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Articles (52)

• Treatment outcomes for patients with Middle Eastern Respiratory Syndrome Coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia

  👤 Al Ghamdi, Mohammed 👤 Alghamdi, Khalid M. 👤 Ghandoora, Yasmeen 👤 Alzahrani, Ameera 👤 Salah, Fatmah 👤 Alsulami, Abdulmoatani 👤 Bawayan, Mayada F. 👤 Vaidya, Dhananjay 👤 Perl, Trish M. 👤 Sood, Geeta ⏰ 2016 📚 BMC Infectious Diseases

• New human coronavirus, HCoV-NL63, associated with severe lower respiratory tract disease in Australia

  👤 Arden, Katherine E. 👤 Nissen, Michael D. 👤 Sloots, Theo P. 👤 Mackay, Ian M. ⏰ 2005 📚 Journal of Medical Virology

• The search for a structural basis for therapeutic intervention against the SARS coronavirus

  👤 Bartlam, Mark 👤 Xue, Xiaoyu 👤 Rao, Zihe ⏰ 2008 📚 Acta Crystallographica Section A: Foundations of Crystallography

• Lopinavir/ritonavir combination therapy amongst symptomatic coronavirus disease 2019 patients in India: Protocol for restricted public health emergency use.

  👤 Bhatnagar, Tarun 👤 Murhekar, Manoj V 👤 Soneja, Manish 👤 Gupta, Nivedita 👤 Giri, Sidhartha 👤 Wig, Naveet 👤 Gangakhedkar, Raman ⏰ 2020 📚 Indian J Med Res

• Clinical management of respiratory syndrome in patients hospitalized for suspected Middle East respiratory syndrome coronavirus infection in the Paris area from 2013 to 2016

  👤 Bleibtreu, A. 👤 Jaureguiberry, S. 👤 Houhou, N. 👤 Boutolleau, D. 👤 Guillot, H. 👤 Vallois, D. 👤 Lucet, J. C. 👤 Robert, J. 👤 Mourvillier, B. 👤 Delemazure, J. 👤 Jaspard, M. 👤 Lescure, F. X. 👤 Rioux, C. 👤 Caumes, E. 👤 Yazdanapanah, Y. ⏰ 2018 📚 BMC Infectious Diseases

• X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases

  👤 Báez-Santos, Yahira M. 👤 Barraza, Scott J. 👤 Wilson, Michael W. 👤 Agius, Michael P. 👤 Mielech, Anna M. 👤 Davis, Nicole M. 👤 Baker, Susan C. 👤 Larsen, Scott D. 👤 Mesecar, Andrew D. ⏰ 2014 📚 Journal of Medicinal Chemistry

• Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the middle east respiratory syndrome coronavirus

  👤 Báez-Santos, Yahira M. 👤 Mielech, Anna M. 👤 Deng, Xufang 👤 Baker, Susan 👤 Mesecar, Andrew D. ⏰ 2014 📚 Journal of Virology

• Multiple nucleic acid binding sites and intrinsic disorder of severe acute respiratory syndrome coronavirus nucleocapsid protein: Implications for ribonucleocapsid protein packaging

  👤 Chang, Chung Ke 👤 Hsu, Yen Lan 👤 Chang, Yuan Hsiang 👤 Chao, Fa An 👤 Wu, Ming Chya 👤 Huang, Yu Shan 👤 Hu, Chin Kun 👤 Huang, Tai Huang ⏰ 2009 📚 Journal of Virology

• Structure-based virtual screening and experimental validation of the discovery of inhibitors targeted towards the human coronavirus nucleocapsid protein

  👤 Chang, Chung Ke 👤 Jeyachandran, Sivakamavalli 👤 Hu, Nien Jen 👤 Liu, Chia Ling 👤 Lin, Shing Yen 👤 Wang, Yong Sheng 👤 Chang, Yu Ming 👤 Hou, Ming Hon ⏰ 2016 📚 Molecular BioSystems

• X-ray structure and enzymatic activity profile of a core papain-like protease of MERS coronavirus with utility for structure-based drug design

  👤 Clasman, Jozlyn R. 👤 Bez-Santos, Yahira M. 👤 Mettelman, Robert C. 👤 O'Brien, Amornrat 👤 Baker, Susan C. 👤 Mesecar, Andrew D. ⏰ 2017 📚 Scientific Reports

• Structural Insights into the Interaction of Coronavirus Papain-Like Proteases and Interferon-Stimulated Gene Product 15 from Different Species

  👤 Daczkowski, Courtney M. 👤 Dzimianski, John V. 👤 Clasman, Jozlyn R. 👤 Goodwin, Octavia 👤 Mesecar, Andrew D. 👤 Pegan, Scott D. ⏰ 2017 📚 Journal of Molecular Biology

• Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus.

  👤 Deng, Xufang 👤 Chen, Yafang 👤 Mielech, Anna M 👤 Hackbart, Matthew 👤 Kesely, Kristina R 👤 Mettelman, Robert C 👤 O'Brien, Amornrat 👤 Chapman, Mackenzie E 👤 Mesecar, Andrew D 👤 Baker, Susan C ⏰ 2020 📚 J Virol

• Central ions and lateral asparagine/glutamine zippers stabilize the post-fusion hairpin conformation of the SARS coronavirus spike glycoprotein

  👤 Duquerroy, Stéphane 👤 Vigouroux, Armelle 👤 Rottier, Peter J.M. 👤 Rey, Félix A. 👤 Jan Bosch, Berend ⏰ 2005 📚 Virology

• Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element

  👤 Galasiti Kankanamalage, Anushka C. 👤 Kim, Yunjeong 👤 Damalanka, Vishnu C. 👤 Rathnayake, Athri D. 👤 Fehr, Anthony R. 👤 Mehzabeen, Nurjahan 👤 Battaile, Kevin P. 👤 Lovell, Scott 👤 Lushington, Gerald H. 👤 Perlman, Stanley 👤 Chang, Kyeong Ok 👤 Groutas, William C. ⏰ 2018 📚 European Journal of Medicinal Chemistry

• Structure-based design, synthesis, and biological evaluation of a series of novel and reversible inhibitors for the severe acute respiratory syndrome - Coronavirus papain-like protease

  👤 Ghosh, Arun K. 👤 Takayama, Jun 👤 Aubin, Yoann 👤 Ratia, Kiira 👤 Chaudhuri, Rima 👤 Baez, Yahira 👤 Sleeman, Katrina 👤 Coughlin, Melissa 👤 Nichols, Daniel B. 👤 Mulhearn, Debbie C. 👤 Prabhakar, Bellur S. 👤 Baker, Susan C. 👤 Johnson, Michael E. 👤 Mesecar, Andrew D. ⏰ 2009 📚 Journal of Medicinal Chemistry

• Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: Design, synthesis, protein-ligand X-ray structure and biological evaluation

  👤 Ghosh, Arun K. 👤 Takayama, Jun 👤 Rao, Kalapala Venkateswara 👤 Ratia, Kiira 👤 Chaudhuri, Rima 👤 Mulhearn, Debbie C. 👤 Lee, Hyun 👤 Nichols, Daniel B. 👤 Baliji, Surendranath 👤 Baker, Susan C. 👤 Johnson, Michael E. 👤 Mesecar, Andrew D. ⏰ 2010 📚 Journal of Medicinal Chemistry

• Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS Coronavirus

  👤 Goetz, D. H. 👤 Choe, Y. 👤 Hansell, E. 👤 Chen, Y. T. 👤 McDowell, M. 👤 Jonsson, C. B. 👤 Roush, W. R. 👤 McKerrow, J. 👤 Craik, C. S. ⏰ 2007 📚 Biochemistry

• Evaluating the 3C-like protease activity of SARS-Coronavirus: Recommendations for standardized assays for drug discovery

  👤 Grum-Tokars, Valerie 👤 Ratia, Kiira 👤 Begaye, Adrian 👤 Baker, Susan C. 👤 Mesecar, Andrew D. ⏰ 2008 📚 Virus Research

• From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design

  👤 Hilgenfeld, Rolf ⏰ 2014 📚 The FEBS journal

• Discovery, synthesis, and structure-based optimization of a series of N -(tert -Butyl)-2-(N -arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease

  👤 Jacobs, Jon 👤 Grum-Tokars, Valerie 👤 Zhou, Ya 👤 Turlington, Mark 👤 Saldanha, S. Adrian 👤 Chase, Peter 👤 Eggler, Aimee 👤 Dawson, Eric S. 👤 Baez-Santos, Yahira M. 👤 Tomar, Sakshi 👤 Mielech, Anna M. 👤 Baker, Susan C. 👤 Lindsley, Craig W. 👤 Hodder, Peter 👤 Mesecar, Andrew 👤 Stauffer, Shaun R. ⏰ 2013 📚 Journal of Medicinal Chemistry

• Clinical Course and Outcomes of Patients with Severe Acute Respiratory Syndrome Coronavirus 2 Infection: a Preliminary Report of the First 28 Patients from the Korean Cohort Study on COVID-19.

  👤 Kim, Eu Suk 👤 Chin, Bum Sik 👤 Kang, Chang Kyung 👤 Kim, Nam Joong 👤 Kang, Yu Min 👤 Choi, Jae Phil 👤 Oh, Dong Hyun 👤 Kim, Jeong Han 👤 Koh, Boram 👤 Kim, Seong Eun 👤 Yun, Na Ra 👤 Lee, Jae Hoon 👤 Kim, Jin Yong 👤 Kim, Yeonjae 👤 Bang, Ji Hwan 👤 Song, Kyoung Ho 👤 Kim, Hong Bin 👤 Chung, Ki Hyun 👤 Oh, Myoung Don ⏰ 2020 📚 J Korean Med Sci

• Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses

  👤 Kim, Yunjeong 👤 Lovell, Scott 👤 Tiew, Kok Chuan 👤 Mandadapu, Sivakoteswara Rao 👤 Alliston, Kevin R. 👤 Battaile, Kevin K. 👤 Groutas, William C. 👤 Chang, Kyeong Ok ⏰ 2012 📚 Journal of Virology

• Recombinant Receptor Binding Domain Protein Induces Partial Protective Immunity in Rhesus Macaques Against Middle East Respiratory Syndrome Coronavirus Challenge

  👤 Lan, Jiaming 👤 Yao, Yanfeng 👤 Deng, Yao 👤 Chen, Hong 👤 Lu, Guangwen 👤 Wang, Wen 👤 Bao, Linlin 👤 Deng, Wei 👤 Wei, Qiang 👤 Gao, George F. 👤 Qin, Chuan 👤 Tan, Wenjie ⏰ 2015 📚 EBioMedicine

• Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin

  👤 Lei, Jian 👤 Hilgenfeld, Rolf ⏰ 2016 📚 Virologica Sinica

• Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein

  👤 Lei, Jian 👤 Kusov, Yuri 👤 Hilgenfeld, Rolf ⏰ 2018 📚 Antiviral Research

• Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features

  👤 Lei, Jian 👤 Mesters, Jeroen R. 👤 Drosten, Christian 👤 Anemüller, Stefan 👤 Ma, Qingjun 👤 Hilgenfeld, Rolf ⏰ 2014 📚 Antiviral Research

• Clinical characteristics of 25 death cases with COVID-19: a retrospective review of medical records in a single medical center, Wuhan, China.

  👤 Li, Xun 👤 Wang, Luwen 👤 Yan, Shaonan 👤 Yang, Fan 👤 Xiang, Longkui 👤 Zhu, Jiling 👤 Shen, Bo 👤 Gong, Zuojiong ⏰ 2020 📚 Int J Infect Dis

• Expression, crystallization and preliminary crystallographic study of the C-terminal half of nsp2 from SARS coronavirus

  👤 Li, Yuanyuan 👤 Ren, Zhilin 👤 Bao, Zehua 👤 Ming, Zhenhua 👤 Li, Xuemei ⏰ 2011 📚 Acta Crystallographica Section F: Structural Biology and Crystallization Communications

• Structure-Based Stabilization of Non-native Protein-Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design.

  👤 Lin, Shan-Meng 👤 Lin, Shih-Chao 👤 Hsu, Jia-Ning 👤 Chang, Chung-Ke 👤 Chien, Ching-Ming 👤 Wang, Yong-Sheng 👤 Wu, Hung-Yi 👤 Jeng, U-Ser 👤 Kehn-Hall, Kylene 👤 Hou, Ming-Hon ⏰ 2020 📚 J Med Chem

• Accessory proteins of SARS-CoV and other coronaviruses

  👤 Liu, Ding Xiang 👤 Fung, To Sing 👤 Chong, Kelvin Kian Long 👤 Shukla, Aditi 👤 Hilgenfeld, Rolf ⏰ 2014 📚 Antiviral Research

• Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease

  👤 Lu, I. Lin 👤 Mahindroo, Neeraj 👤 Liang, Po Huang 👤 Peng, Yi Hui 👤 Kuo, Chih Jung 👤 Tsai, Keng Chang 👤 Hsieh, Hsing Pang 👤 Chao, Yu Sheng 👤 Wu, Su Ying ⏰ 2006 📚 Journal of Medicinal Chemistry

• Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor

  👤 Lu, Lu 👤 Liu, Qi 👤 Zhu, Yun 👤 Chan, Kwok Hung 👤 Qin, Lili 👤 Li, Yuan 👤 Wang, Qian 👤 Chan, Jasper Fuk Woo 👤 Du, Lanying 👤 Yu, Fei 👤 Ma, Cuiqing 👤 Ye, Sheng 👤 Yuen, Kwok Yung 👤 Zhang, Rongguang 👤 Jiang, Shibo ⏰ 2014 📚 Nature Communications

• Influenza C virus and bovine coronavirus esterase reveal a similar catalytic mechanism: New insights for drug discovery

  👤 Mayr, Juliane 👤 Haselhorst, Thomas 👤 Langereis, Martijn A. 👤 Dyason, Jeffrey C. 👤 Huber, Wolfgang 👤 Frey, Barbara 👤 Vlasak, Reinhard 👤 De Groot, Raoul J. 👤 Von Itzstein, Mark ⏰ 2008 📚 Glycoconjugate Journal

• Atlas of coronavirus replicase structure

  👤 Neuman, Benjamin W. 👤 Chamberlain, Peter 👤 Bowden, Fern 👤 Joseph, Jeremiah ⏰ 2014 📚 Virus Research

• Structure and oligomerization state of the C-terminal region of the Middle East respiratory syndrome coronavirus nucleoprotein

  👤 Nguyen, Thi Hong Van 👤 Lichière, Julie 👤 Canard, Bruno 👤 Papageorgiou, Nicolas 👤 Attoumani, Sarah 👤 Ferron, François 👤 Coutard, Bruno ⏰ 2019 📚 Acta Crystallographica Section D: Structural Biology

• Structural Insights into Immune Recognition of the Severe Acute Respiratory Syndrome Coronavirus S Protein Receptor Binding Domain

  👤 Pak, John E. 👤 Sharon, Chetna 👤 Satkunarajah, Malathy 👤 Auperin, Thierry C. 👤 Cameron, Cheryl M. 👤 Kelvin, David J. 👤 Seetharaman, Jayaraman 👤 Cochrane, Alan 👤 Plummer, Francis A. 👤 Berry, Jody D. 👤 Rini, James M. ⏰ 2009 📚 Journal of Molecular Biology

• Drug targets for corona virus: A systematic review.

  👤 Prajapat, Manisha 👤 Sarma, Phulen 👤 Shekhar, Nishant 👤 Avti, Pramod 👤 Sinha, Shweta 👤 Kaur, Hardeep 👤 Kumar, Subodh 👤 Bhattacharyya, Anusuya 👤 Kumar, Harish 👤 Bansal, Seema 👤 Medhi, Bikash ⏰ 2020 📚 Indian J Pharmacol

• [Analysis of baseline liver biochemical parameters in 324 cases with novel coronavirus pneumonia in Shanghai area].

  👤 Qian, Z P 👤 Mei, X 👤 Zhang, Y Y 👤 Zou, Y 👤 Zhang, Z G 👤 Zhu, H 👤 Guo, H Y 👤 Liu, Y 👤 Ling, Y 👤 Zhang, X Y 👤 Wang, J F 👤 Lu, H Z ⏰ 2020 📚 Zhonghua Gan Zang Bing Za Zhi

• Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4 - The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)

  👤 St. John, Sarah E. 👤 Tomar, Sakshi 👤 Stauffer, Shaun R. 👤 Mesecar, Andrew D. ⏰ 2015 📚 Bioorganic and Medicinal Chemistry

• Evaluation of homology modeling of the severe acute respiratory syndrome (SARS) coronavirus main protease for structure based drug design

  👤 Takeda-Shitaka, Mayuko 👤 Nojima, Hiroyuki 👤 Takaya, Daisuke 👤 Kanou, Kazuhiko 👤 Iwadate, Mitsuo 👤 Umeyama, Hideaki ⏰ 2004 📚 Chemical and Pharmaceutical Bulletin

• COVID-19 in a Patient Presenting with Syncope and a Normal Chest X-ray.

  👤 Tape, Chantal 👤 Byrd, Katrina M 👤 Aung, Su 👤 Lonks, John R 👤 Flanigan, Timothy P 👤 Rybak, Natasha R ⏰ 2020 📚 R I Med J (2013)

• QM/QM studies for Michael reaction in coronavirus main protease (3CLPro)

  👤 Taranto, Alex G. 👤 Carvalho, Paulo 👤 Avery, Mitchell A. ⏰ 2008 📚 Journal of Molecular Graphics and Modelling

• Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding

  👤 Turlington, Mark 👤 Chun, Aspen 👤 Tomar, Sakshi 👤 Eggler, Aimee 👤 Grum-Tokars, Valerie 👤 Jacobs, Jon 👤 Daniels, J. Scott 👤 Dawson, Eric 👤 Saldanha, Adrian 👤 Chase, Peter 👤 Baez-Santos, Yahira M. 👤 Lindsley, Craig W. 👤 Hodder, Peter 👤 Mesecar, Andrew D. 👤 Stauffer, Shaun R. ⏰ 2013 📚 Bioorganic and Medicinal Chemistry Letters

• Receptor-binding loops in alphacoronavirus adaptation and evolution

  👤 Wong, Alan H.M. 👤 Tomlinson, Aidan C.A. 👤 Zhou, Dongxia 👤 Satkunarajah, Malathy 👤 Chen, Kevin 👤 Sharon, Chetna 👤 Desforges, Marc 👤 Talbot, Pierre J. 👤 Rini, James M. ⏰ 2017 📚 Nature Communications

• Mechanism for controlling the monomer-dimer conversion of SARS coronavirus main protease

  👤 Wu, Cheng Guo 👤 Cheng, Shu Chun 👤 Chen, Shiang Chuan 👤 Li, Juo Yan 👤 Fang, Yi Hsuan 👤 Chen, Yau Hung 👤 Chou, Chi Yuan ⏰ 2013 📚 Acta Crystallographica Section D: Biological Crystallography

• Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion.

  👤 Xia, Shuai 👤 Liu, Meiqin 👤 Wang, Chao 👤 Xu, Wei 👤 Lan, Qiaoshuai 👤 Feng, Siliang 👤 Qi, Feifei 👤 Bao, Linlin 👤 Du, Lanying 👤 Liu, Shuwen 👤 Qin, Chuan 👤 Sun, Fei 👤 Shi, Zhengli 👤 Zhu, Yun 👤 Jiang, Shibo 👤 Lu, Lu ⏰ 2020 📚 Cell Res

• Nonstructural proteins 7 and 8 of feline coronavirus form a 2:1 heterotrimer that exhibits primer-independent RNA polymerase activity

  👤 Xiao, Yibei 👤 Ma, Qingjun 👤 Restle, Tobias 👤 Shang, Weifeng 👤 Svergun, Dmitri I. 👤 Ponnusamy, Rajesh 👤 Sczakiel, Georg 👤 Hilgenfeld, Rolf ⏰ 2012 📚 Journal of Virology

• Dynamic changes of serum SARS-Coronavirus IgG, pulmonary function and radiography in patients recovering from SARS after hospital discharge

  👤 Xie, Lixin 👤 Liu, Youning 👤 Fan, Baoxing 👤 Xiao, Yueyong 👤 Tian, Qing 👤 Chen, Liangan 👤 Zhao, Hong 👤 Chen, Weijun ⏰ 2005 📚 Respiratory Research

• Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved alpha-ketoamide inhibitors.

  👤 Zhang, Linlin 👤 Lin, Daizong 👤 Sun, Xinyuanyuan 👤 Curth, Ute 👤 Drosten, Christian 👤 Sauerhering, Lucie 👤 Becker, Stephan 👤 Rox, Katharina 👤 Hilgenfeld, Rolf ⏰ 2020 📚 Science

• [Clinical features of 2019 novel coronavirus pneumonia in the early stage from a fever clinic in Beijing].

  👤 Zhang, M Q 👤 Wang, X H 👤 Chen, Y L 👤 Zhao, K L 👤 Cai, Y Q 👤 An, C L 👤 Lin, M G 👤 Mu, X D ⏰ 2020 📚 Zhonghua Jie He He Hu Xi Za Zhi

• Computational simulation of interactions between SARS coronavirus spike mutants and host species-specific receptors

  👤 Zhang, Yuan 👤 Zheng, Nan 👤 Nan, Peng 👤 Cao, Ying 👤 Hasegawa, Masami 👤 Zhong, Yang ⏰ 2007 📚 Computational Biology and Chemistry

• Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease

  👤 Zhu, Lili 👤 George, Shyla 👤 Schmidt, Marco F. 👤 Al-Gharabli, Samer I. 👤 Rademann, Jörg 👤 Hilgenfeld, Rolf ⏰ 2011 📚 Antiviral Research