Over time, the topics studied in Coronavirus Science have shifted. This page enables you to browse topics over the decades.

1980s

🔗 transmissible gastroenteritis (226) 🔗 open reading (215) 🔗 reading frame (222) 🔗 molecular weight (50) 🔗 electron microscopy (149) 🔗 amino acids (205) 🔗 infectious bronchitis (235) 🔗 avian infectious (53) 🔗 mouse hepatitis (371) 🔗 monoclonal antibodies (131) 🔗 nucleocapsid protein (162) 🔗 cell culture (240) 🔗 leader sequence (32) 🔗 acid sequence (108) 🔗 bronchitis virus (233) 🔗 hepatitis virus (437) 🔗 enteric coronavirus (111) 🔗 gastroenteritis virus (188) 🔗 viral particles (45) 🔗 bovine coronavirus (221) 🔗 infected cells (307) 🔗 murine coronavirus (140) 🔗 human coronavirus (623) 🔗 virus strain (138)

1990s

🔗 central nervous (112) 🔗 electron microscopy (149) 🔗 chain reaction (303) 🔗 open reading (215) 🔗 reading frames (100) 🔗 nervous system (116) 🔗 closely related (222) 🔗 transmissible gastroenteritis (226) 🔗 polymerase chain (300) 🔗 infectious peritonitis (181) 🔗 infectious bronchitis (235) 🔗 mouse hepatitis (371) 🔗 amino acids (205) 🔗 cell line (211) 🔗 monoclonal antibodies (131) 🔗 feline infectious (145) 🔗 results indicate (178) 🔗 porcine respiratory (61) 🔗 cleavage site (85) 🔗 spike glycoprotein (99) 🔗 results suggest (206) 🔗 cell culture (240) 🔗 structural proteins (197) 🔗 antigenic sites (26) 🔗 cell surface (110) 🔗 bronchitis virus (233) 🔗 nucleocapsid protein (162) 🔗 bovine coronavirus (221) 🔗 sequence analysis (118) 🔗 hepatitis virus (437) 🔗 acid sequences (44) 🔗 canine coronavirus (102) 🔗 gastroenteritis virus (188) 🔗 nucleotide sequence (93) 🔗 peritonitis virus (67) 🔗 murine coronavirus (140) 🔗 human coronavirus (623) 🔗 spike protein (353) 🔗 viral antigen (73) 🔗 enteric coronavirus (111) 🔗 respiratory coronavirus (129) 🔗 infected cells (307) 🔗 viral proteins (89) 🔗 virus replication (219) 🔗 infectious virus (88) 🔗 coronavirus mouse (66) 🔗 coronavirus infection (270) 🔗 virus strain (138) 🔗 coronavirus strain (67)

early 2000s

🔗 enzyme-linked immunosorbent (105) 🔗 reading frames (100) 🔗 central nervous (112) 🔗 hong kong (99) 🔗 open reading (215) 🔗 western blot (13) 🔗 transmissible gastroenteritis (226) 🔗 electron microscopy (149) 🔗 transcription-polymerase chain (58) 🔗 reverse transcription-polymerase (55) 🔗 chain reaction (303) 🔗 targeted recombination (10) 🔗 closely related (222) 🔗 packaging signal (16) 🔗 causative agent (117) 🔗 nasal swab (58) 🔗 nervous system (116) 🔗 sialic acid (42) 🔗 polymerase chain (300) 🔗 amino acids (205) 🔗 infectious bronchitis (235) 🔗 infectious peritonitis (181) 🔗 mouse hepatitis (371) 🔗 immune response (314) 🔗 highly conserved (80) 🔗 clinical signs (108) 🔗 immunosorbent assay (114) 🔗 cell line (211) 🔗 experimentally infected (47) 🔗 phylogenetic analysis (188) 🔗 fusion core (19) 🔗 severe acute (1373) 🔗 antibody responses (58) 🔗 present study (186) 🔗 data suggest (146) 🔗 feline infectious (145) 🔗 samples collected (74) 🔗 respiratory syndrome (2004) 🔗 respiratory syndrome-associated (90) 🔗 acute respiratory (1734) 🔗 respiratory tract (344) 🔗 cell culture (240) 🔗 results indicate (178) 🔗 fecal samples (92) 🔗 membrane fusion (105) 🔗 clinical specimens (44) 🔗 structural proteins (197) 🔗 results suggest (206) 🔗 serum samples (106) 🔗 spike glycoprotein (99) 🔗 syndrome-associated coronavirus (88) 🔗 recombinant viruses (43) 🔗 bronchitis virus (233) 🔗 hepatitis virus (437) 🔗 samples obtained (25) 🔗 cell surface (110) 🔗 host cell (262) 🔗 infectious disease (312) 🔗 sequence analysis (118) 🔗 viral entry (91) 🔗 canine coronavirus (102) 🔗 bovine coronavirus (221) 🔗 novel coronavirus (684) 🔗 cells expressing (60) 🔗 spike protein (353) 🔗 gastroenteritis coronavirus (57) 🔗 nucleocapsid protein (162) 🔗 gastroenteritis virus (188) 🔗 genome sequence (133) 🔗 turkey coronavirus (48) 🔗 viral replication (258) 🔗 murine coronavirus (140) 🔗 fusion proteins (43) 🔗 spike gene (68) 🔗 coronavirus mouse (66) 🔗 infected cells (307) 🔗 feline coronavirus (148) 🔗 human coronavirus (623) 🔗 viral fusion (38) 🔗 viral genome (96) 🔗 sars coronavirus (282) 🔗 syndrome coronavirus (1074) 🔗 membrane protein (93) 🔗 virus strain (138)

late 2000s

🔗 endoplasmic reticulum (78) 🔗 nasopharyngeal aspirates (24) 🔗 hong kong (99) 🔗 heptad repeat (55) 🔗 public health (392) 🔗 enzyme-linked immunosorbent (105) 🔗 transmissible gastroenteritis (226) 🔗 lipid rafts (8) 🔗 western blot (13) 🔗 reading frames (100) 🔗 central nervous (112) 🔗 open reading (215) 🔗 palm civets (20) 🔗 etiological agent (62) 🔗 electron microscopy (149) 🔗 taken together (1) 🔗 causative agent (117) 🔗 reverse transcription-pcr (19) 🔗 life cycle (63) 🔗 reverse genetics (49) 🔗 chain reaction (303) 🔗 protective immunity (36) 🔗 polymerase chain (300) 🔗 closely related (222) 🔗 angiotensin-converting enzyme (112) 🔗 nervous system (116) 🔗 cytopathic effect (91) 🔗 mouse hepatitis (371) 🔗 amino acids (205) 🔗 nucleic acid (139) 🔗 determine whether (60) 🔗 control subjects (13) 🔗 infectious peritonitis (181) 🔗 innate immune (105) 🔗 cell-cell fusion (34) 🔗 infectious bronchitis (235) 🔗 animal models (72) 🔗 drug design (36) 🔗 immunosorbent assay (114) 🔗 crystal structure (114) 🔗 clinical signs (108) 🔗 tissue culture (67) 🔗 highly pathogenic (100) 🔗 main protease (44) 🔗 cleavage site (85) 🔗 monoclonal antibodies (131) 🔗 enzymatic activity (29) 🔗 receptor-binding domain (99) 🔗 young children (25) 🔗 murine hepatitis (71) 🔗 immune responses (142) 🔗 fecal samples (92) 🔗 real-time rt-pcr (71) 🔗 play important (7) 🔗 cell lines (125) 🔗 wild type (34) 🔗 significantly higher (104) 🔗 human metapneumovirus (19) 🔗 phylogenetic analysis (188) 🔗 transgenic mice (28) 🔗 infectious diseases (94) 🔗 transmembrane domain (51) 🔗 serum samples (106) 🔗 samples collected (74) 🔗 receptor angiotensin-converting (14) 🔗 mice immunized (25) 🔗 tract infections (83) 🔗 feline infectious (145) 🔗 previously described (38) 🔗 findings suggest (77) 🔗 severe acute (1373) 🔗 highly conserved (80) 🔗 previously reported (79) 🔗 data suggest (146)

early 2010s

🔗 enzyme-linked immunosorbent (105) 🔗 endoplasmic reticulum (78) 🔗 western blot (13) 🔗 united states (115) 🔗 poorly understood (52) 🔗 reading frames (100) 🔗 central nervous (112) 🔗 open reading (215) 🔗 life cycle (63) 🔗 causative agent (117) 🔗 renal failure (30) 🔗 transmissible gastroenteritis (226) 🔗 chain reaction (303) 🔗 taken together (1) 🔗 angiotensin-converting enzyme (112) 🔗 fatality rate (123) 🔗 nervous system (116) 🔗 secretory pathway (16) 🔗 public health (392) 🔗 polymerase chain (300) 🔗 dromedary camels (70) 🔗 papain-like protease (67) 🔗 recombination events (46) 🔗 closely related (222) 🔗 amino acids (205) 🔗 nucleic acid (139) 🔗 common ancestor (40) 🔗 crystal structure (114) 🔗 health care (123) 🔗 sialic acid (42) 🔗 mouse hepatitis (371) 🔗 real-time rt-pcr (71) 🔗 middle east (4) 🔗 infectious peritonitis (181) 🔗 monoclonal antibodies (131) 🔗 infectious bronchitis (235) 🔗 clinical signs (108) 🔗 innate immunity (35) 🔗 highly pathogenic (100) 🔗 murine hepatitis (71) 🔗 receptor-binding domain (99) 🔗 reverse transcription (205) 🔗 neutralizing antibodies (122) 🔗 faecal samples (44) 🔗 cell lines (125) 🔗 spike glycoprotein (99) 🔗 phylogenetic analysis (188) 🔗 immune responses (142) 🔗 complete genome (93) 🔗 fecal samples (92) 🔗 high mortality (78) 🔗 significantly higher (104) 🔗 feline infectious (145) 🔗 severe acute (1373) 🔗 cell culture (240) 🔗 distress syndrome (112) 🔗 samples collected (74) 🔗 membrane fusion (105) 🔗 dendritic cells (45) 🔗 type interferon (1) 🔗 previously reported (79) 🔗 accessory proteins (53) 🔗 important role (140) 🔗 first report (99) 🔗 respiratory distress (139) 🔗 data suggest (146) 🔗 tract infections (83) 🔗 respiratory syndrome (2004) 🔗 respiratory tract (344) 🔗 epithelial cells (128) 🔗 results indicate (178) 🔗 nonstructural proteins (57) 🔗 acute respiratory (1734) 🔗 samples obtained (25) 🔗 east respiratory (5) 🔗 respiratory syncytial (49) 🔗 infectious diseases (94) 🔗 results suggest (206) 🔗 receptor binding (86) 🔗 cell surface (110)

late 2010s

🔗 enzyme-linked immunosorbent (105) 🔗 aspartate aminotransferase (16) 🔗 lymph node (56) 🔗 lactate dehydrogenase (30) 🔗 cruise ship (10) 🔗 dipeptidyl peptidase (47) 🔗 lopinavir ritonavir (15) 🔗 reading frame (222) 🔗 angiotensin converting (23) 🔗 ground glass (28) 🔗 electron microscopy (149) 🔗 hong kong (99) 🔗 school closures (5) 🔗 sore throat (23) 🔗 computed tomography (55) 🔗 pleural effusion (23) 🔗 codon usage (17) 🔗 transmissible gastroenteritis (226) 🔗 logistic regression (35) 🔗 seafood market (17) 🔗 open reading (215) 🔗 cytokine storm (25) 🔗 mechanical ventilation (39) 🔗 sleep quality (4) 🔗 economic losses (34) 🔗 angiotensin-converting enzyme (112) 🔗 converting enzyme (162) 🔗 poorly understood (52) 🔗 differentially expressed (14) 🔗 operating room (16) 🔗 body temperature (19) 🔗 causative agent (117) 🔗 central nervous (112) 🔗 odds ratio (31) 🔗 transcription-polymerase chain (58) 🔗 weight loss (41) 🔗 exponential growth (12) 🔗 life cycle (63) 🔗 ground-glass opacity (41) 🔗 reverse transcriptase (87) 🔗 reverse transcription-polymerase (55) 🔗 chain reaction (303) 🔗 glass opacities (51) 🔗 confidence interval (64) 🔗 united states (115) 🔗 mouse hepatitis (371) 🔗 extracorporeal membrane (17) 🔗 papain-like protease (67) 🔗 reverse genetics (49) 🔗 interquartile range (15) 🔗 lymphocyte count (23) 🔗 basic reproduction (30) 🔗 convalescent plasma (22) 🔗 pregnant women (44) 🔗 social distancing (40) 🔗 polymerase chain (300) 🔗 travel restrictions (13) 🔗 crystal structure (114) 🔗 colorectal cancer (9) 🔗 membrane oxygenation (17) 🔗 personal protective (55) 🔗 small intestine (43) 🔗 wild birds (14) 🔗 urgently needed (40) 🔗 immunosorbent assay (114) 🔗 open access (18) 🔗 cardiac injury (16) 🔗 protective equipment (57) 🔗 rectal swabs (30) 🔗 amino acids (205) 🔗 transcriptase polymerase (48) 🔗 south korea (77) 🔗 intermediate hosts (17) 🔗 white blood (25) 🔗 nucleic acid (139) 🔗 dromedary camels (70) 🔗 taken together (1) 🔗 contact tracing (29) 🔗 receptor-binding domain (99)

2020

🔗 hong kong (99) 🔗 lactate dehydrogenase (30) 🔗 cruise ship (10) 🔗 lopinavir ritonavir (15) 🔗 ground glass (28) 🔗 angiotensin converting (23) 🔗 logistic regression (35) 🔗 school closures (5) 🔗 sore throat (23) 🔗 cytokine storm (25) 🔗 computed tomography (55) 🔗 body temperature (19) 🔗 angiotensin-converting enzyme (112) 🔗 converting enzyme (162) 🔗 receptor-binding domain (99) 🔗 operating room (16) 🔗 reverse transcription (205) 🔗 chain reaction (303) 🔗 mechanical ventilation (39) 🔗 seafood market (17) 🔗 polymerase chain (300) 🔗 causative agent (117) 🔗 convalescent plasma (22) 🔗 sleep quality (4) 🔗 exponential growth (12) 🔗 interquartile range (15) 🔗 united states (115) 🔗 south korea (77) 🔗 basic reproduction (30) 🔗 ground-glass opacity (41) 🔗 nucleic acid (139) 🔗 middle east (4) 🔗 spike glycoprotein (99) 🔗 confidence interval (64) 🔗 nasopharyngeal swabs (19) 🔗 glass opacities (51) 🔗 lymphocyte count (23) 🔗 travel restrictions (13) 🔗 urgently needed (40) 🔗 amino acid (454) 🔗 white blood (25) 🔗 real-time reverse (87) 🔗 epithelial cells (128) 🔗 serial interval (19) 🔗 personal protective (55) 🔗 protective equipment (57) 🔗 pregnant women (44) 🔗 throat swab (43) 🔗 position method (1) 🔗 social distancing (40) 🔗 across globe (1) 🔗 statistically significant (37) 🔗 cardiac injury (16) 🔗 contact tracing (29) 🔗 highly contagious (45) 🔗 colorectal cancer (9) 🔗 incubation period (74) 🔗 family members (44) 🔗 heart failure (14) 🔗 c-reactive protein (56) 🔗 close contacts (35) 🔗 closely related (222) 🔗 genome sequences (60) 🔗 symptom onset (46) 🔗 liver function (15) 🔗 social media (17) 🔗 international concern (28) 🔗 multiple organ (24) 🔗 liver injury (9) 🔗 healthcare workers (76) 🔗 reproduction number (45) 🔗 viral load (91) 🔗 fatality rate (123) 🔗 spike protein (353) 🔗 older adults (16) 🔗 chest computed (23) 🔗 significant differences (40) 🔗 intensive care (105) 🔗 systematic review (26) 🔗 cell count (25)