🔗 Protease

Articles (300)

• Deduced sequence of the bovine coronavirus spike protein and identification of the internal proteolytic cleavage site

  👤 Abraham, Sushma 👤 Kienzle, Thomas E. 👤 Lapps, William 👤 Brian, David A. ⏰ 1990 📚 Virology

• Computational modeling of the bat HKU4 coronavirus 3CLpro inhibitors as a tool for the development of antivirals against the emerging Middle East respiratory syndrome (MERS) coronavirus

  👤 Abuhammad, Areej 👤 Al-Aqtash, Rua'a A. 👤 Anson, Brandon J. 👤 Mesecar, Andrew D. 👤 Taha, Mutasem O. ⏰ 2017 📚 Journal of Molecular Recognition

• Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms

  👤 Adedeji, Adeyemi O. 👤 Severson, William 👤 Jonsson, Colleen 👤 Singh, Kamalendra 👤 Weiss, Susan R. 👤 Sarafianosa, Stefan G. ⏰ 2013 📚 Journal of Virology

• A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant

  👤 Agnihothram, Sudhakar 👤 Yount Jr., Boyd L. 👤 Donaldson, Eric F. 👤 Huynh, Jeremy 👤 Menachery, Vineet D. 👤 Gralinski, Lisa E. 👤 Graham, Rachel L. 👤 Becker, Michelle M. 👤 Tomar, Sakshi 👤 Scobey, Trevor D. 👤 Osswald, Heather L. 👤 Whitmore, Alan 👤 Gopal, Robin 👤 Ghosh, Arun K. 👤 Mesecar, Andrew 👤 Zambon, Maria 👤 Heise, Mark 👤 Denison, Mark R. 👤 Baric, Ralph S. ⏰ 2014 📚 mBio

• An efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS-Cov Mpro) inhibitors

  👤 Al-Gharabli, Samer I. 👤 Ali Shah, Syed T. 👤 Weik, Steffen 👤 Schmidt, Marco F. 👤 Mesters, Jeroen R. 👤 Kuhn, Daniel 👤 Klebe, Gerhard 👤 Hilgenfeld, Rolf 👤 Rademann, Jörg ⏰ 2006 📚 ChemBioChem

• Inhibition of the growth of human coronavirus 229E by leupeptin

  👤 Appleyard, G. 👤 Tisdale, M. ⏰ 1985 📚 Journal of General Virology

• Induction of lactogenic immunity to transmissible gastroneteritis virus of swine using an attenuated coronavirus mutant able to survive in the physicochemical environment of the digestive tract

  👤 Aynaud, J. M. 👤 Bernard, S. 👤 Bottreau, E. 👤 Lantier, I. 👤 Salmon, H. 👤 Vannier, Ph ⏰ 1991 📚 Veterinary Microbiology

• Development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3CLpro

  👤 Bacha, Usman 👤 Barrila, Jennifer 👤 Gabelli, Sandra B. 👤 Kiso, Yoshiaki 👤 Mario Amzel, L. 👤 Freire, Ernesto ⏰ 2008 📚 Chemical Biology and Drug Design

• Identification of Novel Inhibitors of the SARS Coronavirus Main Protease 3CLpro

  👤 Bacha, Usman 👤 Barrila, Jennifer 👤 Velazquez-Campoy, Adrian 👤 Leavitt, Stephanie A. 👤 Freire, Ernesto ⏰ 2004 📚 Biochemistry

• Crystal structure of the middle east respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression

  👤 Bailey-Elkin, Ben A. 👤 Knaap, Robert C.M. 👤 Johnson, Garrett G. 👤 Dalebout, Tim J. 👤 Ninaber, Dennis K. 👤 Van Kasteren, Puck B. 👤 Bredenbeek, Peter J. 👤 Snijder, Eric J. 👤 Kikkert, Marjolein 👤 Mark, Brian L. ⏰ 2014 📚 Journal of Biological Chemistry

• Detection of nonstructural protein 6 in murine coronavirus-infected cells and analysis of the transmembrane topology by using bioinformatics and molecular approaches

  👤 Baliji, Surendranath 👤 Cammer, Stephen A. 👤 Sobral, Bruno 👤 Baker, Susan C. ⏰ 2009 📚 Journal of Virology

• Receptor variation and susceptibility to middle east respiratory syndrome coronavirus infection

  👤 Barlan, Arlene 👤 Zhao, Jincun 👤 Sarkar, Mayukh K. 👤 Li, Kun 👤 McCray, Paul B. 👤 Perlman, Stanley 👤 Gallagher, Tom ⏰ 2014 📚 Journal of Virology

• The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity

  👤 Barretto, Naina 👤 Jukneliene, Dalia 👤 Ratia, Kiira 👤 Chen, Zhongbin 👤 Mesecar, Andrew D. 👤 Baker, Susan C. ⏰ 2005 📚 Journal of Virology

• The search for a structural basis for therapeutic intervention against the SARS coronavirus

  👤 Bartlam, Mark 👤 Xue, Xiaoyu 👤 Rao, Zihe ⏰ 2008 📚 Acta Crystallographica Section A: Foundations of Crystallography

• Structural insights into SARS coronavirus proteins

  👤 Bartlam, Mark 👤 Yang, Haitao 👤 Rao, Zihe ⏰ 2005 📚 Current Opinion in Structural Biology

• Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites

  👤 Belouzard, Sandrine 👤 Chu, Victor C. 👤 Whittaker, Gary R. ⏰ 2009 📚 Proceedings of the National Academy of Sciences of the United States of America

• Elastase-mediated activation of the severe acute respiratory syndrome coronavirus spike protein at discrete sites within the S2 domain

  👤 Belouzard, Sandrine 👤 Madu, Ikenna 👤 Whittaker, Gary R. ⏰ 2010 📚 Journal of Biological Chemistry

• Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: Homology modelling and molecular dynamic studies

  👤 Berry, Michael 👤 Fielding, Burtram 👤 Gamieldien, Junaid ⏰ 2015 📚 BMC Structural Biology

• TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium

  👤 Bertram, Stephanie 👤 Dijkman, Ronald 👤 Habjan, Matthias 👤 Heurich, Adeline 👤 Gierer, Stefanie 👤 Glowacka, Ilona 👤 Welsch, Kathrin 👤 Winkler, Michael 👤 Schneider, Heike 👤 Hofmann-Winkler, Heike 👤 Volker Thiel, None 👤 Pöhlmann, Stefan ⏰ 2013 📚 Journal of Virology

• Cleavage and activation of the severe acute respiratory syndrome coronavirus spike protein by human airway trypsin-like protease

  👤 Bertram, Stephanie 👤 Glowacka, Ilona 👤 Müller, Marcel A. 👤 Lavender, Hayley 👤 Gnirss, Kerstin 👤 Nehlmeier, Inga 👤 Niemeyer, Daniela 👤 He, Yuxian 👤 Simmons, Graham 👤 Drosten, Christian 👤 Soilleux, Elizabeth J. 👤 Jahn, Olaf 👤 Steffen, Imke 👤 Pöhlmann, Stefan ⏰ 2011 📚 Journal of Virology

• Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts

  👤 Bertram, Stephanie 👤 Heurich, Adeline 👤 Lavender, Hayley 👤 Gierer, Stefanie 👤 Danisch, Simon 👤 Perin, Paula 👤 Lucas, Jared M. 👤 Nelson, Peter S. 👤 Pöhlmann, Stefan 👤 Soilleux, Elizabeth J. ⏰ 2012 📚 PLoS ONE

• Cathepsin L functionally cleaves the severe acute respiratory syndrome coronavirus class I fusion protein upstream of rather than adjacent to the fusion peptide

  👤 Bosch, Berend Jan 👤 Bartelink, Willem 👤 Rottier, Peter J.M. ⏰ 2008 📚 Journal of Virology

• Membrane ectopeptidases targeted by human coronaviruses

  👤 Bosch, Berend Jan 👤 Smits, Saskia L. 👤 Haagmans, Bart L. ⏰ 2014 📚 Current Opinion in Virology

• The evolution of codon usage in structural and non-structural viral genes: The case of Avian coronavirus and its natural host Gallus gallus

  👤 Brandão, Paulo Eduardo ⏰ 2013 📚 Virus Research

• Expression, purification and characterization of recombinant severe acute respiratory syndrome coronavirus non-structural protein 1

  👤 Brucz, Kimberly 👤 Miknis, Zachary J. 👤 Schultz, L. Wayne 👤 Umland, Timothy C. ⏰ 2007 📚 Protein Expression and Purification

• Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner

  👤 Burkard, Christine 👤 Verheije, Monique H. 👤 Wicht, Oliver 👤 van Kasteren, Sander I. 👤 van Kuppeveld, Frank J. 👤 Haagmans, Bart L. 👤 Pelkmans, Lucas 👤 Rottier, Peter J.M. 👤 Bosch, Berend Jan 👤 de Haan, Cornelis A.M. ⏰ 2014 📚 PLoS Pathogens

• X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases

  👤 Báez-Santos, Yahira M. 👤 Barraza, Scott J. 👤 Wilson, Michael W. 👤 Agius, Michael P. 👤 Mielech, Anna M. 👤 Davis, Nicole M. 👤 Baker, Susan C. 👤 Larsen, Scott D. 👤 Mesecar, Andrew D. ⏰ 2014 📚 Journal of Medicinal Chemistry

• Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the middle east respiratory syndrome coronavirus

  👤 Báez-Santos, Yahira M. 👤 Mielech, Anna M. 👤 Deng, Xufang 👤 Baker, Susan 👤 Mesecar, Andrew D. ⏰ 2014 📚 Journal of Virology

• The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds

  👤 Báez-Santos, Yahira M. 👤 St. John, Sarah E. 👤 Mesecar, Andrew D. ⏰ 2015 📚 Antiviral Research

• Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease

  👤 Békés, Miklós 👤 van der Heden van Noort, Gerbrand J. 👤 Ekkebus, Reggy 👤 Ovaa, Huib 👤 Huang, Tony T. 👤 Lima, Christopher D. ⏰ 2016 📚 Molecular Cell

• Coronavirusibv: Relationships among recent european isolates studied by limited proteolysis of the virion glycopolypeptides

  👤 Cavanagh, D. 👤 Davis, P. J. ⏰ 1987 📚 Avian Pathology

• Coronavirus IBV glycopolypeptides: locational studies using proteases and saponin, a membrane permeabilizer

  👤 Cavanagh, David 👤 Davis, Philip J. 👤 Pappin, Darryl J.C. ⏰ 1986 📚 Virus Research

• Recommendations for coronavirus infection in rheumatic diseases treated with biologic therapy.

  👤 Ceribelli, Angela 👤 Motta, Francesca 👤 De Santis, Maria 👤 Ansari, Aftab A 👤 Ridgway, William M 👤 Gershwin, M Eric 👤 Selmi, Carlo ⏰ 2020 📚 J Autoimmun

• Reversible unfolding of the severe acute respiratory syndrome coronavirus main protease in guanidinium chloride

  👤 Chang, Hui Ping 👤 Chou, Chi Yuan 👤 Chang, Gu Gang ⏰ 2007 📚 Biophysical Journal

• Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors

  👤 Chen, Li Rung 👤 Wang, Yu Chin 👤 Yi, Wen Lin 👤 Chou, Shan Yen 👤 Chen, Shyh Fong 👤 Lee, Tai Liu 👤 Wu, Ying Ta 👤 Kuo, Chih Jung 👤 Chen, Tom Shieh Shung 👤 Juang, Shin Hun ⏰ 2005 📚 Bioorganic and Medicinal Chemistry Letters

• Discovering severe acute respiratory syndrome coronavirus 3CL protease inhibitors: Virtual screening, surface plasmon resonance, and fluorescence resonance energy transfer assays

  👤 Chen, Lili 👤 Chen, Shuai 👤 Gui, Chunshan 👤 Shen, Jianhua 👤 Shen, Xu 👤 Jiang, Hualiang ⏰ 2006 📚 Journal of Biomolecular Screening

• Enzymatic activity characterization of SARS coronavirus 3C-like protease by fluorescence resonance energy transfer technique

  👤 Chen, Shuai 👤 Chen, Li Li 👤 Luo, Hai Bin 👤 Sun, Tao 👤 Chen, Jing 👤 Ye, Fei 👤 Cai, Jian Hua 👤 Shen, Jing Kang 👤 Shen, Xu 👤 Jiang, Hua Liang ⏰ 2005 📚 Acta Pharmacologica Sinica

• Mutation of Gly-11 on the dimer interface results in the complete crystallographic dimer dissociation of severe acute respiratory syndrome coronavirus 3C-like protease: Crystal structure with molecular dynamics simulations

  👤 Chen, Shuai 👤 Hu, Tiancen 👤 Zhang, Jian 👤 Chen, Jing 👤 Chen, Kaixian 👤 Ding, Jianping 👤 Jiang, Hualiang 👤 Shen, Xu ⏰ 2008 📚 Journal of Biological Chemistry

• Residues on the dimer interface of SARS coronavirus 3C-like protease: Dimer stability characterization and enzyme catalytic activity analysis

  👤 Chen, Shuai 👤 Zhang, Jian 👤 Hu, Tiancen 👤 Chen, Kaixian 👤 Jiang, Hualiang 👤 Shen, Xu ⏰ 2008 📚 Journal of Biochemistry

• Coronavirus membrane-associated papain-like proteases induce autophagy through interacting with Beclin1 to negatively regulate antiviral innate immunity

  👤 Chen, Xiaojuan 👤 Wang, Kai 👤 Xing, Yaling 👤 Tu, Jian 👤 Yang, Xingxing 👤 Zhao, Qian 👤 Li, Kui 👤 Chen, Zhongbin ⏰ 2014 📚 Protein and Cell

• SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex

  👤 Chen, Xiaojuan 👤 Yang, Xingxing 👤 Zheng, Yang 👤 Yang, Yudong 👤 Xing, Yaling 👤 Chen, Zhongbin ⏰ 2014 📚 Protein and Cell

• Thiopurine analogue inhibitors of severe acute respiratory syndrome-coronavirus papain-like protease, a deubiquitinating and deISGylating enzyme

  👤 Chen, Xin 👤 Chou, Chi Yuan 👤 Chang, Gu Gang ⏰ 2009 📚 Antiviral Chemistry and Chemotherapy

• Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CL (pro)) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidates.

  👤 Chen, Yu Wai 👤 Yiu, Chin-Pang Bennu 👤 Wong, Kwok-Yin ⏰ 2020 📚 F1000Res

• Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63

  👤 Chen, Zhongbin 👤 Wang, Yanhua 👤 Ratia, Kiira 👤 Mesecar, Andrew D. 👤 Wilkinson, Keith D. 👤 Baker, Susan C. ⏰ 2007 📚 Journal of Virology

• Expression, purification, and characterization of SARS coronavirus RNA polymerase

  👤 Cheng, Ao 👤 Zhang, Wei 👤 Xie, Youhua 👤 Jiang, Weihong 👤 Arnold, Eddy 👤 Sarafianos, Stefan G. 👤 Ding, Jianping ⏰ 2005 📚 Virology

• Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus

  👤 Cheng, Kai Wen 👤 Cheng, Shu Chun 👤 Chen, Wei Yi 👤 Lin, Min Han 👤 Chuang, Shang Ju 👤 Cheng, I. Hsin 👤 Sun, Chiao Yin 👤 Chou, Chi Yuan ⏰ 2015 📚 Antiviral Research

• Mutation of glu-166 blocks the substrate-induced dimerization of SARS coronavirus main protease

  👤 Cheng, Shu Chun 👤 Chang, Gu Gang 👤 Chou, Chi Yuan ⏰ 2010 📚 Biophysical Journal

• Differential recognition of peptides within feline coronavirus polyprotein 1 ab by sera from healthy cats and cats with feline infectious peritonitis

  👤 Chernyavtseva, Anastasia 👤 Cave, Nick J. 👤 Munday, John S. 👤 Dunowska, Magdalena ⏰ 2019 📚 Virology

• Quaternary structure of the severe acute respiratory syndrome (SARS) coronavirus main protease

  👤 Chou, Chi Yuan 👤 Chang, Hui Chuan 👤 Hsu, Wen Chi 👤 Lin, Tien Zheng 👤 Lin, Chao Hsiung 👤 Chang, Gu Gang ⏰ 2004 📚 Biochemistry

• Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus

  👤 Chou, Chi Yuan 👤 Chien, Chia Hui 👤 Han, Yu San 👤 Prebanda, Mojca Trstenjak 👤 Hsieh, Hsing Pang 👤 Turk, Boris 👤 Chang, Gu Gang 👤 Chen, Xin ⏰ 2008 📚 Biochemical Pharmacology

• Structural basis for catalysis and ubiquitin recognition by the Severe acute respiratory syndrome coronavirus papain-like protease

  👤 Chou, Chi Yuan 👤 Lai, Hsing Yi 👤 Chen, Hung Yi 👤 Cheng, Shu Chun 👤 Cheng, Kai Wen 👤 Chou, Ya Wen ⏰ 2014 📚 Acta Crystallographica Section D: Biological Crystallography

• The use of hepatitis C virus NS3/4A and secreted alkaline phosphatase to quantitate cell-cell membrane fusion mediated by severe acute respiratory syndrome coronavirus S protein and the receptor angiotensin-converting enzyme 2

  👤 Chou, Chih Fong 👤 Shen, Shuo 👤 Mahadevappa, Geetha 👤 Lim, Seng Gee 👤 Hong, Wanjin 👤 Tan, Yee Joo ⏰ 2007 📚 Analytical Biochemistry

• Differential domain structure stability of the severe acute respiratory syndrome coronavirus papain-like protease

  👤 Chou, Ya Wen 👤 Cheng, Shu Chun 👤 Lai, Hsing Yi 👤 Chou, Chi Yuan ⏰ 2012 📚 Archives of Biochemistry and Biophysics

• Rapid peptide-based screening on the substrate specificity of severe acute respiratory syndrome (SARS) coronavirus 3C-like protease by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

  👤 Chu, Ling Hon Matthew 👤 Choy, Wai Yan 👤 Tsai, Sau Na 👤 Rao, Zihe 👤 Ngai, Sai Ming ⏰ 2006 📚 Protein Science

• The avian coronavirus infectious bronchitis virus undergoes direct low-pH-dependent fusion activation during entry into host cells

  👤 Chu, Victor C. 👤 McElroy, Lisa J. 👤 Chu, Vicky 👤 Bauman, Beverley E. 👤 Whittaker, Gary R. ⏰ 2006 📚 Journal of Virology

• Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases

  👤 Chuck, Chi Pang 👤 Chen, Chao 👤 Ke, Zhihai 👤 Chi-Cheong Wan, David 👤 Chow, Hak Fun 👤 Wong, Kam Bo ⏰ 2013 📚 European Journal of Medicinal Chemistry

• X-ray structure and enzymatic activity profile of a core papain-like protease of MERS coronavirus with utility for structure-based drug design

  👤 Clasman, Jozlyn R. 👤 Bez-Santos, Yahira M. 👤 Mettelman, Robert C. 👤 O'Brien, Amornrat 👤 Baker, Susan C. 👤 Mesecar, Andrew D. ⏰ 2017 📚 Scientific Reports

• Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases

  👤 Clementz, Mark A. 👤 Chen, Zhongbin 👤 Banach, Bridget S. 👤 Wang, Yanhua 👤 Sun, Li 👤 Ratia, Kiira 👤 Baez-Santos, Yahira M. 👤 Wang, Jie 👤 Takayama, Jun 👤 Ghosh, Arun K. 👤 Li, Kui 👤 Mesecar, Andrew D. 👤 Baker, Susan C. ⏰ 2010 📚 Journal of Virology

• Inhibitory effects of recombinant human cystatin C on human coronaviruses

  👤 Collins, A. R. 👤 Grubb, A. ⏰ 1991 📚 Antimicrobial Agents and Chemotherapy

• Cystatin D, a natural salivary cysteine protease inhibitor, inhibits coronavirus replication at its physiologic concentration

  👤 Collins, A. R. 👤 Grubb, A. ⏰ 1998 📚 Oral Microbiology and Immunology

• Single particle assay of coronavirus membrane fusion with proteinaceous receptor-embedded supported bilayers

  👤 Costello, Deirdre A. 👤 Millet, Jean K. 👤 Hsia, Chih Yun 👤 Whittaker, Gary R. 👤 Daniel, Susan ⏰ 2013 📚 Biomaterials

• Structural Insights into the Interaction of Coronavirus Papain-Like Proteases and Interferon-Stimulated Gene Product 15 from Different Species

  👤 Daczkowski, Courtney M. 👤 Dzimianski, John V. 👤 Clasman, Jozlyn R. 👤 Goodwin, Octavia 👤 Mesecar, Andrew D. 👤 Pegan, Scott D. ⏰ 2017 📚 Journal of Molecular Biology

• Potential antivirals and antiviral strategies against SARS coronavirus infections

  👤 De Clercq, Erik ⏰ 2006 📚 Expert Review of Anti-Infective Therapy

• A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses

  👤 Deng, Xufang 👤 Agnihothram, Sudhakar 👤 Mielech, Anna M. 👤 Nichols, Daniel B. 👤 Wilson, Michael W. 👤 St. John, Sarah E. 👤 Larsen, Scott D. 👤 Mesecar, Andrew D. 👤 Lenschow, Deborah J. 👤 Baric, Ralph S. 👤 Baker, Susan C. ⏰ 2014 📚 Journal of Virology

• Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus.

  👤 Deng, Xufang 👤 Chen, Yafang 👤 Mielech, Anna M 👤 Hackbart, Matthew 👤 Kesely, Kristina R 👤 Mettelman, Robert C 👤 O'Brien, Amornrat 👤 Chapman, Mackenzie E 👤 Mesecar, Andrew D 👤 Baker, Susan C ⏰ 2020 📚 J Virol

• Analysis of coronavirus temperature-sensitive mutants reveals an interplay between the macrodomain and Papain-like protease impacting replication and pathogenesis

  👤 Deng, Xufang 👤 Mettelman, Robert C. 👤 O'Brien, Amornrat 👤 Thompson, John A. 👤 O'Brien, Timothy E. 👤 Baker, Susan C. ⏰ 2019 📚 Journal of Virology

• Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance

  👤 Deng, Xufang 👤 St John, Sarah E. 👤 Osswald, Heather L. 👤 O'Brien, Amornrat 👤 Banach, Bridget S. 👤 Sleeman, Katrina 👤 Ghosh, Arun K. 👤 Mesecar, Andrew D. 👤 Baker, Susan C. ⏰ 2014 📚 Journal of Virology

• Intracellular processing of the N-terminal ORF 1a proteins of the coronavirus MHV-A59 requires multiple proteolytic events

  👤 Denison, Mark R. 👤 Zoltick, Philip W. 👤 Hughes, Scott A. 👤 Giangreco, Bernadette 👤 Olson, Ann L. 👤 Perlman, Stanley 👤 Leibowitz, Julian L. 👤 Weiss, Susan R. ⏰ 1992 📚 Virology

• Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus

  👤 Devaraj, Santhana G. 👤 Wang, Nan 👤 Chen, Zhongbin 👤 Chen, Zihong 👤 Tseng, Monica 👤 Barretto, Naina 👤 Lin, Rongtuan 👤 Peters, Clarence J. 👤 Tseng, Chien Te K. 👤 Baker, Susan C. 👤 Li, Kui ⏰ 2007 📚 Journal of Biological Chemistry

• A guideline for homology modeling of the proteins from newly discovered betacoronavirus, 2019 novel coronavirus (2019-nCoV).

  👤 Dong, Shengjie 👤 Sun, Jiachen 👤 Mao, Zhuo 👤 Wang, Lu 👤 Lu, Yi-Lin 👤 Li, Jiesen ⏰ 2020 📚 J Med Virol

• Cleavage of spike protein of SARS coronavirus by protease factor Xa is associated with viral infectivity

  👤 Du, Lanying 👤 Kao, Richard Y. 👤 Zhou, Yusen 👤 He, Yuxian 👤 Zhao, Guangyu 👤 Wong, Charlotte 👤 Jiang, Shibo 👤 Yuen, Kwok Yung 👤 Jin, Dong Yan 👤 Zheng, Bo Jian ⏰ 2007 📚 Biochemical and Biophysical Research Communications

• Inhibitor design for SARS coronavirus main protease based on "distorted key theory"

  👤 Du, Qi Shi 👤 Sun, Hao 👤 Chou, Kuo Chen ⏰ 2007 📚 Medicinal Chemistry

• The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases

  👤 Earnest, James T. 👤 Hantak, Michael P. 👤 Li, Kun 👤 McCray, Paul B. 👤 Perlman, Stanley 👤 Gallagher, Tom ⏰ 2017 📚 PLoS Pathogens

• Coronavirus and influenza virus proteolytic priming takes place in tetraspanin-enriched membrane microdomains

  👤 Earnest, James T. 👤 Hantak, Michael P. 👤 Park, Jung Eun 👤 Gallagher, Tom ⏰ 2015 📚 Journal of Virology

• Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, And Nipah viruses by using a novel high-throughput screening assay

  👤 Elshabrawy, Hatem A. 👤 Fan, Jilao 👤 Haddad, Christine S. 👤 Ratia, Kiira 👤 Broder, Christopher C. 👤 Caffrey, Michael 👤 Prabhakar, Bellur S. ⏰ 2014 📚 Journal of Virology

• The viral nucleocapsid protein of transmissible gastroenteritis coronavirus (TGEV) is cleaved by caspase-6 and -7 during TGEV-induced apoptosis

  👤 Eléouët, Jean François 👤 Slee, Elizabeth A. 👤 Saurini, Françoise 👤 Castagné, Nathalie 👤 Poncet, Didier 👤 Garrido, Carmen 👤 Solary, Eric 👤 Martin, Seamus J. ⏰ 2000 📚 Journal of Virology

• Human coronavirus-induced neuronal programmed cell death is cyclophilin D dependent and potentially caspase dispensable

  👤 Favreau, Dominique J. 👤 Meessen-Pinard, Mathieu 👤 Desforges, Marc 👤 Talbot, Pierre J. ⏰ 2012 📚 Journal of Virology

• Extensive positive selection drives the evolution of nonstructural proteins in lineage C betacoronaviruses

  👤 Forni, Diego 👤 Cagliani, Rachele 👤 Mozzi, Alessandra 👤 Pozzoli, Uberto 👤 Al-Daghri, Nasser 👤 Clerici, Mario 👤 Sironi, Manuela ⏰ 2016 📚 Journal of Virology

• Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-κB signaling

  👤 Frieman, Matthew 👤 Ratia, Kiira 👤 Johnston, Robert E. 👤 Mesecar, Andrew D. 👤 Baric, Ralph S. ⏰ 2009 📚 Journal of Virology

• Exchange of the coronavirus replicase polyprotein cleavage sites alters protease specificity and processing

  👤 Gadlage, Mark J. 👤 Denison, Mark R. ⏰ 2010 📚 Journal of Virology

• Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element

  👤 Galasiti Kankanamalage, Anushka C. 👤 Kim, Yunjeong 👤 Damalanka, Vishnu C. 👤 Rathnayake, Athri D. 👤 Fehr, Anthony R. 👤 Mehzabeen, Nurjahan 👤 Battaile, Kevin P. 👤 Lovell, Scott 👤 Lushington, Gerald H. 👤 Perlman, Stanley 👤 Chang, Kyeong Ok 👤 Groutas, William C. ⏰ 2018 📚 European Journal of Medicinal Chemistry

• The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies

  👤 Gierer, Stefanie 👤 Bertram, Stephanie 👤 Kaup, Franziska 👤 Wrensch, Florian 👤 Heurich, Adeline 👤 Krämer-Kühl, Annika 👤 Welsch, Kathrin 👤 Winkler, Michael 👤 Meyer, Benjamin 👤 Drosten, Christian 👤 Dittmer, Ulf 👤 von Hahn, Thomas 👤 Simmons, Graham 👤 Hofmann, Heike 👤 Pöhlmann, Stefan ⏰ 2013 📚 Journal of Virology

• Inhibition of proprotein convertases abrogates processing of the middle eastern respiratory syndrome coronavirus spike protein in infected cells but does not reduce viral infectivity

  👤 Gierer, Stefanie 👤 Müller, Marcel A. 👤 Heurich, Adeline 👤 Ritz, Daniel 👤 Springstein, Benjamin L. 👤 Karsten, Christina B. 👤 Schendzielorz, Alexander 👤 Gnirß, Kerstin 👤 Drosten, Christian 👤 Pöhlmann, Stefan ⏰ 2015 📚 Journal of Infectious Diseases

• Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response

  👤 Glowacka, Ilona 👤 Bertram, Stephanie 👤 Müller, Marcel A. 👤 Allen, Paul 👤 Soilleux, Elizabeth 👤 Pfefferle, Susanne 👤 Steffen, Imke 👤 Tsegaye, Theodros Solomon 👤 He, Yuxian 👤 Gnirss, Kerstin 👤 Niemeyer, Daniela 👤 Schneider, Heike 👤 Drosten, Christian 👤 Pöhlmann, Stefan ⏰ 2011 📚 Journal of Virology

• Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS Coronavirus

  👤 Goetz, D. H. 👤 Choe, Y. 👤 Hansell, E. 👤 Chen, Y. T. 👤 McDowell, M. 👤 Jonsson, C. B. 👤 Roush, W. R. 👤 McKerrow, J. 👤 Craik, C. S. ⏰ 2007 📚 Biochemistry

• Coronavirus genome: Prediction of putative functional domains in the non-structural polyprotein by comparative amino acid sequence analysis

  👤 Gorbalenya, Alexander E. 👤 Koonin, Eugene V. 👤 Donchenko, Alexei P. 👤 Blinov, Vladimir M. ⏰ 1989 📚 Nucleic Acids Research

• Putative papain-related thiol proteases of positive-strand RNA viruses Identification of rubi- and aphthovirus proteases and delineation of a novel conserved domain associated with proteases of rubi-, α- and coronaviruses

  👤 Gorbalenya, Alexander E. 👤 Koonin, Eugene V. 👤 Lai, Michael M.C. ⏰ 1991 📚 FEBS Letters

• Evaluating the 3C-like protease activity of SARS-Coronavirus: Recommendations for standardized assays for drug discovery

  👤 Grum-Tokars, Valerie 👤 Ratia, Kiira 👤 Begaye, Adrian 👤 Baker, Susan C. 👤 Mesecar, Andrew D. ⏰ 2008 📚 Virus Research

• NAADP-dependent Ca2+ signaling regulates Middle East respiratory syndrome-coronavirus pseudovirus translocation through the endolysosomal system

  👤 Gunaratne, Gihan S. 👤 Yang, Yang 👤 Li, Fang 👤 Walseth, Timothy F. 👤 Marchant, Jonathan S. ⏰ 2018 📚 Cell Calcium

• Coronaviruses and their therapy

  👤 Haagmans, Bart L. 👤 Osterhaus, Albert D.M.E. ⏰ 2006 📚 Antiviral Research

• Development of a red-shifted fluorescence-based assay for SARS-coronavirus 3CL protease: Identification of a novel class of anti-SARS agents from the tropical marine sponge Axinella corrugata

  👤 Hamill, Pamela 👤 Hudson, Derek 👤 Kao, Richard Y. 👤 Chow, Polly 👤 Raj, Meera 👤 Xu, Hongyan 👤 Richer, Martin J. 👤 Jean, François ⏰ 2006 📚 Biological Chemistry

• Papain-like protease 2 (PLP2) from severe acute respiratory syndrome coronavirus (SARS-CoV): Expression, purification, characterization, and inhibition

  👤 Han, Yu San 👤 Chang, Gu Gang 👤 Juo, Chiun Gung 👤 Lee, Hong Jen 👤 Yen, Shiou Hwei 👤 Hsu, John Tsu An 👤 Chen, Xin ⏰ 2005 📚 Biochemistry

• Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity

  👤 Harcourt, Brian H. 👤 Jukneliene, Dalia 👤 Kanjanahaluethai, Amornrat 👤 Bechill, John 👤 Severson, Kari M. 👤 Smith, Catherine M. 👤 Rota, Paul A. 👤 Baker, Susan C. ⏰ 2004 📚 Journal of Virology

• Ready, set, fuse! the coronavirus spike protein and acquisition of fusion competence

  👤 Heald-Sargent, Taylor 👤 Gallagher, Tom ⏰ 2012 📚 Viruses

• TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein

  👤 Heurich, Adeline 👤 Hofmann-Winkler, Heike 👤 Gierer, Stefanie 👤 Liepold, Thomas 👤 Jahn, Olaf 👤 Pöhlmann, Stefan ⏰ 2014 📚 Journal of Virology

• From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design

  👤 Hilgenfeld, Rolf ⏰ 2014 📚 The FEBS journal

• Critical assessment of the important residues involved in the dimerization and catalysis of MERS Coronavirus Main Protease

  👤 Ho, Bo Lin 👤 Cheng, Shu Chun 👤 Shi, Lin 👤 Wang, Ting Yun 👤 Ho, Kuan I. 👤 Chou, Chi Yuan ⏰ 2015 📚 PLoS ONE

• SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.

  👤 Hoffmann, Markus 👤 Kleine-Weber, Hannah 👤 Schroeder, Simon 👤 Kruger, Nadine 👤 Herrler, Tanja 👤 Erichsen, Sandra 👤 Schiergens, Tobias S 👤 Herrler, Georg 👤 Wu, Nai-Huei 👤 Nitsche, Andreas 👤 Muller, Marcel A 👤 Drosten, Christian 👤 Pohlmann, Stefan ⏰ 2020 📚 Cell

• Highly conserved regions within the spike proteins of human coronaviruses 229E and NL63 determine recognition of their respective cellular receptors

  👤 Hofmann, Heike 👤 Simmons, Graham 👤 Rennekamp, Andrew J. 👤 Chaipan, Chawaree 👤 Gramberg, Thomas 👤 Heck, Elke 👤 Geier, Martina 👤 Wegele, Anja 👤 Marzi, Andrea 👤 Bates, Paul 👤 Pöhlmann, Stefan ⏰ 2006 📚 Journal of Virology

• Critical assessment of important regions in the subunit association and catalytic action of the severe acute respiratory syndrome coronavirus main protease

  👤 Hsu, Wen Chi 👤 Chang, Hui Chuan 👤 Chou, Chi Yuan 👤 Tsai, Pui Jen 👤 Lin, Pei In 👤 Chang, Gu Gang ⏰ 2005 📚 Journal of Biological Chemistry

• Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure

  👤 Hu, Tiancen 👤 Zhang, Yu 👤 Li, Lianwei 👤 Wang, Kuifeng 👤 Chen, Shuai 👤 Chen, Jing 👤 Ding, Jianping 👤 Jiang, Hualiang 👤 Shen, Xu ⏰ 2009 📚 Virology

• 3C-like Proteinase from SARS Coronavirus Catalyzes Substrate Hydrolysis by a General Base Mechanism

  👤 Huang, Changkang 👤 Wei, Ping 👤 Fan, Keqiang 👤 Liu, Ying 👤 Lai, Luhua ⏰ 2004 📚 Biochemistry

• SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells

  👤 Huang, I. Chueh 👤 Bosch, Berend Jan 👤 Li, Fang 👤 Li, Wenhui 👤 Kyoung, Hoa Lee 👤 Ghiran, Sorina 👤 Vasilieva, Natalya 👤 Dermody, Terence S. 👤 Harrison, Stephen C. 👤 Dormitzer, Philip R. 👤 Farzan, Michael 👤 Rottier, Peter J.M. 👤 Choe, Hyeryun ⏰ 2006 📚 Journal of Biological Chemistry

• Dissection of amino-terminal functional domains of murine coronavirus nonstructural protein 3

  👤 Hurst-Hess, Kelley R. 👤 Kuo, Lili 👤 Masters, Paul S. ⏰ 2015 📚 Journal of Virology

• Multiple enzymatic activities associated with severe acute respiratory syndrome coronavirus helicase

  👤 Ivanov, A. 👤 Thiel, Volker 👤 Dobbe, Jessika C. 👤 Van Der Meer, Yvonne 👤 Snijder, Eric J. 👤 Ziebuhrl, John ⏰ 2004 📚 Journal of Virology

• TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection

  👤 Iwata-Yoshikawa, Naoko 👤 Okamura, Tadashi 👤 Shimizu, Yukiko 👤 Hasegawa, Hideki 👤 Takeda, Makoto 👤 Nagata, Noriyo ⏰ 2019 📚 Journal of Virology

• Discovery, synthesis, and structure-based optimization of a series of N -(tert -Butyl)-2-(N -arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease

  👤 Jacobs, Jon 👤 Grum-Tokars, Valerie 👤 Zhou, Ya 👤 Turlington, Mark 👤 Saldanha, S. Adrian 👤 Chase, Peter 👤 Eggler, Aimee 👤 Dawson, Eric S. 👤 Baez-Santos, Yahira M. 👤 Tomar, Sakshi 👤 Mielech, Anna M. 👤 Baker, Susan C. 👤 Lindsley, Craig W. 👤 Hodder, Peter 👤 Mesecar, Andrew 👤 Stauffer, Shaun R. ⏰ 2013 📚 Journal of Medicinal Chemistry

• A fluorogenic peptide cleavage assay to screen for proteolytic activity: Applications for coronavirus spike protein activation

  👤 Jaimes, Javier A. 👤 Millet, Jean K. 👤 Goldstein, Monty E. 👤 Whittaker, Gary R. 👤 Straus, Marco R. ⏰ 2019 📚 Journal of Visualized Experiments

• Identifying inhibitors of the SARS coronavirus proteinase

  👤 Jenwitheesuk, Ekachai 👤 Samudrala, Ram ⏰ 2003 📚 Bioorganic and Medicinal Chemistry Letters

• Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility.

  👤 Ji, Hong-Long 👤 Zhao, Runzhen 👤 Matalon, Sadis 👤 Matthay, Michael A ⏰ 2020 📚 Physiol Rev

• Structure of M(pro) from COVID-19 virus and discovery of its inhibitors.

  👤 Jin, Zhenming 👤 Du, Xiaoyu 👤 Xu, Yechun 👤 Deng, Yongqiang 👤 Liu, Meiqin 👤 Zhao, Yao 👤 Zhang, Bing 👤 Li, Xiaofeng 👤 Zhang, Leike 👤 Peng, Chao 👤 Duan, Yinkai 👤 Yu, Jing 👤 Wang, Lin 👤 Yang, Kailin 👤 Liu, Fengjiang 👤 Jiang, Rendi 👤 Yang, Xinglou 👤 You, Tian 👤 Liu, Xiaoce 👤 Yang, Xiuna 👤 Bai, Fang 👤 Liu, Hong 👤 Liu, Xiang 👤 Guddat, Luke W 👤 Xu, Wenqing 👤 Xiao, Gengfu 👤 Qin, Chengfeng 👤 Shi, Zhengli 👤 Jiang, Hualiang 👤 Rao, Zihe 👤 Yang, Haitao ⏰ 2020 📚 Nature

• A new lead for nonpeptidic active-site-directed inhibitors of the severe acute respiratory syndrome coronavirus main protease discovered by a combination of screening and docking methods

  👤 Kaeppler, Ulrich 👤 Stiefl, Nikolaus 👤 Schiller, Markus 👤 Vicik, Radim 👤 Breuning, Alexander 👤 Schmitz, Werner 👤 Rupprecht, Daniel 👤 Schmuck, Carsten 👤 Baumann, Knut 👤 Ziebuhr, John 👤 Schirmeister, Tanja ⏰ 2005 📚 Journal of Medicinal Chemistry

• Cleavage of the SARS coronavirus spike glycoprotein by airway proteases enhances virus entry into human bronchial epithelial cells in vitro

  👤 Kam, Yiu Wing 👤 Okumura, Yuushi 👤 Kido, Hiroshi 👤 Ng, Lisa F.P. 👤 Bruzzone, Roberto 👤 Altmeyer, Ralf ⏰ 2009 📚 PLoS ONE

• Virtual screening and repurposing of FDA approved drugs against COVID-19 main protease.

  👤 Kandeel, Mahmoud 👤 Al-Nazawi, Mohammed ⏰ 2020 📚 Life Sci

• From SARS and MERS CoVs to SARS-CoV-2: Moving toward more biased codon usage in viral structural and nonstructural genes.

  👤 Kandeel, Mahmoud 👤 Ibrahim, Abdelazim 👤 Fayez, Mahmoud 👤 Al-Nazawi, Mohammed ⏰ 2020 📚 J Med Virol

• Membrane topology of murine coronavirus replicase nonstructural protein 3

  👤 Kanjanahaluethai, Amornrat 👤 Chen, Zhongbin 👤 Jukneliene, Dalia 👤 Baker, Susan C. ⏰ 2007 📚 Virology

• Identification of novel small-molecule inhibitors of severe acute respiratory syndrome-associated coronavirus by chemical genetics

  👤 Kao, Richard Y. 👤 Tsui, Wayne H.W. 👤 Lee, Terri S.W. 👤 Tanner, Julian A. 👤 Watt, Rory M. 👤 Huang, Jian Dong 👤 Hu, Lihong 👤 Chen, Guanhua 👤 Chen, Zhiwei 👤 Zhang, Linqi 👤 He, Tian 👤 Chan, Kwok Hung 👤 Tse, Herman 👤 To, Amanda P.C. 👤 Ng, Louisa W.Y. 👤 Wong, Bonnie C.W. 👤 Tsoi, Hoi Wah 👤 Yang, Dan 👤 Ho, David D. 👤 Yuen, Kwok Yung ⏰ 2004 📚 Chemistry and Biology

• Synthesis, biological evaluation and molecular modeling of a novel series of fused 1,2,3-triazoles as potential anti-coronavirus agents

  👤 Karypidou, Konstantina 👤 Ribone, Sergio R. 👤 Quevedo, Mario A. 👤 Persoons, Leentje 👤 Pannecouque, Christophe 👤 Helsen, Christine 👤 Claessens, Frank 👤 Dehaen, Wim ⏰ 2018 📚 Bioorganic and Medicinal Chemistry Letters

• Biochemical Analysis of Coronavirus Spike Glycoprotein Conformational Intermediates during Membrane Fusion

  👤 Kawase, Miyuki 👤 Kataoka, Michiyo 👤 Shirato, Kazuya 👤 Matsuyama, Shutoku ⏰ 2019 📚 Journal of virology

• Protease-mediated entry via the endosome of human coronavirus 229E

  👤 Kawase, Miyuki 👤 Shirato, Kazuya 👤 Matsuyama, Shutoku 👤 Taguchi, Fumihiro ⏰ 2009 📚 Journal of Virology

• Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry

  👤 Kawase, Miyuki 👤 Shirato, Kazuya 👤 van der Hoek, Lia 👤 Taguchi, Fumihiro 👤 Matsuyama, Shutoku ⏰ 2012 📚 Journal of Virology

• Targeting SARS-CoV-2: A Systematic Drug Repurposing Approach to Identify Promising Inhibitors Against 3C-like Proteinase and 2'-O-RiboseMethyltransferase.

  👤 Khan, Rameez Jabeer 👤 Jha, Rajat Kumar 👤 Amera, GizachewMuluneh 👤 Jain, Monika 👤 Singh, Ekampreet 👤 Pathak, Amita 👤 Singh, Rashmi Prabha 👤 Muthukumaran, Jayaraman 👤 Singh, Amit Kumar ⏰ 2020 📚 J Biomol Struct Dyn

• Identification of Chymotrypsin-like Protease Inhibitors of SARS-CoV-2 Via Integrated Computational Approach.

  👤 Khan, Salman Ali 👤 Zia, Komal 👤 Ashraf, Sajda 👤 Uddin, Reaz 👤 Ul-Haq, Zaheer ⏰ 2020 📚 J Biomol Struct Dyn

• Assessing activity and inhibition of middle east respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors

  👤 Kilianski, Andy 👤 Mielech, Anna M. 👤 Deng, Xufang 👤 Baker, Susan C. ⏰ 2013 📚 Journal of Virology

• Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor

  👤 Kim, Yunjeong 👤 Liu, Hongwei 👤 Galasiti Kankanamalage, Anushka C. 👤 Weerasekara, Sahani 👤 Hua, Duy H. 👤 Groutas, William C. 👤 Chang, Kyeong Ok 👤 Pedersen, Niels C. ⏰ 2016 📚 PLoS Pathogens

• Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses

  👤 Kim, Yunjeong 👤 Lovell, Scott 👤 Tiew, Kok Chuan 👤 Mandadapu, Sivakoteswara Rao 👤 Alliston, Kevin R. 👤 Battaile, Kevin K. 👤 Groutas, William C. 👤 Chang, Kyeong Ok ⏰ 2012 📚 Journal of Virology

• Potent inhibition of feline coronaviruses with peptidyl compounds targeting coronavirus 3C-like protease

  👤 Kim, Yunjeong 👤 Mandadapu, Sivakoteswara Rao 👤 Groutas, William C. 👤 Chang, Kyeong Ok ⏰ 2013 📚 Antiviral Research

• Broad-spectrum inhibitors against 3C-like proteases of feline coronaviruses and feline caliciviruses

  👤 Kim, Yunjeong 👤 Shivanna, Vinay 👤 Narayanan, Sanjeev 👤 Prior, Allan M. 👤 Weerasekara, Sahani 👤 Hua, Duy H. 👤 Galasiti Kankanamalage, Anushka C. 👤 Groutas, William C. 👤 Chang, Kyeong Ok ⏰ 2015 📚 Journal of Virology

• Pre-fusion structure of a human coronavirus spike protein

  👤 Kirchdoerfer, Robert N. 👤 Cottrell, Christopher A. 👤 Wang, Nianshuang 👤 Pallesen, Jesper 👤 Yassine, Hadi M. 👤 Turner, Hannah L. 👤 Corbett, Kizzmekia S. 👤 Graham, Barney S. 👤 McLellan, Jason S. 👤 Ward, Andrew B. ⏰ 2016 📚 Nature

• Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis

  👤 Kirchdoerfer, Robert N. 👤 Wang, Nianshuang 👤 Pallesen, Jesper 👤 Wrapp, Daniel 👤 Turner, Hannah L. 👤 Cottrell, Christopher A. 👤 Corbett, Kizzmekia S. 👤 Graham, Barney S. 👤 McLellan, Jason S. 👤 Ward, Andrew B. ⏰ 2018 📚 Scientific Reports

• Functional analysis of potential cleavage sites in the MERS-coronavirus spike protein

  👤 Kleine-Weber, Hannah 👤 Elzayat, Mahmoud Tarek 👤 Hoffmann, Markus 👤 Pöhlmann, Stefan ⏰ 2018 📚 Scientific Reports

• Completion of the porcine epidemic diarrhoea coronavirus (PEDV) genome sequence

  👤 Kocherhans, R. 👤 Bridgen, A. 👤 Ackermann, M. 👤 Tobler, K. ⏰ 2001 📚 Virus Genes

• Design and synthesis of a series of serine derivatives as small molecule inhibitors of the SARS coronavirus 3CL protease

  👤 Konno, Hiroyuki 👤 Wakabayashi, Masaki 👤 Takanuma, Daiki 👤 Saito, Yota 👤 Akaji, Kenichi ⏰ 2016 📚 Bioorganic and Medicinal Chemistry

• Mutational and inhibitive analysis of SARS coronavirus 3C-like protease by fluorescence resonance energy transfer-based assays

  👤 Kuang, Wan Fen 👤 Chow, Lu Ping 👤 Wu, Mei Hua 👤 Hwang, Lih Hwa ⏰ 2005 📚 Biochemical and Biophysical Research Communications

• Anti-SARS Coronavirus agents: A patent review (2008-present)

  👤 Kumar, Vathan 👤 Jung, Young Sik 👤 Liang, Po Huang ⏰ 2013 📚 Expert Opinion on Therapeutic Patents

• Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CLPro inhibitors

  👤 Kumar, Vathan 👤 Shin, Jin Soo 👤 Shie, Jiun Jie 👤 Ku, Keun Bon 👤 Kim, Chonsaeng 👤 Go, Yun Young 👤 Huang, Kai Fa 👤 Kim, Meehyein 👤 Liang, Po Huang ⏰ 2017 📚 Antiviral Research

• Individual and common inhibitors of coronavirus and picornavirus main proteases

  👤 Kuo, Chih Jung 👤 Liu, Hun Ge 👤 Lo, Yueh Kuei 👤 Seong, Churl Min 👤 Lee, Kee In 👤 Jung, Young Sik 👤 Liang, Po Huang ⏰ 2009 📚 FEBS Letters

• In vitro antiviral activity of phlorotannins isolated from Ecklonia cava against porcine epidemic diarrhea coronavirus infection and hemagglutination

  👤 Kwon, Hyung Jun 👤 Ryu, Young Bae 👤 Kim, Young Min 👤 Song, Naaleum 👤 Kim, Cha Young 👤 Rho, Mun Chual 👤 Jeong, Jae Ho 👤 Cho, Kyoung Oh 👤 Lee, Woo Song 👤 Park, Su Jin ⏰ 2013 📚 Bioorganic and Medicinal Chemistry

• Proteomic analysis of up-regulated proteins in human promonocyte cells expressing severe acute respiratory syndrome coronavirus 3C-like protease

  👤 Lai, Chien Chen 👤 Jou, Ming Jia 👤 Huang, Shiuan Yi 👤 Li, Shih Wein 👤 Wan, Lei 👤 Tsai, Fuu Jen 👤 Lin, Cheng Wen ⏰ 2007 📚 Proteomics

• Tumor necrosis factor-α convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2)

  👤 Lambert, Daniel W. 👤 Yarski, Mike 👤 Warner, Fiona J. 👤 Thornhill, Paul 👤 Parkin, Edward T. 👤 Smith, A. Ian 👤 Hooper, Nigel M. 👤 Turner, Anthony J. ⏰ 2005 📚 Journal of Biological Chemistry

• The complete sequence (22 kilobases) of murine coronavirus gene 1 encoding the putative proteases and RNA polymerase

  👤 Lee, Han Jung 👤 Shieh, Chien Kou 👤 Gorbalenya, Alexander E. 👤 Koonin, Eugene V. 👤 La Monica, Nicola 👤 Tuler, Jeremy 👤 Bagdzhadzhyan, Anush 👤 Lai, Michael M.C. ⏰ 1991 📚 Virology

• Synergistic inhibitor binding to the papain-like protease of human SARS coronavirus: Mechanistic and inhibitor design implications

  👤 Lee, Hyun 👤 Cao, Shuyi 👤 Hevener, Kirk E. 👤 Truong, Lena 👤 Gatuz, Joseph L. 👤 Patel, Kavankumar 👤 Ghosh, Arun K. 👤 Johnson, Michael E. ⏰ 2013 📚 ChemMedChem

• Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin

  👤 Lei, Jian 👤 Hilgenfeld, Rolf ⏰ 2016 📚 Virologica Sinica

• Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein

  👤 Lei, Jian 👤 Kusov, Yuri 👤 Hilgenfeld, Rolf ⏰ 2018 📚 Antiviral Research

• Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features

  👤 Lei, Jian 👤 Mesters, Jeroen R. 👤 Drosten, Christian 👤 Anemüller, Stefan 👤 Ma, Qingjun 👤 Hilgenfeld, Rolf ⏰ 2014 📚 Antiviral Research

• Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses.

  👤 Letko, Michael 👤 Marzi, Andrea 👤 Munster, Vincent ⏰ 2020 📚 Nat Microbiol

• Maturation mechanism of severe acute respiratory syndrome (SARS) coronavirus 3C-like proteinase

  👤 Li, Chunmei 👤 Qi, Yifei 👤 Teng, Xin 👤 Yang, Zongchang 👤 Wei, Ping 👤 Zhang, Changsheng 👤 Tan, Lei 👤 Zhou, Lu 👤 Liu, Ying 👤 Lai, Luhua ⏰ 2010 📚 Journal of Biological Chemistry

• Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice

  👤 Li, Kun 👤 Wohlford-Lenane, Christine L. 👤 Channappanavar, Rudragouda 👤 Park, Jung Eun 👤 Earnest, James T. 👤 Bair, Thomas B. 👤 Bates, Amber M. 👤 Brogden, Kim A. 👤 Flaherty, Heather A. 👤 Gallagher, Tom 👤 Meyerholz, David K. 👤 Perlman, Stanley 👤 McCray, Paul B. ⏰ 2017 📚 Proceedings of the National Academy of Sciences of the United States of America

• Severe acute respiratory syndrome coronavirus papain-like protease suppressed alpha interferon-induced responses through downregulation of extracellular signal-regulated kinase 1-mediated signalling pathways

  👤 Li, Shih Wein 👤 Lai, Chien Chen 👤 Ping, Jia Fong 👤 Tsai, Fuu Jen 👤 Wan, Lei 👤 Lin, Ying Ju 👤 Kung, Szu Hao 👤 Lin, Cheng Wen ⏰ 2011 📚 Journal of General Virology

• SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-β1 via ROS/p38 MAPK/STAT3 pathway

  👤 Li, Shih Wein 👤 Wang, Ching Ying 👤 Jou, Yu Jen 👤 Yang, Tsuey Ching 👤 Huang, Su Hua 👤 Wan, Lei 👤 Lin, Ying Ju 👤 Lin, Cheng Wen ⏰ 2016 📚 Scientific Reports

• SARS coronavirus papain-like protease inhibits the TLR7 signaling pathway through removing Lys63-linked polyubiquitination of TRAF3 and TRAF6

  👤 Li, Shih Wen 👤 Wang, Ching Ying 👤 Jou, Yu Jen 👤 Huang, Su Hua 👤 Hsiao, Li Hsin 👤 Wan, Lei 👤 Lin, Ying Ju 👤 Kung, Szu Hao 👤 Lin, Cheng Wen ⏰ 2016 📚 International Journal of Molecular Sciences

• Correlation between TGF-β1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain-like protease

  👤 Li, Shih Wen 👤 Yang, Tsuey Ching 👤 Wan, Lei 👤 Lin, Ying Ju 👤 Tsai, Fuu Jen 👤 Lai, Chien Chen 👤 Lin, Cheng Wen ⏰ 2012 📚 Proteomics

• A single point mutation creating a furin cleavage site in the spike protein renders porcine epidemic diarrhea coronavirus trypsin independent for cell entry and fusion

  👤 Li, Wentao 👤 Wicht, Oliver 👤 van Kuppeveld, Frank J.M. 👤 He, Qigai 👤 Rottier, Peter J.M. 👤 Bosch, Berend Jan ⏰ 2015 📚 Journal of Virology

• Evolutionary history, potential intermediate animal host, and cross-species analyses of SARS-CoV-2.

  👤 Li, Xingguang 👤 Zai, Junjie 👤 Zhao, Qiang 👤 Nie, Qing 👤 Li, Yi 👤 Foley, Brian T 👤 Chaillon, Antoine ⏰ 2020 📚 J Med Virol

• Characterization and inhibition of SARS-coronavirus main protease

  👤 Liang, Po Huang ⏰ 2006 📚 Current Topics in Medicinal Chemistry

• Picornaviral 3C protease inhibitors and the dual 3C protease/coronaviral 3C-like protease inhibitors

  👤 Liang, Po Huang 👤 Wang, Hui Min ⏰ 2010 📚 Expert Opinion on Therapeutic Patents

• Severe acute respiratory syndrome coronavirus 3C-like protease-induced apoptosis

  👤 Lin, Cheng Wen 👤 Lin, Kuan Hsun 👤 Hsieh, Tsung Han 👤 Shiu, Shi Yi 👤 Li, Jeng Yi ⏰ 2006 📚 FEMS Immunology and Medical Microbiology

• Characterization of trans- and cis-cleavage activity of the SARS coronavirus 3CLpro protease: Basis for the in vitro screening of anti-SARS drugs

  👤 Lin, Cheng Wen 👤 Tsai, Chang Hai 👤 Tsai, Fuu Jen 👤 Chen, Pei Jer 👤 Lai, Chien Chen 👤 Wan, Lei 👤 Chiu, Hua Hao 👤 Lin, Kuan Hsun ⏰ 2004 📚 FEBS Letters

• Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds

  👤 Lin, Cheng Wen 👤 Tsai, Fuu Jen 👤 Tsai, Chang Hai 👤 Lai, Chien Chen 👤 Wan, Lei 👤 Ho, Tin Yun 👤 Hsieh, Chang Chi 👤 Chao, Pei Dawn Lee ⏰ 2005 📚 Antiviral Research

• Binding interaction of SARS coronavirus 3CLpro protease with vacuolar-H+ ATPase G1 subunit

  👤 Lin, Cheng Wen 👤 Tsai, Fuu Jen 👤 Wan, Lei 👤 Lai, Chien Chen 👤 Lin, Kuan Hsun 👤 Hsieh, Tsung Han 👤 Shiu, Shi Yi 👤 Li, Jeng Yi ⏰ 2005 📚 FEBS Letters

• Structural and functional characterization of MERS coronavirus papain-like protease

  👤 Lin, Min Han 👤 Chuang, Shang Ju 👤 Chen, Chiao Che 👤 Cheng, Shu Chun 👤 Cheng, Kai Wen 👤 Lin, Chao Hsiung 👤 Sun, Chiao Yin 👤 Chou, Chi Yuan ⏰ 2014 📚 Journal of Biomedical Science

• Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes

  👤 Lin, Min Han 👤 Moses, David C. 👤 Hsieh, Chih Hua 👤 Cheng, Shu Chun 👤 Chen, Yau Hung 👤 Sun, Chiao Yin 👤 Chou, Chi Yuan ⏰ 2018 📚 Antiviral Research

• The papain-like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme

  👤 Lindner, Holger A. 👤 Fotouhi-Ardakani, Nasser 👤 Lytvyn, Viktoria 👤 Lachance, Paule 👤 Sulea, Traian 👤 Ménard, Robert ⏰ 2005 📚 Journal of Virology

• Selectivity in ISG15 and ubiquitin recognition by the SARS coronavirus papain-like protease

  👤 Lindner, Holger A. 👤 Lytvyn, Viktoria 👤 Qi, Hongtao 👤 Lachance, Paule 👤 Ziomek, Edmund 👤 Ménard, Robert ⏰ 2007 📚 Archives of Biochemistry and Biophysics

• Cell entry of porcine epidemic diarrhea coronavirus is activated by lysosomal proteases

  👤 Liu, Chang 👤 Ma, Yuanmei 👤 Yang, Yang 👤 Zheng, Yuan 👤 Shang, Jian 👤 Zhou, Yusen 👤 Jiang, Shibo 👤 Du, Lanying 👤 Li, Jianrong 👤 Li, Fang ⏰ 2016 📚 Journal of Biological Chemistry

• Potential covalent drugs targeting the main protease of the SARS-CoV-2 coronavirus.

  👤 Liu, Sen 👤 Zheng, Qiang 👤 Wang, Zhiying ⏰ 2020 📚 Bioinformatics

• Bat-to-human: Spike features determining 'host jump' of coronaviruses SARS-CoV, MERS-CoV, and beyond

  👤 Lu, Guangwen 👤 Wang, Qihui 👤 Gao, George F. ⏰ 2015 📚 Trends in Microbiology

• Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease

  👤 Lu, I. Lin 👤 Mahindroo, Neeraj 👤 Liang, Po Huang 👤 Peng, Yi Hui 👤 Kuo, Chih Jung 👤 Tsai, Keng Chang 👤 Hsieh, Hsing Pang 👤 Chao, Yu Sheng 👤 Wu, Su Ying ⏰ 2006 📚 Journal of Medicinal Chemistry

• The potential chemical structure of anti-SARS-CoV-2 RNA-dependent RNA polymerase.

  👤 Lung, Jrhau 👤 Lin, Yu-Shih 👤 Yang, Yao-Hsu 👤 Chou, Yu-Lun 👤 Shu, Li-Hsin 👤 Cheng, Yu-Ching 👤 Liu, Hung Te 👤 Wu, Ching-Yuan ⏰ 2020 📚 J Med Virol

• Protein interferon-stimulated gene 15 conjugation delays but does not overcome coronavirus proliferation in a model of fulminant hepatitis

  👤 Ma, Xue Zhong 👤 Bartczak, Agata 👤 Zhang, Jianhua 👤 He, Wei 👤 Shalev, Itay 👤 Smil, David 👤 Chen, Limin 👤 Phillips, Jim 👤 Feld, Jordan J. 👤 Selzner, Nazia 👤 Levy, Gary 👤 McGilvray, Ian ⏰ 2014 📚 Journal of Virology

• P53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1

  👤 Ma-Lauer, Yue 👤 Carbajo-Lozoya, Javier 👤 Hein, Marco Y. 👤 Müller, Marcel A. 👤 Deng, Wen 👤 Lei, Jian 👤 Meyer, Benjamin 👤 Kusov, Yuri 👤 Von Brunn, Brigitte 👤 Bairad, Dev Raj 👤 Hünten, Sabine 👤 Drosten, Christian 👤 Hermeking, Heiko 👤 Leonhardt, Heinrich 👤 Mann, Matthias 👤 Hilgenfeld, Rolf 👤 Von Brunn, Albrecht ⏰ 2016 📚 Proceedings of the National Academy of Sciences of the United States of America

• Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus

  👤 Mandadapu, Sivakoteswara Rao 👤 Weerawarna, Pathum M. 👤 Prior, Allan M. 👤 Uy, Roxanne Adeline Z. 👤 Aravapalli, Sridhar 👤 Alliston, Kevin R. 👤 Lushington, Gerald H. 👤 Kim, Yunjeong 👤 Hua, Duy H. 👤 Chang, Kyeong Ok 👤 Groutas, William C. ⏰ 2013 📚 Bioorganic and Medicinal Chemistry Letters

• SARS coronavirus: Unusual lability of the nucleocapsid protein

  👤 Mark, John 👤 Li, Xuguang 👤 Cyr, Terry 👤 Fournier, Sylvie 👤 Jaentschke, Bozena 👤 Hefford, Mary Alice ⏰ 2008 📚 Biochemical and Biophysical Research Communications

• Compounds with therapeutic potential against novel respiratory 2019 coronavirus.

  👤 Martinez, Miguel Angel ⏰ 2020 📚 Antimicrob Agents Chemother

• Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2

  👤 Matsuyama, Shutoku 👤 Nagata, Noriyo 👤 Shirato, Kazuya 👤 Kawase, Miyuki 👤 Takeda, Makoto 👤 Taguchi, Fumihiro ⏰ 2010 📚 Journal of Virology

• Middle east respiratory syndrome coronavirus spike protein is not activated directly by cellular furin during viral entry into target cells

  👤 Matsuyama, Shutoku 👤 Shirato, Kazuya 👤 Kawase, Miyuki 👤 Terada, Yutaka 👤 Kawachi, Kengo 👤 Fukushi, Shuetsu 👤 Kamitani, Wataru ⏰ 2018 📚 Journal of Virology

• Two-step conformational changes in a coronavirus envelope glycoprotein mediated by receptor binding and proteolysis

  👤 Matsuyama, Shutoku 👤 Taguchi, Fumihiro ⏰ 2009 📚 Journal of Virology

• Protease-mediated enhancement of severe acute respiratory syndrome coronavirus infection

  👤 Matsuyama, Shutoku 👤 Ujike, Makoto 👤 Morikawa, Shigeru 👤 Tashiro, Masato 👤 Taguchi, Fumihiro ⏰ 2005 📚 Proceedings of the National Academy of Sciences of the United States of America

• Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis

  👤 Mielech, Anna M. 👤 Deng, Xufang 👤 Chen, Yafang 👤 Kindler, Eveline 👤 Wheeler, Dorthea L. 👤 Mesecar, Andrew D. 👤 Thiel, Volker 👤 Perlman, Stanley 👤 Baker, Susan C. ⏰ 2015 📚 Journal of Virology

• Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein

  👤 Mille, Jean Kaoru 👤 Whittaker, Gary R. ⏰ 2014 📚 Proceedings of the National Academy of Sciences of the United States of America

• Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis

  👤 Millet, Jean Kaoru 👤 Whittaker, Gary R. ⏰ 2015 📚 Virus Research

• Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV.

  👤 Morse, Jared S 👤 Lalonde, Tyler 👤 Xu, Shiqing 👤 Liu, Wenshe Ray ⏰ 2020 📚 Chembiochem

• Computational studies of drug repurposing and synergism of lopinavir, oseltamivir and ritonavir binding with SARS-CoV-2 Protease against COVID-19.

  👤 Muralidharan, Nisha 👤 Sakthivel, R 👤 Velmurugan, D 👤 Gromiha, M Michael ⏰ 2020 📚 J Biomol Struct Dyn

• Autoprocessing mechanism of severe acute respiratory syndrome coronavirus 3C-like protease (SARS-CoV 3CLpro) from its polyproteins

  👤 Muramatsu, Tomonari 👤 Kim, Yong Tae 👤 Nishii, Wataru 👤 Terada, Takaho 👤 Shirouzu, Mikako 👤 Yokoyama, Shigeyuki ⏰ 2013 📚 FEBS Journal

• The major subunit ClpG of Escherichia coli CS31A fibrillae as an expression vector for different combinations of two TGEV coronavirus epitopes

  👤 Méchin, Marie Claire 👤 Der Vartanian, Maurice 👤 Martin, Christine ⏰ 1996 📚 Gene

• Studies of severe acute respiratory syndrome coronavirus pathology in human cases and animal models

  👤 Nagata, Noriyo 👤 Iwata-Yoshikawa, N. 👤 Taguchi, Fumihiro ⏰ 2010 📚 Veterinary Pathology

• Structures of the Middle East respiratory syndrome coronavirus 3C-like protease reveal insights into substrate specificity

  👤 Needle, Danielle 👤 Lountos, George T. 👤 Waugh, David S. ⏰ 2015 📚 Acta Crystallographica Section D: Biological Crystallography

• Flavonoid-mediated inhibition of SARS coronavirus 3C-like protease expressed in Pichia pastoris

  👤 Nguyen, Thi Thanh Hanh 👤 Woo, Hye Jin 👤 Kang, Hee Kyoung 👤 Nguyen, Van Dao 👤 Kim, Young Min 👤 Kim, Do Won 👤 Ahn, Sul Ah 👤 Xia, Yongmei 👤 Kim, Doman ⏰ 2012 📚 Biotechnology Letters

• The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species

  👤 Niemeyer, Daniela 👤 Mösbauer, Kirstin 👤 Klein, Eva M. 👤 Sieberg, Andrea 👤 Mettelman, Robert C. 👤 Mielech, Anna M. 👤 Dijkman, Ronald 👤 Baker, Susan C. 👤 Drosten, Christian 👤 Müller, Marcel A. ⏰ 2018 📚 PLoS Pathogens

• Macrolide treatment for COVID-19: Will this be the way forward?

  👤 Ohe, Masashi 👤 Shida, Haruki 👤 Jodo, Satoshi 👤 Kusunoki, Yoshihiro 👤 Seki, Masahide 👤 Furuya, Ken 👤 Goudarzi, Houman ⏰ 2020 📚 Biosci Trends

• Unrevealing sequence and structural features of novel coronavirus using in silico approaches: The main protease as molecular target.

  👤 Ortega, Joseph Thomas 👤 Serrano, Maria Luisa 👤 Pujol, Flor Helene 👤 Rangel, Hector Rafael ⏰ 2020 📚 EXCLI J

• New antiviral drugs, vaccines and classic public health interventions against SARS coronavirus

  👤 Oxford, John S. 👤 Balasingam, Shobana 👤 Chan, Charlotte 👤 Catchpole, Andrew 👤 Lambkin, Robert ⏰ 2005 📚 Antiviral Chemistry and Chemotherapy

• Genetic screen for monitoring severe acute respiratory syndrome coronavirus 3C-like protease

  👤 Parera, Mariona 👤 Clotet, Bonaventura 👤 Martinez, Miguel Angel ⏰ 2004 📚 Journal of Virology

• Diarylheptanoids from Alnus japonica inhibit papain-like protease of severe acute respiratory syndrome coronavirus

  👤 Park, Ji Young 👤 Jeong, Hyung Jae 👤 Kim, Jang Hoon 👤 Kim, Young Min 👤 Park, Su Jin 👤 Kim, Doman 👤 Park, Ki Hun 👤 Lee, Woo Song 👤 Ryu, Young Bae ⏰ 2012 📚 Biological and Pharmaceutical Bulletin

• Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors

  👤 Park, Ji Young 👤 Yuk, Heung Joo 👤 Ryu, Hyung Won 👤 Lim, Su Hwan 👤 Kim, Kyung Su 👤 Park, Ki Hun 👤 Ryu, Young Bae 👤 Lee, Woo Song ⏰ 2017 📚 Journal of Enzyme Inhibition and Medicinal Chemistry

• Lipidation increases antiviral activities of coronavirus fusion-inhibiting peptides

  👤 Park, Jung Eun 👤 Gallagher, Tom ⏰ 2017 📚 Virology

• Proteolytic processing of middle east respiratory syndrome coronavirus spikes expands virus tropism

  👤 Park, Jung Eun 👤 Li, Kun 👤 Barlan, Arlene 👤 Fehr, Anthony R. 👤 Perlman, Stanley 👤 McCray, Paul B. 👤 Gallagher, Tom ⏰ 2016 📚 Proceedings of the National Academy of Sciences of the United States of America

• Protease inhibitors broadly effective against feline, ferret and mink coronaviruses

  👤 Perera, Krishani Dinali 👤 Galasiti Kankanamalage, Anushka C. 👤 Rathnayake, Athri D. 👤 Honeyfield, Amanda 👤 Groutas, William 👤 Chang, Kyeong Ok 👤 Kim, Yunjeong ⏰ 2018 📚 Antiviral Research

• Characterization of amino acid substitutions in feline coronavirus 3C-like protease from a cat with feline infectious peritonitis treated with a protease inhibitor

  👤 Perera, Krishani Dinali 👤 Rathnayake, Athri 👤 Liu, Hongwei 👤 Pedersen, Niels C. 👤 Groutas, William C. 👤 Chang, Kyeong Ok 👤 Kim, Yunjeong ⏰ 2019 📚 Veterinary Microbiology

• Neurovirulent murine coronavirus JHM.SD uses cellular zinc metalloproteases for virus entry and cell-cell fusion

  👤 Phillips, Judith M. 👤 Gallagher, Tom 👤 Weiss, Susan R. ⏰ 2017 📚 Journal of Virology

• An overview of severe acute respiratory syndrome-coronavirus (SARS-CoV) 3CL protease inhibitors: Peptidomimetics and small molecule chemotherapy

  👤 Pillaiyar, Thanigaimalai 👤 Manickam, Manoj 👤 Namasivayam, Vigneshwaran 👤 Hayashi, Yoshio 👤 Jung, Sang Hun ⏰ 2016 📚 Journal of Medicinal Chemistry

• Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved property

  👤 Piotrowski, Yvonne 👤 Hansen, Guido 👤 Boomaars-van Der Zanden, A. Linda 👤 Snijder, Eric J. 👤 Gorbalenya, Alexander E. 👤 Hilgenfeld, Rolf ⏰ 2009 📚 Protein Science

• Drug targets for corona virus: A systematic review.

  👤 Prajapat, Manisha 👤 Sarma, Phulen 👤 Shekhar, Nishant 👤 Avti, Pramod 👤 Sinha, Shweta 👤 Kaur, Hardeep 👤 Kumar, Subodh 👤 Bhattacharyya, Anusuya 👤 Kumar, Harish 👤 Bansal, Seema 👤 Medhi, Bikash ⏰ 2020 📚 Indian J Pharmacol

• ADP-ribose-1″-monophosphatase: A conserved coronavirus enzyme that is dispensable for viral replication in tissue culture

  👤 Putics, Ákos 👤 Filipowicz, Witold 👤 Hall, Jonathan 👤 Gorbalenya, Alexander E. 👤 Ziebuhr, John ⏰ 2005 📚 Journal of Virology

• Endosomal proteolysis by cathepsins is necessary for murine coronavirus mouse hepatitis virus type 2 spike-mediated entry

  👤 Qiu, Zhaozhu 👤 Hingley, Susan T. 👤 Simmons, Graham 👤 Yu, Christopher 👤 Das Sarma, Jayasri 👤 Bates, Paul 👤 Weiss, Susan R. ⏰ 2006 📚 Journal of Virology

• Recent development of 3C and 3CL protease inhibitors for anti-coronavirus and anti-picornavirus drug discovery

  👤 Ramajayam, R. 👤 Tan, Kian Pin 👤 Liang, Po Huang ⏰ 2011 📚 Biochemical Society Transactions

• Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors

  👤 Ramajayam, R. 👤 Tan, Kian Pin 👤 Liu, Hun Ge 👤 Liang, Po Huang ⏰ 2010 📚 Bioorganic and Medicinal Chemistry

• Severe acute respiratory syndrome coronavirus papain-like-protease: Structure of a viral deubiquitinating enzyme

  👤 Ratia, Kiira 👤 Saikatendu, Kumar Singh 👤 Santarsiero, Bernard D. 👤 Barreto, Naina 👤 Baker, Susan C. 👤 Stevens, Raymond C. 👤 Mesecar, Andrew D. ⏰ 2006 📚 Proceedings of the National Academy of Sciences of the United States of America

• Structural Bases of Coronavirus Attachment to Host Aminopeptidase N and Its Inhibition by Neutralizing Antibodies

  👤 Reguera, Juan 👤 Santiago, César 👤 Mudgal, Gaurav 👤 Ordoño, Desiderio 👤 Enjuanes, Luis 👤 Casasnovas, José M. ⏰ 2012 📚 PLoS Pathogens

• Predicted Membrane Topology of the Coronavirus Protein E1

  👤 Rottier, Peter J.M. 👤 Niesters, Hubert G.M. 👤 Lenstra, Johannes A. 👤 Van der Zeijst, Bernard A.M. 👤 Welling, Gjalt W. 👤 Welling-Wester, Sytske ⏰ 1986 📚 Biochemistry

• Potential therapies for coronaviruses

  👤 Savarino, Andrea 👤 Bounavoglia, Canio 👤 Norelli, Sandro 👤 Di Trani, Livia 👤 Cassone, Antonio ⏰ 2006 📚 Expert Opinion on Therapeutic Patents

• Processing of the coronavirus MHV-JHM polymerase polyprotein: Identification of precursors and proteolytic products spanning 400 kilodaltons of ORF1a

  👤 Schiller, Jennifer J. 👤 Kanjanahaluethai, Amornrat 👤 Baker, Susan C. ⏰ 1998 📚 Virology

• Severe acute respiratory syndrome coronavirus replication is severely impaired by MG132 due to proteasome-independent inhibition of M-calpain

  👤 Schneider, Martha 👤 Ackermann, Kerstin 👤 Stuart, Melissa 👤 Wex, Claudia 👤 Protzer, Ulrike 👤 Schätzl, Hermann M. 👤 Gilch, Sabine ⏰ 2012 📚 Journal of Virology

• A novel auto-cleavage assay for studying mutational effects on the active site of severe acute respiratory syndrome coronavirus 3C-like protease

  👤 Shan, Yu Fei 👤 Li, Shou Feng 👤 Xu, Gen Jun ⏰ 2004 📚 Biochemical and Biophysical Research Communications

• Study on substrate specificity at sub sites for severe acute respiratory syndrome coronavirus 3CL protease

  👤 Shan, Yu Fei 👤 Xu, Gen Jun ⏰ 2005 📚 Acta Biochimica et Biophysica Sinica

• TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections

  👤 Shen, Li Wen 👤 Mao, Hui Juan 👤 Wu, Yan Ling 👤 Tanaka, Yoshimasa 👤 Zhang, Wen ⏰ 2017 📚 Biochimie

• Mechanism for controlling the dimer-monomer switch and coupling dimerization to catalysis of the severe acute respiratory syndrome coronavirus 3C-like protease

  👤 Shi, Jiahai 👤 Sivaraman, J. 👤 Song, Jianxing ⏰ 2008 📚 Journal of Virology

• Clinical isolates of human coronavirus 229E bypass the endosome for cell entry

  👤 Shirato, Kazuya 👤 Kanou, Kazuhiko 👤 Kawase, Miyuki 👤 Matsuyama, Shutoku ⏰ 2017 📚 Journal of Virology

• Middle east respiratory syndrome coronavirus infection mediated by the transmembrane serine protease TMPRSS2

  👤 Shirato, Kazuya 👤 Kawase, Miyuki 👤 Matsuyama, Shutoku ⏰ 2013 📚 Journal of Virology

• Wild-type human coronaviruses prefer cell-surface TMPRSS2 to endosomal cathepsins for cell entry

  👤 Shirato, Kazuya 👤 Kawase, Miyuki 👤 Matsuyama, Shutoku ⏰ 2018 📚 Virology

• A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry

  👤 Shulla, Ana 👤 Heald-Sargent, Taylor 👤 Subramanya, Gitanjali 👤 Zhao, Jincun 👤 Perlman, Stanley 👤 Gallagher, Tom ⏰ 2011 📚 Journal of Virology

• Different host cell proteases activate the SARS-coronavirus spike-protein for cell-cell and virus-cell fusion

  👤 Simmons, Graham 👤 Bertram, Stephanie 👤 Glowacka, Ilona 👤 Steffen, Imke 👤 Chaipan, Chawaree 👤 Agudelo, Juliet 👤 Lu, Kai 👤 Rennekamp, Andrew J. 👤 Hofmann, Heike 👤 Bates, Paul 👤 Pöhlmann, Stefan ⏰ 2011 📚 Virology

• Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry

  👤 Simmons, Graham 👤 Gosalia, Dhaval N. 👤 Rennekamp, Andrew J. 👤 Reeves, Jacqueline D. 👤 Diamond, Scott L. 👤 Bates, Paul ⏰ 2005 📚 Proceedings of the National Academy of Sciences of the United States of America

• Proteolytic activation of the SARS-coronavirus spike protein: Cutting enzymes at the cutting edge of antiviral research

  👤 Simmons, Graham 👤 Zmora, Pawel 👤 Gierer, Stefanie 👤 Heurich, Adeline 👤 Pöhlmann, Stefan ⏰ 2013 📚 Antiviral Research

• Comparative analysis of the activation of unfolded protein response by spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus HKU1

  👤 Siu, Kam Leung 👤 Chan, Ching Ping 👤 Kok, Kin Hang 👤 Woo, Patrick C.Y. 👤 Jin, Dong Yan ⏰ 2014 📚 Cell and Bioscience

• Steady-state and pre-steady-state kinetic evaluation of severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro cysteine protease: Development of an ion-pair model for catalysis

  👤 Solowiej, James 👤 Thomson, James A. 👤 Ryan, Kevin 👤 Luo, Chun 👤 He, Mingying 👤 Lou, Jihong 👤 Murray, Brion W. ⏰ 2008 📚 Biochemistry

• Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4 - The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)

  👤 St. John, Sarah E. 👤 Tomar, Sakshi 👤 Stauffer, Shaun R. 👤 Mesecar, Andrew D. ⏰ 2015 📚 Bioorganic and Medicinal Chemistry

• Temperature-sensitive mutants and revertants in the coronavirus nonstructural protein 5 protease (3CLpro) define residues involved in long-distance communication and regulation of protease activity

  👤 Stobart, Christopher C. 👤 Lee, Alice S. 👤 Lu, Xiaotao 👤 Denisona, Mark R. ⏰ 2012 📚 Journal of Virology

• Chimeric exchange of coronavirus nsp5 proteases (3CLpro) identifies common and divergent regulatory determinants of protease activity

  👤 Stobart, Christopher C. 👤 Sexton, Nicole R. 👤 Munjal, Havisha 👤 Lu, Xiaotao 👤 Molland, Katrina L. 👤 Tomar, Sakshi 👤 Mesecar, Andrew D. 👤 Denison, Mark R. ⏰ 2013 📚 Journal of Virology

• Characterization of a coronavirus. I. Structural proteins: Effects of preparative conditions on the migration of protein in polyacrylamide gels

  👤 Sturman, Lawrence S. ⏰ 1977 📚 Virology

• Binding site-based classification of coronaviral papain-like proteases

  👤 Sulea, Traian 👤 Lindner, Holger A. 👤 Purisima, Enrico O. 👤 Ménard, Robert ⏰ 2006 📚 Proteins: Structure, Function and Genetics

• Molecular cloning, expression, purification, and mass spectrometric characterization of 3C-like protease of SARS coronavirus

  👤 Sun, Haifang 👤 Luo, Haibin 👤 Yu, Changying 👤 Sun, Tao 👤 Chen, Jing 👤 Peng, Shuying 👤 Qin, Jun 👤 Shen, Jianhua 👤 Yang, Yiming 👤 Xie, Youhua 👤 Chen, Kaixian 👤 Wang, Yuan 👤 Shen, Xu 👤 Jiang, Hualiang ⏰ 2003 📚 Protein Expression and Purification

• Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling

  👤 Sun, Li 👤 Xing, Yaling 👤 Chen, Xiaojuan 👤 Zheng, Yang 👤 Yang, Yudong 👤 Nichols, Daniel B. 👤 Clementz, Mark A. 👤 Banach, Bridget S. 👤 Li, Kui 👤 Baker, Susan C. 👤 Chen, Zhongbin ⏰ 2012 📚 PLoS ONE

• The nsp9 Replicase Protein of SARS-Coronavirus, Structure and Functional Insights

  👤 Sutton, Geoff 👤 Fry, Elizabeth 👤 Carter, Lester 👤 Sainsbury, Sarah 👤 Walter, Tom 👤 Nettleship, Joanne 👤 Berrow, Nick 👤 Owens, Ray 👤 Gilbert, Robert 👤 Davidson, Andrew 👤 Siddell, Stuart 👤 Poon, Leo L.M. 👤 Diprose, Jonathan 👤 Alderton, David 👤 Walsh, Martin 👤 Grimes, Jonathan M. 👤 Stuart, David I. ⏰ 2004 📚 Structure

• Evaluation of homology modeling of the severe acute respiratory syndrome (SARS) coronavirus main protease for structure based drug design

  👤 Takeda-Shitaka, Mayuko 👤 Nojima, Hiroyuki 👤 Takaya, Daisuke 👤 Kanou, Kazuhiko 👤 Iwadate, Mitsuo 👤 Umeyama, Hideaki ⏰ 2004 📚 Chemical and Pharmaceutical Bulletin

• Inhibition of SARS Coronavirus Infection in Vitro with Clinically Approved Antiviral Drugs

  👤 Tan, Emily L.C. 👤 Ooi, Eng Eong 👤 Lin, Chin Yo 👤 Tan, Hwee Cheng 👤 Ling, Ai Ee 👤 Lim, Bing 👤 Stanton, Lawrence W. ⏰ 2004 📚 Emerging Infectious Diseases

• Severe acute respiratory syndrome coronavirus ORF7a inhibits bone marrow stromal antigen 2 virion tethering through a novel mechanism of glycosylation interference

  👤 Taylor, Justin K. 👤 Coleman, Christopher M. 👤 Postel, Sandra 👤 Sisk, Jeanne M. 👤 Bernbaum, John G. 👤 Venkataraman, Thiagarajan 👤 Sundberg, Eric J. 👤 Frieman, Matthew B. ⏰ 2015 📚 Journal of Virology

• A region of the coronavirus infectious bronchitis virus 1a polyprotein encoding the 3C-like protease domain is subject to rapid turnover when expressed in rabbit reticulocyte lysate

  👤 Tibbles, K. W. 👤 Brierley, I. 👤 Cavanagh, D. 👤 Brown, T. D.K. ⏰ 1995 📚 Journal of General Virology

• Ligand-induced dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 protease (3CLpro): Implications for nsp5 regulation and the development of antivirals

  👤 Tomar, Sakshi 👤 Johnston, Melanie L. 👤 John, Sarah E.St 👤 Osswald, Heather L. 👤 Nyalapatla, Prasanth R. 👤 Paul, Lake N. 👤 Ghosh, Arun K. 👤 Denison, Mark R. 👤 Mesecar, Andrew D. ⏰ 2015 📚 Journal of Biological Chemistry

• Rapid Identification of Potential Inhibitors of SARS-CoV-2 Main Protease by Deep Docking of 1.3 Billion Compounds.

  👤 Ton, Anh-Tien 👤 Gentile, Francesco 👤 Hsing, Michael 👤 Ban, Fuqiang 👤 Cherkasov, Artem ⏰ 2020 📚 Mol Inform

• SARS coronavirus anti-infectives.

  👤 Tong, Tommy R. ⏰ 2006 📚 Recent patents on anti-infective drug discovery

• Therapies for coronaviruses. Part 2: Inhibitors of intracellular life cycle

  👤 Tong, Tommy R. ⏰ 2009 📚 Expert Opinion on Therapeutic Patents

• Antiviral Action of Tryptanthrin Isolated from Strobilanthes cusia Leaf against Human Coronavirus NL63.

  👤 Tsai, Yu-Chi 👤 Lee, Chia-Lin 👤 Yen, Hung-Rong 👤 Chang, Young-Sheng 👤 Lin, Yu-Ping 👤 Huang, Su-Hua 👤 Lin, Cheng-Wen ⏰ 2020 📚 Biomolecules

• Heptad repeat-derived peptides block protease-mediated direct entry from the cell surface of severe acute respiratory syndrome coronavirus but not entry via the endosomal pathway

  👤 Ujike, Makoto 👤 Nishikawa, Hiroki 👤 Otaka, Akira 👤 Yamamoto, Naoki 👤 Yamamoto, Norio 👤 Matsuoka, Masao 👤 Kodama, Eiichi 👤 Fujii, Nobutaka 👤 Taguchi, Fumihiro ⏰ 2008 📚 Journal of Virology

• SARS-coronavirus replication/transcription complexes are membrane-protected and need a host factor for activity in vitro

  👤 Van Hemert, Martijn J. 👤 Van Den Worm, Sjoerd H.E. 👤 Knoops, Kèvin 👤 Mommaas, A. Mieke 👤 Gorbalenya, Alexander E. 👤 Snijder, Eric J. ⏰ 2008 📚 PLoS Pathogens

• Neutralization of Enteric Coronaviruses with Escherichia coli Cells Expressing Single-Chain Fv-Autotransporter Fusions

  👤 Veiga, Esteban 👤 De Lorenzo, Víctor 👤 Fernández, Luis Angel ⏰ 2003 📚 Journal of Virology

• SARS coronavirus papain-like protease up-regulates the collagen expression through non-Samd TGF-β1 signaling

  👤 Wang, Ching Ying 👤 Lu, Chien Yi 👤 Li, Shih Wen 👤 Lai, Chien Chen 👤 Hua, Chun Hung 👤 Huang, Su Hua 👤 Lin, Ying Ju 👤 Hour, Mann Jen 👤 Lin, Cheng Wen ⏰ 2017 📚 Virus Research

• Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design

  👤 Wang, Fenghua 👤 Chen, Cheng 👤 Tan, Wenjie 👤 Yang, Kailin 👤 Yang, Haitao ⏰ 2016 📚 Scientific Reports

• Crystallization and preliminary crystallographic study of human coronavirus NL63 main protease in complex with an inhibitor

  👤 Wang, Fenghua 👤 Tan, Yusheng 👤 Li, Huiyan 👤 Chen, Xia 👤 Wang, Jinshan 👤 Li, Shuang 👤 Fu, Sheng 👤 Zhao, Qi 👤 Chen, Cheng 👤 Su, Dan 👤 Yang, Haitao ⏰ 2014 📚 Acta Crystallographica Section F:Structural Biology Communications

• Recent progress in the discovery of inhibitors targeting coronavirus proteases

  👤 Wang, Haofeng 👤 Xue, Song 👤 Yang, Haitao 👤 Chen, Cheng ⏰ 2016 📚 Virologica Sinica

• Structural and biochemical characterization of SADS-CoV papain-like protease 2.

  👤 Wang, Lu 👤 Hu, Weihua 👤 Fan, Chengpeng ⏰ 2020 📚 Protein Sci

• Lack of association between polymorphisms of MASP2 and susceptibility to SARS coronavirus infection

  👤 Wang, Yan 👤 Yan, Jiangwei 👤 Shi, Yuling 👤 Li, Ping 👤 Liu, Chuanxuan 👤 Ma, Qingjun 👤 Yang, Ruifu 👤 Wang, Xiaoyi 👤 Zhu, Lina 👤 Yang, Xiao 👤 Cao, Cheng ⏰ 2009 📚 BMC Infectious Diseases

• Entry from the cell surface of severe acute respiratory syndrome coronavirus with cleaved S protein as revealed by pseudotype virus bearing cleaved S protein

  👤 Watanabe, Rie 👤 Matsuyama, Shutoku 👤 Shirato, Kazuya 👤 Maejima, Masami 👤 Fukushi, Shuetsu 👤 Morikawa, Shigeru 👤 Taguchi, Fumihiro ⏰ 2008 📚 Journal of Virology

• Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus

  👤 Wen, Chih Chun 👤 Kuo, Yueh Hsiung 👤 Jan, Jia Tsrong 👤 Liang, Po Huang 👤 Wang, Sheng Yang 👤 Liu, Hong Gi 👤 Lee, Ching Kuo 👤 Chang, Shang Tzen 👤 Kuo, Chih Jung 👤 Lee, Shoei Sheng 👤 Hou, Chia Chung 👤 Hsiao, Pei Wen 👤 Chien, Shih Chang 👤 Shyur, Lie Fen 👤 Yang, Ning Sun ⏰ 2007 📚 Journal of Medicinal Chemistry

• Molecular determinants of species specificity in the coronavirus receptor aminopeptidase N (CD13): Influence of N-linked glycosylation

  👤 Wentworth, D. E. 👤 Holmes, K. V. ⏰ 2001 📚 Journal of Virology

• Proteolytic activation of the porcine epidemic diarrhea coronavirus spike fusion protein by trypsin in cell culture

  👤 Wicht, Oliver 👤 Li, Wentao 👤 Willems, Lione 👤 Meuleman, Tom J. 👤 Wubbolts, Richard W. 👤 van Kuppeveld, Frank J.M. 👤 Rottier, Peter J.M. 👤 Bosch, Berend Jan ⏰ 2014 📚 Journal of Virology

• The management of coronavirus infections with particular reference to SARS

  👤 Wong, Samson S.Y. 👤 Yuen, Kwok Yung ⏰ 2008 📚 Journal of Antimicrobial Chemotherapy

• In silico analysis of ORF1ab in coronavirus HKU1 genome reveals a unique putative cleavage site of coronavirus HKU1 3C-like protease

  👤 Woo, Patrick C.Y. 👤 Huang, Yi 👤 Lau, Susanna K.P. 👤 Tsoi, Hoi Wah 👤 Yuen, Kwok Yung ⏰ 2005 📚 Microbiology and Immunology

• Comparative analysis of complete genome sequences of three avian coronaviruses reveals a novel group 3c coronavirus

  👤 Woo, Patrick C.Y. 👤 Lau, Susanna K.P. 👤 Lam, Carol S.F. 👤 Lai, Kenneth K.Y. 👤 Huang, Yi 👤 Lee, Paul 👤 Luk, Geraldine S.M. 👤 Dyrting, Kitman C. 👤 Chan, Kwok Hung 👤 Yuen, Kwok Yung ⏰ 2009 📚 Journal of Virology

• Discovery of seven novel mammalian and avian coronaviruses in the genus Deltacoronavirus supports bat coronaviruses as the gene source of Alphacoronavirus and Betacoronavirus and avian coronaviruses as the gene source of Gammacoronavirus and Deltacoronavirus

  👤 Woo, Patrick C.Y. 👤 Lau, Susanna K.P. 👤 Lam, Carol S.F. 👤 Lau, Candy C.Y. 👤 Tsang, Alan K.L. 👤 Lau, John H.N. 👤 Bai, Ru 👤 Teng, Jade L.L. 👤 Tsang, Chris C.C. 👤 Wang, Ming 👤 Zheng, Bo Jian 👤 Chan, Kwok Hung 👤 Yuen, Kwok Yung ⏰ 2012 📚 Journal of Virology

• Comparative analysis of 22 coronavirus HKU1 genomes reveals a novel genotype and evidence of natural recombination in coronavirus HKU1

  👤 Woo, Patrick C.Y. 👤 Lau, Susanna K.P. 👤 Yip, Cyril C.Y. 👤 Huang, Yi 👤 Tsoi, Hoi Wah 👤 Chan, Kwok Hung 👤 Yuen, Kwok Yung ⏰ 2006 📚 Journal of Virology

• More and more coronaviruses: Human coronavirus HKU1

  👤 Woo, Patrick C.Y. 👤 Lau, Susanna K.P. 👤 Yip, Cyril C.Y. 👤 Huang, Yi 👤 Yuen, Kwok Yung ⏰ 2009 📚 Viruses

• Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features

  👤 Woo, Patrick C.Y. 👤 Wang, Ming 👤 Lau, Susanna K.P. 👤 Xu, Huifang 👤 Poon, Rosana W.S. 👤 Guo, Rongtong 👤 Wong, Beatrice H.L. 👤 Gao, Kai 👤 Tsoi, Hoi Wah 👤 Huang, Yi 👤 Li, Kenneth S.M. 👤 Lam, Carol S.F. 👤 Chan, Kwok Hung 👤 Zheng, Bo Jian 👤 Yuen, Kwok Yung ⏰ 2007 📚 Journal of Virology

• Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus

  👤 Wu, Andong 👤 Wang, Yi 👤 Zeng, Cong 👤 Huang, Xingyu 👤 Xu, Shan 👤 Su, Ceyang 👤 Wang, Min 👤 Chen, Yu 👤 Guo, Deyin ⏰ 2015 📚 Virus Research

• Mechanism for controlling the monomer-dimer conversion of SARS coronavirus main protease

  👤 Wu, Cheng Guo 👤 Cheng, Shu Chun 👤 Chen, Shiang Chuan 👤 Li, Juo Yan 👤 Fang, Yi Hsuan 👤 Chen, Yau Hung 👤 Chou, Chi Yuan ⏰ 2013 📚 Acta Crystallographica Section D: Biological Crystallography

• Small molecules targeting severe acute respiratory syndrome human coronavirus

  👤 Wu, Chung Yi 👤 Jan, Jia Tsrong 👤 Ma, Shiou Hwa 👤 Kuo, Chin Jung 👤 Juan, Hsueh Fen 👤 Cheng, Yih Shyun E. 👤 Hsu, Hsien Hua 👤 Huang, Hsuan Cheng 👤 Wu, Douglass 👤 Brik, Ashraf 👤 Liang, Fu Sen 👤 Liu, Rai Shung 👤 Fang, Jim Min 👤 Chen, Shui Tein 👤 Liang, Po Huang 👤 Wong, Chi Huey ⏰ 2004 📚 Proceedings of the National Academy of Sciences of the United States of America

• Glycan shield and fusion activation of a deltacoronavirus spike glycoprotein fine-tuned for enteric infections

  👤 Xiong, Xiaoli 👤 Tortorici, M. Alejandra 👤 Snijder, Joost 👤 Yoshioka, Craig 👤 Walls, Alexandra C. 👤 Li, Wentao 👤 McGuire, Andrew T. 👤 Rey, Félix A. 👤 Bosch, Berend Jan 👤 Veesler, David ⏰ 2018 📚 Journal of Virology

• Structures of two coronavirus main proteases: Implications for substrate binding and antiviral drug design

  👤 Xue, Xiaoyu 👤 Yu, Hongwei 👤 Yang, Haitao 👤 Xue, Fei 👤 Wu, Zhixin 👤 Shen, Wei 👤 Li, Jun 👤 Zhou, Zhe 👤 Ding, Yi 👤 Zhao, Qi 👤 Zhang, Xuejun C. 👤 Liao, Ming 👤 Bartlam, Mark 👤 Rao, Zihe ⏰ 2008 📚 Journal of Virology

• Proteolytic activation of the spike protein at a novel RRRR/S motif is implicated in furin-dependent entry, syncytium formation, and infectivity of coronavirus infectious bronchitis virus in cultured cells

  👤 Yamada, Yoshiyuki 👤 Ding, Xiang Liu ⏰ 2009 📚 Journal of Virology

• HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus

  👤 Yamamoto, Norio 👤 Yang, Rongge 👤 Yoshinaka, Yoshiyuki 👤 Amari, Shinji 👤 Nakano, Tatsuya 👤 Cinatl, Jindrich 👤 Rabenau, Holger 👤 Doerr, Hans Wilhelm 👤 Hunsmann, Gerhard 👤 Otaka, Akira 👤 Tamamura, Hirokazu 👤 Fujii, Nobutaka 👤 Yamamoto, Naoki ⏰ 2004 📚 Biochemical and Biophysical Research Communications

• Drug design targeting the main protease, the Achilles' heel of coronaviruses

  👤 Yang, Haitao 👤 Bartlam, Mark 👤 Rao, Zihe ⏰ 2006 📚 Current Pharmaceutical Design

• Design of wide-spectrum inhibitors targeting coronavirus main proteases

  👤 Yang, Haitao 👤 Xie, Weiqing 👤 Xue, Xiaoyu 👤 Yang, Kailin 👤 Ma, Jing 👤 Liang, Wenxue 👤 Zhao, Qi 👤 Zhou, Zhe 👤 Pei, Duanqing 👤 Ziebuhr, John 👤 Hilgenfeld, Rolf 👤 Kwok, Yung Yuen 👤 Wong, Luet 👤 Gao, Guangxia 👤 Chen, Saijuan 👤 Chen, Zhu 👤 Ma, Dawei 👤 Bartlam, Mark 👤 Rao, Zihe ⏰ 2005 📚 PLoS Biology

• Design and synthesis of cinanserin analogs as severe acute respiratory syndrome coronavirus 3CL protease inhibitors

  👤 Yang, Qingang 👤 Chen, Lili 👤 He, Xuchang 👤 Gao, Zhenting 👤 Shen, Xu 👤 Bai, Donglu ⏰ 2008 📚 Chemical and Pharmaceutical Bulletin

• Synthesis, crystal structure, structure-activity relationships, and antiviral activity of a potent SARS coronavirus 3CL protease inhibitor

  👤 Yang, Syaulan 👤 Chen, Shu Jen 👤 Hsu, Min Feng 👤 Wu, Jen Dar 👤 Tseng, Chien Te K. 👤 Liu, Yu Fan 👤 Chen, Hua Chien 👤 Kuo, Chun Wei 👤 Wu, Chi Shen 👤 Chang, Li Wen 👤 Chen, Wen Chang 👤 Liao, Shao Ying 👤 Chang, Teng Yuan 👤 Hung, Hsin Hui 👤 Shr, Hui Lin 👤 Liu, Cheng Yuan 👤 Huang, Yu An 👤 Chang, Ling Yin 👤 Hsu, Jen Chi 👤 Peters, Clarence J. 👤 Wang, Andrew H.J. 👤 Hsu, Ming Chu ⏰ 2006 📚 Journal of Medicinal Chemistry

• Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease

  👤 Yang, Xingxing 👤 Chen, Xiaojuan 👤 Bian, Guangxing 👤 Tu, Jian 👤 Xing, Yaling 👤 Wang, Yayun 👤 Chen, Zhongbin ⏰ 2014 📚 Journal of General Virology

• Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus

  👤 Yang, Yang 👤 Du, Lanying 👤 Liu, Chang 👤 Wang, Lili 👤 Ma, Cuiqing 👤 Tang, Jian 👤 Baric, Ralph S. 👤 Jiang, Shibo 👤 Li, Fang ⏰ 2014 📚 Proceedings of the National Academy of Sciences of the United States of America

• Two mutations were critical for bat-to-human transmission of middle east respiratory syndrome coronavirus

  👤 Yang, Yang 👤 Liu, Chang 👤 Du, Lanying 👤 Jiang, Shibo 👤 Shi, Zhengli 👤 Baric, Ralph S. 👤 Li, Fang ⏰ 2015 📚 Journal of Virology

• A systematic review of lopinavir therapy for SARS coronavirus and MERS coronavirus-A possible reference for coronavirus disease-19 treatment option.

  👤 Yao, Tian-Tian 👤 Qian, Jian-Dan 👤 Zhu, Wen-Yan 👤 Wang, Yan 👤 Wang, Gui-Qiang ⏰ 2020 📚 J Med Virol

• Human aminopeptidase N is a receptor for human coronavirus 229E

  👤 Yeager, Curtis L. 👤 Ashmun, Richard A. 👤 Williams, Richard K. 👤 Cardellichio, Christine B. 👤 Shapiro, Linda H. 👤 Look, A. Thomas 👤 Holmes, Kathryn V. ⏰ 1992 📚 Nature

• Recent developments in the virology and antiviral research of severe acute respiratory syndrome coronavirus

  👤 Yeung, Kap Sun 👤 Meanwell, Nicholas A. ⏰ 2007 📚 Infectious Disorders - Drug Targets

• Biosynthesis, structure, and biological activities of envelope protein gp65 of murine coronavirus

  👤 Yokomori, Kyoko 👤 La Monica, Nicola 👤 Makino, Shinji 👤 Shieh, Chien Kou 👤 Lai, Michael M.C. ⏰ 1989 📚 Virology

• P53 degradation by a coronavirus papain-like protease suppresses type I interferon signaling

  👤 Yuan, Lin 👤 Chen, Zhongbin 👤 Song, Shanshan 👤 Wang, Shan 👤 Tian, Chunyan 👤 Xing, Guichun 👤 Chen, Xiaojuan 👤 Xiao, Zhi Xiong 👤 He, Fuchu 👤 Zhang, Lingqiang ⏰ 2015 📚 Journal of Biological Chemistry

• Three Main Inducers of Alphacoronavirus Infection of Enterocytes: Sialic Acid, Proteases, and Low pH

  👤 Yuan, Peng 👤 Yang, Zhou 👤 Song, Han 👤 Wang, Kai 👤 Yang, Yang 👤 Xie, Luyi 👤 Huang, Shilei 👤 Liu, Jia 👤 Ran, Lin 👤 Song, Zhenhui ⏰ 2018 📚 Intervirology

• Conformational changes in the spike glycoprotein of murine coronavirus are induced at 37°C either by soluble murine CEACAM1 receptors or by pH 8

  👤 Zelus, Bruce D. 👤 Schickli, Jeanne H. 👤 Blau, Dianna M. 👤 Weiss, Susan R. 👤 Holmes, Kathryn V. ⏰ 2003 📚 Journal of Virology

• Porcine deltacoronavirus enters cells via two pathways: A protease-mediated one at the cell surface and another facilitated by cathepsins in the endosome

  👤 Zhang, Jialin 👤 Chen, Jianfei 👤 Shi, Da 👤 Shi, Hongyan 👤 Zhang, Xin 👤 Liu, Jianbo 👤 Cao, Liyan 👤 Zhu, Xiangdong 👤 Liu, Ye 👤 Wang, Xiaobo 👤 Ji, Zhaoyang 👤 Feng, Li ⏰ 2019 📚 Journal of Biological Chemistry

• Genomic characterization of equine coronavirus

  👤 Zhang, Jianqiang 👤 Guy, James S. 👤 Snijder, Eric J. 👤 Denniston, Doug A. 👤 Timoney, Peter J. 👤 Balasuriya, Udeni B.R. ⏰ 2007 📚 Virology

• Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved alpha-ketoamide inhibitors.

  👤 Zhang, Linlin 👤 Lin, Daizong 👤 Sun, Xinyuanyuan 👤 Curth, Ute 👤 Drosten, Christian 👤 Sauerhering, Lucie 👤 Becker, Stephan 👤 Rox, Katharina 👤 Hilgenfeld, Rolf ⏰ 2020 📚 Science

• Structure of the main protease from a global infectious human coronavirus, HCoV-HKU1

  👤 Zhao, Qi 👤 Li, Shuang 👤 Xue, Fei 👤 Zou, Yilong 👤 Chen, Cheng 👤 Bartlam, Mark 👤 Rao, Zihe ⏰ 2008 📚 Journal of Virology

• Lysosomal proteases are a determinant of coronavirus tropism

  👤 Zheng, Yuan 👤 Shang, Jian 👤 Yang, Yang 👤 Liu, Chang 👤 Wan, Yushun 👤 Geng, Qibin 👤 Wang, Michelle 👤 Baric, Ralph 👤 Li, Fang ⏰ 2018 📚 Journal of Virology

• Without its N-finger, the main protease of severe acute respiratory syndrome coronavirus can form a novel dimer through its C-terminal domain

  👤 Zhong, Nan 👤 Zhang, Shengnan 👤 Zou, Peng 👤 Chen, Jiaxuan 👤 Kang, Xue 👤 Li, Zhe 👤 Liang, Chao 👤 Jin, Changwen 👤 Xia, Bin ⏰ 2008 📚 Journal of Virology

• Identification of novel proteolytically inactive mutations in coronavirus 3C-like protease using a combined approach

  👤 Zhou, Junwei 👤 Fang, Liurong 👤 Yang, Zhixiang 👤 Xu, Shangen 👤 Lv, Mengting 👤 Sun, Zheng 👤 Chen, Jiyao 👤 Wang, Dang 👤 Gao, Jun 👤 Xiao, Shaobo ⏰ 2019 📚 FASEB journal : official publication of the Federation of American Societies for Experimental Biology

• Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors

  👤 Zhou, Lu 👤 Liu, Ying 👤 Zhang, Weilin 👤 Wei, Ping 👤 Huang, Changkang 👤 Pei, Jianfeng 👤 Yuan, Yaxia 👤 Lai, Luhua ⏰ 2006 📚 Journal of Medicinal Chemistry

• Protease inhibitors targeting coronavirus and filovirus entry

  👤 Zhou, Yanchen 👤 Vedantham, Punitha 👤 Lu, Kai 👤 Agudelo, Juliet 👤 Carrion, Ricardo 👤 Nunneley, Jerritt W. 👤 Barnard, Dale 👤 Pöhlmann, Stefan 👤 McKerrow, James H. 👤 Renslo, Adam R. 👤 Simmons, Graham ⏰ 2015 📚 Antiviral Research

• Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease

  👤 Zhu, Lili 👤 George, Shyla 👤 Schmidt, Marco F. 👤 Al-Gharabli, Samer I. 👤 Rademann, Jörg 👤 Hilgenfeld, Rolf ⏰ 2011 📚 Antiviral Research

• Porcine deltacoronavirus nsp5 inhibits interferon-β production through the cleavage of NEMO

  👤 Zhu, Xinyu 👤 Fang, Liurong 👤 Wang, Dang 👤 Yang, Yuting 👤 Chen, Jiyao 👤 Ye, Xu 👤 Foda, Mohamed Frahat 👤 Xiao, Shaobo ⏰ 2017 📚 Virology

• Porcine deltacoronavirus nsp5 antagonizes type I interferon signaling by cleaving STAT2

  👤 Zhu, Xinyu 👤 Wang, Dang 👤 Zhou, Junwei 👤 Pan, Ting 👤 Chen, Jiyao 👤 Yang, Yuting 👤 Lv, Mengting 👤 Ye, Xu 👤 Peng, Guiqing 👤 Fang, Liurong 👤 Xiao, Shaobo ⏰ 2017 📚 Journal of Virology

• Human coronavirus 229E papain-like proteases have overlapping specificities but distinct functions in viral replication

  👤 Ziebuhr, John 👤 Schelle, Barbara 👤 Karl, Nadja 👤 Minskaia, Ekaterina 👤 Bayer, Sonja 👤 Siddell, Stuart G. 👤 Gorbalenya, Alexander E. 👤 Thiel, Volker ⏰ 2007 📚 Journal of Virology

• DESC1 and MSPL activate influenza a viruses and emerging coronaviruses for host cell entry

  👤 Zmora, Pawel 👤 Blazejewska, Paulina 👤 Moldenhauer, Anna Sophie 👤 Welsch, Kathrin 👤 Nehlmeier, Inga 👤 Wu, Qingyu 👤 Schneider, Heike 👤 Pöhlmann, Stefan 👤 Bertram, Stephanie ⏰ 2014 📚 Journal of Virology

• TMPRSS11A activates the influenza A virus hemagglutinin and the MERS coronavirus spike protein and is insensitive against blockade by HAI-1

  👤 Zmora, Pawel 👤 Hoffmann, Markus 👤 Kollmus, Heike 👤 Moldenhauer, Anna Sophie 👤 Danov, Olga 👤 Braun, Armin 👤 Winkler, Michael 👤 Schughart, Klaus 👤 Stefan Pöhlmann, X. ⏰ 2018 📚 Journal of Biological Chemistry

• Expression and purification of SARS coronavirus proteins using SUMO-fusions

  👤 Zuo, Xun 👤 Mattern, Michael R. 👤 Tan, Robin 👤 Li, Shuisen 👤 Hall, John 👤 Sterner, David E. 👤 Shoo, Joshua 👤 Tran, Hiep 👤 Lim, Peter 👤 Sarafianos, Stefan G. 👤 Kazi, Lubna 👤 Navas-Martin, Sonia 👤 Weiss, Susan R. 👤 Butt, Tauseef R. ⏰ 2005 📚 Protein Expression and Purification