Ryu, Hyung Won 👤 Lim, Su Hwan 👤 Kim, Kyung Su 👤 Park, Ki Hun 👤 Ryu, Young Bae 👤 Lee, Woo Song ⏰ 2017 📚 Journal of Enzyme Inhibition and Medicinal Chemistry

• Protease inhibitors broadly effective against feline, ferret and mink coronaviruses

  👤 Perera, Krishani Dinali 👤 Galasiti Kankanamalage, Anushka C. 👤 Rathnayake, Athri D. 👤 Honeyfield, Amanda 👤 Groutas, William 👤 Chang, Kyeong Ok 👤 Kim, Yunjeong ⏰ 2018 📚 Antiviral Research

• Characterization of amino acid substitutions in feline coronavirus 3C-like protease from a cat with feline infectious peritonitis treated with a protease inhibitor

  👤 Perera, Krishani Dinali 👤 Rathnayake, Athri 👤 Liu, Hongwei 👤 Pedersen, Niels C. 👤 Groutas, William C. 👤 Chang, Kyeong Ok 👤 Kim, Yunjeong ⏰ 2019 📚 Veterinary Microbiology

• An overview of severe acute respiratory syndrome-coronavirus (SARS-CoV) 3CL protease inhibitors: Peptidomimetics and small molecule chemotherapy

  👤 Pillaiyar, Thanigaimalai 👤 Manickam, Manoj 👤 Namasivayam, Vigneshwaran 👤 Hayashi, Yoshio 👤 Jung, Sang Hun ⏰ 2016 📚 Journal of Medicinal Chemistry

• Further requirements for cleavage by the murine coronavirus 3C-like proteinase: Identification of a cleavage site within ORF1b

  👤 Piñón, Josefina D. 👤 Teng, Henry 👤 Weiss, Susan R. ⏰ 1999 📚 Virology

• Severe acute respiratory syndrome coronavirus papain-like-protease: Structure of a viral deubiquitinating enzyme

  👤 Ratia, Kiira 👤 Saikatendu, Kumar Singh 👤 Santarsiero, Bernard D. 👤 Barreto, Naina 👤 Baker, Susan C. 👤 Stevens, Raymond C. 👤 Mesecar, Andrew D. ⏰ 2006 📚 Proceedings of the National Academy of Sciences of the United States of America

• Potential therapies for coronaviruses

  👤 Savarino, Andrea 👤 Bounavoglia, Canio 👤 Norelli, Sandro 👤 Di Trani, Livia 👤 Cassone, Antonio ⏰ 2006 📚 Expert Opinion on Therapeutic Patents

• Mechanism for controlling the dimer-monomer switch and coupling dimerization to catalysis of the severe acute respiratory syndrome coronavirus 3C-like protease

  👤 Shi, Jiahai 👤 Sivaraman, J. 👤 Song, Jianxing ⏰ 2008 📚 Journal of Virology

• Steady-state and pre-steady-state kinetic evaluation of severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro cysteine protease: Development of an ion-pair model for catalysis

  👤 Solowiej, James 👤 Thomson, James A. 👤 Ryan, Kevin 👤 Luo, Chun 👤 He, Mingying 👤 Lou, Jihong 👤 Murray, Brion W. ⏰ 2008 📚 Biochemistry

• Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4 - The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)

  👤 St. John, Sarah E. 👤 Tomar, Sakshi 👤 Stauffer, Shaun R. 👤 Mesecar, Andrew D. ⏰ 2015 📚 Bioorganic and Medicinal Chemistry

• Temperature-sensitive mutants and revertants in the coronavirus nonstructural protein 5 protease (3CLpro) define residues involved in long-distance communication and regulation of protease activity

  👤 Stobart, Christopher C. 👤 Lee, Alice S. 👤 Lu, Xiaotao 👤 Denisona, Mark R. ⏰ 2012 📚 Journal of Virology

• Chimeric exchange of coronavirus nsp5 proteases (3CLpro) identifies common and divergent regulatory determinants of protease activity

  👤 Stobart, Christopher C. 👤 Sexton, Nicole R. 👤 Munjal, Havisha 👤 Lu, Xiaotao 👤 Molland, Katrina L. 👤 Tomar, Sakshi 👤 Mesecar, Andrew D. 👤 Denison, Mark R. ⏰ 2013 📚 Journal of Virology

• Molecular cloning, expression, purification, and mass spectrometric characterization of 3C-like protease of SARS coronavirus

  👤 Sun, Haifang 👤 Luo, Haibin 👤 Yu, Changying 👤 Sun, Tao 👤 Chen, Jing 👤 Peng, Shuying 👤 Qin, Jun 👤 Shen, Jianhua 👤 Yang, Yiming 👤 Xie, Youhua 👤 Chen, Kaixian 👤 Wang, Yuan 👤 Shen, Xu 👤 Jiang, Hualiang ⏰ 2003 📚 Protein Expression and Purification

• Activity of a purified His-tagged 3C-like proteinase from the coronavirus infectious bronchitis virus

  👤 Tibbles, K. W. 👤 Cavanagh, D. 👤 Brown, T. D.K. ⏰ 1999 📚 Virus Research

• Ligand-induced dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 protease (3CLpro): Implications for nsp5 regulation and the development of antivirals

  👤 Tomar, Sakshi 👤 Johnston, Melanie L. 👤 John, Sarah E.St 👤 Osswald, Heather L. 👤 Nyalapatla, Prasanth R. 👤 Paul, Lake N. 👤 Ghosh, Arun K. 👤 Denison, Mark R. 👤 Mesecar, Andrew D. ⏰ 2015 📚 Journal of Biological Chemistry

• Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding

  👤 Turlington, Mark 👤 Chun, Aspen 👤 Tomar, Sakshi 👤 Eggler, Aimee 👤 Grum-Tokars, Valerie 👤 Jacobs, Jon 👤 Daniels, J. Scott 👤 Dawson, Eric 👤 Saldanha, Adrian 👤 Chase, Peter 👤 Baez-Santos, Yahira M. 👤 Lindsley, Craig W. 👤 Hodder, Peter 👤 Mesecar, Andrew D. 👤 Stauffer, Shaun R. ⏰ 2013 📚 Bioorganic and Medicinal Chemistry Letters

• Mutational dynamics of the SARS coronavirus in cell culture and human populations isolated in 2003

  👤 Vega, Vinsensius B. 👤 Ruan, Yijun 👤 Liu, Jianjun 👤 Lee, Wah Heng 👤 Wei, Chia Lin 👤 Se-Thoe, Su Yun 👤 Tang, Kin Fai 👤 Zhang, Tao 👤 Kolatkar, Prasanna R. 👤 Ooi, Eng Eong 👤 Ling, Ai Ee 👤 Stanton, Lawrence W. 👤 Long, Philip M. 👤 Liu, Edison T. ⏰ 2004 📚 BMC Infectious Diseases

• Discovery, diversity and evolution of novel coronaviruses sampled from rodents in China

  👤 Wang, Wen 👤 Lin, Xian Dan 👤 Guo, Wen Ping 👤 Zhou, Run Hong 👤 Wang, Miao Ruo 👤 Wang, Cai Qiao 👤 Ge, Shuang 👤 Mei, Sheng Hua 👤 Li, Ming Hui 👤 Shi, Mang 👤 Holmes, Edward C. 👤 Zhang, Yong Zhen ⏰ 2015 📚 Virology

• In silico analysis of ORF1ab in coronavirus HKU1 genome reveals a unique putative cleavage site of coronavirus HKU1 3C-like protease

  👤 Woo, Patrick C.Y. 👤 Huang, Yi 👤 Lau, Susanna K.P. 👤 Tsoi, Hoi Wah 👤 Yuen, Kwok Yung ⏰ 2005 📚 Microbiology and Immunology

• Comparative analysis of complete genome sequences of three avian coronaviruses reveals a novel group 3c coronavirus

  👤 Woo, Patrick C.Y. 👤 Lau, Susanna K.P. 👤 Lam, Carol S.F. 👤 Lai, Kenneth K.Y. 👤 Huang, Yi 👤 Lee, Paul 👤 Luk, Geraldine S.M. 👤 Dyrting, Kitman C. 👤 Chan, Kwok Hung 👤 Yuen, Kwok Yung ⏰ 2009 📚 Journal of Virology

• Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus

  👤 Wu, Andong 👤 Wang, Yi 👤 Zeng, Cong 👤 Huang, Xingyu 👤 Xu, Shan 👤 Su, Ceyang 👤 Wang, Min 👤 Chen, Yu 👤 Guo, Deyin ⏰ 2015 📚 Virus Research

• Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease

  👤 Yang, Xingxing 👤 Chen, Xiaojuan 👤 Bian, Guangxing 👤 Tu, Jian 👤 Xing, Yaling 👤 Wang, Yayun 👤 Chen, Zhongbin ⏰ 2014 📚 Journal of General Virology

• Identification of novel proteolytically inactive mutations in coronavirus 3C-like protease using a combined approach

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