🔗 Therapeutics

Articles (116)

• Antiviral drugs specific for coronaviruses in preclinical development

  👤 Adedeji, Adeyemi O. 👤 Sarafianos, Stefan G. ⏰ 2014 📚 Current Opinion in Virology

• Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms

  👤 Adedeji, Adeyemi O. 👤 Severson, William 👤 Jonsson, Colleen 👤 Singh, Kamalendra 👤 Weiss, Susan R. 👤 Sarafianosa, Stefan G. ⏰ 2013 📚 Journal of Virology

• A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant

  👤 Agnihothram, Sudhakar 👤 Yount Jr., Boyd L. 👤 Donaldson, Eric F. 👤 Huynh, Jeremy 👤 Menachery, Vineet D. 👤 Gralinski, Lisa E. 👤 Graham, Rachel L. 👤 Becker, Michelle M. 👤 Tomar, Sakshi 👤 Scobey, Trevor D. 👤 Osswald, Heather L. 👤 Whitmore, Alan 👤 Gopal, Robin 👤 Ghosh, Arun K. 👤 Mesecar, Andrew 👤 Zambon, Maria 👤 Heise, Mark 👤 Denison, Mark R. 👤 Baric, Ralph S. ⏰ 2014 📚 mBio

• Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease

  👤 Agostini, Maria L. 👤 Andres, Erica L. 👤 Sims, Amy C. 👤 Graham, Rachel L. 👤 Sheahan, Timothy P. 👤 Lu, Xiaotao 👤 Smith, Everett Clinton 👤 Case, James Brett 👤 Feng, Joy Y. 👤 Jordan, Robert 👤 Ray, Adrian S. 👤 Cihlar, Tomas 👤 Siegel, Dustin 👤 Mackman, Richard L. 👤 Clarke, Michael O. 👤 Baric, Ralph S. 👤 Denison, Mark R. ⏰ 2018 📚 mBio

• Small-Molecule Antiviral β-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

  👤 Agostini, Maria L. 👤 Pruijssers, Andrea J. 👤 Chappell, James D. 👤 Gribble, Jennifer 👤 Lu, Xiaotao 👤 Andres, Erica L. 👤 Bluemling, Gregory R. 👤 Lockwood, Mark A. 👤 Sheahan, Timothy P. 👤 Sims, Amy C. 👤 Natchus, Michael G. 👤 Saindane, Manohar 👤 Kolykhalov, Alexander A. 👤 Painter, George R. 👤 Baric, Ralph S. 👤 Denison, Mark R. ⏰ 2019 📚 Journal of virology

• Passive Transfer of A Germline-like Neutralizing Human Monoclonal Antibody Protects Transgenic Mice Against Lethal Middle East Respiratory Syndrome Coronavirus Infection

  👤 Agrawal, Anurodh Shankar 👤 Ying, Tianlei 👤 Tao, Xinrong 👤 Garron, Tania 👤 Algaissi, Abdullah 👤 Wang, Yanping 👤 Wang, Lili 👤 Peng, Bi Hung 👤 Jiang, Shibo 👤 Dimitrov, Dimiter S. 👤 Tseng, Chien Te K. ⏰ 2016 📚 Scientific Reports

• Emerging prophylaxis strategies against COVID-19.

  👤 Agrawal, Sumita 👤 Goel, Akhil Dhanesh 👤 Gupta, Nitesh ⏰ 2020 📚 Monaldi Arch Chest Dis

• Current Status of Epidemiology, Diagnosis, Therapeutics, and Vaccines for Novel Coronavirus Disease 2019 (COVID-19).

  👤 Ahn, Dae-Gyun 👤 Shin, Hye-Jin 👤 Kim, Mi-Hwa 👤 Lee, Sunhee 👤 Kim, Hae-Soo 👤 Myoung, Jinjong 👤 Kim, Bum-Tae 👤 Kim, Seong-Jun ⏰ 2020 📚 J Microbiol Biotechnol

• Middle east respiratory syndrome coronavirus infection dynamics and antibody responses among clinically diverse patients, Saudi Arabia

  👤 Al-Abdely, Hail M. 👤 Midgley, Claire M. 👤 Alkhamis, Abdulrahim M. 👤 Abedi, Glen R. 👤 Lu, Xiaoyan 👤 Binder, Alison M. 👤 Alanazi, Khalid H. 👤 Tamin, Azaibi 👤 Banjar, Weam M. 👤 Lester, Sandra 👤 Abdalla, Osman 👤 Dahl, Rebecca M. 👤 Mohammed, Mutaz 👤 Trivedi, Suvang 👤 Algarni, Homoud S. 👤 Sakthivel, Senthilkumar K. 👤 Algwizani, Abdullah 👤 Bafaqeeh, Fahad 👤 Alzahrani, Abdullah 👤 Alsharef, Ali Abraheem 👤 Alhakeem, Raafat F. 👤 Jokhdar, Hani A.Aziz 👤 Ghazal, Sameeh S. 👤 Thornburg, Natalie J. 👤 Erdman, Dean D. 👤 Assiri, Abdullah M. 👤 Watson, John T. 👤 Gerber, Susan I. ⏰ 2019 📚 Emerging Infectious Diseases

• Critical care management of adults with community-acquired severe respiratory viral infection.

  👤 Arabi, Yaseen M 👤 Fowler, Robert 👤 Hayden, Frederick G ⏰ 2020 📚 Intensive Care Med

• Hydroxychloroquine for treatment of SARS-CoV-2 infection? Improving our confidence in a model-based approach to dose selection.

  👤 Arnold, Samuel Lm 👤 Buckner, Frederick ⏰ 2020 📚 Clin Transl Sci

• Influence of hydrophobic and electrostatic residues on SARS-coronavirus S2 protein stability: Insights into mechanisms of general viral fusion and inhibitor design

  👤 Aydin, Halil 👤 Al-Khooly, Dina 👤 Lee, Jeffrey E. ⏰ 2014 📚 Protein Science

• Structural insights into SARS coronavirus proteins

  👤 Bartlam, Mark 👤 Yang, Haitao 👤 Rao, Zihe ⏰ 2005 📚 Current Opinion in Structural Biology

• Overview of current therapeutics and novel candidates against influenza, respiratory syncytial virus, and Middle East respiratory syndrome coronavirus infections

  👤 Behzadi, Mohammad Amin 👤 Leyva-Grado, Victor H. ⏰ 2019 📚 Frontiers in Microbiology

• High-throughput screening identifies inhibitors of the SARS coronavirus main proteinase

  👤 Blanchard, Jan E. 👤 Elowe, Nadine H. 👤 Huitema, Carly 👤 Fortin, Pascal D. 👤 Cechetto, Jonathan D. 👤 Eltis, Lindsay D. 👤 Brown, Eric D. ⏰ 2004 📚 Chemistry and Biology

• Molecular targets for the rational design of drugs to inhibit SARS coronavirus

  👤 Brockway, Sarah M. 👤 Denison, Mark R. ⏰ 2004 📚 Drug Discovery Today: Disease Mechanisms

• Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

  👤 Brown, Ariane J. 👤 Won, John J. 👤 Graham, Rachel L. 👤 Dinnon, Kenneth H. 👤 Sims, Amy C. 👤 Feng, Joy Y. 👤 Cihlar, Tomas 👤 Denison, Mark R. 👤 Baric, Ralph S. 👤 Sheahan, Timothy P. ⏰ 2019 📚 Antiviral Research

• Lack of Innate Interferon Responses during SARS Coronavirus Infection in a Vaccination and Reinfection Ferret Model

  👤 Cameron, Mark J. 👤 Kelvin, Alyson A. 👤 Leon, Alberto J. 👤 Cameron, Cheryl M. 👤 Ran, Longsi 👤 Xu, Luoling 👤 Chu, Yong Kyu 👤 Danesh, Ali 👤 Fang, Yuan 👤 Li, Qianjun 👤 Anderson, Austin 👤 Couch, Ronald C. 👤 Paquette, Stephane G. 👤 Fomukong, Ndingsa G. 👤 Kistner, Otfried 👤 Lauchart, Manfred 👤 Rowe, Thomas 👤 Harrod, Kevin S. 👤 Jonsson, Colleen B. 👤 Kelvin, David J. ⏰ 2012 📚 PLoS ONE

• A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19.

  👤 Cao, Bin 👤 Wang, Yeming 👤 Wen, Danning 👤 Liu, Wen 👤 Wang, Jingli 👤 Fan, Guohui 👤 Ruan, Lianguo 👤 Song, Bin 👤 Cai, Yanping 👤 Wei, Ming 👤 Li, Xingwang 👤 Xia, Jiaan 👤 Chen, Nanshan 👤 Xiang, Jie 👤 Yu, Ting 👤 Bai, Tao 👤 Xie, Xuelei 👤 Zhang, Li 👤 Li, Caihong 👤 Yuan, Ye 👤 Chen, Hua 👤 Li, Huadong 👤 Huang, Hanping 👤 Tu, Shengjing 👤 Gong, Fengyun 👤 Liu, Ying 👤 Wei, Yuan 👤 Dong, Chongya 👤 Zhou, Fei 👤 Gu, Xiaoying 👤 Xu, Jiuyang 👤 Liu, Zhibo 👤 Zhang, Yi 👤 Li, Hui 👤 Shang, Lianhan 👤 Wang, Ke 👤 Li, Kunxia 👤 Zhou, Xia 👤 Dong, Xuan 👤 Qu, Zhaohui 👤 Lu, Sixia 👤 Hu, Xujuan 👤 Ruan, Shunan 👤 Luo, Shanshan 👤 Wu, Jing 👤 Peng, Lu 👤 Cheng, Fang 👤 Pan, Lihong 👤 Zou, Jun 👤 Jia, Chunmin 👤 Wang, Juan 👤 Liu, Xia 👤 Wang, Shuzhen 👤 Wu, Xudong 👤 Ge, Qin 👤 He, Jing 👤 Zhan, Haiyan 👤 Qiu, Fang 👤 Guo, Li 👤 Huang, Chaolin 👤 Jaki, Thomas 👤 Hayden, Frederick G 👤 Horby, Peter W 👤 Zhang, Dingyu 👤 Wang, Chen ⏰ 2020 📚 N Engl J Med

• Remdesivir for severe acute respiratory syndrome coronavirus 2 causing COVID-19: An evaluation of the evidence.

  👤 Cao, Yu-Chen 👤 Deng, Qi-Xin 👤 Dai, Shi-Xue ⏰ 2020 📚 Travel Med Infect Dis

• Coronavirus in severe acute respiratory syndrome (SARS)

  👤 Chan, Henry L.Y. 👤 Tsui, Stephen K.W. 👤 Sung, Joseph J.Y. ⏰ 2003 📚 Trends in Molecular Medicine

• Structure-based virtual screening and experimental validation of the discovery of inhibitors targeted towards the human coronavirus nucleocapsid protein

  👤 Chang, Chung Ke 👤 Jeyachandran, Sivakamavalli 👤 Hu, Nien Jen 👤 Liu, Chia Ling 👤 Lin, Shing Yen 👤 Wang, Yong Sheng 👤 Chang, Yu Ming 👤 Hou, Ming Hon ⏰ 2016 📚 Molecular BioSystems

• Thiopurine analogue inhibitors of severe acute respiratory syndrome-coronavirus papain-like protease, a deubiquitinating and deISGylating enzyme

  👤 Chen, Xin 👤 Chou, Chi Yuan 👤 Chang, Gu Gang ⏰ 2009 📚 Antiviral Chemistry and Chemotherapy

• Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CL (pro)) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidates.

  👤 Chen, Yu Wai 👤 Yiu, Chin-Pang Bennu 👤 Wong, Kwok-Yin ⏰ 2020 📚 F1000Res

• Harnessing the immune system via FcgammaR function in immune therapy: A pathway to next-gen mAbs.

  👤 Chenoweth, Alicia M 👤 Wines, Bruce D 👤 Anania, Jessica C 👤 Mark Hogarth, P ⏰ 2020 📚 Immunol Cell Biol

• Mouse dipeptidyl peptidase 4 is not a functional receptor for middle east respiratory syndrome coronavirus infection

  👤 Cockrell, Adam S. 👤 Peck, Kayla M. 👤 Yount, Boyd L. 👤 Agnihothram, Sudhakar S. 👤 Scobey, Trevor 👤 Curnes, Nicole R. 👤 Baric, Ralph S. 👤 Heise, Mark T. ⏰ 2014 📚 Journal of Virology

• What Have We Learned about Middle East Respiratory Syndrome Coronavirus Emergence in Humans? A Systematic Literature Review

  👤 Dawson, Patrick 👤 Malik, Mamunur Rahman 👤 Parvez, Faruque 👤 Morse, Stephen S. ⏰ 2019 📚 Vector-Borne and Zoonotic Diseases

• Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture

  👤 De Wilde, Adriaan H. 👤 Jochmans, Dirk 👤 Posthuma, Clara C. 👤 Zevenhoven-Dobbe, Jessika C. 👤 Van Nieuwkoop, Stefan 👤 Bestebroer, Theo M. 👤 Van Den Hoogen, Bernadette G. 👤 Neyts, Johan 👤 Snijder, Eric J. ⏰ 2014 📚 Antimicrobial Agents and Chemotherapy

• SARS and MERS: Recent insights into emerging coronaviruses

  👤 De Wit, Emmie 👤 Van Doremalen, Neeltje 👤 Falzarano, Darryl 👤 Munster, Vincent J. ⏰ 2016 📚 Nature Reviews Microbiology

• An “Old” protein with a new story: Coronavirus endoribonuclease is important for evading host antiviral defenses

  👤 Deng, Xufang 👤 Baker, Susan C. ⏰ 2018 📚 Virology

• Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance

  👤 Deng, Xufang 👤 St John, Sarah E. 👤 Osswald, Heather L. 👤 O'Brien, Amornrat 👤 Banach, Bridget S. 👤 Sleeman, Katrina 👤 Ghosh, Arun K. 👤 Mesecar, Andrew D. 👤 Baker, Susan C. ⏰ 2014 📚 Journal of Virology

• COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics.

  👤 Dhama, Kuldeep 👤 Sharun, Khan 👤 Tiwari, Ruchi 👤 Dadar, Maryam 👤 Malik, Yashpal Singh 👤 Singh, Karam Pal 👤 Chaicumpa, Wanpen ⏰ 2020 📚 Hum Vaccin Immunother

• Systematic assembly of a full-length infectious clone of human coronavirus NL63

  👤 Donaldson, Eric F. 👤 Yount, Boyd 👤 Sims, Amy C. 👤 Burkett, Susan 👤 Pickles, Raymond J. 👤 Baric, Ralph S. ⏰ 2008 📚 Journal of Virology

• Middle East respiratory syndrome coronavirus: transmission, virology and therapeutic targeting to aid in outbreak control

  👤 Durai, Prasannavenkatesh 👤 Batool, Maria 👤 Shah, Masaud 👤 Choi, Sangdun ⏰ 2015 📚 Experimental & molecular medicine

• Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin

  👤 Falzarano, Darryl 👤 De Wit, Emmie 👤 Martellaro, Cynthia 👤 Callison, Julie 👤 Munster, Vincent J. 👤 Feldmann, Heinz ⏰ 2013 📚 Scientific Reports

• Full-genome sequence of human betacoronavirus 2c Jordan-N3/2012 after serial passage in mammalian cells

  👤 Frey, Kenneth G. 👤 Redden, Cassie L. 👤 Bishop-Lilly, Kimberly A. 👤 Johnson, Reed 👤 Hensley, Lisa E. 👤 Raviprakash, Kanakatte 👤 Luke, Thomas 👤 Kochel, Tad 👤 Mokashi, Vishwesh P. 👤 Defang, Gabriel N. ⏰ 2014 📚 Genome Announcements

• Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element

  👤 Galasiti Kankanamalage, Anushka C. 👤 Kim, Yunjeong 👤 Damalanka, Vishnu C. 👤 Rathnayake, Athri D. 👤 Fehr, Anthony R. 👤 Mehzabeen, Nurjahan 👤 Battaile, Kevin P. 👤 Lovell, Scott 👤 Lushington, Gerald H. 👤 Perlman, Stanley 👤 Chang, Kyeong Ok 👤 Groutas, William C. ⏰ 2018 📚 European Journal of Medicinal Chemistry

• Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS Coronavirus

  👤 Goetz, D. H. 👤 Choe, Y. 👤 Hansell, E. 👤 Chen, Y. T. 👤 McDowell, M. 👤 Jonsson, C. B. 👤 Roush, W. R. 👤 McKerrow, J. 👤 Craik, C. S. ⏰ 2007 📚 Biochemistry

• Characterization of novel monoclonal antibodies against MERS-coronavirus spike protein

  👤 Goo, Junghyun 👤 Jeong, Yuji 👤 Park, Young Shin 👤 Yang, Eunji 👤 Jung, Dae Im 👤 Rho, Semi 👤 Park, Uni 👤 Sung, Hyeyeong 👤 Park, Pil Gu 👤 Choi, Jung ah 👤 Seo, Sang Hwan 👤 Cho, Nam Hyuck 👤 Lee, Hyeja 👤 Lee, Jae Myun 👤 Kim, Jae Ouk 👤 Song, Manki ⏰ 2020 📚 Virus Research

• COVID-19 Infection: Implications for Perioperative and Critical Care Physicians.

  👤 Greenland, John R 👤 Michelow, Marilyn D 👤 Wang, Linlin 👤 London, Martin J ⏰ 2020 📚 Anesthesiology

• Murine coronavirus infection activates the aryl hydrocarbon receptor in an indoleamine 2,3-dioxygenase-independent manner, contributing to cytokine modulation and proviral TCDD-inducible-PARP expression

  👤 Grunewald, Matthew E. 👤 Shaban, Mohamed G. 👤 MacKin, Samantha R. 👤 Fehr, Anthony R. 👤 Perlman, Stanley ⏰ 2020 📚 Journal of Virology

• NAADP-dependent Ca2+ signaling regulates Middle East respiratory syndrome-coronavirus pseudovirus translocation through the endolysosomal system

  👤 Gunaratne, Gihan S. 👤 Yang, Yang 👤 Li, Fang 👤 Walseth, Timothy F. 👤 Marchant, Jonathan S. ⏰ 2018 📚 Cell Calcium

• Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics.

  👤 Gurwitz, David ⏰ 2020 📚 Drug Dev Res

• Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics.

  👤 Gurwitz, David ⏰ 2020 📚 Drug Dev Res

• Coronaviruses and their therapy

  👤 Haagmans, Bart L. 👤 Osterhaus, Albert D.M.E. ⏰ 2006 📚 Antiviral Research

• A single amino acid substitution (R441A) in the receptor-binding domain of SARS coronavirus spike protein disrupts the antigenic structure and binding activity

  👤 He, Yuxian 👤 Li, Jingjing 👤 Jiang, Shibo ⏰ 2006 📚 Biochemical and Biophysical Research Communications

• TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein

  👤 Heurich, Adeline 👤 Hofmann-Winkler, Heike 👤 Gierer, Stefanie 👤 Liepold, Thomas 👤 Jahn, Olaf 👤 Pöhlmann, Stefan ⏰ 2014 📚 Journal of Virology

• Novel Gold Nanorod-Based HR1 Peptide Inhibitor for Middle East Respiratory Syndrome Coronavirus

  👤 Huang, Xinyu 👤 Li, Meng 👤 Xu, Yurui 👤 Zhang, Jikang 👤 Meng, Xia 👤 An, Xueying 👤 Sun, Lei 👤 Guo, Leilei 👤 Shan, Xue 👤 Ge, Junliang 👤 Chen, Jiao 👤 Luo, Yadong 👤 Wu, Heming 👤 Zhang, Yu 👤 Jiang, Qing 👤 Ning, Xinghai ⏰ 2019 📚 ACS Applied Materials and Interfaces

• COVID-19 spike-host cell receptor GRP78 binding site prediction.

  👤 Ibrahim, Ibrahim M 👤 Abdelmalek, Doaa H 👤 Elshahat, Mohammed E 👤 Elfiky, Abdo A ⏰ 2020 📚 J Infect

• Structural characterization of the fusion-active complex of severe acute respiratory syndrome (SARS) coronavirus

  👤 Ingallinella, Paolo 👤 Bianchi, Elisabetta 👤 Finotto, Marco 👤 Cantoni, Giovanna 👤 Eckert, Debra M. 👤 Supekar, Vinit M. 👤 Bruckmann, Chiara 👤 Carfi, Andrea 👤 Pessi, Antonello ⏰ 2004 📚 Proceedings of the National Academy of Sciences of the United States of America

• WHO International Health Regulations Emergency Committee for the COVID-19 outbreak.

  👤 Jee, Youngmee ⏰ 2020 📚 Epidemiol Health

• Update: Public Health Response to the Coronavirus Disease 2019 Outbreak - United States, February 24, 2020.

  👤 Jernigan, Daniel B ⏰ 2020 📚 MMWR Morb Mortal Wkly Rep

• The First Disease X is Caused by a Highly Transmissible Acute Respiratory Syndrome Coronavirus.

  👤 Jiang, Shibo 👤 Shi, Zheng-Li ⏰ 2020 📚 Virol Sin

• Virology, Epidemiology, Pathogenesis, and Control of COVID-19.

  👤 Jin, Yuefei 👤 Yang, Haiyan 👤 Ji, Wangquan 👤 Wu, Weidong 👤 Chen, Shuaiyin 👤 Zhang, Weiguo 👤 Duan, Guangcai ⏰ 2020 📚 Viruses

• Structure of M(pro) from COVID-19 virus and discovery of its inhibitors.

  👤 Jin, Zhenming 👤 Du, Xiaoyu 👤 Xu, Yechun 👤 Deng, Yongqiang 👤 Liu, Meiqin 👤 Zhao, Yao 👤 Zhang, Bing 👤 Li, Xiaofeng 👤 Zhang, Leike 👤 Peng, Chao 👤 Duan, Yinkai 👤 Yu, Jing 👤 Wang, Lin 👤 Yang, Kailin 👤 Liu, Fengjiang 👤 Jiang, Rendi 👤 Yang, Xinglou 👤 You, Tian 👤 Liu, Xiaoce 👤 Yang, Xiuna 👤 Bai, Fang 👤 Liu, Hong 👤 Liu, Xiang 👤 Guddat, Luke W 👤 Xu, Wenqing 👤 Xiao, Gengfu 👤 Qin, Chengfeng 👤 Shi, Zhengli 👤 Jiang, Hualiang 👤 Rao, Zihe 👤 Yang, Haitao ⏰ 2020 📚 Nature

• Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus

  👤 Josset, Laurence 👤 Menachery, Vineet D. 👤 Gralinski, Lisa E. 👤 Agnihothram, Sudhakar 👤 Sova, Pavel 👤 Carter, Victoria S. 👤 Yount, Boyd L. 👤 Graham, Rachel L. 👤 Baric, Ralph S. 👤 Katzea, Michael G. ⏰ 2013 📚 mBio

• Pharmacologic Treatments and Supportive Care for Middle East Respiratory Syndrome.

  👤 Kain, Taylor 👤 Lindsay, Patrick J 👤 Adhikari, Neill K J 👤 Arabi, Yaseen M 👤 Van Kerkhove, Maria D 👤 Fowler, Robert A ⏰ 2020 📚 Emerg Infect Dis

• Infection and Rapid Transmission of SARS-CoV-2 in Ferrets.

  👤 Kim, Young-Il 👤 Kim, Seong-Gyu 👤 Kim, Se-Mi 👤 Kim, Eun-Ha 👤 Park, Su-Jin 👤 Yu, Kwang-Min 👤 Chang, Jae-Hyung 👤 Kim, Eun Ji 👤 Lee, Seunghun 👤 Casel, Mark Anthony B 👤 Um, Jihye 👤 Song, Min-Suk 👤 Jeong, Hye Won 👤 Lai, Van Dam 👤 Kim, Yeonjae 👤 Chin, Bum Sik 👤 Park, Jun-Sun 👤 Chung, Ki-Hyun 👤 Foo, Suan-Sin 👤 Poo, Haryoung 👤 Mo, In-Pil 👤 Lee, Ok-Jun 👤 Webby, Richard J 👤 Jung, Jae U 👤 Choi, Young Ki ⏰ 2020 📚 Cell Host Microbe

• Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses

  👤 Kim, Yunjeong 👤 Lovell, Scott 👤 Tiew, Kok Chuan 👤 Mandadapu, Sivakoteswara Rao 👤 Alliston, Kevin R. 👤 Battaile, Kevin K. 👤 Groutas, William C. 👤 Chang, Kyeong Ok ⏰ 2012 📚 Journal of Virology

• Anti-SARS Coronavirus agents: A patent review (2008-present)

  👤 Kumar, Vathan 👤 Jung, Young Sik 👤 Liang, Po Huang ⏰ 2013 📚 Expert Opinion on Therapeutic Patents

• Use of DAMPs and SAMPs as Therapeutic Targets or Therapeutics: A Note of Caution.

  👤 Land, Walter Gottlieb ⏰ 2020 📚 Mol Diagn Ther

• Engineering Coronaviruses to Evaluate Emergence and Pathogenic Potential

  👤 Lau, Susanna K.P. 👤 Woo, Patrick C.Y. ⏰ 2016 📚 Trends in Microbiology

• Increasing the translation of mouse models of MERS coronavirus pathogenesis through kinetic hematological analysis

  👤 Leist, Sarah R. 👤 Jensen, Kara L. 👤 Baric, Ralph S. 👤 Sheahan, Timothy P. ⏰ 2019 📚 PLoS ONE

• Middle East respiratory syndrome coronavirus (MERS-CoV): Challenges inidentifying its source and controlling its spread

  👤 Lu, Lu 👤 Liu, Qi 👤 Du, Lanying 👤 Jiang, Shibo ⏰ 2013 📚 Microbes and Infection

• Compounds with therapeutic potential against novel respiratory 2019 coronavirus.

  👤 Martinez, Miguel Angel ⏰ 2020 📚 Antimicrob Agents Chemother

• Combination siRNA therapy against feline coronavirus can delay the emergence of antiviral resistance in vitro

  👤 McDonagh, Phillip 👤 Sheehy, Paul A. 👤 Norris, Jacqueline M. ⏰ 2015 📚 Veterinary Microbiology

• Middle East respiratory syndrome.

  👤 Memish, Ziad A 👤 Perlman, Stanley 👤 Van Kerkhove, Maria D 👤 Zumla, Alimuddin ⏰ 2020 📚 Lancet

• Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV.

  👤 Morse, Jared S 👤 Lalonde, Tyler 👤 Xu, Shiqing 👤 Liu, Wenshe Ray ⏰ 2020 📚 Chembiochem

• Establishment and validation of a pseudovirus neutralization assay for SARS-CoV-2.

  👤 Nie, Jianhui 👤 Li, Qianqian 👤 Wu, Jiajing 👤 Zhao, Chenyan 👤 Hao, Huan 👤 Liu, Huan 👤 Zhang, Li 👤 Nie, Lingling 👤 Qin, Haiyang 👤 Wang, Meng 👤 Lu, Qiong 👤 Li, Xiaoyu 👤 Sun, Qiyu 👤 Liu, Junkai 👤 Fan, Changfa 👤 Huang, Weijin 👤 Xu, Miao 👤 Wang, Youchun ⏰ 2020 📚 Emerg Microbes Infect

• Engineering a stable CHO cell line for the expression of a MERS-coronavirus vaccine antigen

  👤 Nyon, Mun Peak 👤 Du, Lanying 👤 Tseng, Chien Te Kent 👤 Seid, Christopher A. 👤 Pollet, Jeroen 👤 Naceanceno, Kevin S. 👤 Agrawal, Anurodh 👤 Algaissi, Abdullah 👤 Peng, Bi Hung 👤 Tai, Wanbo 👤 Jiang, Shibo 👤 Bottazzi, Maria Elena 👤 Strych, Ulrich 👤 Hotez, Peter J. ⏰ 2018 📚 Vaccine

• Prolonged shedding of human coronavirus in hematopoietic cell transplant recipients: Risk factors and viral genome evolution

  👤 Ogimi, Chikara 👤 Greninger, Alexander L. 👤 Waghmare, Alpana A. 👤 Kuypers, Jane M. 👤 Shean, Ryan C. 👤 Xie, Hu 👤 Leisenring, Wendy M. 👤 Stevens-Ayers, Terry L. 👤 Jerome, Keith R. 👤 Englund, Janet A. 👤 Boeckh, Michael ⏰ 2017 📚 Journal of Infectious Diseases

• Early events during human coronavirus OC43 entry to the cell

  👤 Owczarek, Katarzyna 👤 Szczepanski, Artur 👤 Milewska, Aleksandra 👤 Baster, Zbigniew 👤 Rajfur, Zenon 👤 Sarna, Michal 👤 Pyrc, Krzysztof ⏰ 2018 📚 Scientific Reports

• Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review.

  👤 Pang, Junxiong 👤 Wang, Min Xian 👤 Ang, Ian Yi Han 👤 Tan, Sharon Hui Xuan 👤 Lewis, Ruth Frances 👤 Chen, Jacinta I-Pei 👤 Gutierrez, Ramona A 👤 Gwee, Sylvia Xiao Wei 👤 Chua, Pearleen Ee Yong 👤 Yang, Qian 👤 Ng, Xian Yi 👤 Yap, Rowena Ks 👤 Tan, Hao Yi 👤 Teo, Yik Ying 👤 Tan, Chorh Chuan 👤 Cook, Alex R 👤 Yap, Jason Chin-Huat 👤 Hsu, Li Yang ⏰ 2020 📚 J Clin Med

• Initial Public Health Response and Interim Clinical Guidance for the 2019 Novel Coronavirus Outbreak - United States, December 31, 2019-February 4, 2020.

  👤 Patel, Anita 👤 Jernigan, Daniel B ⏰ 2020 📚 MMWR Morb Mortal Wkly Rep

• SARS-CoV-2: A Storm is Raging.

  👤 Pedersen, Savannah F 👤 Ho, Ya-Chi ⏰ 2020 📚 J Clin Invest

• The SARS-Coronavirus-host interactome: Identification of cyclophilins as target for pan-Coronavirus inhibitors

  👤 Pfefferle, Susanne 👤 Schöpf, Julia 👤 Kögl, Manfred 👤 Friedel, Caroline C. 👤 Müller, Marcel A. 👤 Carbajo-Lozoya, Javier 👤 Stellberger, Thorsten 👤 von Dall'Armi, Ekatarina 👤 Herzog, Petra 👤 Kallies, Stefan 👤 Niemeyer, Daniela 👤 Ditt, Vanessa 👤 Kuri, Thomas 👤 Züst, Roland 👤 Pumpor, Ksenia 👤 Hilgenfeld, Rolf 👤 Schwarz, Frank 👤 Zimmer, Ralf 👤 Steffen, Imke 👤 Weber, Friedemann 👤 Thiel, Volker 👤 Herrler, Georg 👤 Thiel, Heinz Jürgen 👤 Schwegmann-Weßels, Christel 👤 Pöhlmann, Stefan 👤 Haas, Jürgen 👤 Drosten, Christian 👤 von Brunn, Albrecht ⏰ 2011 📚 PLoS Pathogens

• Virus pathogen Database and Analysis Resource (ViPR): A comprehensive bioinformatics Database and Analysis Resource for the Coronavirus research community

  👤 Pickett, Brett E. 👤 Greer, Douglas S. 👤 Zhang, Yun 👤 Stewart, Lucy 👤 Zhou, Liwei 👤 Sun, Guangyu 👤 Gu, Zhiping 👤 Kumar, Sanjeev 👤 Zaremba, Sam 👤 Larsen, Christopher N. 👤 Jen, Wei 👤 Klem, Edward B. 👤 Scheuermann, Richard H. ⏰ 2012 📚 Viruses

• A three-stemmed mRNA pseudoknot in the SARS coronavirus frameshift signal

  👤 Plant, Ewan P. 👤 Pérez-Alvarado, Gabriela C. 👤 Jacobs, Jonathan L. 👤 Mukhopadhyay, Bani 👤 Hennig, Mirko 👤 Dinman, Jonathan D. ⏰ 2005 📚 PLoS Biology

• Structure of severe acute respiratory syndrome coronavirus receptor-binding domain complexed with neutralizing antibody

  👤 Prabakaran, Ponraj 👤 Gan, Jianhua 👤 Feng, Yang 👤 Zhu, Zhongyu 👤 Choudhry, Vidita 👤 Xiao, Xiaodong 👤 Ji, Xinhua 👤 Dimitrov, Dimiter S. ⏰ 2006 📚 Journal of Biological Chemistry

• Nucleoside analogues for the treatment of coronavirus infections

  👤 Pruijssers, Andrea J. 👤 Denison, Mark R. ⏰ 2019 📚 Current Opinion in Virology

• An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus

  👤 Qin, Chuan 👤 Wang, Jianwei 👤 Wei, Qiang 👤 She, Mingpeng 👤 Marasco, Wayne A. 👤 Jiang, Hong 👤 Tu, Xinming 👤 Zhu, Hua 👤 Ren, Lili 👤 Gao, Li 👤 Guo, Li 👤 Huang, Lan 👤 Yang, Renquan 👤 Cong, Zhe 👤 Guo, Lan 👤 Wang, Yanbin 👤 Liu, Yali 👤 Sun, Lili 👤 Duan, Shumin 👤 Qu, Jianguo 👤 Chen, Liangbiao 👤 Tong, Wei 👤 Ruan, Li 👤 Liu, Peimao 👤 Zhang, Hua 👤 Zhang, Jianmin 👤 Zhang, Huiyuan 👤 Liu, Depei 👤 Liu, Qian 👤 Hong, Tao 👤 He, Wei ⏰ 2005 📚 Journal of Pathology

• Optimizing COVID-19 candidate therapeutics: Thinking Without Borders.

  👤 Rayner, Craig R 👤 Smith, Patrick F 👤 Hershberger, Kevin 👤 Wesche, David ⏰ 2020 📚 Clin Transl Sci

• COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?

  👤 Sargiacomo, Camillo 👤 Sotgia, Federica 👤 Lisanti, Michael P ⏰ 2020 📚 Aging (Albany NY)

• Systems approaches to coronavirus pathogenesis

  👤 Schäfer, Alexandra 👤 Baric, Ralph S. 👤 Ferris, Martin T. ⏰ 2014 📚 Current Opinion in Virology

• Perspectives on monoclonal antibody therapy as potential therapeutic intervention for Coronavirus disease-19 (COVID-19).

  👤 Shanmugaraj, Balamurugan 👤 Siriwattananon, Konlavat 👤 Wangkanont, Kittikhun 👤 Phoolcharoen, Waranyoo ⏰ 2020 📚 Asian Pac J Allergy Immunol

• Saracatinib inhibits middle east respiratory syndrome-coronavirus replication in vitro

  👤 Shin, Jin Soo 👤 Jung, Eunhye 👤 Kim, Meehyein 👤 Baric, Ralph S. 👤 Go, Yun Young ⏰ 2018 📚 Viruses

• Coronaviruses Lacking Exoribonuclease Activity Are Susceptible to Lethal Mutagenesis: Evidence for Proofreading and Potential Therapeutics

  👤 Smith, Everett Clinton 👤 Blanc, Hervé 👤 Vignuzzi, Marco 👤 Denison, Mark R. ⏰ 2013 📚 PLoS Pathogens

• Acetazolamide, Nifedipine and Phosphodiesterase Inhibitors: Rationale for Their Utilization as Adjunctive Countermeasures in the Treatment of Coronavirus Disease 2019 (COVID-19).

  👤 Solaimanzadeh, Isaac ⏰ 2020 📚 Cureus

• Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4 - The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)

  👤 St. John, Sarah E. 👤 Tomar, Sakshi 👤 Stauffer, Shaun R. 👤 Mesecar, Andrew D. ⏰ 2015 📚 Bioorganic and Medicinal Chemistry

• Identification of a novel inhibitor against middle east respiratory syndrome coronavirus

  👤 Sun, Yaping 👤 Zhang, Huaidong 👤 Shi, Jian 👤 Zhang, Zhe 👤 Gong, Rui ⏰ 2017 📚 Viruses

• Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine.

  👤 Tai, Wanbo 👤 He, Lei 👤 Zhang, Xiujuan 👤 Pu, Jing 👤 Voronin, Denis 👤 Jiang, Shibo 👤 Zhou, Yusen 👤 Du, Lanying ⏰ 2020 📚 Cell Mol Immunol

• Coronavirus membrane fusion mechanism offers as a potential target for antiviral development.

  👤 Tang, Tiffany 👤 Bidon, Miya 👤 Jaimes, Javier A 👤 Whittaker, Gary R 👤 Daniel, Susan ⏰ 2020 📚 Antiviral Res

• MERS coronavirus nsp1 participates in an efficient propagation through a specific interaction with viral RNA

  👤 Terada, Yutaka 👤 Kawachi, Kengo 👤 Matsuura, Yoshiharu 👤 Kamitani, Wataru ⏰ 2017 📚 Virology

• Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody.

  👤 Tian, Xiaolong 👤 Li, Cheng 👤 Huang, Ailing 👤 Xia, Shuai 👤 Lu, Sicong 👤 Shi, Zhengli 👤 Lu, Lu 👤 Jiang, Shibo 👤 Yang, Zhenlin 👤 Wu, Yanling 👤 Ying, Tianlei ⏰ 2020 📚 Emerg Microbes Infect

• Ligand-induced dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 protease (3CLpro): Implications for nsp5 regulation and the development of antivirals

  👤 Tomar, Sakshi 👤 Johnston, Melanie L. 👤 John, Sarah E.St 👤 Osswald, Heather L. 👤 Nyalapatla, Prasanth R. 👤 Paul, Lake N. 👤 Ghosh, Arun K. 👤 Denison, Mark R. 👤 Mesecar, Andrew D. ⏰ 2015 📚 Journal of Biological Chemistry

• Rapid Identification of Potential Inhibitors of SARS-CoV-2 Main Protease by Deep Docking of 1.3 Billion Compounds.

  👤 Ton, Anh-Tien 👤 Gentile, Francesco 👤 Hsing, Michael 👤 Ban, Fuqiang 👤 Cherkasov, Artem ⏰ 2020 📚 Mol Inform

• Broad-spectrum coronavirus antiviral drug discovery

  👤 Totura, Allison L. 👤 Bavari, Sina ⏰ 2019 📚 Expert Opinion on Drug Discovery

• Development of Medical Countermeasures to Middle East Respiratory Syndrome Coronavirus

  👤 Uyeki, Timothy M. 👤 Erlandson, Karl J. 👤 Korch, George 👤 O'Hara, Michael 👤 Wathen, Michael 👤 Hu-Primmer, Jean 👤 Hojvat, Sally 👤 Stemmy, Erik J. 👤 Donabedian, Armen ⏰ 2016 📚 Emerging infectious diseases

• Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26.

  👤 Vankadari, Naveen 👤 Wilce, Jacqueline A ⏰ 2020 📚 Emerg Microbes Infect

• Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design

  👤 Wang, Fenghua 👤 Chen, Cheng 👤 Tan, Wenjie 👤 Yang, Kailin 👤 Yang, Haitao ⏰ 2016 📚 Scientific Reports

• Structural and biochemical characterization of SADS-CoV papain-like protease 2.

  👤 Wang, Lu 👤 Hu, Weihua 👤 Fan, Chengpeng ⏰ 2020 📚 Protein Sci

• Subunit Vaccines Against Emerging Pathogenic Human Coronaviruses.

  👤 Wang, Ning 👤 Shang, Jian 👤 Jiang, Shibo 👤 Du, Lanying ⏰ 2020 📚 Front Microbiol

• The infectious bronchitis coronavirus envelope protein alters Golgi pH to protect the spike protein and promote the release of infectious virus

  👤 Westerbeck, Jason W. 👤 Machamer, Carolyn E. ⏰ 2019 📚 Journal of Virology

• PRESCIENT: platform for the rapid evaluation of antibody success using integrated microfluidics enabled technology.

  👤 Wippold, Jose A 👤 Wang, Han 👤 Tingling, Joseph 👤 Leibowitz, Julian L 👤 de Figueiredo, Paul 👤 Han, Arum ⏰ 2020 📚 Lab Chip

• Genome-wide screen reveals valosin-containing protein requirement for coronavirus exit from endosomes

  👤 Wong, Hui Hui 👤 Kumar, Pankaj 👤 Tay, Felicia Pei Ling 👤 Moreau, Dimitri 👤 Liu, Ding Xiang 👤 Bard, Frédéric ⏰ 2015 📚 Journal of Virology

• Antiviral applications of RNAi for coronavirus

  👤 Wu, Chang Jer 👤 Chan, Yi Lin ⏰ 2006 📚 Expert Opinion on Investigational Drugs

• Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion.

  👤 Xia, Shuai 👤 Liu, Meiqin 👤 Wang, Chao 👤 Xu, Wei 👤 Lan, Qiaoshuai 👤 Feng, Siliang 👤 Qi, Feifei 👤 Bao, Linlin 👤 Du, Lanying 👤 Liu, Shuwen 👤 Qin, Chuan 👤 Sun, Fei 👤 Shi, Zhengli 👤 Zhu, Yun 👤 Jiang, Shibo 👤 Lu, Lu ⏰ 2020 📚 Cell Res

• Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential.

  👤 Xu, Jimin 👤 Shi, Pei-Yong 👤 Li, Hongmin 👤 Zhou, Jia ⏰ 2020 📚 ACS Infect Dis

• Severe acute respiratory syndrome coronavirus entry into host cells: Opportunities for therapeutic intervention

  👤 Yeung, Kap Sun 👤 Yamanaka, Gregory A. 👤 Meanwell, Nicholas A. ⏰ 2006 📚 Medicinal Research Reviews

• Exceptionally potent neutralization of middle east respiratory syndrome coronavirus by human monoclonal antibodies

  👤 Ying, Tianlei 👤 Du, Lanying 👤 Ju, Tina W. 👤 Prabakaran, Ponraj 👤 Lau, Candy C.Y. 👤 Lu, Lu 👤 Liu, Qi 👤 Wang, Lili 👤 Feng, Yang 👤 Wang, Yanping 👤 Zheng, Bo Jian 👤 Yuen, Kwok Yung 👤 Jiang, Shibo 👤 Dimitrov, Dimiter S. ⏰ 2014 📚 Journal of Virology

• Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus

  👤 Yount, Boyd 👤 Curtis, Kristopher M. 👤 Fritz, Elizabeth A. 👤 Hensley, Lisa E. 👤 Jahrling, Peter B. 👤 Prentice, Erik 👤 Denison, Mark R. 👤 Geisbert, Thomas W. 👤 Baric, Ralph S. ⏰ 2003 📚 Proceedings of the National Academy of Sciences of the United States of America

• Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China.

  👤 Yu, Fei 👤 Du, Lanying 👤 Ojcius, David M 👤 Pan, Chungen 👤 Jiang, Shibo ⏰ 2020 📚 Microbes Infect

• A safe and convenient pseudovirus-based inhibition assay to detect neutralizing antibodies and screen for viral entry inhibitors against the novel human coronavirus MERS-CoV

  👤 Zhao, Guangyu 👤 Du, Lanying 👤 Ma, Cuiqing 👤 Li, Ye 👤 Li, Lin 👤 Poon, Vincent Km 👤 Wang, Lili 👤 Yu, Fei 👤 Zheng, Bo Jian 👤 Jiang, Shibo 👤 Zhou, Yusen ⏰ 2013 📚 Virology Journal

• A novel nanobody targeting middle east respiratory syndrome coronavirus (MERS-CoV) receptor-binding domain has potent cross-neutralizing activity and protective efficacy against MERS-CoV

  👤 Zhao, Guangyu 👤 He, Lei 👤 Sun, Shihui 👤 Qiu, Hongjie 👤 Tai, Wanbo 👤 Chen, Jiawei 👤 Li, Jiangfan 👤 Chen, Yuehong 👤 Guo, Yan 👤 Wang, Yufei 👤 Shang, Jian 👤 Ji, Kaiyuan 👤 Fan, Ruiwen 👤 Du, Enqi 👤 Jiang, Shibo 👤 Li, Fang 👤 Du, Lanying 👤 Zhou, Yusen ⏰ 2018 📚 Journal of Virology

• Protease inhibitors targeting coronavirus and filovirus entry

  👤 Zhou, Yanchen 👤 Vedantham, Punitha 👤 Lu, Kai 👤 Agudelo, Juliet 👤 Carrion, Ricardo 👤 Nunneley, Jerritt W. 👤 Barnard, Dale 👤 Pöhlmann, Stefan 👤 McKerrow, James H. 👤 Renslo, Adam R. 👤 Simmons, Graham ⏰ 2015 📚 Antiviral Research

• Host-directed therapies for improving poor treatment outcomes associated with the middle east respiratory syndrome coronavirus infections

  👤 Zumla, Alimuddin 👤 Azhar, Esam I. 👤 Arabi, Yaseen 👤 Alotaibi, Badriah 👤 Rao, Martin 👤 McCloskey, Brian 👤 Petersen, Eskild 👤 Maeurer, Markus ⏰ 2015 📚 International Journal of Infectious Diseases